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1. 发明授权

US5707647A Adjunctive polymer system for use with medical device 失效
公开(公告)号：US5707647A
公开(公告)日：1998-01-13
申请号：US749029
申请日：1996-11-14
申请人： Richard L. Dunn , Gerald L. Yewey , Jeffrey L. Southard , John E. Urheim
发明人： Richard L. Dunn , Gerald L. Yewey , Jeffrey L. Southard , John E. Urheim
IPC分类号： A61L17/00 , A61K9/00 , A61L15/44 , A61L15/62 , A61L15/64 , A61L17/06 , A61L24/00 , A61L26/00 , A61L27/00 , A61L27/54 , A61L27/58 , A61L29/00 , A61L29/14 , A61L29/16 , A61L31/14 , A61L31/16 , A61L15/22
CPC分类号： A61K9/0024 , A61L15/44 , A61L15/62 , A61L15/64 , A61L17/06 , A61L24/0042 , A61L26/0066 , A61L26/0076 , A61L26/009 , A61L27/54 , A61L27/58 , A61L29/148 , A61L29/16 , A61L31/148 , A61L31/16 , A61L2300/00 , A61L2300/43 , A61L2300/602 , A61L2300/606 , A61L2300/62 , Y10S528/905 , Y10S602/904
摘要： A medical device which is a surgically implantable device coated with an adjunctive polymer system. The adjunctive polymer system forms a solid matrix when introduced into a human or animal body. The adjunctive polymer system can contain a drug or a medicament which is released over time from the solid matrix. The adjunctive polymer system contacts body tissue into which the surgically implantable device is implanted.

2. 发明授权

US5717030A Adjunctive polymer system for use with medical device 失效
标题翻译：用于医疗器械的辅助聚合物系统
公开(公告)号：US5717030A
公开(公告)日：1998-02-10
申请号：US761522
申请日：1996-12-06
申请人： Richard L. Dunn , Gerald L. Yewey , Jeffrey L. Southard , John E. Urheim
发明人： Richard L. Dunn , Gerald L. Yewey , Jeffrey L. Southard , John E. Urheim
IPC分类号： A61L17/00 , A61K9/00 , A61L15/44 , A61L15/62 , A61L15/64 , A61L17/06 , A61L24/00 , A61L26/00 , A61L27/00 , A61L27/54 , A61L27/58 , A61L29/00 , A61L29/14 , A61L29/16 , A61L31/14 , A61L31/16 , A61L15/12
CPC分类号： A61K9/0024 , A61L15/44 , A61L15/62 , A61L15/64 , A61L17/06 , A61L24/0042 , A61L26/0066 , A61L26/0076 , A61L26/009 , A61L27/54 , A61L27/58 , A61L29/148 , A61L29/16 , A61L31/148 , A61L31/16 , A61L2300/00 , A61L2300/43 , A61L2300/602 , A61L2300/606 , A61L2300/62 , Y10S528/905 , Y10S602/904
摘要： A medical device which is a surgically implantable device coated with an adjunctive polymer system. The adjunctive polymer system forms a solid matrix when introduced into a human or animal body. The adjunctive polymer system can contain a drug or a medicament which is released over time from the solid matrix. The adjunctive polymer system contacts body tissue into which the surgically implantable device is implanted.
摘要翻译：一种医疗装置，其是涂覆有辅助聚合物系统的外科可植入装置。辅助性聚合物体系在引入人或动物体内时形成固体基质。辅助性聚合物体系可以含有药物或随时间从固体基质释放的药物。辅助性聚合物系统接触植入了手术植入装置的身体组织。

3. 发明授权

US06809079B2 Compositions and methods for treating female sexual arousal disorder using hydrophobic-calcitonin gene related peptide 失效
标题翻译：使用疏水降钙素基因相关肽治疗女性性觉醒障碍的组合物和方法
公开(公告)号：US06809079B2
公开(公告)日：2004-10-26
申请号：US10041244
申请日：2002-01-08
申请人： Jeffrey L. Southard , Gerald L. Yewey , Gary J. Rosenthal
发明人： Jeffrey L. Southard , Gerald L. Yewey , Gary J. Rosenthal
IPC分类号： A61K3800
CPC分类号： A61K9/0034 , A61K38/23
摘要： The present invention provides a method and composition for the treatment of Female Sexual Arousal Disorder. Calcitonin gene-related peptide, a naturally occurring substance in the human body, is chemically conjugated to a hydrophobic agent thereby increasing its permeability across the skin membrane. When locally applied to female genitalia localized blood flow is promoted thus resulting in increased sexual arousal.
摘要翻译：本发明提供了一种治疗女性性唤醒障碍的方法和组合物。降钙素基因相关肽是人体中天然存在的物质，与疏水剂化学偶联，从而增加其穿过皮肤膜的渗透性。当地方适用于女性生殖器时，会促进局部血流，从而增加性唤起。

4. 发明授权

US5962006A Polymer formulation for prevention of surgical adhesions 失效
标题翻译：用于预防手术粘连的聚合物制剂
公开(公告)号：US5962006A
公开(公告)日：1999-10-05
申请号：US877391
申请日：1997-06-17
申请人： Jeffrey L. Southard , Richard L. Dunn
发明人： Jeffrey L. Southard , Richard L. Dunn
IPC分类号： A61L31/06 , A61K9/08 , A61K47/22 , A61K47/34
CPC分类号： A61L31/06
摘要： The invention is directed to a polymer formulation in which a pharmaceutically acceptable, biocompatible, biodegradable and/or bioerodible, water-coagulable thermoplastic polymer or copolymer which is substantially insoluble in an aqueous medium is dissolved in .epsilon.-caprolactone, a pharmaceutically-acceptable, moderately water-soluble organic solvent. When brought in contact with an aqueous environment, such as body or tissue fluids, the .epsilon.-caprolactone slowly dissipates into the aqueous fluid. As the .epsilon.-caprolactone dissipates, the water-insoluble thermoplastic polymer coagulates to form a flexible matrix. Preferably, the thermoplastic polymer is a copolymer of caprolactone or methylene carbonate and lactide or glycolide monomers. More preferably, the thermoplastic polymer is poly(DL-lactide-co-caprolactone). The polymer formulation may also contain a biologically active agent and/or a rate modifying agents to control the rate of release of the biologically active agent. The invention is also directed to a method of making the pliable matrix and the pliable matrix itself.
摘要翻译：本发明涉及聚合物制剂，其中基本上不溶于水性介质的药学上可接受的，生物相容的，可生物降解的和/或可生物腐蚀的可水凝的热塑性聚合物或共聚物溶解在ε-己内酯中，其药学上可接受的，适度的水溶性有机溶剂。当与诸如身体或组织液体的水性环境接触时，ε-己内酯缓慢地散入到含水流体中。当ε-己内酯消散时，水不溶性热塑性聚合物凝结形成柔性基质。优选地，热塑性聚合物是己内酯或碳酸亚甲酯与丙交酯或乙交酯单体的共聚物。更优选地，热塑性聚合物是聚（DL-丙交酯 - 共 - 己内酯）。聚合物制剂还可含有生物活性剂和/或速率调节剂以控制生物活性剂的释放速率。本发明还涉及一种制造柔韧性基质和柔韧性基体本身的方法。

5. 发明申请

US20080069865A1 Controlled Release Cgrp Delivery Composition for Cardiovascular and Renal Indications 失效
标题翻译：用于心血管和肾脏适应症的控制释放Cgrp递送组成
公开(公告)号：US20080069865A1
公开(公告)日：2008-03-20
申请号：US10586209
申请日：2005-01-13
申请人： Jeffrey L. Southard , George L. Southard
发明人： Jeffrey L. Southard , George L. Southard
IPC分类号： A61K38/23 , A61K31/765 , A61K9/127 , A61K9/50 , A61P9/10
CPC分类号： A61K9/7007 , A61K9/0024 , A61K9/1647 , A61K38/225 , A61K47/60 , A61K47/61
摘要： The present invention provides methods of treating heart failure and improving renal function, and/or preventing the advancement of heart failure into advanced stages, and methods of counteracting ischemia due to a myocardial infarction by providing improved methods of administering a therapeutically effective amount CGRP as a controlled release formulation. The therapies can be administered on an outpatient or inpatient basis and can further be used as maintenance therapies.
摘要翻译：本发明提供了治疗心力衰竭和改善肾功能和/或预防心脏衰竭进展到晚期的方法，以及通过提供治疗有效量的CGRP作为治疗的改进方法来抵抗由于心肌梗塞导致的缺血的方法控释制剂。治疗方法可以门诊或住院治疗，还可作为维持治疗。

6. 发明授权

US5722950A Method for remote delivery of an aerosolized liquid 失效
标题翻译：用于远程传送雾化液体的装置和方法
公开(公告)号：US5722950A
公开(公告)日：1998-03-03
申请号：US476796
申请日：1995-06-07
申请人： Shawn M. Fujita , Jeffrey L. Southard
发明人： Shawn M. Fujita , Jeffrey L. Southard
IPC分类号： A61D7/00 , A61M31/00
CPC分类号： A61D7/00
摘要： The invention provides an apparatus for remote delivery of an aerosolized liquid by laparoscopic technique, a method of delivering an aerosolized liquid into the body of an animal by means of the apparatus, and a kit that contains components of the apparatus.
摘要翻译：本发明提供一种用于通过腹腔镜技术远程传送气雾化液体的装置，通过该装置将气雾化液体输送到动物体内的方法，以及包含该装置的组件的试剂盒。

7. 发明申请

US20090023643A1 Methods For Treating Acute Myocardial Infarction By Administering Calcitonin Gene Related Peptide And Compositions Containing The Same 审中-公开
标题翻译：通过管理降钙素基因相关肽及其组成物治疗急性心肌梗死的方法
公开(公告)号：US20090023643A1
公开(公告)日：2009-01-22
申请号：US10586036
申请日：2005-01-13
申请人： Jeffrey L. Southard , George Lee Southard
发明人： Jeffrey L. Southard , George Lee Southard
IPC分类号： A61K38/17 , A61P9/00
CPC分类号： A61K38/17
摘要： This invention relates to methods of treating acute myocardial infarction by administering calcitonin gene related peptide (CGRP). This invention also relates to preventing an acute myocardial infarction by administering calcitonin gene related peptide (CGRP). This invention further relates to compositions of CGRP for use in such methods. This invention also relates to the use of calcitonin gene related peptide in the manufacture of medicament for treating or preventing an acute myocardial infarction in a subject or for treating a subject suspected of having an acute myocardial infarction.
摘要翻译：本发明涉及通过施用降钙素基因相关肽（CGRP）治疗急性心肌梗死的方法。本发明还涉及通过施用降钙素基因相关肽（CGRP）来预防急性心肌梗死。本发明还涉及用于这些方法的CGRP的组合物。本发明还涉及降钙素基因相关肽在制备用于治疗或预防受试者的急性心肌梗塞或用于治疗疑似患有急性心肌梗死的受试者的药物中的用途。

8. 发明申请

US20110244005A1 CONTROLLED RELEASE CGRP DELIVERY COMPOSITION FOR CARDIOVASCULAR AND RENAL INDICATIONS 审中-公开
标题翻译：用于心血管和肾脏适应症的控制释放CGRP递送组合物
公开(公告)号：US20110244005A1
公开(公告)日：2011-10-06
申请号：US13162285
申请日：2011-06-16
申请人： Jeffrey L. Southard , George L. Southard
发明人： Jeffrey L. Southard , George L. Southard
IPC分类号： A61K9/14 , A61K38/02 , A61P9/10
CPC分类号： A61K9/7007 , A61K9/0024 , A61K9/1647 , A61K38/225 , A61K47/60 , A61K47/61
摘要： The present invention provides methods of treating heart failure and improving renal function, and/or preventing the advancement of heart failure into advanced stages, and methods of counteracting ischemia due to a myocardial infarction by providing improved methods of administering a therapeutically effective amount CGRP as a controlled release formulation. The therapies can be administered on an outpatient or inpatient basis and can further be used as maintenance therapies.
摘要翻译：本发明提供了治疗心力衰竭和改善肾功能和/或预防心脏衰竭进展到晚期的方法，以及通过提供治疗有效量的CGRP作为治疗的改进方法来抵抗由于心肌梗塞导致的缺血的方法控释制剂。治疗方法可以门诊或住院治疗，还可作为维持治疗。

9. 发明授权

US07976847B2 Controlled release CGRP delivery composition for cardiovascular and renal indications 失效
标题翻译：用于心血管和肾脏适应症的受控释放的CGRP递送组合物
公开(公告)号：US07976847B2
公开(公告)日：2011-07-12
申请号：US10586209
申请日：2005-01-13
申请人： Jeffrey L. Southard , George L. Southard
发明人： Jeffrey L. Southard , George L. Southard
IPC分类号： A61K38/23 , A61K9/52
CPC分类号： A61K9/7007 , A61K9/0024 , A61K9/1647 , A61K38/225 , A61K47/60 , A61K47/61
摘要： The present invention provides methods of treating heart failure and improving renal function, and/or preventing the advancement of heart failure into advanced stages, and methods of counteracting ischemia due to a myocardial infarction by providing improved methods of administering a therapeutically effective amount CGRP as a controlled release formulation. The therapies can be administered on an outpatient or inpatient basis and can further be used as maintenance therapies.
摘要翻译：本发明提供了治疗心力衰竭和改善肾功能和/或预防心脏衰竭进展到晚期的方法，以及通过提供治疗有效量的CGRP作为治疗的改进方法来抵抗由于心肌梗塞导致的缺血的方法控释制剂。治疗方法可以门诊或住院治疗，还可作为维持治疗。

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