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1. 发明申请

US20050124624A1 4-(4-methylpiperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-yl-amino)phenyl]-benzamide for threating ang ii-mediated diseases 审中-公开
标题翻译： 4-（4-甲基哌嗪-1-基甲基）-n- [4-甲基-3-（4-吡啶-3-基）嘧啶-2-基氨基）苯基] - 苯甲酰胺，用于诱导血管紧张素Ⅱ介导的疾病
公开(公告)号：US20050124624A1
公开(公告)日：2005-06-09
申请号：US10507642
申请日：2003-03-14
申请人： Richard Gilbert , Darren Kelly , David Feldman
发明人： Richard Gilbert , Darren Kelly , David Feldman
IPC分类号： C07D401/04 , A61K31/00 , A61K31/41 , A61K31/505 , A61K31/506 , A61K31/549 , A61K45/06 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/12 , A61P43/00 , A61K31/366 , A61K31/401 , A61K31/4178
CPC分类号： A61K45/06 , A61K31/00 , A61K31/41 , A61K31/505 , A61K31/549 , A61K2300/00
摘要： A PDGF receptor tyrosine kinase inhibitor, especially a 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide of the formula I or a pharmaceutically acceptable salt thereof can be used in the treatment of angiotensin II-induced diseases and a combination which comprises (a) a PDGF receptor tyrosine kinase inhibitor preferably N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and (b) at least one compound selected from an antihypertensive, an aldosterone antagonist, an aldosterone synthase inhibitor and/or an angiotensin receptor blocker agent and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the treatment of hypertension and hypertension-induced diseases.
摘要翻译： PDGF受体酪氨酸激酶抑制剂，特别是4-（4-甲基哌嗪-1-基甲基）-N- [4-甲基-3-（4-吡啶-3-基）嘧啶-2-基氨基）苯基] - 苯甲酰胺式I或其药学上可接受的盐可用于治疗血管紧张素II诱导的疾病和组合，其包含（a）PDGF受体酪氨酸激酶抑制剂，优选N- {5- [4-（4-甲基 - 哌嗪子基） - 甲基） - 苯甲酰氨基] -2-甲基苯基} -4-（3-吡啶基）-2-嘧啶胺和（b）至少一种选自抗高血压剂，醛固酮拮抗剂，醛固酮合酶抑制剂和/ 血管紧张素受体阻断剂和任选的至少一种用于同时，分开或顺序使用的药学上可接受的载体，特别是用于治疗高血压和高血压诱发的疾病。

2. 发明申请

US20100292335A1 USE OF ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物的使用
公开(公告)号：US20100292335A1
公开(公告)日：2010-11-18
申请号：US12526974
申请日：2008-02-14
申请人： Duncan J. Campbell , Richard Gilbert , Darren Kelly
发明人： Duncan J. Campbell , Richard Gilbert , Darren Kelly
IPC分类号： A61K31/165 , C07C237/22 , A61P9/10
CPC分类号： A61K31/165
摘要： The present invention provides methods for the prevention of, delay of progression to or the treatment of diseases modulated by an increase in tissue bradykinin levels by administering to a warm-blooded animal a therapeutically effective amount of a renin inhibitor, or a pharmaceutically acceptable salt thereof, alone or in combination with (i)) an ACE inhibitor or a pharmaceutically acceptable salt thereof, (II) an angiotensin II receptor blocker, or a pharmaceutically acceptable salt of either.
摘要翻译：本发明提供了通过向温血动物施用治疗有效量的肾素抑制剂或其药学上可接受的盐来预防，延缓进展或治疗由组织缓激肽水平升高而调节的疾病的方法单独或与（i）组合）ACE抑制剂或其药学上可接受的盐，（II）血管紧张素II受体阻断剂或其药学上可接受的盐。

3. 发明授权

US07769440B2 Electromanipulation device and method 有权
标题翻译：电动装置及方法
公开(公告)号：US07769440B2
公开(公告)日：2010-08-03
申请号：US10605126
申请日：2003-09-10
申请人： Andrew M. Hoff , Richard Gilbert , Richard Heller , Mark J. Jaroszeski
发明人： Andrew M. Hoff , Richard Gilbert , Richard Heller , Mark J. Jaroszeski
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61N1/0424 , A61N1/325 , C12N15/87
摘要： The present invention is a device for electromanipulation of chemical species in vivo relative to a target tissue including a nonconductive, conformable array base adapted to be placed coincident to the target tissue, a plurality of electrode elements projecting from the array base towards the target tissue, the electrode elements addressable individually, an electrical source coupled to the plurality of electrodes, a control means interposed between the electrical source and the plurality of electrode elements and in circuit communication therein, the control means adapted to establish an electrical potential between at least two electrodes, and a delivery means adapted to introduce chemical species to the target tissue.
摘要翻译：本发明是一种用于相对于靶组织在体内电化学物质的装置，该靶组织包括适于与靶组织重合放置的非导电适形阵列基底，从阵列基底朝向靶组织突出的多个电极元件，所述电极元件单独寻址，耦合到所述多个电极的电源，插入在所述电源和所述多个电极元件之间并且与所述多个电极元件中的电路连通的控制装置，所述控制装置适于在至少两个电极之间建立电位以及适于将化学物种引入目标组织的递送装置。

4. 发明申请

US20090131994A1 Passive Electric Field Focus System for In Vivo and In Vitro Applications 有权
标题翻译：被动电场聚焦系统体内和体外应用
公开(公告)号：US20090131994A1
公开(公告)日：2009-05-21
申请号：US12246958
申请日：2008-10-07
申请人： Jose I. Rey , Richard Gilbert , Mark J. Jaroszeski , Richard Heller
发明人： Jose I. Rey , Richard Gilbert , Mark J. Jaroszeski , Richard Heller
IPC分类号： A61N1/05 , C12N13/00
CPC分类号： A61N1/327 , A61N1/325 , C12M35/02
摘要： The present invention provides a system and method of directing, focusing, or concentrating electrical charges within a defined electric field so that these charges can be used to exert forces on cells and tissues in vivo and/or cell cultures in vitro. The present invention reduces and/or eliminates the damage at a target site that would normally be caused by an electrode that acts as a current source or sink to accomplish the same task.
摘要翻译：本发明提供了在限定的电场内引导，聚焦或集中电荷的系统和方法，使得这些电荷可以用于在体外对体内和/或细胞培养物上的细胞和组织施加力。本发明减少和/或消除了通常由用作电流源或吸收器来完成相同任务的电极引起的目标位置处的损伤。

5. 发明申请

US20070134805A1 Molecular detector arrangement 审中-公开
标题翻译：分子检测器布置
公开(公告)号：US20070134805A1
公开(公告)日：2007-06-14
申请号：US11581070
申请日：2006-10-16
申请人： Richard Gilbert
发明人： Richard Gilbert
IPC分类号： G01N21/00
CPC分类号： G01N21/658
摘要： A method of detecting the presence or absence of an analyte in a sample uses an analyte carrier with a calibration dye held in a region near a metal surface. A reporter dye is held away from a region near the metal surface and is displaceably attached to a selective agent. The selective agent is capable of binding to an analyte so that when the analyte binds to the selective agent the reporter dye detaches and moves to a region near a metal surface. The difference in response to illumination from the reporter dye and calibration dye can be used to detect the presence, amount or absence of an analyte sample.
摘要翻译：检测样品中分析物的存在或不存在的方法使用分析物载体，其中校准染料保持在金属表面附近的区域中。报告染料被远离金属表面附近的区域，并且可移动地连接到选择剂上。选择剂能够结合分析物，使得当分析物结合选择剂时，报道染料分离并移动到金属表面附近的区域。报告染料和校正染料对照明的响应差异可用于检测分析物样品的存在，数量或不存在。

6. 发明授权

US06937890B2 Nonpenetrating electroporation device 有权
标题翻译：非穿透电穿孔装置
公开(公告)号：US06937890B2
公开(公告)日：2005-08-30
申请号：US09772561
申请日：2001-01-30
申请人： Mark J. Jaroszeski , Richard Gilbert , Richard Heller
发明人： Mark J. Jaroszeski , Richard Gilbert , Richard Heller
IPC分类号： A61N1/30 , A61N1/32 , C12M1/42
CPC分类号： A61N1/327 , A61N1/0424 , A61N1/0476
摘要： The manipulator includes a support and at least one member affixed to and extending away from the support. The member has at least two differentially activatable areas of conductivity. The members are configured to establish a first electromagnetic field in vivo between selected areas of conductivity sufficient to manipulate a molecule relative to a target tissue and to establish a second, typically higher, electromagnetic field sufficient to cause transient permeability of a cell membrane within the target tissue. Restraining means are also described for restricting movement of the members with relation to each other. One method of using the device is for enhancing the delivery of a molecule into a tissue site; another is for poration of the tissue alone or in combination with the migration. The target tissue may include a tumor, organ, or wound site.
摘要翻译：操纵器包括支撑件和固定到支撑件上并远离支撑件的至少一个构件。该构件具有至少两个差异可激活的导电区域。构件被构造成在体内在选择的导电区域之间建立第一电磁场，以便相对于目标组织操纵分子并建立足以引起靶内细胞膜瞬时通透的第二，通常较高的电磁场组织。还描述了用于限制构件相对于彼此的运动的限制装置。使用该装置的一种方法是用于增强分子进入组织部位的递送; 另一种是单独或与移植相结合的组织的培养。靶组织可以包括肿瘤，器官或伤口部位。

7. 发明授权

US06929949B1 Corona ion generating method and apparatus for the manipulation of molecules and biological cells 有权
标题翻译：用于操作分子和生物细胞的电晕离子产生方法和装置
公开(公告)号：US06929949B1
公开(公告)日：2005-08-16
申请号：US10250219
申请日：2003-06-13
申请人： Drew Hoff , Mark J. Jaroszeski , Richard Gilbert , Richard Heller
发明人： Drew Hoff , Mark J. Jaroszeski , Richard Gilbert , Richard Heller
IPC分类号： C12N13/00 , C12N15/87
CPC分类号： C12N15/87 , C12M35/08 , C12N13/00
摘要： The present invention provides a method and apparatus adapted to facilitate the entry of a preselected molecule into the intracellular space of a cellular sample through the use of ions generated by a corona charge source. With the present method and apparatus, molecules are manipulated within cells and in the extracellular space surrounding the cells. Manipulation enhances the permeability of cell barriers to allow the subsequent introduction of molecules of interest into the interior of a cell.
摘要翻译：本发明提供了一种适于通过使用由电晕电荷源产生的离子来促进预选分子进入细胞样品的细胞内空间的方法和装置。利用本发明的方法和装置，分子在细胞内和细胞周围的细胞外空间中被操纵。操纵增强细胞屏障的渗透性，以允许随后将感兴趣的分子引入细胞内部。

8. 发明申请

US20050081869A1 Smoking article 有权
标题翻译：吸烟文章
公开(公告)号：US20050081869A1
公开(公告)日：2005-04-21
申请号：US10923917
申请日：2004-08-23
申请人： Philip Biggs , Richard Gilbert , Kevin McAdam , Bhasker Natarajan
发明人： Philip Biggs , Richard Gilbert , Kevin McAdam , Bhasker Natarajan
IPC分类号： A24B15/14 , A24B15/16 , A24D3/14 , A24B15/00
CPC分类号： A24B15/16 , A24B15/14 , A24D3/14
摘要： The invention relates to a reconstituted smoking material which comprises a non-polyol aerosol generator, tobacco (optional), binder (optional) and inorganic filler. A further polyol aerosol generator may also be contained in the smoking material. There is also provided a smoking article containing such material in a conventional arrangement or with a core axially disposed within an annulus. A further aspect of the invention is the provision of a polyol or non-polyol aerosol generator disposed in the filter element of a smoking article, which may contain the inventive smoking material. The aerosol material on the filter is eluted into the aerosol of the smoke on burning of the smoking article.
摘要翻译：本发明涉及一种重组烟草材料，其包括非多元醇气溶胶发生器，烟草（任选的），粘合剂（任选的）和无机填料。另外的多元醇气溶胶发生器也可以包含在吸烟材料中。还提供了一种以常规布置包含这种材料或者轴向设置在环形空间中的芯的吸烟制品。本发明的另一方面是提供一种设置在吸烟制品的过滤元件中的多元醇或非多元醇气溶胶发生器，其可以包含本发明的吸烟材料。过滤器上的气溶胶材料在吸烟物品的燃烧时被洗脱到烟雾的气溶胶中。

9. 发明申请

US20050033501A1 MISFIRE DETECTION IN AN INTERNAL COMBUSTION ENGINE 失效
标题翻译：内燃机中的MISFIRE检测
公开(公告)号：US20050033501A1
公开(公告)日：2005-02-10
申请号：US10637121
申请日：2003-08-08
申请人： Louis Liu , Richard Gilbert , Donald Kultgen , Jeffrey Naber , Hanlong Yang
发明人： Louis Liu , Richard Gilbert , Donald Kultgen , Jeffrey Naber , Hanlong Yang
IPC分类号： G01M15/11 , G01M15/00
CPC分类号： G01M15/11
摘要： A method and system for a misfire detection acquires (301) a series of acceleration data (302) representative of acceleration behavior of an engine. The data is sampled (304) to obtain acceleration data samples at a rate sufficient to obtain up to fourth-order perturbations of the data. The samples are filtered (322) to provide bandwidth limited samples, which are provided to at least two channels (325, 329). The samples are pattern matched (332) in a first channel to enhance harmonic phenomena and pattern canceled (330) in a second channel to enhance random phenomena. Hard and random misfires are detected (334) dependent on a magnitude of the filtered acceleration data samples. Preferably, a third channel (335) is added to detect multiple misfires.
摘要翻译：用于失火检测的方法和系统获取（301）代表发动机的加速行为的一系列加速度数据（302）。数据被采样（304）以获得加速度数据样本，其速率足以获得数据的高达四阶扰动。对样本进行滤波（322）以提供带宽限制的样本，其被提供给至少两个信道（325,329）。样品在第一通道中被模式匹配（332）以增强第二通道中的谐波现象和模式取消（330），以增强随机现象。检测到硬和随机的失火（334），这取决于经滤波的加速度数据样本的大小。优选地，添加第三通道（335）以检测多次失火。

10. 外观设计

USD412822S Blade holder 失效
公开(公告)号：USD412822S
公开(公告)日：1999-08-17
申请号：US93112
申请日：1998-09-03
申请人： Richard Gilbert , Eric Ranieri
设计人： Richard Gilbert , Eric Ranieri

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