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1. 发明授权

US5158598A Bithienyl derivatives, and herbicidal use for agents containing them 失效
标题翻译：二氯甲烷衍生物及其除草剂用于含有它们的物质
公开(公告)号：US5158598A
公开(公告)日：1992-10-27
申请号：US389820
申请日：1989-08-04
申请人： Reiner Kober , Joachim Leyendecker , Rainer Seele , Klaus Fischer , Hans Theobald , Bruno Wuerzer , Karl-Otto Westphalen , Norbert Meyer
发明人： Reiner Kober , Joachim Leyendecker , Rainer Seele , Klaus Fischer , Hans Theobald , Bruno Wuerzer , Karl-Otto Westphalen , Norbert Meyer
IPC分类号： A01N43/10 , A01N43/36 , A01N43/40 , A01N43/42 , A01N43/52 , A01N43/74 , A01N43/80 , C07D333/16 , C07D333/28 , C07D333/34 , C07D333/38 , C07D333/42 , C07D409/14 , C07D413/14 , C07D417/14
CPC分类号： C07D409/14 , A01N43/10 , A01N43/36 , A01N43/40 , A01N43/42 , A01N43/52 , A01N43/74 , A01N43/80 , C07D333/16 , C07D333/28 , C07D333/34 , C07D333/38 , C07D333/42 , C07D413/14 , C07D417/14
摘要： Bithienyl derivatives of the formula Ia ##STR1## where the substituents have the following meanings: R.sup.1, R.sup.2 hydrogen, halogen, nitro, formyl, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -haloalkyl, C.sub.3 -C.sub.8 -cycloalkyl, C.sub.3 -C.sub.8 -cycloalkoxy, C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy, C.sub.1 -C.sub.4 -alkylthio, C.sub.1 -C.sub.4 -haloalkylthio, substituted or unsubstituted C.sub.1 -C.sub.6 -alkylcarbonyl, substituted or unsubstituted C.sub.3 -C.sub.6 -cycloalkylcarbonyl, substituted or unsubstituted C.sub.1 -C.sub.6 -alkoxycarbonyl and/or phenylcarbonyl;R.sup.3 hydrogen, halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkylthio, C.sub.1 -C.sub.4 -haloalkyl or C.sub.1 -C.sub.4 -haloalkoxy;A --CSNH.sub.2 ;substituted or unsubstituted oxazol-2-yl, oxazol-5-yl, isoxazol-3-yl, pyrazol-3-yl, pyrazol-5-yl, thiazol-2-yl or a corresponding benzofused radical;methods of manufacturing compounds Ia and agents containing a bithienyl derivative of the general formula I ##STR2## where B is --CSNH.sub.2 ;substituted or unsubstituted pyridyl, quinolinyl, phenyl, naphthyl, furyl, pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl or a corresponding benzofused radical.
摘要翻译：式Ia Ia的双噻吩基衍生物其中取代基具有以下含义：R 1，R 2氢，卤素，硝基，甲酰基，C 1 -C 6 - 烷基，C 1 -C 6 - 卤代烷基，C 3 -C 8环烷基，C 3 -C 8 取代或未取代的C 1 -C 6 - 烷基羰基，取代或未取代的C 3 -C 6 - 环烷基羰基，取代或未取代的C 1 -C 6 - 烷氧基，C 1 -C 4 - 烷氧基，C 1 -C 4 - 卤代烷氧基， C6烷氧基羰基和/或苯基羰基; R3，卤素，C1-C4烷基，C1-C4-烷氧基，C1-C4-烷硫基，C1-C4-卤代烷基或C1-C4-卤代烷氧基; A -CSNH2; 取代或未取代的恶唑-2-基，恶唑-5-基，异恶唑-3-基，吡唑-3-基，吡唑-5-基，噻唑-2-基或相应的苯并稠合基; 制备化合物Ia的方法和含有通式I的二噻吩基衍生物的试剂，其中B是-CSNH 2; 取代或未取代的吡啶基，喹啉基，苯基，萘基，呋喃基，吡咯基，吡唑基，咪唑基，恶唑基，异恶唑基，噻唑基或相应的苯并稠合基团。

2. 发明授权

US5171353A Sulfonamides 失效
标题翻译：磺胺
公开(公告)号：US5171353A
公开(公告)日：1992-12-15
申请号：US521032
申请日：1990-05-09
申请人： Klaus Fischer , Horst Mayer , Klaus Ditrich , Gerhard Hamprecht , Bruno Wuerzer , Karl-Otto Westphalen
发明人： Klaus Fischer , Horst Mayer , Klaus Ditrich , Gerhard Hamprecht , Bruno Wuerzer , Karl-Otto Westphalen
IPC分类号： A01N43/90 , C07D471/04 , C07D473/06 , C07D473/40
CPC分类号： C07D471/04 , A01N43/90 , C07D473/06 , C07D473/40
摘要： Sulfonamides of the general formula I ##STR1## where R.sup.1 is hydrogen of C.sub.1 -C.sub.4 -alkyl,R.sup.2 is hydrogen or substituted or unsubstituted C.sub.1 -C.sub.6 -alkyl; C.sub.3 -C.sub.4 -alkenyl; C.sub.3 -C.sub.4 -alkynyl or substituted or unsubstituted saturated or singly unsaturated 5- to 7- membered heteroaryl;R.sup.3 and R.sup.4 are halogen; substituted or unsubstituted C.sub.1 -C.sub.4 -alkoxy C.sub.1 -C.sub.4 -alkylthio, C.sub.2 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 -alkenyloxy, C.sub.2 -C.sub.6 -alkenylthio, C.sub.2 -C.sub.6 -alkynyl, C.sub.2 -C.sub.6 -alkynyloxy, C.sub.2 -C.sub.6 -alkynylthio, C.sub.3 -C.sub.6 -cycloalkyl, C.sub.3 -C.sub.6 -cycloalkylthio, C.sub.5 -C.sub.6 -cycloalkenyl, C.sub.3 -C.sub.6 -cycloalkoxy, C.sub.5 -C.sub.6 -cycloalkenyloxy, C.sub.5 -C.sub.6 -cycloalkenylthio, phenyl, phenoxy, phenylthio, benzyl, benzyloxy or benzylthio;the group given for R.sup.2, or NR.sup.7 R.sup.8, where R.sup.7 and R.sup.8 are hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.3 -C.sub.6 -alkenyl, C.sub.3 -C.sub.6 -alkynyl, C.sub.3 -C.sub.6 -cycloalkyl, C.sub.5 -C.sub.6 -cycloalkenyl, substituted or unsubstituted phenyl and/or benzyl bedeuten, or issubstituted or unsubstituted C.sub.4 -C.sub.6 -alkylene which may be interrupted or oxygen, sulfur or nitrogen;X is nitrogen or .dbd.CR.sup.5 14 ,where R.sup.5 is one of the radicals R.sup.3,n is 0 or 1 andA is substituted or unsubstituted mono- or dinuclear aryl containing one or two nitrogen, oxygen and/or sulfur atoms,and their agriculturally useful salts, and herbicidal and growth-regulating agents containing them.
摘要翻译：其中R 1是C 1 -C 4 - 烷基的氢，R 2是氢或被取代或未被取代的C 1 -C 6 - 烷基的磺酰胺， C3-C4-烯基; C3-C4-炔基或取代或未取代的饱和或单不饱和5-至7-元杂芳基; R3和R4是卤素; 取代或未取代的C 1 -C 4 - 烷氧基C 1 -C 4 - 烷硫基，C 2 -C 6 - 链烯基，C 2 -C 6 - 烯氧基，C 2 -C 6 - 烯硫基，C 2 -C 6炔基，C 2 -C 6 - 炔氧基，C 2 -C 6 - 炔硫基， C 3 -C 6环烷基，C 3 -C 6环烷硫基，C 5 -C 6环环烯基，C 3 -C 6环烷氧基，C 5 -C 6环环烯氧基，C 5 -C 6环环硫基，苯基，苯氧基，苯硫基，苄基，苄氧基或苄硫基; R2或NR7R8的基团，其中R7和R8是氢，C1-C6-烷基，C3-C6-烯基，C3-C6-炔基，C3-C6-环烷基，C5-C6-环烯基，取代或未取代的苯基或/或苄基叔丁基醚，或者是可被中断的取代或未取代的C 4 -C 6亚烷基或氧，硫或氮; X是氮或= CR514，其中R5是基团R3之一，n是0或1，A是含有一个或两个氮，氧和/或硫原子的取代或未取代的单核或二核芳基及其农业上有用的盐，和含有它们的除草和生长调节剂。

3. 发明授权

US5252540A Sulfonamides 失效
标题翻译：磺胺类
公开(公告)号：US5252540A
公开(公告)日：1993-10-12
申请号：US760156
申请日：1991-09-16
申请人： Elisabeth Heistracher , Klaus Fischer , Horst Mayer , Thomas Saupe , Gerhard Hamprecht , Klaus Ditrich , Thomas Kuekenhoehner , Matthias Gerber , Helmut Walter , Karl-Otto Westphalen
发明人： Elisabeth Heistracher , Klaus Fischer , Horst Mayer , Thomas Saupe , Gerhard Hamprecht , Klaus Ditrich , Thomas Kuekenhoehner , Matthias Gerber , Helmut Walter , Karl-Otto Westphalen
IPC分类号： A01N43/08 , A01N43/10 , A01N43/36 , A01N43/50 , A01N43/56 , A01N43/78 , A01N43/80 , C07D207/34 , C07D207/416 , C07D231/14 , C07D231/16 , C07D231/54 , C07D231/56 , C07D233/90 , C07D261/18 , C07D263/34 , C07D271/04 , C07D271/06 , C07D271/08 , C07D271/10 , C07D277/20 , C07D277/32 , C07D277/34 , C07D277/56 , C07D285/06 , C07D307/68 , C07D307/71 , C07D333/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
CPC分类号： C07D231/16 , C07D207/34 , C07D231/14 , C07D231/54 , C07D231/56 , C07D233/90 , C07D261/18 , C07D263/34 , C07D277/32 , C07D277/34 , C07D285/06 , C07D307/68 , C07D307/71 , C07D333/38 , C07D401/12 , C07D409/12
摘要： Sulfonamides of the formula I ##STR1## where A is an unsubstituted or substituted aromatic or heteroaromatic radical; W is oxygen or sulfur; B is an unsubstituted or substituted furyl, thienyl, pyrrolyl, oxazolyl, isothiazolyl, imidazolyl, pyrazolyl, thiadiazolyl, oxadiazolyl or triazolyl radical, and the environmentally compatible salts thereof are prepared as described and are used as herbicides.
摘要翻译：式I的磺酰胺（I）其中A是未取代或取代的芳族或杂芳族基团; W是氧或硫; B是未取代或取代的呋喃基，噻吩基，吡咯基，恶唑基，异噻唑基，咪唑基，吡唑基，噻二唑基，恶二唑基或三唑基，并且其环境相容的盐如所述制备并用作除草剂。

4. 发明授权

US10820938B2 Tissue fusion instrument, in particular a tissue fusion forceps 有权
公开(公告)号：US10820938B2
公开(公告)日：2020-11-03
申请号：US13552769
申请日：2012-07-19
申请人： Klaus Fischer , Achim Brodbeck , Daniel Schaeller
发明人： Klaus Fischer , Achim Brodbeck , Daniel Schaeller
IPC分类号： A61B18/14 , A61B18/00
摘要： A tissue fusion instrument having electrodes that are only connected in a punctiform manner to their electrode carrier such that they are electrically conducting and thus, heat-conducting.

5. 发明授权

US08979845B2 Electrosurgical forceps 有权
标题翻译：电外科钳
公开(公告)号：US08979845B2
公开(公告)日：2015-03-17
申请号：US13391105
申请日：2010-08-11
申请人： Daniel Schäller , Klaus Fischer , Dieter Hafner
发明人： Daniel Schäller , Klaus Fischer , Dieter Hafner
IPC分类号： A61B18/18 , A61B18/14
CPC分类号： A61B18/18 , A61B18/1442 , A61B2018/1412 , A61B2018/1455
摘要： Electrosurgical forceps for efficiently severing of hollow organs, in particular vessels. The electrosurgical forceps have a first branch and a second branch for gripping the hollow organ. The forceps have at least one neutral electrode on the second branch, at least one first coagulation electrode and a second coagulation electrode that is disposed on the first branch for applying a first HF current by means of the coagulation electrode, and at least one cutting device, which is arranged between the coagulation electrodes in order to sever the hollow organ in a cutting region. The cutting device has a cutting electrode for applying a second HF current between the cutting and neutral electrodes. The coagulation electrodes are arranged spaced apart from one another in such a way that the first HF current does not flow through or only a minor amount of the same flows through the cutting region.
摘要翻译：用于有效切断中空器官，特别是血管的电外科钳。电外科钳具有用于夹持中空器官的第一分支和第二分支。镊子在第二分支上具有至少一个中性电极，至少一个第一凝固电极和第二凝固电极，其设置在第一分支上，用于通过凝结电极施加第一HF电流;以及至少一个切割装置，其设置在凝结电极之间，以切断切割区域中的中空器官。切割装置具有用于在切割和中性电极之间施加第二HF电流的切割电极。凝固电极彼此间隔开，使得第一HF电流不流过或仅少量相同的流动通过切割区域。

6. 发明授权

US08915913B2 Electrosurgical instrument 有权
标题翻译：电外科器械
公开(公告)号：US08915913B2
公开(公告)日：2014-12-23
申请号：US13390135
申请日：2010-07-21
申请人： Klaus Fischer , Daniel Schäller , Achim Brodbeck , Markus Enderle
发明人： Klaus Fischer , Daniel Schäller , Achim Brodbeck , Markus Enderle
IPC分类号： A61B18/18 , A61B18/14 , A61B18/00
CPC分类号： A61B18/1447 , A61B2018/0016 , A61B2018/1475 , A61B2218/002 , A61B2218/007
摘要： An electrosurgical instrument for minimally invasive surgery, the instrument including two gripping parts which can be brought together into a gripping direction or moved apart counter to the gripping direction. At least one gripping part includes three or more electrically conductive sections, electrically insulated relative to each other. Each electrically conductive section may be separately connected to a high frequency (RF) current generator such that each electrically conductive section can be configured in various electrical configurations by the RF current generator.
摘要翻译：一种用于微创手术的电外科器械，该仪器包括两个夹持部分，其可以一起被夹在一起，或者相对于夹持方向移动。至少一个夹持部分包括相对于彼此电绝缘的三个或更多个导电部分。每个导电部分可以单独地连接到高频（RF）电流发生器，使得每个导电部分可以由RF电流发生器配置成各种电气配置。

7. 发明授权

US08623016B2 Electrosurgical instrument 有权
标题翻译：电外科器械
公开(公告)号：US08623016B2
公开(公告)日：2014-01-07
申请号：US11631042
申请日：2005-05-25
申请人： Klaus Fischer
发明人： Klaus Fischer
IPC分类号： A61B18/18
CPC分类号： A61B18/1442 , A61B2018/00083 , A61B2018/1462
摘要： The invention concerns an electrosurgical instrument comprising two articulated branches, which can be actuated in the manner of a squeezing tool. The instrument further comprises electrode parts at the distal ends of the branches for grasping tissue and for conducting a coagulating current through the tissue in order to cause it to coagulate as well as current-supplying devices for supplying the coagulating current to the electrode parts from an HF generator. At least one device for preventing a short circuit is arranged and configured on the electrode parts in such a way that the electrode parts are unable to touch.
摘要翻译：本发明涉及一种电外科器械，其包括可以挤压工具的方式致动的两个铰接的分支。该仪器还包括用于抓握组织的分支的远端处的电极部分，并且用于通过组织进行凝结电流以使其凝结，以及用于从凝固电流供应凝结电流的电流供应装置高频发生器。至少一个用于防止短路的装置被布置和配置在电极部分上，使得电极部分不能接触。

8. 发明申请

US20130218069A1 HEMOSTASIS INSTRUMENT 审中-公开
标题翻译： HEMOSTASIS仪器
公开(公告)号：US20130218069A1
公开(公告)日：2013-08-22
申请号：US13881269
申请日：2011-10-24
申请人： Alexander Neugebauer , Klaus Fischer , Markus D. Enderle
发明人： Alexander Neugebauer , Klaus Fischer , Markus D. Enderle
IPC分类号： A61B18/08 , A61B18/04 , A61B5/00 , A61M5/00
CPC分类号： A61B18/08 , A61B5/4836 , A61B18/042 , A61B18/1477 , A61B2018/00559 , A61B2018/00589 , A61B2018/0063 , A61B2018/00994 , A61B2018/1425 , A61B2018/147 , A61M5/00 , H05H1/2406 , H05H2245/122
摘要： A hemostasis instrument for actively stopping the bleeding, in particular after an open, laparoscopic, or endoscopic operation on a patient, having several hemostasis components. The hemostasis instrument has at least the following hemostasis components:—a thermal hemostasis device for tissue coagulation by producing a temperature above the coagulation temperature of biological tissue by means of a coagulation electrode;—a biochemical hemostasis device for producing a silent electric discharge by means of at least one discharge electrode, and an insulating device, wherein the insulating device is arranged between the discharge electrode and the tissue to be treated;—a supplying device for supplying substances that influence blood clotting to the tissue to be treated, and—a supply device for supplying noble gas to the tissue to be treated.
摘要翻译：一种用于积极止血的止血装置，特别是在对患者进行开腹，腹腔镜或内窥镜手术之后，具有多种止血成分。止血器具有至少以下止血成分： - 通过凝结电极产生温度高于生物组织的凝固温度的组织凝结的热止血装置; - 用于通过手段产生无声放电的生化止血装置至少一个放电电极和绝缘装置，其中所述绝缘装置布置在所述放电电极和待处理组织之间; - 用于将影响凝血的物质供应到待治疗组织的供应装置，以及用于向被处理组织供给稀有气体的供给装置。

9. 发明申请

US20120172874A1 MULTIFUNCTIONAL ELEMENT AND METHOD TO PREVENT THE CARBONISATION OF TISSUE BY MEANS OF A MULTIFUNCTIONAL ELEMENT 有权
标题翻译：多功能元件和多功能元件用于预防组织碳化的方法
公开(公告)号：US20120172874A1
公开(公告)日：2012-07-05
申请号：US13395367
申请日：2010-09-07
申请人： Klaus Fischer , Alexander Neugebauer , Markus Enderle , Matthias Zenker
发明人： Klaus Fischer , Alexander Neugebauer , Markus Enderle , Matthias Zenker
IPC分类号： A61B18/12
CPC分类号： A61B18/042 , H05H1/24 , H05H1/46 , H05H2277/10
摘要： A multi-functional element suitable for performing at least two surgical/therapeutic interventions, for example, the injection and cutting of tissue, with an anti-carbonization device to prevent the carbonization of tissue upon plasma coagulation by way of a suitable surgical instrument, where the surgical instrument has a feed line for an oxidizing agent, a feed line for a gas and an electrode for generating a plasma. A gas oxidizing agent mixture for producing a gas oxidizing agent plasma is provided by the anti-carbonization device.
摘要翻译：一种多功能元件，其适用于使用抗碳化装置进行至少两个外科/治疗干预，例如注射和切割组织，以通过合适的手术器械来防止血浆凝固时组织的碳化，其中手术器具具有用于氧化剂的供给管线，用于气体的进料管线和用于产生等离子体的电极。用于制造气体氧化剂等离子体的气体氧化剂混合物是由该抗碳化装置提供的。

10. 发明申请

US20120071868A1 CRYOSURGICAL INSTRUMENT 审中-公开
公开(公告)号：US20120071868A1
公开(公告)日：2012-03-22
申请号：US13265789
申请日：2010-04-14
申请人： Klaus Fischer , Mara Szyrach , Markus Enderle
发明人： Klaus Fischer , Mara Szyrach , Markus Enderle
IPC分类号： A61B18/02
CPC分类号： A61B10/02 , A61B18/02 , A61B90/39 , A61B2017/00809 , A61B2017/306 , A61B2018/00041
摘要： A cryosurgical instrument, in particular a biopsy instrument for transbronchial biopsy, having an elongated instrument base body with a distal and proximal end, in relation to the operational position, a cooled section close to the distal end and which removes tissue, said section being designed such that surrounding biological material adheres thereto, by means of cryoadhesion, when said instrument is in use in the cooled state, and a security section provided at a distance from the tissue removal section and which comprises means for preventing or reducing the adhesion of biological material.
摘要翻译：一种冷冻手术器械，特别是用于经支气管活检的活检器械，具有相对于操作位置具有远端和近端的细长仪器基体，靠近远端的冷却部分，其移除组织，所述部分被设计使得当所述仪器在冷却状态下使用时，周围的生物材料通过冷冻粘附粘附在其上，以及设置在离开组织去除部分一定距离处的安全部分，并且包括用于防止或减少生物材料的粘附的装置。

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