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1. 发明申请

US20050158856A1 Methods for producing functional antigen presenting dendritic cells using biodegradable microparticles for delivery of antigenic materials 审中-公开
标题翻译：使用可生物降解的微粒产生功能性抗原呈递树突细胞的方法用于递送抗原性材料
公开(公告)号：US20050158856A1
公开(公告)日：2005-07-21
申请号：US10884519
申请日：2004-07-01
申请人： Richard Edelson , Carole Berger , Douglas Hanlon , Hong Shen
发明人： Richard Edelson , Carole Berger , Douglas Hanlon , Hong Shen
IPC分类号： A61K9/16 , A61K9/50 , C12N5/0784 , C12N5/08
CPC分类号： C12N5/0639 , A61K39/0011 , A61K2035/128 , A61K2039/5152 , A61K2039/5154 , A61K2039/5158 , A61K2039/55555 , C12N2533/40
摘要： Methods are provided for producing functional antigen presenting dendritic cells. The dendritic cells are produced by treating an extracorporeal quantity of a subject's blood to induce differentiation of blood monocytes into dendritic cells. The dendritic cells may be exposed to cellular material encapsulated within a biodegradable polymer material to produce the antigen presenting dendritic cells.
摘要翻译：提供用于产生呈递树突细胞的功能性抗原的方法。通过治疗体外数量的受试者的血液以诱导血液单核细胞分化成树突细胞来产生树突状细胞。树突细胞可以暴露于包封在可生物降解的聚合物材料内的细胞材料以产生呈递树突状细胞的抗原。

2. 发明授权

US09284301B2 Soluble guanylate cyclase activators 有权
标题翻译：可溶性鸟苷酸环化酶活化剂
公开(公告)号：US09284301B2
公开(公告)日：2016-03-15
申请号：US13636760
申请日：2011-03-22
申请人： Darby Schmidt , Subharekha Raghavan , John Stelmach , Jian Guo , Jonathan Groeper , Linda Brockunier , Keith Rosauer , Hong Shen , Rui Liang , Fa-Xiang Ding
发明人： Darby Schmidt , Subharekha Raghavan , John Stelmach , Jian Guo , Jonathan Groeper , Linda Brockunier , Keith Rosauer , Hong Shen , Rui Liang , Fa-Xiang Ding
IPC分类号： C07D403/14 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
CPC分类号： C07D403/14 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The invention relates to compounds having the structure of Formula (I) and pharmaceutically acceptable salts thereof, which are soluble guanylate cyclase activators. The compounds are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.
摘要翻译：本发明涉及具有式（I）结构的化合物及其药学上可接受的盐，它们是可溶性鸟苷酸环化酶活化剂。这些化合物能够调节人体的环鸟苷酸（“cGMP”）的产生，并且通常适用于治疗和预防与受干扰的cGMP平衡有关的疾病。该化合物可用于治疗或预防心血管疾病，内皮功能障碍，舒张功能障碍，动脉粥样硬化，高血压，肺动脉高压，心绞痛，血栓形成，再狭窄，心肌梗死，中风，心功能不全，肺性高血压，勃起功能障碍，支气管哮喘，慢性肾功能不全，糖尿病或肝硬化。

3. 发明授权

US09193717B2 Mineralocorticoid receptor antagonists 有权
标题翻译：盐皮质激素受体拮抗剂
公开(公告)号：US09193717B2
公开(公告)日：2015-11-24
申请号：US14350888
申请日：2012-10-08
申请人： Hong Shen , Christine Yang , Jason M. Cox , Kun Liu
发明人： Hong Shen , Christine Yang , Jason M. Cox , Kun Liu
IPC分类号： C07D413/04 , C07D413/14 , C07D403/04 , A61K31/422 , A61K31/4439 , A61K31/506 , A61K31/5377
CPC分类号： C07D413/04 , A61K31/422 , A61K31/4439 , A61K31/506 , A61K31/5377 , C07D403/04 , C07D413/14
摘要： The present invention is directed to compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, that are aldosterone receptor antagonists which might be useful for treating aldosterone-mediated diseases. The invention furthermore relates to processes for preparing compounds of the Formula (I), to their possible use for the treatment of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical compositions which comprise compounds of the Formula (I).
摘要翻译：本发明涉及可用于治疗醛固酮介导的疾病的醛固酮受体拮抗剂的式（I）化合物及其药学上可接受的盐。本发明还涉及制备式（I）化合物，其可能用于治疗上述疾病和为此目的制备药物的方法，以及包含式（I）化合物的药物组合物。

4. 发明申请

US20130193573A1 METHODS OF STRESS BALANCING IN GALLIUM ARSENIDE WAFER PROCESSING 有权
公开(公告)号：US20130193573A1
公开(公告)日：2013-08-01
申请号：US13360489
申请日：2012-01-27
申请人： Hong Shen
发明人： Hong Shen
IPC分类号： H01L23/48 , H01L21/28 , H01L21/66
CPC分类号： H01L29/452 , H01L21/76898 , H01L21/8252 , H01L24/45 , H01L24/48 , H01L24/83 , H01L24/97 , H01L27/02 , H01L29/20 , H01L33/12 , H01L2224/0401 , H01L2224/04026 , H01L2224/05647 , H01L2224/05655 , H01L2224/05664 , H01L2224/13101 , H01L2224/29294 , H01L2224/293 , H01L2224/32225 , H01L2224/32245 , H01L2224/45124 , H01L2224/45144 , H01L2224/45147 , H01L2224/48091 , H01L2224/48227 , H01L2224/48247 , H01L2224/48647 , H01L2224/48655 , H01L2224/48664 , H01L2224/48747 , H01L2224/48755 , H01L2224/48764 , H01L2224/48847 , H01L2224/48855 , H01L2224/48864 , H01L2224/73265 , H01L2224/81815 , H01L2224/83192 , H01L2224/83815 , H01L2224/85205 , H01L2224/85207 , H01L2224/97 , H01L2924/00011 , H01L2924/10329 , H01L2924/12042 , H01L2924/1305 , H01L2924/15311 , H01L2924/15313 , H01L2924/181 , H01L2924/00014 , H01L2924/014 , H01L2224/83 , H01L2924/00 , H01L2224/83205 , H01L2924/00012
摘要： Systems, apparatuses, and methods related to the design, fabrication, and manufacture of gallium arsenide (GaAs) integrated circuits are disclosed. Copper can be used as the contact material for a GaAs integrated circuit. Metallization of the wafer and through-wafer vias can be achieved through copper plating processes disclosed herein. To avoid warpage, the tensile stress of a conductive layer deposited onto a GaAs substrate can be offset by depositing a compensating layer having negative stress over the GaAs substrate. GaAs integrated circuits can be singulated, packaged, and incorporated into various electronic devices.

5. 发明申请

US20130012511A1 SOLUBLE GUANYLATE CYCLASE ACTIVATORS 有权
标题翻译：可溶性冠状动脉激素
公开(公告)号：US20130012511A1
公开(公告)日：2013-01-10
申请号：US13636760
申请日：2011-03-22
申请人： Darby Schmidt , Subharekha Raghavan , John Stelmach , Jian Guo , Jonathan Groeper , Linda Brockunier , Keith Rosauer , Hong Shen , Rui Liang , Fa-Xiang Ding
发明人： Darby Schmidt , Subharekha Raghavan , John Stelmach , Jian Guo , Jonathan Groeper , Linda Brockunier , Keith Rosauer , Hong Shen , Rui Liang , Fa-Xiang Ding
IPC分类号： C07D403/14 , A61K31/506 , C07D471/04 , C07D401/14 , C07D413/14 , A61K31/5377 , C07D417/14 , C07D403/04 , A61P9/00 , A61P9/10 , A61P9/12 , A61P9/04 , A61P7/02 , A61P11/00 , A61P15/00 , A61P11/06 , A61P13/12 , A61P3/10 , A61P1/16 , A61P9/08 , A61P7/10 , A61P3/00 , A61P3/06 , C07D487/04
CPC分类号： C07D403/14 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The invention relates to compounds having the structure of Formula (I) and pharmaceutically acceptable salts thereof, which are soluble guanylate cyclase activators. The compounds are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.
摘要翻译：本发明涉及具有式（I）结构的化合物及其药学上可接受的盐，它们是可溶性鸟苷酸环化酶活化剂。这些化合物能够调节身体产生的环鸟苷酸（cGMP），通常适用于治疗和预防与受干扰的cGMP平衡有关的疾病。该化合物可用于治疗或预防心血管疾病，内皮功能障碍，舒张功能障碍，动脉粥样硬化，高血压，肺动脉高压，心绞痛，血栓形成，再狭窄，心肌梗死，中风，心功能不全，肺性高血压，勃起功能障碍，支气管哮喘，慢性肾功能不全，糖尿病或肝硬化。

6. 发明申请

US20120226051A1 ORGANIC DICARBOXYLIC ACIDS, SALTS AND PREPARATION METHOD THEREOF 有权
标题翻译：有机二羧酸，盐及其制备方法
公开(公告)号：US20120226051A1
公开(公告)日：2012-09-06
申请号：US13509985
申请日：2010-11-12
申请人： Shaohua Gou , Hong Shen , Yindi Zhang , Jianping Shen , Yanqin Zhu , Luzhong Feng , Jianwei Wu , Dekang Chen
发明人： Shaohua Gou , Hong Shen , Yindi Zhang , Jianping Shen , Yanqin Zhu , Luzhong Feng , Jianwei Wu , Dekang Chen
IPC分类号： C07D231/56 , C07D233/64
CPC分类号： C07D231/56
摘要： Organic dicarboxylic acid compounds, salts and preparation methods thereof. The said compounds have activity of resisting oxidation damage to crystalline lens of eyes. The structures of the above organic dicarboxylic acid compounds are shown as formula (1).
摘要翻译：有机二羧酸化合物，其盐及其制备方法。所述化合物具有抵抗眼睛晶状体的氧化损伤的活性。上述有机二羧酸化合物的结构如式（1）所示。

7. 发明申请

US20120153476A1 ETCHED WAFERS AND METHODS OF FORMING THE SAME 有权
标题翻译：蚀刻波形及其形成方法
公开(公告)号：US20120153476A1
公开(公告)日：2012-06-21
申请号：US12971465
申请日：2010-12-17
申请人： Hong Shen
发明人： Hong Shen
IPC分类号： H01L23/48 , H01L21/768
CPC分类号： H01L21/76898 , H01L21/3081 , H01L21/6835 , H01L2221/68327 , H01L2221/6834 , H01L2221/68381
摘要： Etched wafers and methods of forming the same are disclosed. In one embodiment, a method of etching a wafer is provided. The method includes forming a metal hard mask on the wafer using electroless plating, patterning the metal hard mask, and etching a plurality of features on the wafer using an etcher. The plurality of featured are defined by the metal hard mask.
摘要翻译：公开了蚀刻的晶片及其形成方法。在一个实施例中，提供了蚀刻晶片的方法。该方法包括使用化学镀在晶片上形成金属硬掩模，图案化金属硬掩模，以及使用蚀刻器蚀刻晶片上的多个特征。多个特征由金属硬掩模定义。

8. 发明授权

US08107699B2 Feature processing for lung nodules in computer assisted diagnosis 有权
标题翻译：计算机辅助诊断肺结节特征处理
公开(公告)号：US08107699B2
公开(公告)日：2012-01-31
申请号：US12170639
申请日：2008-07-10
申请人： Lin Hong , Christopher V. Alvino , Hong Shen
发明人： Lin Hong , Christopher V. Alvino , Hong Shen
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T2207/30061 , G06T2207/30064
摘要： Feature processing is provided for lung nodules in computer-assisted diagnosis. A feature that may better distinguish nodules from background is extracted using a Hough transform. Rather than relying on a specific boundary shape, the Hough transform accumulates evidence associated with a region, such as a ring region. The accumulated evidence provides a feature score without requiring a nodule to fit a specific shape. In another approach, a background level is determined from extracted features. Rather than attempting to normalize an image prior to extraction, the features are normalized. The feature normalization and generalized Hough transform extraction may be used together or alone.
摘要翻译：在计算机辅助诊断中为肺结节提供特征处理。使用霍夫变换提取可以更好地区分结节与背景的特征。霍夫变换不是依赖于特定的边界形状，而是累积与区域相关联的证据，例如环形区域。积累的证据提供了一个特征分数，而不需要结节来适应特定的形状。在另一种方法中，从提取的特征确定背景级别。在尝试在提取之前对图像进行归一化，而不是将特征归一化。特征归一化和广义霍夫变换提取可以一起使用或单独使用。

9. 发明授权

US08103077B2 Method and system for locating opaque regions in chest X-ray radiographs 失效
标题翻译：用于定位胸部X线片中不透明区域的方法和系统
公开(公告)号：US08103077B2
公开(公告)日：2012-01-24
申请号：US11951372
申请日：2007-12-06
申请人： Lin Hong , Ying Li , Hong Shen
发明人： Lin Hong , Ying Li , Hong Shen
IPC分类号： G06K9/00
CPC分类号： G06T7/12
摘要： A method and system for locating an opaque region, such as a heart region in a chest X-ray radiograph is disclosed. In order to segment a heart region in a chest X-ray radiograph, a heart region boundary is generated based on lung boundaries in the chest X-ray radiograph and an average heart region model. A location of the lower boundary of the heart region in the chest X-ray radiograph is then determined. Left and right portions of the heart region boundary are independently registered to corresponding portions of the lung boundaries, and upper and lower portions of the heart region boundary are adjusted based on the left and right portions in order to form a smooth contour.
摘要翻译：公开了一种用于定位不透明区域的方法和系统，例如胸部X射线照片中的心脏区域。为了在胸部X射线照片中分割心脏区域，基于胸部X射线照片和平均心脏区域模型中的肺边界产生心脏区域边界。然后确定胸部X线片中的心脏区域的下边界的位置。心脏区域边界的左右部分独立地登记到肺边界的对应部分，并且基于左右部分来调整心脏区域边界的上部和下部以形成平滑轮廓。

10. 发明授权

US08073214B2 Computer aided lesion assessment in dynamic contrast enhanced breast MRI images 有权
标题翻译：计算机辅助病变评估动态对比增强胸部MRI图像
公开(公告)号：US08073214B2
公开(公告)日：2011-12-06
申请号：US12117155
申请日：2008-05-08
申请人： Lin Hong , Hong Shen , Shuping Qing
发明人： Lin Hong , Hong Shen , Shuping Qing
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T2207/10096 , G06T2207/30096
摘要： A method for performing computer-assisted lesion assessment includes acquiring contrast enhanced MRI data. A region of interest is identified. Kinetic properties, morphological properties and pattern of enhancement are determined for the identified region of interest. A score is calculated for each of the kinetic properties, morphological properties, pattern of enhancement. A cumulative score is calculated for the identified region of interest. The scores are provided to a medical practitioner to assist in diagnosing the identified region of interest.
摘要翻译：用于执行计算机辅助病变评估的方法包括获取对比度增强的MRI数据。确定感兴趣的区域。确定感兴趣区域的动力学性质，形态特征和增强模式。计算每个动力学性质，形态特征，增强模式的得分。计算所识别的感兴趣区域的累积分数。分数被提供给医生以帮助诊断所识别的感兴趣的区域。

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