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1. 发明授权

US06548286B1 Methods for increasing the efficiency of recombinant AAV product 失效
标题翻译：提高重组AAV产品效率的方法
公开(公告)号：US06548286B1
公开(公告)日：2003-04-15
申请号：US09060102
申请日：1998-04-14
申请人： Richard Jude Samulski , Xiao Xiao , Richard Snyder
发明人： Richard Jude Samulski , Xiao Xiao , Richard Snyder
IPC分类号： C12N701
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C12N7/00 , C12N2710/10322 , C12N2710/10343 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143 , C12N2750/14152
摘要： The present invention relates to methods and compositions for increasing the production of high titre stocks of recombinant AAV (rAAV) through regulation of expression of the AAV REP and CAP proteins. The methods and compositions of the invention are based on the observation that the low level expression of the AAV REP protein increases the production of AAV viral capsid protein and efficiency of packaging resulting in production of higher titre recombinant viral stocks. The invention encompasses recombinant AAV vectors that direct the expression of AAV REP and CAP proteins and the use of such vectors for the production of novel stable cell lines capable of generating high titre rAAV vectors. The invention provides methods for regulating the expression of the AAV REP gene at the transcriptional and post-translational level. The methods and compositions of the invention can be used to produce high titre stocks of rAAV which can be used in gene therapy for the purpose of transferring genetic information into appropriate host cells for the management and correction of human diseases including inherited and acquired disorders.
摘要翻译：本发明涉及通过调节AAV REP和CAP蛋白的表达来增加重组AAV（rAAV）的高滴度储备的生产的方法和组合物。本发明的方法和组合基于AAV REP蛋白的低水平表达增加AAV病毒衣壳蛋白的产生和包装效率的观察，导致产生较高滴度的重组病毒种群。本发明包括引导AAV REP和CAP蛋白的表达的重组AAV载体，以及这些载体用于产生能产生高滴度rAAV载体的新型稳定细胞系的用途。本发明提供了在转录和翻译后水平调节AAV REP基因表达的方法。本发明的方法和组合物可用于生产高滴度的rAAV，其可用于基因治疗，以将遗传信息转移到合适的宿主细胞中，用于管理和矫正包括遗传和获得性疾病在内的人类疾病。

2. 发明授权

US07229823B2 Methods for increasing the efficiency of recombinant AAV product 有权
标题翻译：提高重组AAV产品效率的方法
公开(公告)号：US07229823B2
公开(公告)日：2007-06-12
申请号：US10261188
申请日：2002-09-30
申请人： Richard Jude Samulski , Xiao Xiao , Richard Snyder
发明人： Richard Jude Samulski , Xiao Xiao , Richard Snyder
IPC分类号： C12N5/00 , C12N15/00 , C12N15/63 , C12P21/06
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C12N7/00 , C12N2710/10322 , C12N2710/10343 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143 , C12N2750/14152
摘要： The present invention relates to methods and compositions for increasing the production of high titre stocks of recombinant AAV (rAAV) through regulation of expression of the AAV REP and CAP proteins. The methods and compositions of the invention are based on the observation that the low level expression of the AAV REP protein increases the production of AAV viral capsid protein and efficiency of packaging resulting in production of higher titre recombinant viral stocks. The invention encompasses recombinant AAV vectors that direct the expression of AAV REP and CAP proteins and the use of such vectors for the production of novel stable cell lines capable of generating high titre rAAV vectors. The invention provides methods for regulating the expression of the AAV REP gene at the transcriptional and post-translational level. The methods and compositions of the invention can be used to produce high titre stocks of rAAV which can be used in gene therapy for the purpose of transferring genetic information into appropriate host cells for the management and correction of human diseases including inherited and acquired disorders.
摘要翻译：本发明涉及通过调节AAV REP和CAP蛋白的表达来增加重组AAV（rAAV）的高滴度储备的生产的方法和组合物。本发明的方法和组合基于AAV REP蛋白的低水平表达增加AAV病毒衣壳蛋白的产生和包装效率的观察，导致产生较高滴度的重组病毒种群。本发明包括引导AAV REP和CAP蛋白的表达的重组AAV载体，以及这些载体用于产生能产生高滴度rAAV载体的新型稳定细胞系的用途。本发明提供了在转录和翻译后水平调节AAV REP基因表达的方法。本发明的方法和组合物可用于生产高滴度的rAAV，其可用于基因治疗，以将遗传信息转移到合适的宿主细胞中，用于管理和矫正包括遗传和获得性疾病在内的人类疾病。

3. 发明授权

US11303259B2 Method and circuit for bypassing spurious resonance in lumped, distributed and waveguide element networks 有权
公开(公告)号：US11303259B2
公开(公告)日：2022-04-12
申请号：US16689623
申请日：2019-11-20
申请人： Richard Snyder
发明人： Richard Snyder
IPC分类号： H03H7/01
摘要： Disclosed herein are methods and circuits that prevent energy that would produce a spurious resonance from lumped, distributed or waveguide circuit elements by using for example a low pass filter with a cut-off below the first spurious resonance frequency and bypassing the energy at frequencies at or above the first spurious resonance frequency through a secondary path. This secondary path is high pass in nature, with a cutoff substantially similar to the low pass filter. The two paths are combined at the common output, using a lowpass matching network.

4. 发明申请

US20050129924A1 Process of simultaneously molding a plurality of composite shingles 有权
标题翻译：同时成型多个复合瓦片的工艺
公开(公告)号：US20050129924A1
公开(公告)日：2005-06-16
申请号：US10736919
申请日：2003-12-16
申请人： Joong Kim , Thomas MacKinnon , Richard Snyder , Husnu Kalkanoglu , Gregory Jacobs
发明人： Joong Kim , Thomas MacKinnon , Richard Snyder , Husnu Kalkanoglu , Gregory Jacobs
IPC分类号： B29C49/00 , B29C49/04 , B29C49/22 , B29C49/52 , B32B3/26 , E04D1/20 , E04D1/22 , E04D1/24 , E04D1/28
CPC分类号： B29C49/22 , B29C49/04 , B29C49/52 , B29C2793/009 , B29K2075/00 , B29L2031/104 , E04D1/22 , E04D1/24 , E04D1/28 , Y10T428/1376 , Y10T428/24355 , Y10T428/24496 , Y10T428/249981 , Y10T428/249991 , Y10T428/249992
摘要： A process of simultaneously molding either a plurality of composite shingles or double walled shingles or other substantially planar exterior building products is provided, each being comprised of two or more layers of thermoplastic shingle material, such that a weatherable capstock material is provided outside a core material, in the form of a composite parison that is then blow molded in a hollow mold, to produce novel shingles according to the process. Ventilation and/or insulation can be provided to a hollow interior between spaced apart walls of a double walled shingle.
摘要翻译：提供了同时模制多个复合瓦楞板或双层壁板或其他基本上平面的外部建筑产品的方法，每个由两层或更多层热塑性木瓦材料组成，使得在芯材外部提供耐候性的覆盖材料，以复合型坯的形式，然后在中空模具中吹塑成型，以根据该方法产生新颖的带状疱。通风和/或绝缘可以提供给双壁木瓦间隔壁之间的中空内部。

5. 发明申请

US20050283281A1 System and method for vertical flight planning 有权
标题翻译：垂直飞行计划的系统和方法
公开(公告)号：US20050283281A1
公开(公告)日：2005-12-22
申请号：US10871668
申请日：2004-06-21
申请人： Gary Hartmann , Michael Jackson , Brian O'Laughlin , Richard Snyder , Rosa Weber
发明人： Gary Hartmann , Michael Jackson , Brian O'Laughlin , Richard Snyder , Rosa Weber
IPC分类号： G01C21/00 , G05D1/00 , G05D1/06
CPC分类号： G05D1/0607 , G01C21/00
摘要： A method for performing performance prediction with respect to a vertical flight plan. A system performs performance prediction with respect to a vertical flight plan of an aircraft that includes determining which vertical flight plan rules of a plurality of vertical flight rules that have been loaded in a predictions processor are active by monitoring for criteria that are used to initiate or terminate one or more of the vertical flight plan rules. Aircraft state is predicted at waypoints along a lateral flight path in view of active vertical flight plan rules, and the predicted aircraft state is updated within an integrated flight plan database that stores prediction performance data associated with the aircraft's flight.
摘要翻译：一种用于对垂直飞行计划进行性能预测的方法。系统对飞行器的垂直飞行计划执行性能预测，其包括通过监视用于启动的标准来确定已经加载在预测处理器中的多个垂直飞行规则的哪些垂直飞行计划规则是活动的终止一个或多个垂直飞行计划规则。考虑到主动垂直飞行计划规则，沿着侧向飞行路径的航路点预测飞行器状态，并且在集成的飞行计划数据库内更新预测的飞行器状态，该飞行器状态存储与飞行器的飞行相关联的预测演奏数据。

6. 发明授权

US6162269A Filter assembly for cleaning cooling air for engines 失效
标题翻译：用于清洁发动机冷却空气的过滤器组件
公开(公告)号：US6162269A
公开(公告)日：2000-12-19
申请号：US299320
申请日：1999-04-26
申请人： Roy E. Greenlees , Richard Snyder , Kenneth S. Schultz , R. Ryan Greenlees
发明人： Roy E. Greenlees , Richard Snyder , Kenneth S. Schultz , R. Ryan Greenlees
IPC分类号： F01P11/12 , F02B77/00
CPC分类号： F01P11/12 , Y10S55/28
摘要： An engine filter assembly for cleaning cooling air for an internal-combustion engine for use in high-debris environment such as in roofing-removing machines includes a filter housing attached to the machine at a remote position. The filter housing houses a two-stage air filter that consists of a cylindrical-shaped filter element with an outer pre-filter covering. Both the carburetor air inlet and a fan housing leading to the cooling fan on the engine are connected to the filter housing by tubing. A shield protects the engine from direct contact with loose or air-borne materials during the operation of the machine. A thermal sensing device reads the temperature of the engine and automatically shuts down the engine if the temperature rises beyond specification, reducing the chance of engine failure.
摘要翻译：一种用于清洁用于高碎片环境的内燃机的冷却空气的发动机过滤器组件，例如在屋顶除尘机中包括在远程位置附接到机器的过滤器壳体。过滤器壳体容纳两级空气过滤器，其由具有外部预过滤器覆盖物的圆柱形过滤元件组成。化油器空气入口和通向发动机上的冷却风扇的风扇壳都通过管道连接到过滤器壳体。屏蔽罩可保护发动机在机器运行过程中与松散或空气传播的材料直接接触。如果温度升高超过规格，热感测装置读取发动机的温度并自动关闭发动机，减少发动机故障的机会。

7. 发明授权

US6048572A Method and apparatus for making thermochromic battery tester 失效
标题翻译：制造热变色电池测试仪的方法和装置
公开(公告)号：US6048572A
公开(公告)日：2000-04-11
申请号：US140379
申请日：1998-08-26
申请人： James H. Shacklett, III , Philip M. Henry , Richard Snyder
发明人： James H. Shacklett, III , Philip M. Henry , Richard Snyder
IPC分类号： G01R31/36 , H01M2/10 , H01M6/50 , B05D5/12 , B05B7/06
CPC分类号： H01M6/5044 , H01M2/1094 , H01M6/505 , G01R31/3627 , G01R31/3686 , Y10T29/53135
摘要： A battery tester device that may be integrated into a label of battery. The battery tester device includes first dielectric layer, a conductive layer adjacent the first dielectric layer, a temperature sensitive indicator layer in thermal contact with the conductive layer, and thermal insulation adjacent the conductive layer. The thermal insulation includes a second dielectric layer and thermally insulative material combined with the second dielectric layer for enhancing the structural strength of the second dielectric layer.
摘要翻译：可以集成到电池标签中的电池测试仪器。电池测试装置包括第一电介质层，与第一电介质层相邻的导电层，与导电层热接触的温度敏感指示层和与导电层相邻的热绝缘。热绝缘体包括与第二电介质层结合的第二电介质层和绝热材料，用于增强第二电介质层的结构强度。

8. 发明申请

US20200177150A1 Method and Circuit for Bypassing Spurious Resonance in Lumped, Distributed and Waveguide Element Networks 审中-公开
公开(公告)号：US20200177150A1
公开(公告)日：2020-06-04
申请号：US16689623
申请日：2019-11-20
申请人： Richard Snyder
发明人： Richard Snyder
IPC分类号： H03H7/01
摘要： Disclosed herein are methods and circuits that prevent energy that would produce a spurious resonance from lumped, distributed or waveguide circuit elements by using for example a low pass filter with a cut-off below the first spurious resonance frequency and bypassing the energy at frequencies at or above the first spurious resonance frequency through a secondary path. This secondary path is high pass in nature, with a cutoff substantially similar to the low pass filter. The two paths are combined at the common output, using a lowpass matching network.

9. 发明授权

US08341679B2 Intelligent device system and method for distribution of digital signals on a wideband signal distribution system 有权
标题翻译：用于在宽带信号分配系统上分配数字信号的智能设备系统和方法
公开(公告)号：US08341679B2
公开(公告)日：2012-12-25
申请号：US12564663
申请日：2009-09-22
申请人： Earl Hennenhoefer , Richard Snyder , Robert Stine
发明人： Earl Hennenhoefer , Richard Snyder , Robert Stine
IPC分类号： H04N7/16 , H04J3/16 , H04N7/173 , H04J3/24
CPC分类号： H04N21/43632 , H04H20/63 , H04L5/143 , H04N7/106 , H04N7/108 , H04N7/17309 , H04N21/2143 , H04N21/23 , H04N21/2365 , H04N21/2383 , H04N21/239 , H04N21/2408 , H04N21/4347 , H04N21/43637 , H04N21/437 , H04N21/4382 , H04N21/44245 , H04N21/64738
摘要： A plurality of intelligent device systems for use with a wideband signal distribution network, and methods for transmitting digital information and receiving digital and non-digital information onto and off of an RF carrier through a wideband signal distribution network, are disclosed. The intelligent device systems provide networks of intelligent devices that modulate and demodulate digital video, IP video/data/voice and digital wireless onto, and off of, a wideband signal distribution system, such as an analog carrier system, using existing EIA/TIA 568 standard wiring infrastructure. The methods modulate and demodulate digital video, IP video/data/voice and digital wireless onto, and off of, a wideband distribution system, such as an analog carrier system, and separate IP portions from non-IP portions.
摘要翻译：公开了一种用于宽带信号分配网络的多个智能设备系统，以及用于通过宽带信号分配网络发送数字信息并将数字和非数字信息接收到RF载波上和从RF载波接收的方法。智能设备系统提供智能设备网络，其将数字视频，IP视频/数据/语音和数字无线调制和解调到使用现有EIA / TIA 568的宽带信号分配系统（例如模拟载波系统）上标准接线基础设施。该方法将数字视频，IP视频/数据/语音和数字无线调制和解调到诸如模拟载波系统之类的宽带分配系统，以及与非IP部分分开的IP部分。

10. 发明申请

US20060214336A1 Composite building product 失效
标题翻译：复合建筑产品
公开(公告)号：US20060214336A1
公开(公告)日：2006-09-28
申请号：US11390590
申请日：2006-03-28
申请人： Joong Kim , Thomas MacKinnon , Richard Snyder , Husnu Kalkanoglu , Gregory Jacobs
发明人： Joong Kim , Thomas MacKinnon , Richard Snyder , Husnu Kalkanoglu , Gregory Jacobs
IPC分类号： B29C45/14
CPC分类号： B29C49/22 , B29C49/04 , B29C49/52 , B29C2793/009 , B29K2075/00 , B29L2031/104 , E04D1/22 , E04D1/24 , E04D1/28 , Y10T428/1376 , Y10T428/24355 , Y10T428/24496 , Y10T428/249981 , Y10T428/249991 , Y10T428/249992
摘要： A simultaneously molded plurality of composite shingles or double walled shingles or other substantially planar exterior building products are provided, each being comprised of two or more layers of thermoplastic shingle material, such that a weatherable capstock material is provided outside a core material, in the form of a composite parison that is then blow molded in a hollow mold, to produce novel shingles. Ventilation and/or insulation can be provided to a hollow interior between spaced apart walls of a double walled shingle.
摘要翻译：提供了同时成型的多个复合瓦片或双层壁板或其它基本上平面的外部建筑产品，每个由两层或更多层热塑性瓦片材料组成，使得在核心材料外部提供耐候性覆盖材料，形式的复合型坯，然后在中空模具中吹塑，以产生新颖的带状疱疹。通风和/或绝缘可以提供给双壁木瓦间隔壁之间的中空内部。

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