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1. 发明授权

US4622330A Antiprotozoal 3-amino or substituted amino pyrazoles 失效
标题翻译：抗原雄激素3-氨基或取代的氨基吡唑
公开(公告)号：US4622330A
公开(公告)日：1986-11-11
申请号：US622337
申请日：1984-06-19
申请人： Richard J. Bochis , Richard A. Dybas , Edward F. Rogers
发明人： Richard J. Bochis , Richard A. Dybas , Edward F. Rogers
IPC分类号： A23K1/16 , C07D231/38 , A01N43/56 , A01N43/78 , C07D231/52 , C07D417/04
CPC分类号： C07D231/38 , A23K20/137
摘要： Novel 3-amino or substituted amino pyrazoles are disclosed as having antiprotozoal and antiparasitic activity in particular anticoccidial activity and are useful for controlling cecal and or intestinal coccidiosis when administered in minor quantities to animals, in particular to poultry usually in admixture with animal sustenance.
摘要翻译：新的3-氨基或取代的氨基吡唑被公开为具有特异抗球虫活性的抗原虫和抗寄生虫活性，并且当以少量施用于动物，特别是通常与动物饲养物混合的家禽时，可用于控制盲肠和/或肠球虫病。

2. 发明授权

US3957997A Anticoccidial complexes of 4,4'-dinitrocarbanilides 失效
标题翻译： 4,4（40-二硝基苯甲酰胺）的抗球虫复合物
公开(公告)号：US3957997A
公开(公告)日：1976-05-18
申请号：US509380
申请日：1974-09-26
申请人： Edward F. Rogers , Richard A. Dybas , John Hannah
发明人： Edward F. Rogers , Richard A. Dybas , John Hannah
IPC分类号： A61K31/44 , A61K31/505 , C07D213/69 , C07D215/22 , C07D215/227 , C07D239/36
CPC分类号： C07D213/69 , A61K31/44 , A61K31/505 , C07D215/227 , C07D239/36
摘要： Substituted 2- and 4-pyridones, pyrimidin-2- and 6-ones and tetrahydroquinolones when complexed with 4,4'-dinitrocarbanilide provide agents which are active coccidiostats and which produce minimal toxic side effects. Processes for the preparation of these complexes as well as compositions suitable for administration to poultry for the prevention and cure of coccidiosis are also disclosed.
摘要翻译：当与4,4'-二硝基苯甲酰胺络合时，取代的2-和4-吡啶酮，嘧啶-2-酮和四氢喹诺酮提供作为活性球虫抑制剂并且产生最小的毒副作用的药剂。还公开了用于制备这些复合物的方法以及适于给予家禽以预防和治愈球虫病的组合物。

3. 发明授权

US4044133A Anticoccidial compositions 失效
标题翻译：抗球虫组合物
公开(公告)号：US4044133A
公开(公告)日：1977-08-23
申请号：US623183
申请日：1975-10-16
申请人： Edward F. Rogers , John Hannah , Richard A. Dybas
发明人： Edward F. Rogers , John Hannah , Richard A. Dybas
IPC分类号： C07D495/04 , A61K31/505
CPC分类号： C07D495/04
摘要： Novel compounds of the following formula: ##STR1## wherein R' is alkyl of 1 to 3 carbon atoms, X.sup.- is a nontoxic anion; b and c are positive numbers having values such that the positive charge of b moles of cation are neutralized by c moles of anion X.sup.- ; and -.sup.+ is a bicyclic heterocyclic base, of the group consisting of: ##STR2## wherein the dotted lines indicates that the methyl group can be present or a hydrogen group can be present, with the proviso that the two alpha methyl groups are not present at the same time, but that one alpha methyl group is required. These compounds have superior coccidiostatic activity.
摘要翻译：下式的新型化合物：其中R'是1至3个碳原子的烷基，X是无毒阴离子; b和c是正数，其值使得b摩尔阳离子的正电荷被c摩尔阴离子X + 31 {L; 和+是双环杂环碱，由以下组成的组：A + TR B + TR C 其中虚线表示甲基可以存在或可以存在氢基团，条件是两个α甲基不同时存在，但需要一个α甲基。这些化合物具有优异的抗球虫抑制活性。

4. 发明授权

US4017505A 1-(N-Octylthiocarbonyl)-2-(4-thiazolyl)benzimidazole 失效
标题翻译： 1-（N-辛基硫代羰基）-2-（4-噻唑基）苯并咪唑
公开(公告)号：US4017505A
公开(公告)日：1977-04-12
申请号：US625335
申请日：1975-10-23
申请人： Edward F. Rogers , Wallace T. Ashton , Richard A. Dybas
发明人： Edward F. Rogers , Wallace T. Ashton , Richard A. Dybas
IPC分类号： C07D417/04 , C07D417/00
CPC分类号： C07D417/04
摘要： New benzimidazoles substituted at the 1-position with carbonyl substituents and at the 2-position with a 4-thiazolyl group are effective fungicides and anthelmintics. The compounds as well as processes for their preparation are described along with antifungal and anthelmintic compositions for their use. The 1-position substituent is a hydrocarbon group of from 5 to 12 carbon atoms connected to the carbonyl group through an oxygen or a sulfur atom. The compounds are generally prepared by contacting a 1-unsubstituted benzimidazole with a hydrocarbon radical substituted chloroformate or chlorothiol formate.
摘要翻译：在1-位被羰基取代基取代的2-苯并咪唑和2-噻唑基的2-位是有效的杀真菌剂和驱肠虫剂。该化合物及其制备方法与抗真菌和驱虫剂组合物一起使用。 1位取代基是通过氧或硫原子连接到羰基的5至12个碳原子的烃基。通常通过使1-未取代的苯并咪唑与烃基取代的氯甲酸酯或氯代硫代甲酸酯接触来制备化合物。

5. 发明授权

US4006143A Heterocyclic substituted pyrimidine compounds 失效
标题翻译：杂环取代嘧啶化合物
公开(公告)号：US4006143A
公开(公告)日：1977-02-01
申请号：US623211
申请日：1975-10-16
申请人： Edward F. Rogers , John Hannah , Richard A. Dybas
发明人： Edward F. Rogers , John Hannah , Richard A. Dybas
IPC分类号： C07D495/04 , C07D401/14
CPC分类号： C07D495/04
摘要： Novel compounds of the following formula: ##STR1## WHEREIN R' is alkyl of 1 to 3 carbon atoms, X.sup.- is a nontoxic anion; b and c are positive numbers having values such that the positive charge of b moles of cation are neutralized by c moles of anion X.sup.-; and -N is a bicyclic heterocyclic base, of the group consisting of: ##STR2## wherein the dotted line indicates that the methyl group can be present or a hydrogen group can be present, with the proviso that the two alpha methyl groups are not present at the same time, but that one alpha methyl group is required. These compounds have superior coccidiostatic activity.
摘要翻译：下式的新化合物：其中R 1为1至3个碳原子的烷基，X 1为无毒阴离子; b和c是具有这样的值的正数，使得b摩尔阳离子的正电荷被C摩尔阴离子X 1中和; 并且-N是双环杂环碱，由以下组成的组：其中虚线表示甲基可以存在或可以存在氢基，其中条件是两个α甲基不同时存在，但需要一个α甲基。这些化合物具有优异的抗球虫抑制活性。

6. 发明授权

US4739113A Bis(cyclopropanecarboxamido)alkadienedioic acids as renal dipeptidase inhibitors 失效
标题翻译：双（环丙烷甲酰氨基）链烷二酸作为肾二肽酶抑制剂
公开(公告)号：US4739113A
公开(公告)日：1988-04-19
申请号：US868472
申请日：1986-05-30
申请人： Wallace T. Ashton , Anna Chen , Edward F. Rogers
发明人： Wallace T. Ashton , Anna Chen , Edward F. Rogers
IPC分类号： A61K31/16 , A61K31/195 , A61P43/00 , C07C67/00 , C07C231/00 , C07C233/12 , C07C233/63 , C07C103/737 , A61K31/19 , A61K31/215
CPC分类号： A61K31/195 , C07C233/12
摘要： Novel chemical compounds are provided which selectively inhibit the metabolism of renal dipeptidase (E.C.3.4.13.11) and therefore are useful in combination with antibacterial products. These chemical compounds are (Z,Z)-.alpha.,.alpha.'-bis(2,2-disubstituted cyclopropanecarboxamido)-.alpha.,.alpha.'-alkadienedioic acids.

7. 发明授权

US4053602A Compositions for treating coccidiosis containing 5-deazariboflavin and its derivatives 失效
标题翻译：用于治疗含有5-二氮唑吗啉及其衍生物的结肠病的组合物
公开(公告)号：US4053602A
公开(公告)日：1977-10-11
申请号：US737890
申请日：1976-11-02
申请人： Donald W. Graham , Edward F. Rogers , Wallace T. Ashton
发明人： Donald W. Graham , Edward F. Rogers , Wallace T. Ashton
IPC分类号： C07D471/04 , A23K1/16 , A61K31/505 , A61K31/675 , A61P33/02
CPC分类号： A61K31/505 , A23K20/116 , A61K31/675
摘要： 5-Deazariboflavin, its phosphate ester and non-toxic salts thereof and its novel bis(loweralkoxymethylene) derivatives have antiprotozoal and antiparasitic activity. They are particularly useful for controlling cecal and/or intestinal coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with animal sustenance. The compounds are included in compositions useful for the prevention and treatment of coccidiosis in poultry.
摘要翻译： 5-脱氮甲黄蛋白，其磷酸酯和无毒盐及其新型双（低级烷氧基亚甲基）衍生物具有抗原虫和抗寄生虫活性。当少量给予动物，特别是通常与动物饲养物混合的家禽时，它们特别有用于控制盲肠和/或肠球虫病。该化合物包括在用于预防和治疗家禽中的球虫病的组合物中。

8. 发明授权

US4079069A 5-Deazariboflavin and its derivatives 失效
标题翻译： 5-deazariboflavin及其衍生物
公开(公告)号：US4079069A
公开(公告)日：1978-03-14
申请号：US794771
申请日：1977-05-09
申请人： Donald W. Graham , Edward F. Rogers , Wallace T. Ashton
发明人： Donald W. Graham , Edward F. Rogers , Wallace T. Ashton
IPC分类号： C07D471/04 , A23K1/16 , A61K31/505 , A61K31/675 , A61P33/02 , C07D521/00
CPC分类号： A61K31/505 , A23K20/116 , A61K31/675
摘要： 5-Deazariboflavin, its phosphate ester and nontoxic salts thereof and its novel bis(loweralkoxymethylene) derivatives have antiprotozoal and antiparasitic activity. They are particularly useful for controlling cecal and/or intestinal coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with animal sustenance. The compounds are included in compositions useful for the prevention and treatment of coccidiosis in poultry.

9. 发明授权

US4017504A Antifungal 1-substituted benzimidazoles 失效
标题翻译：抗真菌剂1-取代苯并咪唑
公开(公告)号：US4017504A
公开(公告)日：1977-04-12
申请号：US586439
申请日：1975-06-12
申请人： Wallace T. Ashton , Edward F. Rogers
发明人： Wallace T. Ashton , Edward F. Rogers
IPC分类号： C07C59/01 , C07D417/00
CPC分类号： C07C59/01
摘要： New water soluble benzimidazoles with a high degree of stability, which are substituted at the 1-position with carboxyalkoxycarbonyl substituents and at the 2-position with a 4-thiazolyl group are effective fungicides and anthelmintics. The compounds as well as processes for their preparation are described along with antifungal and anthelmintic compositions for their use. The 1-position substituent is a carboxyalkoxycarbonyl group of from 3 to 11 carbon atoms including certain salts and derivatives of the carboxy group. The compounds are generally prepared by contacting a 1-unsubstituted benzimidazole with a protected carboxyalkoxycarbonyl chloride.
摘要翻译：具有高度稳定性的新的水溶性苯并咪唑在1-位被羧基烷氧基羰基取代基取代，在2-位被4-噻唑基取代是有效的杀真菌剂和驱肠虫剂。该化合物及其制备方法与抗真菌和驱虫剂组合物一起使用。 1-位取代基是含有3-11个碳原子的羧基烷氧基羰基，包括某些盐和羧基衍生物。通常通过使1-未取代的苯并咪唑与受保护的羧基烷氧基羰基氯接触来制备化合物。

10. 发明授权

US4290966A Process for the preparation of traumatin 失效
标题翻译：制备创伤剂的方法
公开(公告)号：US4290966A
公开(公告)日：1981-09-22
申请号：US193790
申请日：1980-10-03
申请人： Jeannette E. Brown , Edward F. Rogers , Donald W. Graham
发明人： Jeannette E. Brown , Edward F. Rogers , Donald W. Graham
IPC分类号： C07C59/76 , C07D317/30 , C11C1/00
CPC分类号： C07D317/30 , C07C59/76
摘要： Traumatin, 12-oxo-trans (E) -10-docecenoic acid, is prepared from 10-oxomethyldecanoate by reaction with (triphenylphosphoranylene)acetaldehyde to form 12-oxomethyldodecenoate; blocking the 12-oxo group; hydrolyzing the ester group; and deblocking the 12-oxo group.
摘要翻译：通过与（三苯基亚磷酰）乙醛反应，由10-氧代甲基癸酸酯制备外消旋，12-氧代 - 反式（E）-10-十六烯酸，形成十二碳烯酸12-氧代甲酯; 封闭了12个氧代基团; 水解酯基; 并将12-氧代基团解封。

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