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    • 4. 发明授权
    • Perfected process for the preparation of stable nitroxide radicals
    • 用于制备稳定的氮氧自由基的完美工艺
    • US07745478B2
    • 2010-06-29
    • US11574582
    • 2005-08-25
    • Maria CaldararoRiccardo PoMarco Ricci
    • Maria CaldararoRiccardo PoMarco Ricci
    • A61K31/404
    • C07D209/44
    • Process for the preparation of stable nitroxide radicals (I) starting from N-benzylphthalimide in three steps. In the first step, the N-benzylphthalimide is transformed into N-benzyl-1,1,3,3-tetralkylisoindoline by treatment with a Grignard reagent prepared in methyl-tert-butyl ether. In the second step, the N-benzyl-1,1,3,3-tetraalkylisoindoline is transformed into 1,1,3,3-tetra-alkylisoindoline by hydrogenolysis. In the third step, the 1,1,3,3-tetra-alkyl-isoindoline is transformed into the nitroxide radical by oxidation with hydrogen peroxide in the presence of a catalyst selected from acids and salts of polymolybdic or polytungstic acids.
    • 从N-苄基邻苯二甲酰亚胺开始三步制备稳定的氮氧自由基(I)的方法。 在第一步中,通过用在甲基叔丁基醚中制备的格氏试剂处理,将N-苄基邻苯二甲酰亚胺转化成N-苄基-1,1,3,3-四烷基异吲哚啉。 在第二步中,N-苄基-1,1,3,3-四烷基异吲哚啉通过氢解转化为1,1,3,3-四烷基异吲哚啉。 在第三步中,通过在选自酸和多钼酸或多钨酸的盐的催化剂的存在下,用过氧化氢氧化将1,1,3,3-四烷基 - 异吲哚啉转化为硝基氧基。
    • 5. 发明申请
    • Perfected Process for the Preparation of Stable Nitroxide Radicals
    • 用于制备稳定的硝基氧自由基的完善方法
    • US20070282113A1
    • 2007-12-06
    • US11574582
    • 2005-08-25
    • Maria CaldararoRiccardo PoMarco Ricci
    • Maria CaldararoRiccardo PoMarco Ricci
    • C07C209/66
    • C07D209/44
    • Process for the preparation of stable nitroxide radicals (I) starting from N-benzylphthalimide in three steps. In the first step, the N-benzylphthalimide is transformed into N-benzyl-1,1,3,3-tetralkylisoindoline by treatment with a Grignard reagent prepared in methyl-tert-butyl ether In the second step, the N-benzyl-1,1,3,3-tetraalkylisoindoline is transformed into 1,1,3,3-tetra-alkylisoindoline by hydrogenolysis. In the third step, the 1,1,3,3-tetra-alkyl-isoindoline is transformed into the nitroxide radical by oxidation with hydrogen peroxide in the presence of a catalyst selected from acids and salts of polymolybdic or polytungstic acids.
    • 从N-苄基邻苯二甲酰亚胺开始三步制备稳定的氮氧自由基(I)的方法。 在第一步中,通过用在甲基叔丁基醚中制备的格氏试剂处理,将N-苄基邻苯二甲酰亚胺转化成N-苄基-1,1,3,3-四烷基异吲哚啉。在第二步中,将N-苄基-1 ,1,3,3-四烷基异吲哚啉通过氢解转化为1,1,3,3-四烷基异吲哚啉。 在第三步中,通过在选自酸和多钼酸或多钨酸的盐的催化剂的存在下,用过氧化氢氧化将1,1,3,3-四烷基 - 异吲哚啉转化为硝基氧基。