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1. 发明授权

US06291447B1 Granulatimide compounds and uses thereof 失效
标题翻译：肉桂酰亚胺化合物及其用途
公开(公告)号：US06291447B1
公开(公告)日：2001-09-18
申请号：US09258991
申请日：1999-02-26
申请人： Raymond Andersen , Michel Roberge , Jasbinder Sanghera , Daniel Leung , Edward Piers , Roberto GS Berlinck , Robert Britton
发明人： Raymond Andersen , Michel Roberge , Jasbinder Sanghera , Daniel Leung , Edward Piers , Roberto GS Berlinck , Robert Britton
IPC分类号： C07D48714
CPC分类号： C07D487/14 , C07H9/06 , C07H19/044 , C07H19/23
摘要： Novel granulatimide compounds and pharmaceutical formulations thereof are provided. Compounds of this invention have the general formula: wherein are independently R or Z as defined below, or in combination F and F′ is Ar1 as defined below; Ar1 is a monocyclic, bicyclic or tricyclic, fully or partially aromatic system containing five or six membered carbocyclic or, oxygen, nitrogen or sulphur containing heterocyclic rings, optionally substituted with R or Z; W is selected from the group consisting of formula (i); (ii) or (iii), wherein the structures are as follows:
摘要翻译：提供了新的颗粒酰亚胺化合物及其药物制剂。本发明的化合物具有以下通式：其中独立地为如下定义的R或Z，或者组合F和F'如下定义的Ar 1; Ar 1是单环，双环或三环，全部或部分芳族体系，其含有五或六个任选被R或Z取代的W，W选自由式（ⅰ）组成的组; （ii）或（iii），其中结构如下：

2. 发明授权

US07410951B2 Biologically active peptides and compositions, their use 失效
标题翻译：生物活性肽和组合物，其用途
公开(公告)号：US07410951B2
公开(公告)日：2008-08-12
申请号：US11034922
申请日：2005-01-14
申请人： Raymond Andersen , John Coleman , Dilip De Silva , Fangming Kong , Edward Piers , Debra Wallace , Michel Roberge , Theresa Allen
发明人： Raymond Andersen , John Coleman , Dilip De Silva , Fangming Kong , Edward Piers , Debra Wallace , Michel Roberge , Theresa Allen
IPC分类号： C07K5/06
CPC分类号： C07K5/0205 , A61K38/00 , C07K5/0827
摘要： Derivatives of hemiasterlin or Geodiamolide G having anti-mitotic activities and useful in treating cancer. These derivatives are represented by formula I wherein Y, n, R1, R2, R3, R7, R70, R71, R72, R74, and R75 are as defined in the specification.
摘要翻译：具有抗有丝分裂活性并可用于治疗癌症的半精球蛋白或地高二聚G的衍生物。这些衍生物由式I表示，其中Y，n，R 1，R 2，R 3，R 7，，R 70，R 71，R 72，R 74和R 75， SUB>如说明书中所定义。

3. 发明申请

US20090264487A1 HEMIASTERLIN ANALOGS 审中-公开
标题翻译： HEMIASTERLIN模拟
公开(公告)号：US20090264487A1
公开(公告)日：2009-10-22
申请号：US12491839
申请日：2009-06-25
申请人： Raymond ANDERSEN , Edward Piers , James Nieman , John Coleman , Michel Roberge
发明人： Raymond ANDERSEN , Edward Piers , James Nieman , John Coleman , Michel Roberge
IPC分类号： A61K31/421 , C12N5/00 , A61K31/216 , A61K31/195 , C07D263/04 , C07C229/34 , A61P35/00
CPC分类号： C07K5/0205 , A61K38/00 , C07C271/22 , Y02P20/55
摘要： This invention provides analogs of hemiasterlin, methods of synthesis of the analogs and use of the analogs as a cytotoxic anti-mitotic agents.
摘要翻译：本发明提供半精球蛋白类似物，合成类似物的方法和类似物作为细胞毒性抗有丝分裂剂的用途。

4. 发明授权

US07579323B1 Hemiasterlin analogs 失效
标题翻译：半球蛋白类似物
公开(公告)号：US07579323B1
公开(公告)日：2009-08-25
申请号：US09581511
申请日：1998-12-13
申请人： Raymond Andersen , Edward Piers , James Nieman , John Coleman , Michel Roberge
发明人： Raymond Andersen , Edward Piers , James Nieman , John Coleman , Michel Roberge
IPC分类号： C07K5/06
CPC分类号： C07K5/0205 , A61K38/00 , C07C271/22
摘要： This invention provides analogs of hemiasterlin, methods of synthesis of the analogs and use of the analogs as cytotoxic and anti-mitotic agents.
摘要翻译：本发明提供半精球蛋白类似物，合成类似物的方法和类似物作为细胞毒性和抗有丝分裂剂的用途。

5. 发明授权

US07772397B2 Biologically active peptides and compositions, their use 有权
标题翻译：生物活性肽和组合物，其用途
公开(公告)号：US07772397B2
公开(公告)日：2010-08-10
申请号：US12176716
申请日：2008-07-21
申请人： Raymond Andersen , John Coleman , Dilip De Silva , Fangming Kong , Edward Piers , Debra Wallace , Michel Roberge , Theresa Allen
发明人： Raymond Andersen , John Coleman , Dilip De Silva , Fangming Kong , Edward Piers , Debra Wallace , Michel Roberge , Theresa Allen
IPC分类号： C07D471/04
CPC分类号： C07K5/0205 , A61K38/00 , C07K5/0827
摘要： This invention relates to derivatives of hemiasterlin or Geodiamolide G having anti-mitotic activities and useful in treating cancer. These derivatives are represented by general formula I, wherein Y, n, R1, R2, R3, R6, R7, R70, R71, R72, R74, and R75 are as defined in the specification.
摘要翻译：本发明涉及具有抗有丝分裂活性并可用于治疗癌症的半球蛋白或衍生物的衍生物。这些衍生物由通式I表示，其中Y，n，R 1，R 2，R 3，R 6，R 7，R 70，R 71，R 72，R 74和R 75如说明书中所定义。

6. 发明申请

US20090088573A1 BIOLOGICALLY ACTIVE PEPTIDES AND COMPOSITIONS, THEIR USE 有权
标题翻译：生物活性肽和组合物，其使用
公开(公告)号：US20090088573A1
公开(公告)日：2009-04-02
申请号：US12176716
申请日：2008-07-21
申请人： Raymond ANDERSEN , John Coleman , Dilip De Silva , Fangming Kong , Edward Piers , Debra Wallace , Michel Roberge , Theresa Allen
发明人： Raymond ANDERSEN , John Coleman , Dilip De Silva , Fangming Kong , Edward Piers , Debra Wallace , Michel Roberge , Theresa Allen
IPC分类号： C07D471/04
CPC分类号： C07K5/0205 , A61K38/00 , C07K5/0827
摘要： This invention relates to derivatives of hemiasterlin or Geodiamolide G having anti-mitotic activities and useful in treating cancer. These derivatives are represented by general formula I, wherein Y, n, R1, R2, R3, R6, R7, R70, R71, R72, R74, and R75 are as defined in the specification.
摘要翻译：本发明涉及具有抗有丝分裂活性并可用于治疗癌症的半球蛋白或衍生物的衍生物。这些衍生物由通式I表示，其中Y，n，R 1，R 2，R 3，R 6，R 7，R 70，R 71，R 72，R 74和R 75如说明书中所定义。

7. 发明授权

US6153590A Biologically active peptides and compositions, their use 失效
标题翻译：生物活性肽和组合物，其用途
公开(公告)号：US6153590A
公开(公告)日：2000-11-28
申请号：US930584
申请日：1998-02-02
申请人： Raymond Andersen , John Coleman , Dilip De Silva , Fangming Kong , Edward Piers , Debra Wallace , Michel Roberge , Teresa Allen
发明人： Raymond Andersen , John Coleman , Dilip De Silva , Fangming Kong , Edward Piers , Debra Wallace , Michel Roberge , Teresa Allen
IPC分类号： A61K38/00 , A61P35/00 , C07K5/02 , C07K5/027 , C07K5/078 , C07K5/08 , C07K5/083
CPC分类号： C07K5/0205 , C07K5/0827 , A61K38/00
摘要： Compounds of general formula I ##STR1## wherein: R.sub.1 and R.sub.70 independently represent a hydrogen atom or an optionally substituted alkyl or acyl group; R.sub.2 represents a hydrogen atom or an optionally substituted alkyl or acyl group or is absent when R.sub.6 represents a group --CH.dbd. as hereinafter described; R.sub.73 represents a hydrogen atom or an optional substituent or is absent when R.sub.6 represents a methylene group or a group --CH.dbd. as hereinafter described; Y represents an optional substituent; n represents 0, 1, 2, 3, or 4; R.sub.3 represents a hydrogen atom, or an optionally substituted alkyl group; R.sub.74 represents a hydrogen atom, a hydroxy group or an optionally substituted alkyl or acyl group; R.sub.7 represents a hydrogen atom or an alkyl group; R.sub.75 represents an optionally substituted alkyl group; and i) R.sub.6 and R.sub.71 independently represent a hydrogen atom or an optionally substituted alkyl or acyl group; and R.sub.72 represents a hydrogen atom; or ii) R.sub.71 represents a hydrogen atom or an optionally susbtituted alkyl or acyl group and R.sub.72 represents a hydrogen atom or R.sub.71 and R.sub.72 are joined together such that a double bond is formed between the carbon atoms to which they are attached; and R.sub.6 represents an optionally substituted methylene group bonded to the indole moiety thereby forming a tricyclic moiety; or R.sub.6 represents an optionally substituted group --CH.dbd. bonded to the indole moiety thereby to form an aromatic tricyclic moiety; for use in therapy and as antimitotic reagents are described.
摘要翻译： PCT No.PCT / GB96 / 00942 Sec。 371日期1998年2月2日 102（e）1998年2月2日PCT 1996年4月22日PCT PCT。出版物WO96 / 33211 日期：1996年10月24日通式I化合物其中：R 1和R 70独立地表示氢原子或任选取代的烷基或酰基; R2表示氢原子或任选取代的烷基或酰基，或当R6表示基团-CH =时不存在，如下所述; 当R 6表示亚甲基或-CH =如下所述时，R 73表示氢原子或任选的取代基或不存在; Y表示任选的取代基; n表示0,1,2,3或4; R3表示氢原子或任选取代的烷基; R 74表示氢原子，羟基或任选取代的烷基或酰基; R7表示氢原子或烷基; R75表示任选取代的烷基; 和i）R 6和R 71独立地表示氢原子或任选取代的烷基或酰基; R 72表示氢原子; 或ii）R 71表示氢原子或任选取代的烷基或酰基，R 72表示氢原子或R 71和R 72连接在一起，使得在它们所连接的碳原子之间形成双键; 并且R 6表示与吲哚部分键合的任选取代的亚甲基，从而形成三环部分; 或R6表示与吲哚部分键合的任选取代的基团-CH =，从而形成芳族三环部分; 用于治疗和用作抗有益剂的试剂。

8. 发明申请

US20060014727A1 Angiogenic compounds and uses thereof 审中-公开
标题翻译：血管生成化合物及其用途
公开(公告)号：US20060014727A1
公开(公告)日：2006-01-19
申请号：US11158291
申请日：2005-06-20
申请人： Aly Karsan , Michel Roberge , Raymond Andersen , Ingrid Pollet
发明人： Aly Karsan , Michel Roberge , Raymond Andersen , Ingrid Pollet
IPC分类号： C07J31/00 , A61K31/56
CPC分类号： G01N33/5064 , A61K31/575 , A61K38/1825 , A61K38/1866 , C07J31/00 , C07J31/006 , G01N33/5008 , G01N33/5017 , G01N33/5026 , A61K2300/00
摘要： The invention provides sterol sulphate compounds and compositions that are capable of promoting angiogenesis. The invention also provides methods and uses for these compounds.
摘要翻译：本发明提供能够促进血管生成的硫酸固醇化合物和组合物。本发明还提供了这些化合物的方法和用途。

9. 发明申请

US20050222126A1 Antiangiogenic compounds and an assay for inhibitors of cell invasion 审中-公开
标题翻译：抗血管生成化合物和细胞侵袭抑制剂的测定
公开(公告)号：US20050222126A1
公开(公告)日：2005-10-06
申请号：US11069590
申请日：2005-02-28
申请人： Calvin Roskelley , Raymond Andersen , David Williams , Michel Roberge , Shoukat Dedhar , Aly Karsan , Andrew Minchinton
发明人： Calvin Roskelley , Raymond Andersen , David Williams , Michel Roberge , Shoukat Dedhar , Aly Karsan , Andrew Minchinton
IPC分类号： A61K31/395 , A61K31/403 , C07D209/86 , C07D225/02 , C07D295/13 , A61K31/551
CPC分类号： C07D295/13 , A61K31/395 , A61K31/403 , C07D209/86 , C07D225/02
摘要： This invention provides the use of macrocyclic amines for inhibition of cellular invasion or angiogenesis. Compounds and pharmaceutical compositions of this invention are useful in the treatment of conditions characterized by cellular invasion or angiogenesis, including cancer. Compounds that may be used in this invention include the motuporamines.
摘要翻译：本发明提供了大环胺用于抑制细胞侵袭或血管发生的用途。本发明的化合物和药物组合物可用于治疗以细胞侵袭或血管生成为特征的病症，包括癌症。可用于本发明的化合物包括异丁胺。

10. 发明申请

US20080255090A1 Ceratamines A and B, and Analogues, Syntheses and Pharmaceutical Compositions Thereof 审中-公开
标题翻译： Ceratamines A和B及其类似物，合成和药物组合物
公开(公告)号：US20080255090A1
公开(公告)日：2008-10-16
申请号：US10571932
申请日：2004-09-15
申请人： Raymond J. Andersen , Michel Roberge , Emiliano Manzo
发明人： Raymond J. Andersen , Michel Roberge , Emiliano Manzo
IPC分类号： C07D487/04 , A61K31/55 , A61P35/00
CPC分类号： C07D487/04
摘要： Antimitotic compounds and salts are provided in which the compound has the structure (formula (I)): wherein X and Y are substituted or unsubstituted and are selected from carbon atoms and atoms of groups 15 and 16 of the periodic table; Z is selected from N—R, O and S; U is selected from CR1, N, NH, NR, S and O, R1, R2, and R3 are independently selected from H, NH2, NHR, NR2, SH, SR, SiR3, OH, OR, F, CI, Br, I, ═O, ═S and R; W is selected from O, S, and H2; R4 is selected from H, R, OH, OR, SH, SR, NH2, NHR, NR2 and halide; R is selected from H, substituted or unsubstituted aryl, and substituted or unsubstituted 1 to 20 carbon linear, branched, or cyclic, saturated or unsaturated alkyl, in which alkyl carbon atoms are replaced by 0 to 10 oxygen, 0 to 10 sulphur, and 0 to 10 N atoms; and wherein bonds to carbon atoms or to any of X, Y, Z and U are saturated or unsaturated; and providing that when W is H2, R4 is not H, OH, or unsubstituted phenyl.
摘要翻译：提供了其中化合物具有结构（式（I））的反仿构化合物和盐：其中X和Y是取代或未取代的，并且选自周期表第15和16族的碳原子和原子; Z选自N-R，O和S; U选自CR 1，N，NH，NR，S和O，R 1，R 2和R 3 独立地选自H，NH 2，NHR，NR 2，SH，SR，SiR 3，OH，OR， F，Cl，Br，I，-O，-S和R; W选自O，S和H 2; R 4选自H，R，OH，OR，SH，SR，NH 2，NHR，NR 2和卤素; R选自H，取代或未取代的芳基和取代或未取代的1至20个直链，支链或环状饱和或不饱和的烷基，其中烷基碳原子被0至10个氧，0至10个硫代替，以及 0〜10N原子; 并且其中与碳原子或X，Y，Z和U中的任一个的键是饱和或不饱和的; 并且当W是H 2 H时，R 4不是H，OH或未被取代的苯基。

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