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1. 发明授权

US4996205A Composition and method of use of pyrido[3,4-f]pyrrolo[1,2-b][1,2,5]triazepines 失效
标题翻译：吡啶并[3,4-f]吡咯并[1,2-b] [1,2,5]三氮杂的组成和使用方法
公开(公告)号：US4996205A
公开(公告)日：1991-02-26
申请号：US468402
申请日：1990-01-19
申请人： Richard C. Effland , Larry Davis , Kevin J. Kapples , Gordon E. Olsen
发明人： Richard C. Effland , Larry Davis , Kevin J. Kapples , Gordon E. Olsen
IPC分类号： C07D471/14
CPC分类号： C07D471/14
摘要： Pyrido[3,4-f]pyrrolo[1,2-b][1,2,5]triazepines and methods for treating depression, alleviating pain and inflammation, and enhancing memory utilizing compounds or compositions thereof are disclosed.
摘要翻译：公开了吡啶并[3,4-f]吡咯并[1,2-b] [1,2,5]三氮和用于治疗抑郁症，缓解疼痛和炎症以及利用化合物或其组合物增强记忆的方法。

2. 发明授权

US4879382A Pyrido(3,4-f)pyrrolo(1,2-b)(1,2,5)triazepines 失效
标题翻译：吡啶并（3,4-f）吡咯并（1,2-b）（1,2,5）三氮杂
公开(公告)号：US4879382A
公开(公告)日：1989-11-07
申请号：US223847
申请日：1988-07-25
申请人： Richard C. Effland , Larry Davis , Kevin J. Kapples , Gordon E. Olsen
发明人： Richard C. Effland , Larry Davis , Kevin J. Kapples , Gordon E. Olsen
IPC分类号： C07D471/04 , A61K31/55 , A61P25/00 , A61P25/04 , A61P25/24 , A61P25/26 , A61P29/00 , C07D471/14
CPC分类号： C07D471/14
摘要： Pyrido[3,4-f]pyrrolo[1,2-b][1,2]triazepines and methods for treating depression, alleviating pain and inflammation, and enhancing memory utilizing compounds or compositions thereof are disclosed.
摘要翻译：公开了吡啶并[3,4-f]吡咯并[1,2-b] [1,2]三氮和用于治疗抑郁症，缓解疼痛和炎症以及利用化合物或其组合物增强记忆的方法。

3. 发明授权

US4914103A Pyrido(3,4-F)pyrrolo(1,2-B)(1,2,5)triazepines 失效
标题翻译：吡啶（3,4-F）吡咯并（1,2-B）（1,2,5）三氮杂
公开(公告)号：US4914103A
公开(公告)日：1990-04-03
申请号：US397922
申请日：1989-08-24
申请人： Richard C. Effland , Larry Davis , Kevin J. Kapples , Gordon E. Olsen
发明人： Richard C. Effland , Larry Davis , Kevin J. Kapples , Gordon E. Olsen
IPC分类号： C07D471/14
CPC分类号： C07D471/14
摘要： Pyrido[3,4-f]pyrrolo[1,2-b][1,2,5]triazepines and methods for treating depression, alleviating pain and inflammation, and enhancing memory utilizing compounds or compositions thereof are disclosed.
摘要翻译：公开了吡啶并[3,4-f]吡咯并[1,2-b] [1,2,5]三氮和用于治疗抑郁症，缓解疼痛和炎症以及利用化合物或其组合物增强记忆的方法。

4. 发明授权

US4608374A 11-substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines as antipsychotic and analgesic agents 失效
标题翻译： 11-取代的5H，11H-吡咯并[2,1-c] [1,4]苯并氧杂吖庚因作为抗精神病药和镇痛药
公开(公告)号：US4608374A
公开(公告)日：1986-08-26
申请号：US549098
申请日：1983-11-07
申请人： Richard C. Effland , Larry Davis , Kevin J. Kapples
发明人： Richard C. Effland , Larry Davis , Kevin J. Kapples
IPC分类号： A61K31/00 , A61K31/55 , A61P25/04 , A61P25/18 , A61P25/24 , A61P25/26 , C07D207/32 , C07D207/333 , C07D401/06 , C07D498/04 , A61K31/40 , C07D403/06
CPC分类号： C07D207/333 , C07D401/06
摘要： There are described to novel 11-substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines of the general formula ##STR1## where m and n are each independently 0, 1 or 2 and m+n is 1 or 2, X and Y are each independently hydrogen, loweralkyl or halogen, and R is hydrogen, cyano, --C(NH.sub.2)NOH, ##STR2## unsubstituted loweralkyl, or substituted loweralkyl having one to three substituents each of which being independently cyano, hydroxy, cyclohexyl, furyl, thienyl, ##STR3## k being 1, 2 or 3, W being each independently hydrogen, halogen, hydroxy, loweralkyl, trifluoromethyl, loweralkoxy, nitro, amino, diloweralkylamino, phenoxy, or benzyloxy, and Z being hydrogen, loweralkyl or halogen, which are useful as antipsychotic and analgesic agents; novel intermediate compounds therefor; and methods of synthesizing the foregoing compounds.

5. 发明授权

US4812450A Spiro((piperidine-pyrrolidine- or hexahydroazepinyl substituted) pyrrolo(2,1-C) (1,4)benzoxazepines) 失效
标题翻译：螺（（哌啶 - 吡咯烷或六氢氮杂吖啶基）吡咯并（2,1-C）（1,4）苯并氧氮杂）
公开(公告)号：US4812450A
公开(公告)日：1989-03-14
申请号：US79557
申请日：1987-07-30
申请人： Richard C. Effland , Larry Davis , Kevin J. Kapples
发明人： Richard C. Effland , Larry Davis , Kevin J. Kapples
IPC分类号： C07D498/10 , A61K31/55 , A61P9/12 , A61P25/04 , C07D401/04 , C07D401/14 , C07D498/20 , C07D498/22 , A61K31/555 , C07D403/04
CPC分类号： C07D401/04 , C07D401/14
摘要： This invention relates to spiro-[(piperidine-, pyrrolidine-, or -hexahyroazepinyl substituted) pyrrolo[2,1-c][1,4]-benzoxazepines] having the following formula ##STR1## wherein R is hydrogen, lower alkyl, arylloweralkyl, acyl, lower alkenyl, lower alkynyl, and loweralkylbenzisoxazole; X is hydrogen, halogen, loweralkoxy, and trifluoromethyl; Y is hydrogen; 2' or 3' acyl, formyl, carbinol of the formula ##STR2## wherein R.sub.1 and R.sub.2 are the same or different and are independently hydrogen, loweralkyl, arylloweralkyl, aryl, loweralkenyl, lower alkynyl and lower alkylbenzisoxazole; loweralkyl, loweralkenyl and halogen; and n is an integer of 1 to 3. The compounds of this invention display utility as analgesic and antihypertensive agents.

6. 发明授权

US4918069A Spiro[(piperidine- pyrrolidine- or hexahydroazepinyl substituted) pyrrolo[2,][1,4]benzoxazepines] 失效
标题翻译：螺[（哌啶 - 吡咯烷 - 或六氢氮杂吖啶基）吡咯并[2,1-c] [1,4]苯并氧氮杂]
公开(公告)号：US4918069A
公开(公告)日：1990-04-17
申请号：US290343
申请日：1988-12-29
申请人： Richard C. Effland , Larry Davis , Kevin J. Kapples
发明人： Richard C. Effland , Larry Davis , Kevin J. Kapples
IPC分类号： C07D401/04 , C07D401/14 , C07D498/20
CPC分类号： C07D401/04 , C07D401/14
摘要： This invention relates to spiro-[(piperidine-, pyrrolidine-, or -hexahydroazepinyl substituted) pyrrolo[2,1-c][1,4]-benzoxazepines] having the following formula ##STR1## wherein R is hydrogen, lower alkyl, arylloweralkyl, acyl, lower alkenyl, lower alkynyl, and loweralkylbenzisoxazole; X is hydrogen, halogen, loweralkoxy, and trifluoromethyl; Y is hydrogen; 2' or 3' acyl, formyl, carbinol of the formula ##STR2## where R.sub.1 and R.sub.2 are the same or different and are independently hydrogen, loweralkyl, arylloweralkyl, aryl, loweralkenyl, lower alkynyl and lower alkylbenzisoxazole; loweralkyl, loweralkenyl and halogen; and n is an integer of 1 to 3. The compounds of this invention display utility as analgesic and antihypertensive agents.
摘要翻译：本发明涉及具有下列结构式的螺[ - （哌啶 - ，吡咯烷 - 或六氢氮杂环己烷基取代的）吡咯并[2,1-c] [1,4] - 苯并恶唑]，其中R是氢，低级烷基，芳基低级烷基，酰基，低级烯基，低级炔基和低级烷基苯并异恶唑; X是氢，卤素，低级烷氧基和三氟甲基; Y是氢; 其中R 1和R 2相同或不同并且独立地是氢，低级烷基，芳基低级烷基，芳基，低级烯基，低级炔基和低级烷基苯并异恶唑;式2'或3'酰基，甲酰基甲醇，低级烷基，低级烯基和卤素; 并且n为1至3的整数。本发明化合物显示出作为镇痛和抗高血压药物的用途。

7. 发明授权

US4667039A 11-substituted 5H,11H-pyrrolo(2,1-C) (1,4)benzoxazepines as antipsychotic and analgesic agents 失效
标题翻译： 11-取代的5H，11H-吡咯并（2,1-C）（1,4）苯并氧杂吖庚因作为抗精神病药和镇痛药
公开(公告)号：US4667039A
公开(公告)日：1987-05-19
申请号：US811135
申请日：1985-12-19
申请人： Richard C. Effland , Larry Davis , Kevin J. Kapples
发明人： Richard C. Effland , Larry Davis , Kevin J. Kapples
IPC分类号： C07D401/06 , C07D498/04
CPC分类号： C07D401/06
摘要： There are described to novel 11-substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines of the general formula ##STR1## where m and n are each independently 0, 1 or 2 and m+n is 1 or 2, X and Y are each independently hydrogen, loweralkyl or halogen, and R is hydrogen, cyano, --C(NH.sub.2)NOH, ##STR2## unsubstituted loweralkyl, or substituted loweralkyl having one to three substituents each of which being independently cyano, hydroxy, cyclohexyl, furyl, thienyl, ##STR3## k being 1, 2 or 3, W being each independently hydrogen, halogen, hydroxy, loweralkyl, trifluoromethyl, loweralkoxy, nitro, amino, diloweralkylamino, phenoxy, or benzyloxy, and Z being hydrogen, loweralkyl or halogen, which are useful as antipsychotic and analgesic agents; novel intermediate compounds therefor; and methods of synthesizing the foregoing compounds.
摘要翻译：描述了通式为其中m和n各自独立地为0,1或2的新的11-取代的5H，11H-吡咯并[2,1-c] [1,4]苯并氧氮杂，m和n各自独立地为0,1或2，m + n为1或2，X和Y各自独立地为氢，低级烷基或卤素，R为氢，氰基，-C（NH 2）NOH，未取代的低级烷基或具有一至三个取代基的取代的低级烷基，独立地是氰基，羟基，环己基，呋喃基，噻吩基，是1,2或3，W各自独立地为氢，卤素，羟基，低级烷基，三氟甲基，低级烷氧基，硝基，氨基，二卤烷基氨基，苯氧基或苄氧基，Z为氢，低级烷基或卤素，其可用作抗精神病药和止痛剂; 新型中间体化合物; 和上述化合物的合成方法。

8. 发明授权

US5215984A Antihypertensive spiro(piperidine- pyrrolidine- or hexahydroazepinyl substituted) pyrrolo(2,1-c)(1,4)benzoxazepines) 失效
标题翻译：抗高血压螺（哌啶 - 吡咯烷或六氢氮杂环己基取代的）吡咯并（2,1-c）（1,4）苯并氧氮杂）
公开(公告)号：US5215984A
公开(公告)日：1993-06-01
申请号：US440947
申请日：1989-11-24
申请人： Richard C. Effland , Larry Davis , Kevin J. Kapples
发明人： Richard C. Effland , Larry Davis , Kevin J. Kapples
IPC分类号： C07D401/04 , C07D401/14 , C07D498/20
CPC分类号： C07D401/04 , C07D401/14
摘要： This invention relates to spiro-](piperidine-, pyrrolidine-, or -hexahydroazepinyl substituted) pyrrolo[2,1-c][1,4]-benzoxazepines] having the following formula ##STR1## wherein R is hydrogen, lower alkyl, arylloweralkyl, acyl, lower alkenyl, lower alkynyl, and loweralkylbenzisoxazole; X is hydrogen, halogen, loweralkoxy, and trifluoromethyl; Y is hydrogen; 2' or 3' acyl, formyl, carbinol of the formula ##STR2## where R.sub.1 and R.sub.2 are the same or different and are independently hydrogen, loweralkyl, arylloweralkyl, aryl, loweralkenyl, lower alkynyl and lower alkylbenzisoxazole; loweralkyl, loweralkenyl and halogen; and n is an integer of 1 to 3. The compounds of this invention display utility as analgesic and antihypertensive agents.
摘要翻译：本发明涉及具有下列结构式的螺 - - （哌啶 - ，吡咯烷 - 或六氢氮杂环己烷基取代的）吡咯并[2,1-c] [1,4] - 苯并恶唑[其中R是氢，低级烷基，芳基低级烷基，酰基，低级烯基，低级炔基和低级烷基苯并异恶唑; X是氢，卤素，低级烷氧基和三氟甲基; Y是氢; 其中R 1和R 2相同或不同并且独立地是氢，低级烷基，芳基低级烷基，芳基，低级烯基，低级炔基和低级烷基苯并异恶唑;式2'或3'酰基，甲酰基甲醇，低级烷基，低级烯基和卤素; 并且n为1至3的整数。本发明化合物显示出作为镇痛和抗高血压药物的用途。

9. 发明授权

US4681879A 11-substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines as antipsychotic and analgesic agents 失效
标题翻译： 11-取代的5H，11H-吡咯并[2,1-c] [1,4]苯并氧杂吖庚因作为抗精神病药和镇痛药
公开(公告)号：US4681879A
公开(公告)日：1987-07-21
申请号：US713938
申请日：1985-03-20
申请人： Richard C. Effland , Larry Davis , Kevin J. Kapples
发明人： Richard C. Effland , Larry Davis , Kevin J. Kapples
IPC分类号： C07D401/06 , C07D498/04 , C07D413/04 , A61K31/40 , A61K31/445
CPC分类号： C07D401/06
摘要： There are described novel 11-substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines of the general formula ##STR1## where m and n are each independently 0, 1 or 2 and m+n is 1 or 2, X and Y are each independently hydrogen, loweralkyl or halogen, and R is hydrogen, cyano, --C(NH.sub.2)NOH, ##STR2## unsubstituted loweralkyl, or substituted loweralkyl having one to three substituents each of which being independently cyano, hydroxy, cycloalkyl of 3-6 carbon atoms, furyl, thienyl, ##STR3## k being 1, 2 or 3, W being each indepentently hydrogen, halogen, hydroxy, loweralkyl, trifluoromethyl, loweralkoxy, nitro, amino, diloweralkylamino, phenoxy, or benzyloxy, and Z being hydrogen, loweralkyl or halogen, which are useful as antipsychotic and analgesic agents; novel intermediate compounds therefor; and methods of synthesizing the foregoing compounds.
摘要翻译：描述了通式（IMA）（I）的新颖的11取代的5H，11H-吡咯并[2,1-c] [1,4]苯并氧杂吖庚因，其中m和n各自独立地为0,1或2，m + n为1或2，X和Y各自独立地为氢，低级烷基或卤素，R为氢，氰基，-C（NH 2）NOH，未取代的低级烷基或具有一至三个取代基的取代的低级烷基，独立地是氰基，羟基，3-6个碳原子的环烷基，呋喃基，噻吩基，1,2或3个，各自独立地为氢，卤素，羟基，低级烷基，三氟甲基，低级烷氧基，硝基，氨基，二低级烷基氨基，苯氧基或苄氧基，Z为氢，低级烷基或卤素，可用作抗精神病药和镇痛药; 新型中间体化合物; 和上述化合物的合成方法。

10. 发明授权

US5221682A Heteroarylamino- and heteroaryloxypyridinamines and related compounds 失效
标题翻译：杂芳基氨基和杂芳氧基吡啶胺及相关化合物
公开(公告)号：US5221682A
公开(公告)日：1993-06-22
申请号：US695156
申请日：1991-05-03
申请人： Richard C. Effland , Joseph T. Klein , Gordon E. Olsen , Larry Davis , Russell R. L. Hamer , Brian S. Freed
发明人： Richard C. Effland , Joseph T. Klein , Gordon E. Olsen , Larry Davis , Russell R. L. Hamer , Brian S. Freed
IPC分类号： C07D213/74 , C07D213/89 , C07D401/12 , C07D403/12
CPC分类号： C07D213/74 , C07D213/89 , C07D401/12 , C07D403/12
摘要： There are described compounds of the formula ##STR1## where n is 0 or 1;X is O or NR.sub.2, R.sub.2 being hydrogen, loweralkyl or loweralkylcarbonyl;R is hydrogen, loweralkyl, arylloweralkyl or loweralkylcarbonyl; andR.sub.1 is ##STR2## wherein R.sub.3 is hydrogen, loweralkyl or loweralkylcarbonyl; m is 1 or 2; each R.sub.4 is independently hydrogen or loweralkyl; and Y is hydrogen, halogen, loweralkyl, loweralkoxy or trifluoromethyl;which compounds are useful as topical antiinflammatory agents for the treatment of various dematoses.
摘要翻译：描述式为“IMAGE”的化合物，其中n为0或1; X是O或NR 2，R 2是氢，低级烷基或低级烷基羰基; R是氢，低级烷基，芳基低级烷基或低级烷基羰基; R1是其中R3是氢，低级烷基或低级烷基羰基; m为1或2; 每个R 4独立地是氢或低级烷基; Y为氢，卤素，低级烷基，低级烷氧基或三氟甲基; 哪些化合物可用作治疗各种甲状腺炎的局部抗炎药。

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