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1. 发明授权

US06266563B1 Method and apparatus for treating cardiac arrhythmia 有权
标题翻译：治疗心律失常的方法和装置
公开(公告)号：US06266563B1
公开(公告)日：2001-07-24
申请号：US09391026
申请日：1999-09-07
申请人： Bruce H. KenKnight , Raymond E. Ideker , Robert S. Booker, III , Stephen J. Hahn
发明人： Bruce H. KenKnight , Raymond E. Ideker , Robert S. Booker, III , Stephen J. Hahn
IPC分类号： A61N139
CPC分类号： A61N1/3918 , A61N1/3937 , A61N1/3943
摘要： An implantable system for the antitachycardia pacing of the heart of a patient in need of such treatment comprises a plurality of primary electrodes, a power supply, and a control circuit. At least one of the primary electrodes is configured for positioning through the coronary sinus ostium and in a vein on the left surface of the patient's heart.
摘要翻译：用于需要这种治疗的患者心脏的抗心动过速起搏的可植入系统包括多个初级电极，电源和控制电路。主电极中的至少一个构造成用于定位穿过患者心脏的左侧表面的冠状窦口和静脉。

2. 发明授权

US06243603B1 Methods and apparatus for detecting medical conditions of the heart 有权
标题翻译：检测心脏病情的方法和装置
公开(公告)号：US06243603B1
公开(公告)日：2001-06-05
申请号：US09153407
申请日：1998-09-15
申请人： Raymond E. Ideker , Bruce H. KenKnight
发明人： Raymond E. Ideker , Bruce H. KenKnight
IPC分类号： A61N139
CPC分类号： A61N1/3918
摘要： An implantable system for detecting electrical activity from a patient's heart comprises a first sensing electrode configured for positioning through the coronary sinus ostium and within a vein on the left surface of the left ventricle of the heart for sensing electrical activity from the heart, and a detector operatively associated with the first sensing electrode for determining (e.g., diagnosing or prognosing) a medical condition of the heart with the sensed electrical activity. Typically the system further comprises a second sensing electrode configured for positioning in the right ventricle of the heart, where the detector is operatively associated with both the first sensing electrode and the second sensing electrode. The second sensing electrode may be positioned in other locations as well, such as also within a vein on the left surface of the left ventricle of the heart (although spaced apart from the first sensing electrode), in the right atrium, in the superior vena cava, etc. Finally, a third sensing electrode may also be included, with the third electrode positioned in any of the foregoing locations (again, spaced apart from the first and second electrodes), with the detector operatively associated with all of the first, second, and third sensing electrodes. Determination of a medical condition may be carried out by any suitable means, such as by detecting premature beats in the heart. The method is particularly useful for identifying the chamber of premature beat origin.
摘要翻译：用于从患者心脏检测电活动的可植入系统包括构造成用于定位穿过冠状窦口和心脏左心室左表面的静脉内的第一感测电极，用于感测来自心脏的电活动;以及检测器可操作地与第一感测电极相关联，用于利用感测到的电活动来确定（例如，诊断或预测）心脏的医学状况。通常，该系统还包括被配置用于定位在心脏的右心室中的第二感测电极，其中检测器与第一感测电极和第二感测电极两者可操作地相关联。第二感测电极也可以位于其他位置，例如也在心脏左心室左侧的静脉内（尽管与第一感测电极间隔开），在右心房中，在上腔静脉卡瓦等。最后，还可以包括第三感测电极，其中第三电极位于上述任何位置（再次与第一和第二电极间隔开），检测器与所有第一，第二和第三感测电极。可以通过任何合适的手段来进行医学状态的确定，例如通过检测心脏中的过早搏动。该方法对于识别过早搏动起源的室特别有用。

3. 发明授权

US06205357B1 Methods and apparatus for detecting and treating medical conditions of the heart 有权
标题翻译：检测和治疗心脏病情的方法和装置
公开(公告)号：US06205357B1
公开(公告)日：2001-03-20
申请号：US09206022
申请日：1998-12-04
申请人： Raymond E. Ideker , Jay A. Warren , Bruce H. KenKnight
发明人： Raymond E. Ideker , Jay A. Warren , Bruce H. KenKnight
IPC分类号： A61N139
CPC分类号： A61N1/3622
摘要： An implantable system for detecting electrical activity from a patient's heart comprises a first sensing electrode configured for positioning through the coronary sinus ostium and within a vein on the left surface of the left ventricle of the heart for sensing electrical activity from the heart, and a detector operatively associated with the first sensing electrode for determining (e.g., diagnosing or prognosing) a medical condition of the heart with the sensed electrical activity. Typically the system further comprises a second sensing electrode configured for positioning in the right ventricle of the heart, where the detector is operatively associated with both the first sensing electrode and the second sensing electrode. The second sensing electrode may be positioned in other locations as well, such as also within a vein on the left surface of the left ventricle of the heart (although spaced apart from the first sensing electrode), in the right atrium, in the superior vena cava, etc. Finally, a third sensing electrode may also be included, with the third electrode positioned in any of the foregoing locations (again, spaced apart from the first and second electrodes), with the detector operatively associated with all of the first, second, and third sensing electrodes. Determination of a medical condition may be carried out by any suitable means, such as by detecting premature beats in the heart. The method is particularly useful for identifying the chamber of premature beat origin.
摘要翻译：用于从患者心脏检测电活动的可植入系统包括构造成用于定位穿过冠状窦口和心脏左心室左表面的静脉内的第一感测电极，用于感测来自心脏的电活动;以及检测器可操作地与第一感测电极相关联，用于利用感测到的电活动来确定（例如，诊断或预测）心脏的医学状况。通常，该系统还包括被配置用于定位在心脏的右心室中的第二感测电极，其中检测器与第一感测电极和第二感测电极两者可操作地相关联。第二感测电极也可以位于其他位置，例如也在心脏左心室左侧的静脉内（尽管与第一感测电极间隔开），在右心房中，在上腔静脉卡瓦等。最后，还可以包括第三感测电极，其中第三电极位于上述任何位置（再次与第一和第二电极间隔开），检测器与所有第一，第二和第三感测电极。可以通过任何合适的手段来进行医学状态的确定，例如通过检测心脏中的过早搏动。该方法对于识别过早搏动起源的室特别有用。

4. 发明授权

US6002962A Implantable triphasic waveform defibrillator 失效
标题翻译：植入式三相波形除颤器
公开(公告)号：US6002962A
公开(公告)日：1999-12-14
申请号：US59819
申请日：1998-04-14
申请人： Jian Huang , Bruce H. KenKnight , Raymond E. Ideker
发明人： Jian Huang , Bruce H. KenKnight , Raymond E. Ideker
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3906
摘要： An implantable system for the defibrillation or cardioversion of a patient's heart comprises a plurality of electrodes configured for delivering a defibrillation pulse along a predetermined current pathway in the heart. The plurality of electrodes includes a first electrode configured for positioning in the patient's heart. The system includes a power supply and a control circuit. The control circuit is operatively associated with the electrodes and the power supply.
摘要翻译：用于病人心脏的除颤或心脏复律的可植入系统包括多个电极，其被配置用于沿心脏中的预定电流通路输送除颤脉冲。多个电极包括构造成用于定位在患者心脏中的第一电极。该系统包括电源和控制电路。控制电路可操作地与电极和电源相关联。

5. 发明授权

US5978704A Method and apparatus for treating cardiac arrhythmia 失效
公开(公告)号：US5978704A
公开(公告)日：1999-11-02
申请号：US868095
申请日：1997-06-03
申请人： Raymond E. Ideker , Bruce H. KenKnight
发明人： Raymond E. Ideker , Bruce H. KenKnight
IPC分类号： A61N1/39
CPC分类号： A61N1/3918 , A61N1/395
摘要： An implantable system for the defibrillation or cardioversion of the atria and the ventricles of a patient's heart comprises: a first catheter configured for positioning in the right ventricle of the heart; a second catheter configured for positioning through the coronary sinus ostium and in the coronary sinus of the heart, with the first and second catheters together carrying at least three defibrillation electrodes; a power supply; anda control circuit operatively associated with the power supply and the electrodes. The control circuit is configured for delivering an atrial defibrillation pulse through at least two of the electrodes, or a ventricular defibrillation pulse through at least two of the electrodes.

6. 发明授权

US06246908B1 Method and apparatus for rapidly predicting outcome of arrhythmia therapy 失效
标题翻译：快速预测心律失常治疗结局的方法和装置
公开(公告)号：US06246908B1
公开(公告)日：2001-06-12
申请号：US09498898
申请日：2000-02-04
申请人： Nipon Chattipakorn , Raymond E. Ideker , Bruce H. KenKnight
发明人： Nipon Chattipakorn , Raymond E. Ideker , Bruce H. KenKnight
IPC分类号： A61N139
CPC分类号： A61N1/3956
摘要： A method for predicting the outcome of arrhythmia therapy in a subject in need thereof comprises the steps of: (a) detecting an arrhythmia in the heart of a subject; (b) delivering a first arrhythmia therapy pulse to the heart of the subject; and then (c) determining the presence or absence of overlapping cycles in the heart of the subject, the presence of overlapping cycles indicating that the first arrhythmia therapy pulse did not successfully treat the arrhythmia. Overlapping cycles are preferably determined through the calculation of an overlapping cycles index (OCI). Apparatus for carrying out the method is also disclosed.
摘要翻译：用于预测有需要的受试者的心律失常治疗结果的方法包括以下步骤：（a）检测受试者心脏中的心律失常; （b）向受试者的心脏递送第一心律失常治疗脉搏; 然后（c）确定在受试者的心脏中存在或不存在重叠循环，指示第一心律失常治疗脉冲未能成功治疗心律失常的重叠周期的存在。重叠循环优选通过计算重叠循环指数（OCI）来确定。还公开了用于执行该方法的装置。

7. 发明授权

US06275730B1 Method and apparatus for treating cardiac arrythmia 有权
标题翻译：治疗心脏性心律失常的方法和装置
公开(公告)号：US06275730B1
公开(公告)日：2001-08-14
申请号：US09390442
申请日：1999-09-07
申请人： Bruce H. KenKnight , Raymond E. Ideker , Robert S. Booker, III , Stephen J. Hahn
发明人： Bruce H. KenKnight , Raymond E. Ideker , Robert S. Booker, III , Stephen J. Hahn
IPC分类号： A61N139
CPC分类号： A61N1/3937 , A61N1/3918 , A61N1/3943
摘要： An implantable system for the cardioversion of the heart of a patient in need of such treatment comprises a plurality of primary electrodes, a power supply, and a control circuit. Preferably, at least one auxiliary electrode is also included. The plurality of primary electrodes are configured for delivering a cardiversion pulse along a predetermined current pathway in a first portion of the heart, the current pathway defining a weak field area in a second portion of the heart.
摘要翻译：用于需要这种治疗的患者的心脏的心脏复律的可植入系统包括多个初级电极，电源和控制电路。优选地，还包括至少一个辅助电极。多个主电极被配置用于沿着心脏的第一部分中的预定电流通路输送引导脉冲，该电流通路在心脏的第二部分中限定弱磁场区域。

8. 发明授权

US6122553A Method and apparatus for treating cardiac arrhythmia 有权
公开(公告)号：US6122553A
公开(公告)日：2000-09-19
申请号：US393857
申请日：1999-09-09
申请人： Raymond E. Ideker , Bruce H. KenKnight
发明人： Raymond E. Ideker , Bruce H. KenKnight
IPC分类号： A61N1/39 , A61N5/05
CPC分类号： A61N1/3918 , A61N1/395
摘要： An implantable system for the defibrillation or cardioversion of the atria and the ventricles of a patient's heart comprises: a first catheter configured for positioning in the right ventricle of the heart; a second catheter configured for positioning through the coronary sinus ostium and in the coronary sinus of the heart, with the first and second catheters together carrying at least three defibrillation electrodes; a power supply; and a control circuit operatively associated with the power supply and the electrodes. The control circuit is configured for delivering an atrial defibrillation pulse through at least two of the electrodes, or a ventricular defibrillation pulse through at least two of the electrodes.

9. 发明授权

US5978705A Method and apparatus for treating cardiac arrhythmia using auxiliary pulse 失效
标题翻译：使用辅助脉冲治疗心律失常的方法和装置
公开(公告)号：US5978705A
公开(公告)日：1999-11-02
申请号：US39143
申请日：1998-03-13
申请人： Bruce H. KenKnight , Raymond E. Ideker , Robert S. Booker, III , Stephen J. Hahn
发明人： Bruce H. KenKnight , Raymond E. Ideker , Robert S. Booker, III , Stephen J. Hahn
IPC分类号： A61N1/39 , A61N1/05
CPC分类号： A61N1/3937 , A61N1/3918 , A61N1/3943
摘要： An implantable system for the defibrillation or cardioversion of the heart of a patient in need of such treatment comprises a plurality of primary electrodes, a power supply, and a control circuit. Preferably, at least one auxiliary electrode is also included. The plurality of primary electrodes are configured for delivering a defibrillation pulse along a predetermined current pathway in a first portion of the heart, the current pathway defining a weak field area in a second portion of the heart. The at least one auxiliary electrode is configured for delivering an auxiliary pulse to the a portion of the heart where the primary shock field intensity is at or near a minimum. The control circuit is operatively associated with the primary electrodes, the auxiliary electrode, and the power supply, with the control circuit configured for delivering a cardioversion sequence comprising an auxiliary pulse sufficient to induce a cessation of propagation in the weak field area through the auxiliary electrode, followed by a defibrillation pulse through the primary electrodes delivered during the cessation of propagation in the weak field area.
摘要翻译：用于需要这种治疗的患者的心脏的除颤或心脏复律的可植入系统包括多个初级电极，电源和控制电路。优选地，还包括至少一个辅助电极。多个主电极被配置用于沿心脏的第一部分中的预定电流通路输送除颤脉冲，该电流通路在心脏的第二部分中限定弱磁场区域。所述至少一个辅助电极被配置为将辅助脉冲传送到心脏的一部分，其中主要的冲击电场强度处于或接近最小值。所述控制电路与所述主电极，所述辅助电极和所述电源可操作地相关联，所述控制电路被配置用于传送包括辅助脉冲的复律序列，所述辅助脉冲足以引起通过所述辅助电极在所述弱磁场区域中的传播停止，然后通过在弱磁场区域中传播停止期间传递的主电极的除颤脉冲。

10. 发明授权

US06470211B1 Method and apparatus for treating cardiac arrhythmia 失效
标题翻译：治疗心律失常的方法和装置
公开(公告)号：US06470211B1
公开(公告)日：2002-10-22
申请号：US09641571
申请日：2000-08-18
申请人： Raymond E. Ideker , Bruce H. KenKnight
发明人： Raymond E. Ideker , Bruce H. KenKnight
IPC分类号： A61N139
CPC分类号： A61N1/3918 , A61N1/395
摘要： An implantable system for the defibrillation or cardioversion of the atria and the ventricles of a patient's heart comprises: a first catheter configured for positioning in the right ventricle of the heart; a second catheter configured for positioning through the coronary sinus ostium and in the coronary sinus of the heart, with the first and second catheters together carrying at least three defibrillation electrodes; a power supply; and a control circuit operatively associated with the power supply and the electrodes. The control circuit is configured for delivering an atrial defibrillation pulse through at least two of the electrodes, or a ventricular defibrillation pulse through at least two of the electrodes.
摘要翻译：用于病人心脏的心房和心室的除颤或心脏复律的可植入系统包括：配置用于定位在心脏右心室中的第一导管; 构造成用于定位穿过冠状窦口和心脏冠状窦的第二导管，其中第一和第二导管一起携带至少三个除颤电极; 电源; 以及与电源和电极可操作地相关联的控制电路。控制电路被配置为通过至少两个电极输送心房除颤脉冲，或者通过至少两个电极的心室除颤脉冲。

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