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1. 发明申请

US20080001083A1 Electronic drive and acquisition system for mass spectrometry 有权
标题翻译：用于质谱的电子驱动和采集系统
公开(公告)号：US20080001083A1
公开(公告)日：2008-01-03
申请号：US11800421
申请日：2007-05-03
申请人： Rembrandt Schaefer , Mohammad Majrradi , Ara Chutjian , Murray Darrach , John MacAskill , Tuan Tran , Gary Burke , Stojan Madzunkov , Brent Blaes , John Thomas , Ryan Stern , David Zhu
发明人： Rembrandt Schaefer , Mohammad Majrradi , Ara Chutjian , Murray Darrach , John MacAskill , Tuan Tran , Gary Burke , Stojan Madzunkov , Brent Blaes , John Thomas , Ryan Stern , David Zhu
IPC分类号： H01J49/02
CPC分类号： H01J49/022 , H01J49/0031 , H01J49/424
摘要： The present invention discloses an mixed signal RF drive electronics board that offers small, low power, reliable, and customizable method for driving and generating mass spectra from a mass spectrometer, and for control of other functions such as electron ionizer, ion focusing, single-ion detection, multi-channel data accumulation and, if desired, front-end interfaces such as pumps, valves, heaters, and columns.
摘要翻译：本发明公开了一种混合信号射频驱动电路板，它提供了用于从质谱仪驱动和产生质谱的小型，低功率，可靠和可定制的方法，并且用于控制其他功能，例如电子离子发生器，离子聚焦，离子检测，多通道数据积累，以及如果需要的话，前端接口如泵，阀，加热器和色谱柱。

2. 发明授权

US07772550B2 Electronic drive and acquisition system for mass spectrometry 有权
标题翻译：用于质谱的电子驱动和采集系统
公开(公告)号：US07772550B2
公开(公告)日：2010-08-10
申请号：US11800421
申请日：2007-05-03
申请人： Rembrandt Thomas Schaefer , Mohammad Mojarradi , Ara Chutjian , Murray R. Darrach , John MacAskill , Tuan Tran , Gary R. Burke , Stojan M. Madzunkov , Brent R. Blaes , John L. Thomas , Ryan A. Stern , David Q. Zhu
发明人： Rembrandt Thomas Schaefer , Mohammad Mojarradi , Ara Chutjian , Murray R. Darrach , John MacAskill , Tuan Tran , Gary R. Burke , Stojan M. Madzunkov , Brent R. Blaes , John L. Thomas , Ryan A. Stern , David Q. Zhu
IPC分类号： H01J49/26
CPC分类号： H01J49/022 , H01J49/0031 , H01J49/424
摘要： The present invention discloses an mixed signal RF drive electronics board that offers small, low power, reliable, and customizable method for driving and generating mass spectra from a mass spectrometer, and for control of other functions such as electron ionizer, ion focusing, single-ion detection, multi-channel data accumulation and, if desired, front-end interfaces such as pumps, valves, heaters, and columns.
摘要翻译：本发明公开了一种混合信号射频驱动电路板，它提供了用于从质谱仪驱动和产生质谱的小型，低功率，可靠和可定制的方法，并且用于控制其他功能，例如电子离子发生器，离子聚焦，离子检测，多通道数据积累，以及如果需要的话，前端接口如泵，阀，加热器和色谱柱。

3. 发明授权

US06583702B2 Quadrupole mass spectrometer driver with higher signal levels 失效
标题翻译：具有较高信号电平的四极杆质谱仪驱动器
公开(公告)号：US06583702B2
公开(公告)日：2003-06-24
申请号：US10165252
申请日：2002-06-05
申请人： Ara Chutjian , Dean Aalami , Murray Darrach , Otto Orient
发明人： Ara Chutjian , Dean Aalami , Murray Darrach , Otto Orient
IPC分类号： H01E2734
CPC分类号： H02M7/53806
摘要： Driving a quadrapole mass spectrometer includes obtaining an air core transformer with a primary and a secondary, matching the secondary to the mass spectrometer, and driving the primary based on first and second voltage levels. Driving of the primary is via an isolating stage that minimizes low level drive signal coupling.
摘要翻译：驱动四极杆质谱仪包括获得具有初级和次级的空气变压器，与次级质谱仪匹配，并且基于第一和第二电压电平驱动初级。主要的驱动是通过使低电平驱动信号耦合最小化的隔离级。

4. 发明申请

US20050170523A1 Chemical sensor system 失效
标题翻译：化学传感器系统
公开(公告)号：US20050170523A1
公开(公告)日：2005-08-04
申请号：US10293966
申请日：2002-11-12
申请人： Murray Darrach , Ara Chutjian
发明人： Murray Darrach , Ara Chutjian
IPC分类号： G01N1/00 , G01N27/64 , H01J49/02 , H01J49/06
CPC分类号： H01J49/48 , G01N27/64 , H01J27/028 , H01J49/06 , H01J49/147 , Y10T436/145555 , Y10T436/147777 , Y10T436/163333 , Y10T436/170769 , Y10T436/173076 , Y10T436/19 , Y10T436/24 , Y10T436/25
摘要： A chemical sensing apparatus and method for the detection of sub parts-per-trillion concentrations of molecules in a sample by optimizing electron utilization in the formation of negative ions is provided. A variety of media may be sampled including air, seawater, dry sediment, or undersea sediment. An electrostatic mirror is used to reduce the kinetic energy of an electron beam to zero or near-zero kinetic energy.
摘要翻译：提供了一种用于通过优化负离子形成中的电子利用来检测样品中每分子百万分之一分子浓度的化学感测装置和方法。可以对各种介质进行采样，包括空气，海水，干沉积物或海底沉积物。使用静电镜将电子束的动能降低到零或接近零的动能。

5. 发明授权

US06434031B1 Driving a quadrupole mass spectrometer via an isolating stage 有权
公开(公告)号：US06434031B1
公开(公告)日：2002-08-13
申请号：US09813654
申请日：2001-03-20
申请人： Ara Chutjian , Dean Aalami , Murray Darrach , Otto Orient
发明人： Ara Chutjian , Dean Aalami , Murray Darrach , Otto Orient
IPC分类号： H01J3700
摘要： Driving a quadrupole mass spectrometer includes obtaining an air core transformer with a primary and a secondary, matching the secondary to the mass spectrometer, and driving the primary based on first and second voltage levels. Driving of the primary is via an isolating stage that minimizes low level drive signal coupling.

6. 发明授权

US06205043B1 Power supply with air core transformer and seperated power supplies for high dynamic range 失效
标题翻译：电源采用空心变压器和分离电源，动态范围广
公开(公告)号：US06205043B1
公开(公告)日：2001-03-20
申请号：US09392351
申请日：1999-09-08
申请人： Ara Chutjian , Dean Aalami , Murray Darrach , Otto Orient
发明人： Ara Chutjian , Dean Aalami , Murray Darrach , Otto Orient
IPC分类号： H02M7155
CPC分类号： H02M7/53806
摘要： A power supply for a quadrupole mass spectrometer which operates using an RF signal. The RF signal is controllable via a feedback loop. The feedback loop is from the output, through a comparator, and compared to a digital signal. An air core transformer is used to minimize the weight. The air core transformer is driven via two out of phase sawtooth signals which drive opposite ends of the transformer.
摘要翻译：用于使用RF信号工作的四极杆质谱仪的电源。 RF信号可以通过反馈回路进行控制。反馈回路来自输出，通过比较器，并与数字信号进行比较。使用空心变压器来减轻重量。空心变压器通过驱动变压器相对端的两个异相锯齿信号驱动。

7. 发明授权

US08116981B2 Detector using mass spectroscopy for characterization of biological community 有权
标题翻译：检测器使用质谱来表征生物群落
公开(公告)号：US08116981B2
公开(公告)日：2012-02-14
申请号：US10447674
申请日：2003-05-28
申请人： Ara Chutjian , Murray R. Darrach , Roger G. Kern
发明人： Ara Chutjian , Murray R. Darrach , Roger G. Kern
IPC分类号： G01N33/48 , B01D59/44
CPC分类号： G01N33/6848
摘要： Provided are methods and systems for rapidly and effectively characterizing a cell as belonging to a particular genus, species, strain, or having a particular phenotype. The methods and systems utilize mass spectrometry and low-energy negative ionization to detect cell surface markers indicative of a particular cell.
摘要翻译：提供了用于将细胞快速有效地表征为属于特定属，物种，菌株或具有特定表型的方法和系统。该方法和系统利用质谱法和低能量负电离来检测指示特定细胞的细胞表面标志物。

8. 发明授权

US4818868A Trochoidal analysis of scattered electrons in a merged electron-ion beam geometry 失效
标题翻译：在合并的电子 - 离子束几何中的散射电子的卷积分析
公开(公告)号：US4818868A
公开(公告)日：1989-04-04
申请号：US154713
申请日：1988-02-11
申请人： Ara Chutjian
发明人： Ara Chutjian
IPC分类号： G01T1/29 , H01S1/00 , G01K1/08 , H01J3/14
CPC分类号： G01T1/29
摘要： The method and apparatus of this invention provides a plurality of measurements indicative of the absolute cross section for excitation of an ion beam. The ion beam is merged for excitation by specific energies of electrons in an electron beam. Both beams are merged in an evacuated enclosure having a longitudinal magnetic field and a crossed uniform electric field. The ions and electrons interact over a known merged longitudinal length in a merged beam area. After collision, the electron and ion beams are demerged. Forward and backward-scattered electrons are collected and position-detected by a pair of microchannel plate arrays located at opposite ends of the longitudinal beam-merging area. A series of electron and ion primary current measurements are taken at full ion and electron beam strength. Measurements are also taken at greatly reduced beam strength to obtain a beam overlap profile.
摘要翻译：本发明的方法和装置提供多个指示离子束激发的绝对横截面的测量结果。离子束通过电子束中的特定能量的电子被合并以进行激发。两个梁合并在具有纵向磁场和交叉均匀电场的真空外壳中。离子和电子在合并光束区域中的已知合并纵向长度上相互作用。碰撞后，电子和离子束被分流。通过位于纵向束合并区域的相对端的一对微通道板阵列收集正向和反向散射的电子并进行位置检测。在全离子和电子束强度下进行一系列电子和离子初级电流测量。在大大减小的光束强度下也进行测量以获得光束重叠轮廓。

9. 发明授权

US06521898B2 High-efficiency electron ionizer for a mass spectrometer array 失效
标题翻译：用于质谱仪阵列的高效电子离子发生器
公开(公告)号：US06521898B2
公开(公告)日：2003-02-18
申请号：US09903475
申请日：2001-07-10
申请人： Ara Chutjian , Murray R. Darrach , Otto J. Orient
发明人： Ara Chutjian , Murray R. Darrach , Otto J. Orient
IPC分类号： H01J4914
CPC分类号： H01J49/14
摘要： The present invention provides an improved electron ionizer for use in a quadrupole mass spectrometer. The improved electron ionizer includes a repeller plate that ejects sample atoms or molecules, an ionizer chamber, a cathode that emits an electron beam into the ionizer chamber, an exit opening for excess electrons to escape, at least one shim plate to collimate said electron beam, extraction apertures, and a plurality of lens elements for focusing the extracted ions onto entrance apertures.
摘要翻译：本发明提供一种用于四极质谱仪的改进的电离子发生器。改进的电子离子发生器包括排出样品原子或分子的排斥板，离子化器室，向电离器室中发射电子束的阴极，用于过量电子逸出的出口，至少一个垫板以准直所述电子束，提取孔，以及用于将提取的离子聚焦到入口孔上的多个透镜元件。

10. 发明授权

US06271527B1 High-efficiency electron ionizer for a mass spectrometer array 失效
标题翻译：用于质谱仪阵列的高效电子离子发生器
公开(公告)号：US06271527B1
公开(公告)日：2001-08-07
申请号：US09588991
申请日：2000-06-06
申请人： Ara Chutjian , Murray R. Darrach , Otto J. Orient
发明人： Ara Chutjian , Murray R. Darrach , Otto J. Orient
IPC分类号： H01J4914
CPC分类号： H01J49/14
摘要： The present invention provides an improved electron ionizer for use in a quadrupole mass spectrometer. The improved electron ionizer includes a repeller plate that ejects sample atoms or molecules, an ionizer chamber, a cathode that emits an electron beam into the ionizer chamber, an exit opening for excess electrons to escape, at least one shim plate to collimate said electron beam, extraction apertures, and a plurality of lens elements for focusing the extracted ions onto entrance apertures.
摘要翻译：本发明提供一种用于四极质谱仪的改进的电离子发生器。改进的电子离子发生器包括排出样品原子或分子的排斥板，离子化器室，向电离器室中发射电子束的阴极，用于过量电子逸出的出口，至少一个垫板以准直所述电子束，提取孔，以及用于将提取的离子聚焦到入口孔上的多个透镜元件。

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