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1. 发明申请

US20100137225A1 PHAGE DISPLAYED CELL BINDING PEPTIDES 有权
标题翻译： PHAGE显示细胞结合肽
公开(公告)号：US20100137225A1
公开(公告)日：2010-06-03
申请号：US12701397
申请日：2010-02-05
申请人： Richard E. Herman , Ekaterina G. Makienko , Douglas L. Badders , Mark Fuller
发明人： Richard E. Herman , Ekaterina G. Makienko , Douglas L. Badders , Mark Fuller
IPC分类号： A61K38/08 , C07K1/107 , A61P43/00
CPC分类号： C07K14/001 , A61K47/62 , C07K2319/035 , C07K2319/33 , C12N15/1037
摘要： This disclosure provides the construction, expression, and selection of the mutated genes that encode novel Trp cage polypeptides with desirable binding properties, as well as the novel Trp cage polypeptides themselves. The substances or targets bound by these novel Trp cage polypeptides may be but need not be proteins or polypeptides. Targets may include other biological or synthetic macromolecules as well as other organic and inorganic substances. Further, targets may also include a single or multiple cell or tissue types. The present invention achieves genetic variants of Trp cage-encoding nucleic acids through controlled random mutagenesis of the nucleic acids yielding a mixture of Trp cage polypeptides that are capable of binding targets.
摘要翻译：本公开提供编码具有所需结合特性的新型Trp笼多肽的突变基因的构建，表达和选择，以及新型Trp笼多肽本身。由这些新型Trp笼多肽结合的物质或靶标可能不一定是蛋白质或多肽。目标可以包括其他生物或合成大分子以及其它有机和无机物质。此外，靶也可以包括单个或多个细胞或组织类型。本发明通过控制随机诱变获得Trp笼编码核酸的遗传变体，产生能够结合靶标的Trp笼多肽的混合物。

2. 发明授权

US07772189B2 Phage displayed cell binding peptides 有权
标题翻译：噬菌体展示细胞结合肽
公开(公告)号：US07772189B2
公开(公告)日：2010-08-10
申请号：US12701397
申请日：2010-02-05
申请人： Richard E. Herman , Ekaterina G. Makienko , Douglas L. Badders , Mark Fuller
发明人： Richard E. Herman , Ekaterina G. Makienko , Douglas L. Badders , Mark Fuller
IPC分类号： A61K38/00 , C07K7/06
CPC分类号： C07K14/001 , A61K47/62 , C07K2319/035 , C07K2319/33 , C12N15/1037
摘要： This disclosure provides the construction, expression, and selection of the mutated genes that encode novel Trp cage polypeptides with desirable binding properties, as well as the novel Trp cage polypeptides themselves. The substances or targets bound by these novel Trp cage polypeptides may be but need not be proteins or polypeptides. Targets may include other biological or synthetic macromolecules as well as other organic and inorganic substances. Further, targets may also include a single or multiple cell or tissue types. The present invention achieves genetic variants of Trp cage-encoding nucleic acids through controlled random mutagenesis of the nucleic acids yielding a mixture of Trp cage polypeptides that are capable of binding targets.
摘要翻译：本公开提供编码具有所需结合特性的新型Trp笼多肽的突变基因的构建，表达和选择，以及新型Trp笼多肽本身。由这些新型Trp笼多肽结合的物质或靶标可能不一定是蛋白质或多肽。目标可以包括其他生物或合成大分子以及其它有机和无机物质。此外，靶还可以包括单个或多个细胞或组织类型。本发明通过控制随机诱变获得Trp笼编码核酸的遗传变体，产生能够结合靶标的Trp笼多肽的混合物。

3. 发明申请

US20070197444A1 PHAGE DISPLAYED CELL BINDING PEPTIDES 失效
标题翻译： PHAGE显示细胞结合肽
公开(公告)号：US20070197444A1
公开(公告)日：2007-08-23
申请号：US11627863
申请日：2007-01-26
申请人： Richard E. Herman , Ekaterina G. Makienko , Douglas L. Badders , Mark Fuller
发明人： Richard E. Herman , Ekaterina G. Makienko , Douglas L. Badders , Mark Fuller
IPC分类号： A61K48/00 , A61K38/10 , C07K7/08
CPC分类号： C07K14/001 , A61K47/62 , C07K2319/035 , C07K2319/33 , C12N15/1037
摘要： A tryptophan cage binding domain polypeptide containing of all or part of amino acid sequence AAADX1YX2QWLX3X4X5GPX6SGRPPPX7 (SEQ ID NO: 4), wherein Xn represents an amino acid found in position n, the polypeptide comprising a tryptophan cage (Trp cage). A cell binding domain polypeptide having an amino acid sequence produced by phage display.
摘要翻译：含有全部或部分氨基酸序列AAADX 1 YX 2 QWLX 3 X 4的色氨酸结构域多肽

4. 发明授权

US07704953B2 Phage displayed cell binding peptides 失效
标题翻译：噬菌体展示细胞结合肽
公开(公告)号：US07704953B2
公开(公告)日：2010-04-27
申请号：US11627863
申请日：2007-01-26
申请人： Richard E. Herman , Ekaterina G. Makienko , Douglas L. Badders , Mark Fuller
发明人： Richard E. Herman , Ekaterina G. Makienko , Douglas L. Badders , Mark Fuller
IPC分类号： A61K38/00
CPC分类号： C07K14/001 , A61K47/62 , C07K2319/035 , C07K2319/33 , C12N15/1037
摘要： The present disclosure relates to the construction, expression, and selection of genes that encode novel Trp cage polypeptides with desirable cell and/or tissue binding properties, as well as the novel Trp cage polypeptides themselves. A polypeptide of this disclosure may contain all or part of amino acid sequence AAADX1YX2QWLX3X4X5GPX6SGRPPPX7 (SEQ ID NO: 4), wherein Xn represents an amino acid found in position n, the polypeptide comprising a tryptophan cage (Trp cage).
摘要翻译：本公开涉及编码具有期望的细胞和/或组织结合特性的新型Trp笼多肽的基因的构建，表达和选择，以及新型Trp笼多肽本身。本公开的多肽可以包含氨基酸序列AAADX1YX2QWLX3X4X5GPX6SGRPPPX7（SEQ ID NO：4）的全部或部分，其中Xn表示位置n中发现的氨基酸，所述多肽包含色氨酸笼（Trp笼）。

5. 外观设计

USD863518S1 Heater 有权
公开(公告)号：USD863518S1
公开(公告)日：2019-10-15
申请号：US29529851
申请日：2015-06-10
申请人： Mark Fuller , Susan Fuller , James Doyle , Riae Yoo , Dezso Molnar , Scott Winslow
设计人： Mark Fuller , Susan Fuller , James Doyle , Riae Yoo , Dezso Molnar , Scott Winslow
摘要： FIG. 1 is a front view of a heater.
FIG. 2 is a left view thereof.
FIG. 3 is a right view thereof.
FIG. 4 is a rear view thereof.
FIG. 5 is a top view thereof; and,
FIG. 6 is a bottom view thereof.
In the drawings, the broken lines depict unclaimed subject matter only and form no part of the claimed design.

6. 发明申请

US20190013688A1 Peak Power Spreading 审中-公开
公开(公告)号：US20190013688A1
公开(公告)日：2019-01-10
申请号：US16027212
申请日：2018-07-03
申请人： Mark Fuller , Maria Villamil , John Canavan
发明人： Mark Fuller , Maria Villamil , John Canavan
IPC分类号： H02J7/00 , B05B17/08 , G05B19/042
摘要： A system including a battery system to provide additional power during peak operating conditions is described. The system may avoid or reduce the need for extensive infrastructure associated with a power delivery system capable of providing peak power, but may instead, rely on infrastructure that need only provide power needed on an average basis.

7. 外观设计

USD732637S1 Water display 有权
标题翻译：水显示
公开(公告)号：USD732637S1
公开(公告)日：2015-06-23
申请号：US29450004
申请日：2013-03-15
申请人： Mark Fuller , Jules Moretti , Peter Kopik
设计人： Mark Fuller , Jules Moretti , Peter Kopik

8. 发明申请

US20140240958A1 Luminous Water Wall Display 有权
标题翻译：发光水墙显示
公开(公告)号：US20140240958A1
公开(公告)日：2014-08-28
申请号：US14167982
申请日：2014-01-29
申请人： Mark Fuller , James Doyle , Howard Tsi
发明人： Mark Fuller , James Doyle , Howard Tsi
IPC分类号： F21S10/00
CPC分类号： B05B17/085 , F21W2121/02 , G09F13/22 , G09F13/24 , G09F19/02 , G09F19/22 , G09F19/226
摘要： A water display is described having a lighting array emanating light that travels through a wall. Water flows down the wall to vary the appearance of the light that shines through the wall. The flow of water and particular lights being turned on and off may be controlled. Dramatic visual effects are provided including the appearance of moving art.
摘要翻译：描述了一种水显示器，其具有发出穿过壁的光的照明阵列。水流向墙壁，以改变通过墙壁照射的光线的外观。可以控制水的流动和特定的灯被打开和关闭。提供戏剧性的视觉效果，包括移动艺术的外观。

9. 发明申请

US20140203101A1 Water Shooter Device and Associated Visual Water Effects 审中-公开
标题翻译：水射击装置和相关的视觉水影响
公开(公告)号：US20140203101A1
公开(公告)日：2014-07-24
申请号：US14134983
申请日：2013-12-19
申请人： Mark Fuller , Jim Doyle , Eric Galpin , Don Lariviere
发明人： Mark Fuller , Jim Doyle , Eric Galpin , Don Lariviere
IPC分类号： B05B17/08
CPC分类号： B05B17/08 , B05B9/04 , F04F5/24 , F41B9/0031 , F41B9/0059 , F41B9/0071 , F41B9/0087
摘要： A device to shoot water into the air for a water display is described. The configuration of the shooter allows a stream of water to be shot out that contains reduced or no air exiting the device with the water, which provides a non-frothy appearance. The device may control the velocity of the water being shot by the device so that unique visual effects may be achieved, including an effect where a volume of water is suspended in the air.
摘要翻译：描述了将水喷入空气中以进行水显示的装置。射击者的配置允许喷射水流，其中包含减少的或没有空气与水一起离开设备，这提供了不起泡的外观。该装置可以控制由装置射出的水的速度，使得可以实现独特的视觉效果，包括一定量的水悬浮在空气中的效果。

10. 发明授权

US08511828B2 Image projection on dynamic water mist screen 有权
标题翻译：动态水雾屏幕上的图像投影
公开(公告)号：US08511828B2
公开(公告)日：2013-08-20
申请号：US13172713
申请日：2011-06-29
申请人： Mark Fuller , James Doyle
发明人： Mark Fuller , James Doyle
IPC分类号： G03B21/53 , G03B21/14
CPC分类号： G09F19/18 , G03B3/12 , G03B21/10 , G03B21/608 , G09F13/24
摘要： A multimedia presentation system a projector to project images toward an audience. A plurality of nozzles are partially submerged in a body of water at locations between the projector and the audience. The plurality of nozzles are located at different distances from the projector. Each of the plurality of nozzles is arranged to produce a fan like water mist onto which the projector projects images. A controller is coupled to the projector and the plurality of nozzles. The controller causes the projector to project images and at least one of the plurality of nozzles to produce a water mist in a synchronized sequence such that the images appear at different distances from the projector at different times. The controller may further control the orientation of each nozzle to vary the distance by inclining the plane of the water mist relative to the surface of the body of water.
摘要翻译：一种多媒体演示系统，用于向观众投影图像的投影仪。在投影机和观众之间的位置处，多个喷嘴部分地浸没在水体中。多个喷嘴位于与投影仪不同的距离处。多个喷嘴中的每一个布置成产生投影仪投影图像的风扇，如水雾。控制器耦合到投影仪和多个喷嘴。控制器使得投影仪投影图像和多个喷嘴中的至少一个以产生同步顺序的水雾，使得图像在不同时间出现在与投影仪不同的距离处。控制器可以通过使水雾的平面相对于水体的表面倾斜来进一步控制每个喷嘴的取向以改变距离。

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