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1. 发明授权

US06809185B1 Multipurpose antibody derivatives 有权
标题翻译：多用抗体衍生物
公开(公告)号：US06809185B1
公开(公告)日：2004-10-26
申请号：US09625049
申请日：2000-07-24
申请人： Reinhilde Schoonjans , Nico Mertens , Walter Fiers , Roland Contreras
发明人： Reinhilde Schoonjans , Nico Mertens , Walter Fiers , Roland Contreras
IPC分类号： C07K1600
CPC分类号： C07K16/2809 , A61K38/00 , C07K16/00 , C07K16/40 , C07K16/468 , C07K2317/73 , C07K2319/00
摘要： The present invention relates to a class of molecules specified as novel multipurpose antibody derivatives. This class of molecules is created by heterodimerization of two constituting components. Heterodimerization is obtained by the specific heterotypic interaction of a chosen VH-CH1 combination of immunoglobulin domains, with a chosen VL-CL combination of immunoglobulin domains. The appropriate VH and VL domains in the VHCH1 and VLCL context, a binding specificity can be constitituted by the heterodimerization scaffold itself. One or both of the comprising VHCH1 and VLCL chains can thus be extended at either the N- or the C-terminus or both with other molecules, such as a toxin polypeptide, an enzyme, a hormone, a cytokine, a signaling molecule, or a single chain linked Fv fragment with the same or a different specificity.
摘要翻译：本发明涉及一类被指定为新型多功能抗体衍生物的分子。这类分子是由两种构成成分的异二聚化产生的。通过选择的免疫球蛋白结构域的VH-CH1组合与选择的免疫球蛋白结构域的VL-CL组合的特异性异型相互作用获得异二聚化。 VHCH1和VLCL环境中适当的VH和VL结构域，结合特异性可以由异二聚化支架本身构成。因此，包含VHCH1和VLCL链的一个或两个可以在N-或C-末端延伸，或者与其它分子例如毒素多肽，酶，激素，细胞因子，信号传导分子或具有相同或不同特异性的单链连接的Fv片段。

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