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1. 发明授权

US06649647B1 Trioxane derivatives 有权
标题翻译：三恶烷衍生物
公开(公告)号：US06649647B1
公开(公告)日：2003-11-18
申请号：US09743860
申请日：2002-04-15
申请人： Richard Haynes , Ho-Wai Chan , Wai-Lun Lam , Hing-Wo Tsang , Wen-Luan Hsiao , Hans-Georg Lerchen , Jörg Baumgarten
发明人： Richard Haynes , Ho-Wai Chan , Wai-Lun Lam , Hing-Wo Tsang , Wen-Luan Hsiao , Hans-Georg Lerchen , Jörg Baumgarten
IPC分类号： A61K31357
CPC分类号： C07D491/20 , C07D493/20
摘要： This invention relates to compounds containing a trioxane moiety, especially certain artemisinin derivatives, which have cytotoxic and antitumour activity and their use in the treatment of cancer. Some of these compounds comprise a ligand which is capable of binding to a nucleic acid and a group containing a trioxane moiety which is capable of acting as source of free radicals which are capable of chemically interacting with a nucleic acid. Processes for the preparation of such compounds and pharmaceutical compositions containing such compounds are also provided.
摘要翻译：本发明涉及含有三恶烷部分的化合物，特别是具有细胞毒性和抗肿瘤活性的某些青蒿素衍生物，以及它们在治疗癌症中的用途。这些化合物中的一些包括能够结合核酸的配体和含有能够作为与核酸发生化学相互作用的自由基源的三氧杂环己烷部分的基团。还提供了制备这些化合物的方法和含有这些化合物的药物组合物。

2. 发明申请

US20070191354A1 Antiparasitic artemisinin derivatives (endoperoxides) 失效
标题翻译：抗寄生虫青蒿素衍生物（内过氧化物）
公开(公告)号：US20070191354A1
公开(公告)日：2007-08-16
申请号：US11329297
申请日：2006-01-09
申请人： Richard Haynes , William Lam , Ho-Wai Chan , Hing-Wo Tsang , Man-Ki Cheung , Gisela Greif , Gabriele Schmuck , Arnd Voerste
发明人： Richard Haynes , William Lam , Ho-Wai Chan , Hing-Wo Tsang , Man-Ki Cheung , Gisela Greif , Gabriele Schmuck , Arnd Voerste
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/404 , A61K31/353 , C07D493/14
CPC分类号： A61K31/355 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/452 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D493/18 , Y02A50/411
摘要： This invention relates to the use of certain C-10 substituted derivatives of artemisinin of general formula (I) in the treatment and/or prophylaxis of diseases caused by infection with a parasite, certain novel C-10 substitued derivatives of artemisinin, processes for their preparation and pharmaceutical compositions containing such C-10 substituted derivatives. The compounds are particularly effective in the treatment of malaria, neosporosis and coccidiosis.
摘要翻译：本发明涉及通式（I）的青蒿素的某些C-10取代衍生物在治疗和/或预防由寄生虫感染引起的疾病，某些新陈代谢的青蒿素C-10衍生物中的应用，含有这种C-10取代衍生物的制剂和药物组合物。这些化合物在治疗疟疾，新孢子虫病和球虫病方面特别有效。

3. 发明申请

US20060287305A1 Antiparasitic artemisinin derivatives (endoperoxides) 审中-公开
标题翻译：抗寄生虫青蒿素衍生物（内过氧化物）
公开(公告)号：US20060287305A1
公开(公告)日：2006-12-21
申请号：US11329275
申请日：2006-01-09
申请人： Richard Haynes , William Lam , Ho-Wai Chan , Hing-Wo Tsang , Man-Ki Cheung , Gisela Greif , Gabriele Schmuck , Arnd Voerste
发明人： Richard Haynes , William Lam , Ho-Wai Chan , Hing-Wo Tsang , Man-Ki Cheung , Gisela Greif , Gabriele Schmuck , Arnd Voerste
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/405 , A61K31/353 , C07D493/14
CPC分类号： A61K31/355 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/452 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D493/18 , Y02A50/411
摘要： This invention relates to the use of certain C-10 substituted derivatives of artemisinin of general formula (I) in the treatment and/or prophylaxis of diseases caused by infection with a parasite, certain novel C-10 substitued derivatives of artemisinin, processes for their preparation and pharmaceutical compositions containing such C-10 substituted derivatives. The compounds are particularly effective in the treatment of malaria, neosporosis and coccidiosis.
摘要翻译：本发明涉及通式（I）的青蒿素的某些C-10取代衍生物在治疗和/或预防由寄生虫感染引起的疾病，某些新陈代谢的青蒿素C-10衍生物中的应用，含有这种C-10取代衍生物的制剂和药物组合物。这些化合物在治疗疟疾，新孢子虫病和球虫病方面特别有效。

4. 发明申请

US20070021409A1 Antiparasitic artemisinin derivatives (endoperoxides) 失效
公开(公告)号：US20070021409A1
公开(公告)日：2007-01-25
申请号：US11329274
申请日：2006-01-09
申请人： Richard Haynes , William Lam , Ho-Wai Chan , Hing-Wo Tsang , Man-Ki Cheung , Gisela Greif , Gabriele Schmuck , Arnd Voerste
发明人： Richard Haynes , William Lam , Ho-Wai Chan , Hing-Wo Tsang , Man-Ki Cheung , Gisela Greif , Gabriele Schmuck , Arnd Voerste
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/452 , A61K31/427 , A61K31/422 , A61K31/4178 , A61K31/4025 , A61K31/355 , C07D493/14
CPC分类号： A61K31/355 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/452 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D493/18 , Y02A50/411
摘要： This invention relates to the use of certain C-10 substituted derivatives of artemisinin of general formula (I) in the treatment and/or prophylaxis of diseases caused by infection with a parasite, certain novel C-10 substitued derivatives of artemisinin, processes for their preparation and pharmaceutical compositions containing such C-10 substituted derivatives. The compounds are particularly effective in the treatment of malaria, neosporosis and coccidiosis.

5. 发明授权

US4033833A Method of selectively electroplating an area of a surface 失效
标题翻译：选择性地电镀表面区域的方法
公开(公告)号：US4033833A
公开(公告)日：1977-07-05
申请号：US703326
申请日：1976-07-08
申请人： John Louis Bestel , Richard Haynes , Venkataraman Srinivasan
发明人： John Louis Bestel , Richard Haynes , Venkataraman Srinivasan
IPC分类号： C25D5/02 , C25D5/08 , C25D7/00 , H05K3/24
CPC分类号： C25D5/02 , C25D5/08 , H01L2924/0002 , H05K3/241 , H05K3/243 , Y10S204/07
摘要： A method of selectively plating an area of a substrate surface is disclosed. The method comprises contact masking at least one charged anode, spaced from the surface, with a dielectric member which is maintained between the anode and the surface, along their corresponding opposed surface areas, out of contact with the surface. The surface is cathodically charged. The masked anode is contacted with a stream of an electroplating electrolyte. The stream of electrolyte then contacts at least a portion of the charged surface, including the area to be plated, to fully flow electrolyte thereover to selectively electroplate the area.
摘要翻译：公开了一种选择性地电镀衬底表面区域的方法。所述方法包括：与表面间隔开的至少一个带电荷的阳极与电介质构件接触掩蔽，所述绝缘构件沿其相应的对置表面区域保持在阳极和表面之间，与表面不接触。表面是阴极充电的。掩蔽的阳极与电镀电解液的流接触。然后，电解液流接触带电表面的至少一部分，包括待镀覆的区域，以便在其上完全流动电解质以选择性地电镀该区域。

6. 发明授权

US4443305A Emulsion electrowinning 失效
标题翻译：乳液电解冶金
公开(公告)号：US4443305A
公开(公告)日：1984-04-17
申请号：US490602
申请日：1983-05-02
申请人： Richard Haynes
发明人： Richard Haynes
IPC分类号： C25C1/00
CPC分类号： C25C1/00
摘要： A process of electrodepositing a metal from an organic phase containing a salt or complex of that metal includes the steps of creating a dispersion of the organic phase in a conducting aqueous electrolyte with which it is immiscible and electrodepositing the metal onto a cathode which is immersed in the organic phase or the dispersion.
摘要翻译：从包含该金属的盐或络合物的有机相中电沉积金属的方法包括以下步骤：在导电的含水电解质中形成有机相的分散体，其与其不混溶并将金属电沉积到浸入有机相或分散体。

7. 发明申请

US20060043916A1 Motor system having multiple motor torque constants 审中-公开
标题翻译：电机系统具有多个电机转矩常数
公开(公告)号：US20060043916A1
公开(公告)日：2006-03-02
申请号：US10932670
申请日：2004-09-01
申请人： Mark Henslee , Richard Haynes , John Gamble
发明人： Mark Henslee , Richard Haynes , John Gamble
IPC分类号： H02P7/00
CPC分类号： H02P25/18
摘要： A variable speed electric motor to drive a variable load over a substantially continuous range of speed. The motor has a plurality of winding combinations that may be switched into and out of the motor circuit. A torque controller selects the winding combination in response to motor speed to deliver torque efficiently to the load throughout the speed range.
摘要翻译：一种变速电动机，用于在基本连续的速度范围内驱动可变负载。马达具有可以被切换到马达回路中的多个绕组组合。扭矩控制器根据电机速度选择绕组组合，以便在整个速度范围内有效地向负载提供扭矩。

8. 发明授权

US06928756B1 Jump assisting spring heel shoe 失效
标题翻译：跳跃辅助弹力脚跟鞋
公开(公告)号：US06928756B1
公开(公告)日：2005-08-16
申请号：US10378314
申请日：2003-03-03
申请人： Richard Haynes
发明人： Richard Haynes
IPC分类号： A43B13/18 , A43B13/28 , A43B21/30
CPC分类号： A43B13/183
摘要： A shoe includes a shoe top structure secured to a sole having a sole forward segment for making contact with a shoe support surface such as the floor of a basketball court, and a sole rearward segment which arches upwardly and then extends rearwardly from the sole forward segment to be spaced above the shoe support surface, and including a heel in the form of a heel panel mounted beneath the sole rearward segment, and including spring means biasing the heel panel downwardly a certain distance from the sole rearward segment to define a vertical gap between the sole rearward segment and the heel panel. As a result of this construction, a downward thrust of a wearer heel inside the shoe presses the heel panel firmly against the shoe support surface drives the heel panel upwardly toward the sole rearward segment against the biasing of the spring means, thereby storing energy in the spring means. As the wearer rises off the heel panel, the spring means causes the heel panel to exert a downward force on the support surface, the spring means thereby adding upward acceleration to the wearer body to cause the wearer to rise higher in his or her step or jump than he or she would without this shoe.
摘要翻译：鞋包括固定到鞋底的鞋面结构，鞋底具有用于与鞋支撑表面（例如篮球场的地板）接触的鞋底前部，以及向后弯曲然后从鞋底前部向后延伸的鞋底后部在鞋支撑表面上方间隔开，并且包括安装在鞋底后部段下方的后跟板形式的脚后跟，并且包括将脚跟板向下偏压到鞋底后部段一定距离的弹簧装置，鞋底后跟部分和脚跟面板。作为这种结构的结果，鞋内的穿着者脚跟的向下推力将鞋跟面板牢固地压靠在鞋支撑表面上，克服弹簧装置的偏压将鞋跟面朝向鞋底后部向上驱动，从而将能量储存在春天的意思。随着佩戴者从脚后跟板上升下来，弹簧装置使鞋跟面板向支撑表面施加向下的力，弹簧装置从而向穿着者身体增加向上的加速度，以使佩戴者在他或她的台阶上升得更高，或者跳过比他或她没有这个鞋子。

9. 发明授权

US5278509A Method for monitoring battery discharge by determining the second derivative of battery voltage over time 失效
标题翻译：通过确定电池电压随时间的二阶导数来监测电池放电的方法
公开(公告)号：US5278509A
公开(公告)日：1994-01-11
申请号：US829635
申请日：1992-02-03
申请人： Richard Haynes , Robert B. Levy
发明人： Richard Haynes , Robert B. Levy
IPC分类号： G01R31/36 , G01N27/416 , H02J7/04
CPC分类号： G01R31/3665
摘要： The state of charge of a rechargeable battery (12), such as those made from lithium, nickel-cadmium or metal hydrides, can be accurately determined by monitoring the rate of change of battery voltage over time (dv/dt), which parameter has empirically been found to change dramatically as the battery reaches complete discharge.
摘要翻译：可以通过监视电池电压随时间的变化率（dv / dt）来准确地确定可再充电电池（12）的充电状态，例如由锂，镍镉或金属氢化物制成的充电状态，该参数具有经验发现随着电池达到完全放电，发生了显着变化。

10. 发明授权

US4479922A Solvent treatment in the separation of palladium and/or gold from other platinum group and base metals 失效
标题翻译：从其他铂族和贱金属中分离钯和/或金的溶剂处理
公开(公告)号：US4479922A
公开(公告)日：1984-10-30
申请号：US482077
申请日：1983-04-04
申请人： Richard Haynes , Anna M. Jackson , Martin K. Zierold
发明人： Richard Haynes , Anna M. Jackson , Martin K. Zierold
IPC分类号： C01G7/00 , C01G55/00 , C22B3/34
CPC分类号： C22B3/0031 , C01G55/001 , C01G7/003 , Y02P10/234
摘要： We have discovered that by pretreating a thioether (R'--S--R) containing organic phase to be used as an extractant in a solvent extraction process for separating platinum group metals from base metals and/or each other in aqueous solution with a mild oxidant, e.g., cupric chloride, in an acidified aqueous phase, the tendency of stable emulsion formation during extraction can be substantially eliminated.
摘要翻译：我们已经发现通过在用温和氧化剂在水溶液中分离铂族金属和/或彼此的溶剂萃取方法中预处理含有有机相的硫醚（R'-SR）作为萃取剂，例如，氯化铜，在酸化水相中，可以基本上消除萃取期间稳定的乳液形成的趋势。

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