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1. 发明授权

US07781378B2 Protective coating for array material deposition 有权
标题翻译：用于阵列材料沉积的保护涂层
公开(公告)号：US07781378B2
公开(公告)日：2010-08-24
申请号：US10939121
申请日：2004-09-10
申请人： Reid N. Orth , David M. Lin , Theodore G. Clark , Yung-Fu Chang , Harold G. Craighead , Jose Manuel Moran-Mirabal
发明人： Reid N. Orth , David M. Lin , Theodore G. Clark , Yung-Fu Chang , Harold G. Craighead , Jose Manuel Moran-Mirabal
IPC分类号： C40B50/00
CPC分类号： B01J19/0046 , B01J2219/00432 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659
摘要： An array is formed with a protective cover on a substrate. The protective cover is patterned to produce an array of openings to the substrate. Desired material is deposited on the substrate through the openings. The protective cover may then be removed. In one embodiment, the protective cover is a conformal polymer, such as di-para-xylylene. It may be removed by mechanical peeling. The material may be biological material such as DNA. The protective cover may be used to prevent non-specific hybridization in inter-spot regions by performing hybridization with the cover still in place. Hybridization that occurs in such regions between the spots may be removed with removal of the protective cover.
摘要翻译：在衬底上形成有保护罩的阵列。将保护盖图案化以产生到基板的开口阵列。期望的材料通过开口沉积在基底上。然后可以移除保护盖。在一个实施方案中，保护性覆盖物是保形聚合物，例如二对二甲苯。可以通过机械剥离除去。该材料可以是诸如DNA的生物材料。保护罩可以用于通过与盖仍然在位的杂交来防止斑间区域中的非特异性杂交。在斑点之间的这些区域中发生的杂交可以通过去除保护盖而被去除。

2. 发明授权

US09493022B2 Methods and apparatus for high-throughput formation of nano-scale arrays 有权
标题翻译：用于高通量形成纳米级阵列的方法和装置
公开(公告)号：US09493022B2
公开(公告)日：2016-11-15
申请号：US13389113
申请日：2010-08-05
申请人： Christine P. Tan , David M. Lin , Harold G. Craighead
发明人： Christine P. Tan , David M. Lin , Harold G. Craighead
IPC分类号： B41M3/00 , B81C1/00
CPC分类号： B41M3/006 , B81C1/00031 , B81C2201/0184 , B81C2201/0187
摘要： An apparatus for forming an array of deposits on a substrate is disclosed. The apparatus may include a stencil capable of releasable attached to the substrate and having an array of openings and at least one alignment mark. The apparatus may further include a high throughput deposition printer aligned with the stencil to form an array of deposits on the substrate. The array of deposits may be aligned with the array of openings through the at least one alignment mark and an optional alignment device. Methods of manufacturing the stencil and using it to generate multiplexed or combinatorial arrays are also disclosed.
摘要翻译：公开了一种用于在衬底上形成沉积物阵列的装置。该装置可以包括能够可释放地附接到基底并具有开口阵列和至少一个对准标记的模版。该装置还可以包括与模板对准的高通量沉积打印机，以在衬底上形成沉积物阵列。沉积物阵列可以与通过至少一个对准标记的开口阵列和可选的对准装置对齐。还公开了制造模板并将其用于生成多路复用或组合阵列的方法。

3. 发明申请

US20120180676A1 Methods and Apparatus for High-Throughput Formation of Nano-Scale Arrays 有权
标题翻译：纳米尺度阵列高通量形成的方法与装置
公开(公告)号：US20120180676A1
公开(公告)日：2012-07-19
申请号：US13389113
申请日：2010-08-05
申请人： Christine P. Tan , David M. Lin , Harold G. Craighead
发明人： Christine P. Tan , David M. Lin , Harold G. Craighead
IPC分类号： B05C17/06 , B41M1/12
CPC分类号： B41M3/006 , B81C1/00031 , B81C2201/0184 , B81C2201/0187
摘要： An apparatus for forming an array of deposits on a substrate is disclosed. The apparatus may include a stencil capable of releasable attached to the substrate and having an array of openings and at least one alignment mark. The apparatus may further include a high throughput deposition printer aligned with the stencil to form an array of deposits on the substrate. The array of deposits may be aligned with the array of openings through the at least one alignment mark and an optional alignment device. Methods of manufacturing the stencil and using it to generate multiplexed or combinatorial arrays are also disclosed.
摘要翻译：公开了一种用于在衬底上形成沉积物阵列的装置。该装置可以包括能够可释放地附接到基底并具有开口阵列和至少一个对准标记的模版。该装置还可以包括与模板对准的高通量沉积打印机，以在衬底上形成沉积物阵列。沉积物阵列可以与通过至少一个对准标记的开口阵列和可选的对准装置对齐。还公开了制造模板并将其用于生成多路复用或组合阵列的方法。

4. 发明授权

US09605298B2 Device and methods for molecular analysis 有权
公开(公告)号：US09605298B2
公开(公告)日：2017-03-28
申请号：US13389259
申请日：2010-08-06
申请人： Harold G. Craighead , Benjamin R. Cipriany , Stephen Levy , Paul Soloway
发明人： Harold G. Craighead , Benjamin R. Cipriany , Stephen Levy , Paul Soloway
IPC分类号： C12Q1/68 , B01L3/00
CPC分类号： C12Q1/68 , B01L3/502761 , B01L2200/0663 , B01L2300/0654 , C12Q1/6827 , C12Q2537/164 , C12Q2565/629 , C12Q2565/631 , C12Q2561/113
摘要： Systems and methods are provided for high speed sorting of objects in a continuous body of fluid. The object can be analyzed within one or more interrogation volumes that allow for simultaneous or time-correlated measurement of the object's properties. A processor can interpret the properties of the object and then measured and then direct the object to one of a plurality of downstream flow paths. In some embodiments, the sorting of the object is based on two or more properties of the object. The sorting process can be repeated to create a network of sorting events.

5. 发明授权

US09007213B2 Methods and systems for object identification and for authentication 有权
标题翻译：用于物体识别和认证的方法和系统
公开(公告)号：US09007213B2
公开(公告)日：2015-04-14
申请号：US12297489
申请日：2007-04-19
申请人： Keith L. Aubin , Jeffrey W. Baldwin , Harold G. Craighead , Brian H. Houston , Jeevak M. Parpia , Robert B. Reichenbach , Maxim Zalalutdinov
发明人： Keith L. Aubin , Jeffrey W. Baldwin , Harold G. Craighead , Brian H. Houston , Jeevak M. Parpia , Robert B. Reichenbach , Maxim Zalalutdinov
IPC分类号： G08B13/14 , G06K19/067 , G06K7/10 , G06K19/07
CPC分类号： G06K19/0672 , G06K7/10336 , G06K19/0723
摘要： Methods and systems for object identification and/or authentication.
摘要翻译：用于对象识别和/或认证的方法和系统。

6. 发明授权

US08691588B2 Nanofilter devices using elastomeric micro to nanochannel interfaces and methods based thereon 有权
标题翻译：使用弹性体微纳通道界面的纳滤器装置和基于此的方法
公开(公告)号：US08691588B2
公开(公告)日：2014-04-08
申请号：US13391508
申请日：2010-08-20
申请人： Seung-min Park , Yun Suk Huh , David Erickson , Harold G. Craighead
发明人： Seung-min Park , Yun Suk Huh , David Erickson , Harold G. Craighead
IPC分类号： B29C43/44 , B29C43/00 , B29C59/02
CPC分类号： G01N21/658 , B01D67/0088 , B01D71/70 , B01D2323/283 , B01L3/502707 , B01L3/502761 , B01L2200/0663 , B01L2300/0816 , B01L2300/0896 , B01L2300/123 , B01L2400/0421 , B81B2201/058 , B81C1/00071 , B82Y30/00 , G01N33/48721
摘要： A method is provided for fabricating a nanochannel. The method comprises providing a microchannel and controlling collapse of the microchannel so that it collapses to form a nanochannel of desired dimensions. The method employs a collapsible, flexible material such as the elastomer polydimethylsiloxane (PDMS) to form the nanochannel. A master is provided that is configured to have geometric conditions that promote a desired frequency of microchannel collapse. A collapsible material having a stiffness that also promotes a desired frequency of microchannel collapse is molded on the master. The molded collapsible material is removed from the master and bonded to a base, thereby forming the microchannel, which then collapses (or is collapsed) to form the nanochannel of desired dimensions. Nanofluidic and microfluidic devices comprising complex nanochannel structures and micro to nanochannel transitions are also provided.
摘要翻译：提供了制造纳米通道的方法。该方法包括提供微通道并控制微通道的塌陷，使得其塌缩以形成具有期望尺寸的纳米通道。该方法采用可折叠的柔性材料，例如弹性体聚二甲基硅氧烷（PDMS）以形成纳米通道。提供了一个主设备，其配置为具有促进微通道倒塌的期望频率的几何条件。在主体上模制具有也促进所需频率的微通道塌陷的刚度的可折叠材料。模制的可折叠材料从主体中取出并结合到基底上，从而形成微通道，然后将其收缩（或折叠）以形成所需尺寸的纳米通道。还提供了包括复杂纳米通道结构和微到纳通道转换的纳流体和微流体装置。

7. 发明授权

US08541940B2 Electrospun light-emitting fibers 有权
标题翻译： Electrospun发光纤维
公开(公告)号：US08541940B2
公开(公告)日：2013-09-24
申请号：US13337977
申请日：2011-12-27
申请人： Jose M. Moran-Mirabal , Harold G. Craighead , George G. Malliaras , Héctor D. Abruna , Jason D. Slinker
发明人： Jose M. Moran-Mirabal , Harold G. Craighead , George G. Malliaras , Héctor D. Abruna , Jason D. Slinker
IPC分类号： H01L51/50 , H01L51/52 , H01L51/54
CPC分类号： C09K11/06 , B82Y20/00 , C09K11/02 , C09K2211/1007 , C09K2211/1029 , C09K2211/185 , D01D5/0007 , D01F1/04 , D01F1/06 , G02B6/02033 , G02B6/107
摘要： The invention teaches electrospun light-emitting fibers made from ionic transition metal complexes (“iTMCs”) such as [Ru(bpy)3]2+(PF6−)2]/PEO mixtures with dimensions in the 10.0 nm to 5.0 micron range and capable of highly localized light emission at low operating voltages such as 3-4 V with turn-on voltages approaching the band-gap limit of the organic semiconductor that may be used as point source light emitters on a chip.
摘要翻译：本发明教导了由离子过渡金属络合物（“iTMC”）例如[Ru（bpy）3] 2+（PF 6 - ）2] / PEO混合物制成的电纺丝发光纤维，其尺寸在10.0nm至5.0μm的范围内，能够在诸如3-4V的低工作电压下具有高度局部化的发光，其接通电压接近可用作芯片上的点光源发光体的有机半导体的带隙极限。

8. 发明申请

US20130118228A1 STRESS-BASED SENSOR, METHOD, AND APPLICATIONS 有权
标题翻译：基于应力的传感器，方法和应用
公开(公告)号：US20130118228A1
公开(公告)日：2013-05-16
申请号：US13637861
申请日：2011-03-31
申请人： Jeevak M. Parpia , Harold G. Craighead , Darren R. Southworth , Leon M. Bellan
发明人： Jeevak M. Parpia , Harold G. Craighead , Darren R. Southworth , Leon M. Bellan
IPC分类号： G01N33/497
CPC分类号： G01N33/497 , G01N29/022
摘要： A composite, analyte sensor includes a substrate; a micro- or nano-electro-mechanical (MEMS; NEMS) resonator that is coupled to the substrate at least two edge locations (i.e., it is at least doubly-clamped) of the resonator, wherein the resonator is in a statically-buckled state near a buckling transition point of the resonator; and a chemically-responsive substance covering at least a portion of the surface of the resonator that will undergo a conformational change upon exposure to a given analyte. The resonator may be a double-clamped, statically-buckled beam (or bridge), a multiply-clamped, statically-buckled dome (or crater), or other resonator geometry. The sensor may include two or more at least double-clamped, statically-buckled, composite MEMS or NEMS resonators each operating near a buckling transition point of the respective resonator, and each characterized by a different resonant frequency. A method for sensing an analyte in ambient air.
摘要翻译：复合分析物传感器包括基底; 谐振器的至少两个边缘位置（即，它至少被双钳位）耦合到衬底的微机械或纳米机电（MEMS; NEMS）谐振器，其中所述谐振器处于静态弯曲在谐振器的屈曲转变点附近; 以及覆盖谐振器表面的至少一部分的化学响应物质，其在暴露于给定的分析物时将经历构象变化。谐振器可以是双夹紧，静态弯曲梁（或桥），多夹紧，静态弯曲的圆顶（或火山口）或其他谐振器几何形状。传感器可以包括两个或更多个至少双夹紧，静态弯曲的复合MEMS或NEMS谐振器，每个谐振器在相应谐振器的屈曲转变点附近操作，并且每个谐振器的特征在于不同的谐振频率。用于感测环境空气中的分析物的方法。

9. 发明授权

US07942568B1 Active micromixer using surface acoustic wave streaming 有权
标题翻译：使用表面声波流动的有源微混合器
公开(公告)号：US07942568B1
公开(公告)日：2011-05-17
申请号：US11155108
申请日：2005-06-17
申请人： Darren W. Branch , Grant D. Meyer , Harold G. Craighead
发明人： Darren W. Branch , Grant D. Meyer , Harold G. Craighead
IPC分类号： B01F11/02
CPC分类号： B01F11/0266 , B01F13/0059 , Y10S366/04
摘要： An active micromixer uses a surface acoustic wave, preferably a Rayleigh wave, propagating on a piezoelectric substrate to induce acoustic streaming in a fluid in a microfluidic channel. The surface acoustic wave can be generated by applying an RF excitation signal to at least one interdigital transducer on the piezoelectric substrate. The active micromixer can rapidly mix quiescent fluids or laminar streams in low Reynolds number flows. The active micromixer has no moving parts (other than the SAW transducer) and is, therefore, more reliable, less damaging to sensitive fluids, and less susceptible to fouling and channel clogging than other types of active and passive micromixers. The active micromixer is adaptable to a wide range of geometries, can be easily fabricated, and can be integrated in a microfluidic system, reducing dead volume. Finally, the active micromixer has on-demand on/off mixing capability and can be operated at low power.
摘要翻译：有源微混合器使用在压电衬底上传播的表面声波，优选瑞利波，以在微流体通道中的流体中引起声流。可以通过将RF激励信号施加到压电基板上的至少一个叉指式换能器来产生表面声波。活性微混合器可以在低雷诺数流中快速混合静态流体或层流。活性微混合器没有移动部件（SAW传感器除外），因此比其他类型的有源和无源微混合器更可靠，对敏感流体的损害较小，并且不易受到结垢和通道堵塞的影响。活性微混合器适用于宽范围的几何形状，可以容易地制造，并且可以集成在微流体系统中，从而减少死体积。最后，有源微混频器具有按需开/关混合能力，可以低功耗运行。

10. 发明申请

US20110111401A1 METHOD FOR SEQUENCING NUCLEIC ACID MOLECULES 审中-公开
标题翻译：用于测序核酸分子的方法
公开(公告)号：US20110111401A1
公开(公告)日：2011-05-12
申请号：US12841819
申请日：2010-07-22
申请人： Jonas KORLACH , Watt W. Webb , Michael Levene , Stephen Turner , Harold G. Craighead , Mathieu Foquet
发明人： Jonas KORLACH , Watt W. Webb , Michael Levene , Stephen Turner , Harold G. Craighead , Mathieu Foquet
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6869 , Y10S436/80 , Y10S436/805 , Y10T436/143333 , C12Q2565/537 , C12Q2537/149 , C12Q2561/113 , C12Q2521/543 , C12Q2565/518 , C12Q2561/12
摘要： The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the polymerization reaction is measured on a molecule of nucleic acid, i.e. the activity of a nucleic acid polymerizing enzyme on the template nucleic acid molecule to be sequenced is followed in real time. The sequence is deduced by identifying which base is being incorporated into the growing complementary strand of the target nucleic acid by the catalytic activity of the nucleic acid polymerizing enzyme at each step in the sequence of base additions. A polymerase on the target nucleic acid molecule complex is provided in a position suitable to move along the target nucleic acid molecule and extend the oligonucleotide primer at an active site. A plurality of labelled types of nucleotide analogs are provided proximate to the active site, with each distinguishable type of nucleotide analog being complementary to a different nucleotide in the target nucleic acid sequence. The growing nucleic acid strand is extended by using the polymerase to add a nucleotide analog to the nucleic acid strand at the active site, where the nucleotide analog being added is complementary to the nucleotide of the target nucleic acid at the active site. The nucleotide analog added to the oligonucleotide primer as a result of the polymerizing step is identified. The steps of providing labelled nucleotide analogs, polymerizing the growing nucleic acid strand, and identifying the added nucleotide analog are repeated so that the nucleic acid strand is further extended and the sequence of the target nucleic acid is determined.
摘要翻译：本发明涉及对具有多个碱基的靶核酸分子进行测序的方法。在其原理中，聚合反应中碱添加的时间顺序是在核酸分子上测量的，即核酸聚合酶在待测序的模板核酸分子上的活性被实时跟踪。通过在碱添加序列的每个步骤中通过核酸聚合酶的催化活性鉴定哪个碱基被掺入靶核酸的生长互补链中来推断该序列。在靶核酸分子复合物上提供聚合酶，其适于沿着靶核酸分子移动并在活性位点延伸寡核苷酸引物。多个标记类型的核苷酸类似物在活性位点附近提供，每种可区分类型的核苷酸类似物与靶核酸序列中的不同核苷酸互补。生长的核酸链通过使用聚合酶延伸到活性位点处的核酸链的核苷酸类似物，其中加入的核苷酸类似物与活性位点上的靶核酸的核苷酸互补。鉴定作为聚合步骤的结果添加到寡核苷酸引物中的核苷酸类似物。重复提供标记的核苷酸类似物，聚合生长的核酸链和鉴定添加的核苷酸类似物的步骤，使得核酸链进一步延长并确定靶核酸的序列。

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