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1. 发明授权

US4672218A Method for determining the onset of crystallization 失效
标题翻译：确定结晶开始的方法
公开(公告)号：US4672218A
公开(公告)日：1987-06-09
申请号：US678114
申请日：1984-12-04
申请人： Ray W. Chrisman , Richard D. McLachlan , Richard S. Harner
发明人： Ray W. Chrisman , Richard D. McLachlan , Richard S. Harner
IPC分类号： G01N21/49 , B01D9/02 , G01N21/51 , G01N21/85 , G01N25/14
CPC分类号： G01N25/147 , G01N21/51 , G01N21/8507
摘要： A method for determining the onset of nucleation wherein a zone of a translucent fluid in which crystals may be formed is illuminated by a beam of light. When crystallization commences the crystals in the illuminated zone reflect and scatter light. Some of the scattered light is collected and transmitted to a light sensitive detector operable to generate a signal indicative of nucleation. Upon detection of nucleation either manual or automatic procedures may be instituted to modify the crystallization process in an appropriate manner.
摘要翻译：用于确定成核开始的方法，其中可以形成晶体的半透明流体的区域被光束照射。当结晶开始时，照射区域中的晶体反射和散射光。一些散射光被收集并传输到可操作以产生指示成核的信号的光敏检测器。当检测到成核时，可以进行手动或自动程序以适当的方式改变结晶过程。

2. 发明申请

US20090059218A1 STABLE TURBIDITY CALIBRATION STANDARDS 有权
标题翻译：稳定的涡度校准标准
公开(公告)号：US20090059218A1
公开(公告)日：2009-03-05
申请号：US12195779
申请日：2008-08-21
申请人： Richard S. Harner , J. Keith Harris , William A. Heeschen , Mary Beth Seasholtz
发明人： Richard S. Harner , J. Keith Harris , William A. Heeschen , Mary Beth Seasholtz
IPC分类号： G01J1/10
CPC分类号： G01N21/4785
摘要： The present invention relates to a turbidity calibration standard comprising: a number of from 1 to 5 sequentially-interfaced layers, wherein each layer independently comprises a light-permeable polymer or light-permeable interpolymer; a measured light transmission modulating amount of at least one light transmission modulator, which is distributed in any one or more of the layers; and a light-permeable container, which contains the layers and the at least one light transmission modulator. Also, the invention relates to methods of making and using the standard, and kits comprising the standard.
摘要翻译：浊度校准标准本发明涉及一种浑浊度校准标准，其包括：多个1至5个顺序界面层，其中各层独立地包含透光聚合物或透光互聚物; 分布在任何一个或多个层中的至少一个光传输调制器的测量光透射调制量; 以及容纳所述层和所述至少一个光透射调制器的透光性容器。此外，本发明涉及制备和使用该标准品的方法，以及包含该标准品的试剂盒。

3. 发明授权

US09447201B2 Polymerization inhibitor composition and method of inhibiting polymerization of distillable monomers 有权
标题翻译：聚合抑制剂组合物和抑制可蒸馏单体聚合的方法
公开(公告)号：US09447201B2
公开(公告)日：2016-09-20
申请号：US13147733
申请日：2010-02-18
申请人： Kishore K. Kar , Michael D. Cloeter , Olan Stanley Fruchey , Richard S. Harner , Krzysztof Matyjaszewski , Renaud Nicolay , Jaroslav Mosná{hacek over (c)}ek
发明人： Kishore K. Kar , Michael D. Cloeter , Olan Stanley Fruchey , Richard S. Harner , Krzysztof Matyjaszewski , Renaud Nicolay , Jaroslav Mosná{hacek over (c)}ek
IPC分类号： C07C51/50 , C07C67/62 , C08F2/42 , C07C51/44 , C08F2/40
CPC分类号： C08F2/42 , C07C51/44 , C07C51/50 , C08F2/40 , C07C57/04
摘要： The present invention relates to a polymerization inhibitor composition and a method of inhibiting polymerization of distillable monomers in liquid and evaporated/condensed phases with the polymerization inhibitor composition. The polymerization inhibitor composition is useful for inhibiting polymerization of the distillable monomers during manufacture, purification (e.g., distillation), handling, and storage thereof.
摘要翻译：本发明涉及聚合抑制剂组合物和通过聚合抑制剂组合物抑制可蒸馏单体在液体和蒸发/冷凝相中的聚合的方法。聚合抑制剂组合物可用于在制造，纯化（例如蒸馏），处理和储存期间抑制可蒸馏单体的聚合。

4. 发明授权

US4909588A Sealed fiber optic probe 失效
标题翻译：密封光纤探头
公开(公告)号：US4909588A
公开(公告)日：1990-03-20
申请号：US236571
申请日：1988-08-25
申请人： Richard S. Harner , Bruce W. Gutzmann
发明人： Richard S. Harner , Bruce W. Gutzmann
IPC分类号： G02B6/24 , G02B6/36
CPC分类号： G02B6/241 , G02B6/3624
摘要： A fiber optic probe adapted to be immersed in a fluid medium has an opening at one end in which is accommodated an optical window through which light may be transmitted from and to the optical fibers. Seals between the optical element and the probe body are provided to prevent the leakage of fluid past the window into the probe body. One or more resilient biasing springs constantly apply a yieldable, compressive force on the seals regardless of thermal expansion and contraction of any part of the probe.
摘要翻译：适于浸入流体介质中的光纤探针在其一端具有一个开口，在该窗口中容纳有一个光学窗口，光从该光学窗口可以从光纤传输到光纤。提供光学元件和探针体之间的密封以防止流体经过窗口泄漏到探针体中。一个或多个弹性偏压弹簧不断地对密封件施加可屈服的压缩力，而不管探针的任何部分的热膨胀和收缩。

5. 发明授权

US07745167B2 Fiber-optic probes and methods of measuring biological materials 有权
标题翻译：光纤探头和测量生物材料的方法
公开(公告)号：US07745167B2
公开(公告)日：2010-06-29
申请号：US11528872
申请日：2006-09-28
申请人： Richard S. Harner , Timm R. Richardson , Keith L. Haney , Torben R. Bruck , Lawrence C. Chew
发明人： Richard S. Harner , Timm R. Richardson , Keith L. Haney , Torben R. Bruck , Lawrence C. Chew
IPC分类号： C12N1/00 , C12Q1/02 , G02B6/00 , C02F1/00 , G01N21/00
CPC分类号： G01N21/474 , G01N21/51
摘要： A method for monitoring fluid media, such as a dynamic biological system, in a biological reactor containing developing culture fluid media. The method includes the step of directing light into the fluid media by way of one or more optical fibers to produce an illuminated fluid media and then measuring the intensity of light reflected from the illuminated fluid media by way of one or more optical fibers, the optical fibers being partitioned from the fluid media by a transparent window having inner and outer surfaces; the fibers having ends terminating adjacent to and confronting the inner surface of the window and extending in a direction away from the window, the corresponding ends of the fibers being radially and circumferentially spaced from one another, the corresponding ends of the fibers having converging and intersecting longitudinal projections therefrom, the intersecting longitudinal projections from the fibers being entirely within the window. Additionally, a fiber-optic probe is discussed.
摘要翻译：一种用于在含有显影培养液介质的生物反应器中监测流体介质如动态生物系统的方法。该方法包括通过一根或多根光纤将光引导到流体介质中以产生照明的流体介质，然后通过一根或多根光纤测量从被照射的流体介质反射的光的强度的步骤，该光学纤维通过具有内表面和外表面的透明窗口与流体介质隔开; 纤维的端部邻近并面向窗口的内表面并且沿远离窗口的方向延伸，纤维的相应端部彼此径向和周向间隔开，纤维的相应端部具有会聚和相交来自纤维的交叉纵向突起完全在窗内。另外，讨论了光纤探针。

6. 发明申请

US20100118130A1 DIGITAL IMAGING SYSTEM 审中-公开
标题翻译：数字成像系统
公开(公告)号：US20100118130A1
公开(公告)日：2010-05-13
申请号：US12615564
申请日：2009-11-10
申请人： J. Keith Harris , David A. Hayes , Richard S. Harner , William A. Heeschen
发明人： J. Keith Harris , David A. Hayes , Richard S. Harner , William A. Heeschen
IPC分类号： H04N7/18 , G06K9/00 , H04N5/33
CPC分类号： G01N21/51
摘要： The invention is an image capturing device comprising a lens to capture the image of the one or more samples which are located in an image capturing chamber, a nest receptacle to hold the one or more samples during imaging, and at least one illuminating source to illuminate the one or more samples. The chamber, lighting and nest receptacle are configured to minimize undesired reflections and improve the image quality.
摘要翻译：本发明是一种图像捕获装置，其包括：用于捕获位于图像捕获室中的一个或多个样本的图像的镜头，用于在成像期间保持所述一个或多个样本的巢容器，以及至少一个照明源一个或多个样品。房间，照明和窝窝被配置为最小化不期望的反射并提高图像质量。

7. 发明授权

US6118520A Dual analysis probe 失效
标题翻译：双分析探针
公开(公告)号：US6118520A
公开(公告)日：2000-09-12
申请号：US768422
申请日：1996-12-18
申请人： Richard S. Harner
发明人： Richard S. Harner
IPC分类号： G01N21/55 , G01N21/85 , G01N21/00
CPC分类号： G01N21/8507 , G01N21/552
摘要： A single fiber optic probe capable of measuring at least two different properties of a medium. More specifically, a single probe having an integral optical element which is capable of directing light to perform at least two distinct spectrometric analyses on a medium. For example, the single probe may be used to monitor a solid phase and dissolved solids in a multiphase medium.
摘要翻译：能够测量介质的至少两种不同特性的单个光纤探针。更具体地，具有整体光学元件的单个探针，其能够引导光在介质上执行至少两个不同的光谱分析。例如，单个探针可以用于监测多相介质中的固相和溶解的固体。

8. 发明授权

US4988155A In-line fiber optic probe interface 失效
标题翻译：在线光纤探头接口
公开(公告)号：US4988155A
公开(公告)日：1991-01-29
申请号：US369745
申请日：1989-06-22
申请人： Richard S. Harner , Charles J. Myers
发明人： Richard S. Harner , Charles J. Myers
IPC分类号： G01N21/05 , B08B3/04 , G01N21/01 , G01N21/85 , G02B6/36 , G02B6/38
CPC分类号： G02B6/3887 , B08B3/04 , G01N21/85 , G02B6/3807 , B08B2240/02 , G01N2201/08 , G02B6/3624
摘要： An in-line fiber optic probe interface includes a sample cell with a bore therein defining an optical axis. A controller housing is centered by o-ring seals in the bore and a pathlength controller is mounted on the housing. A fiber optic probe is disposed in the housing and controller, sealed thereto by o-ring seals at multiple points to maintain the probe in appropriate alignment on the optical axis.
摘要翻译：在线光纤探针接口包括其中具有限定光轴的孔的样品池。控制器外壳以孔内的O形圈密封为中心，并且路径长度控制器安装在外壳上。光纤探针设置在壳体和控制器中，通过多个点处的O形环密封将其密封，以将探针保持在光轴上适当的对准。

9. 发明申请

US20110290635A1 POLYMERIZATION INHIBITOR COMPOSITION AND METHOD OF INHIBITING POLYMERIZATION OF DISTILLABLE MONOMERS 有权
标题翻译：聚合抑制剂组合物和抑制可分散单体聚合的方法
公开(公告)号：US20110290635A1
公开(公告)日：2011-12-01
申请号：US13147733
申请日：2010-02-18
申请人： Kishore K. Kar , Michael D. Cloeter , Olan Stanley Fruchey , Richard S. Harner , Krzysztof Matyjaszewski , Renaud Nicolay , Jaroslav Mosnacek
发明人： Kishore K. Kar , Michael D. Cloeter , Olan Stanley Fruchey , Richard S. Harner , Krzysztof Matyjaszewski , Renaud Nicolay , Jaroslav Mosnacek
IPC分类号： C07C69/54 , C09K3/00
CPC分类号： C08F2/42 , C07C51/44 , C07C51/50 , C08F2/40 , C07C57/04
摘要： The present invention relates to a polymerization inhibitor composition and a method of inhibiting polymerization of distillable monomers in liquid and evaporated/condensed phases with the polymerization inhibitor composition. The polymerization inhibitor composition is useful for inhibiting polymerization of the distillable monomers during manufacture, purification (e.g., distillation), handling, and storage thereof.
摘要翻译：本发明涉及聚合抑制剂组合物和通过聚合抑制剂组合物抑制可蒸馏单体在液体和蒸发/冷凝相中的聚合的方法。聚合抑制剂组合物可用于在制造，纯化（例如蒸馏），处理和储存期间抑制可蒸馏单体的聚合。

10. 发明授权

US07843560B2 Stable turbidity calibration standards 有权
标题翻译：浊度校准标准稳定
公开(公告)号：US07843560B2
公开(公告)日：2010-11-30
申请号：US12195779
申请日：2008-08-21
申请人： Richard S. Harner , J. Keith Harris , William A. Heeschen , Mary Beth Seasholtz
发明人： Richard S. Harner , J. Keith Harris , William A. Heeschen , Mary Beth Seasholtz
IPC分类号： G01J1/10
CPC分类号： G01N21/4785
摘要： The present invention relates to a turbidity calibration standard comprising: a number of from 1 to 5 sequentially-interfaced layers, wherein each layer independently comprises a light-permeable polymer or light-permeable interpolymer; a measured light transmission modulating amount of at least one light transmission modulator, which is distributed in any one or more of the layers; and a light-permeable container, which contains the layers and the at least one light transmission modulator. Also, the invention relates to methods of making and using the standard, and kits comprising the standard.
摘要翻译：浊度校准标准本发明涉及一种浑浊度校准标准，其包括：多个1至5个顺序界面层，其中各层独立地包含透光聚合物或透光互聚物; 分布在任何一个或多个层中的至少一个光传输调制器的测量光透射调制量; 以及容纳所述层和所述至少一个光透射调制器的透光性容器。此外，本发明涉及制备和使用该标准品的方法，以及包含该标准品的试剂盒。

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