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1. 发明授权

US4262002A Discovery of A73A, a new efrotomycin-like antibiotic in fermentation broth 失效
标题翻译：发现A73A，发酵液中的一种新的类似霉菌素的抗生素
公开(公告)号：US4262002A
公开(公告)日：1981-04-14
申请号：US51318
申请日：1979-06-22
申请人： Ray S. Dewey , James E. Flor , Sheldon B. Zimmerman , Patrick J. Cassidy , Satoshi Omura , Ruiko Oiwa
发明人： Ray S. Dewey , James E. Flor , Sheldon B. Zimmerman , Patrick J. Cassidy , Satoshi Omura , Ruiko Oiwa
IPC分类号： A23K1/16 , A23K1/17 , A61K31/44 , A61K31/443 , A61P31/04 , C07D405/12 , C12P17/16 , C12R1/465 , A01N43/40
CPC分类号： C12R1/465 , C12P17/16
摘要： There is disclosed a new antibiotic agent, A73A, produced by Streptomyces viridifaciens MA-4864 (ATCC 31495) under suitable conditions. Said antibiotic shows antibacterial and growth-permittant activity.
摘要翻译：公开了在合适的条件下由链霉菌（Streptomyces viridifaciens）MA-4864（ATCC 31495）生产的新型抗生素A73A。所述抗生素显示抗菌和生长 - 吸收剂活性。

2. 发明授权

US4304859A Process for producing A73A, a new Efrotomycin-like antibiotic in fermentation broth 失效
标题翻译：生产A73A的方法，一种新型的发酵液中的类似霉菌素的抗生素
公开(公告)号：US4304859A
公开(公告)日：1981-12-08
申请号：US201097
申请日：1980-10-27
申请人： Ray S. Dewey , James E. Flor , Sheldon B. Zimmerman , Patrick J. Cassidy , Satoshi Omura , Ruiko Oiwa
发明人： Ray S. Dewey , James E. Flor , Sheldon B. Zimmerman , Patrick J. Cassidy , Satoshi Omura , Ruiko Oiwa
IPC分类号： C07H7/02 , C12P17/16
CPC分类号： C12R1/465 , C07H7/02 , C12P17/16 , Y10S435/886
摘要： There is disclosed a new antibiotic agent, A73A, produced by Streptomyces viridifaciens MA-4864 (ATCC 31495) under suitable conditions. Said antibiotic shows antibacterial and growth-permittant activity.
摘要翻译：公开了在合适的条件下由链霉菌（Streptomyces viridifaciens）MA-4864（ATCC 31495）生产的新型抗生素A73A。所述抗生素显示抗菌和生长 - 吸收剂活性。

3. 发明授权

US4264736A Antibiotic 890A.sub.10 失效
标题翻译：抗生素890A10
公开(公告)号：US4264736A
公开(公告)日：1981-04-28
申请号：US79122
申请日：1979-09-26
申请人： Patrick J. Cassidy , Sheldon B. Zimmerman , Josefino B. Tunac , Sebastian Hernandez
发明人： Patrick J. Cassidy , Sheldon B. Zimmerman , Josefino B. Tunac , Sebastian Hernandez
IPC分类号： C07D477/20 , C12P17/18
CPC分类号： C07D477/20 , C12P17/184 , Y10S435/886
摘要： The antibiotic MSD 890A.sub.10 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotic 890A.sub.10) is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing species of Streptomyces on suitable fermentation media.
摘要翻译：抗生素MSD 890A10及其药学上可接受的盐（以下称为抗生素890A10）对革兰氏阳性菌和革兰氏阴性细菌均有活性。抗生素通过在合适的发酵培养基上种植链霉菌来生产。

4. 发明授权

US4264735A Method of producing antibiotic 890A.sub.9 失效
标题翻译：生产抗生素890A9的方法
公开(公告)号：US4264735A
公开(公告)日：1981-04-28
申请号：US74373
申请日：1979-09-10
申请人： Patrick J. Cassidy , Sheldon B. Zimmerman , Josefino B. Tunac , Sebastian Hernandez
发明人： Patrick J. Cassidy , Sheldon B. Zimmerman , Josefino B. Tunac , Sebastian Hernandez
IPC分类号： C07D477/20 , C12P17/18
CPC分类号： C07D477/20 , C12P17/184 , Y10S435/886
摘要： The antibiotic MSD 890A.sub.9 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotic 890A.sub.9) is active against both gram-positive and gram-negative bacteria. The antibiotic is produced by growing species of Streptomyces on suitable fermentation media.
摘要翻译：抗生素MSD 890A9及其药学上可接受的盐（以下称为抗生素890A9）对革兰氏阳性菌和革兰氏阴性细菌均有活性。抗生素通过在合适的发酵培养基上种植链霉菌来生产。

5. 发明授权

US4162324A Antibiotics 890A.sub.1 and 890A.sub.3 失效
标题翻译：抗生素890A {HD 1 {B和890A {HD 3
公开(公告)号：US4162324A
公开(公告)日：1979-07-24
申请号：US827504
申请日：1977-08-25
申请人： Patrick J. Cassidy , Robert T. Goegelman , Edward O. Stapley , Sebastian Hernandez
发明人： Patrick J. Cassidy , Robert T. Goegelman , Edward O. Stapley , Sebastian Hernandez
IPC分类号： C12P17/18 , C07D487/04 , A61K31/40
CPC分类号： C12R1/465 , C12P17/184 , Y10S435/886
摘要： The antibiotics MSD 890A.sub.1 and MSD 890A.sub.3 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotics 890A.sub.1 and 890A.sub.3) are active against both gram-positive and gram-negative bacteria. The antibiotics are produced by growing species of Streptomyces on suitable fermentation media.
摘要翻译：抗生素MSD 890A1和MSD 890A3及其药学上可接受的盐（以下称为抗生素890A1和890A3）对革兰氏阳性菌和革兰氏阴性细菌均有活性。抗生素通过在合适的发酵培养基上种植链霉菌来生产。

6. 发明授权

US4207395A Process for deacylating N-acyl-6-substituted-2-[2-aminoethylthio]-1-carbadethiapen-2-em-3-carbox ylic acids 失效
标题翻译： N-酰基-6-取代-2- [2-氨基乙硫基] -1-碳杂萘-2-烯-3-羧酸脱酰胺的方法
公开(公告)号：US4207395A
公开(公告)日：1980-06-10
申请号：US956951
申请日：1978-11-02
申请人： Patrick J. Cassidy , Jean S. Kahan
发明人： Patrick J. Cassidy , Jean S. Kahan
IPC分类号： C12P17/18
CPC分类号： C12R1/05 , C12P17/184
摘要： Disclosed is a process for enzymatically cleaving the acyl group from N-acyl-6-substituted-2-substituted-1-carbadethiapen-2-em-3-carboxylic acids. The acylated substrate and the deacylated product are antibiotics.
摘要翻译：公开了一种从N-酰基-6-取代-2-取代-1-碳代萘二烯-2-基-3-羧酸中酶切割酰基的方法。酰化底物和脱酰基化产物是抗生素。

7. 发明授权

US06277425B1 Method for producing an extruded cooked food product 失效
标题翻译：挤出熟食品的制造方法
公开(公告)号：US06277425B1
公开(公告)日：2001-08-21
申请号：US09221887
申请日：1998-12-28
申请人： J. Barry Nash , Salvatore M. Pileggi , Patrick J. Cassidy , Richard R. Hawkins , Jonathan Bosworth
发明人： J. Barry Nash , Salvatore M. Pileggi , Patrick J. Cassidy , Richard R. Hawkins , Jonathan Bosworth
IPC分类号： A23P113
CPC分类号： A21C11/16 , A23L7/17 , A23P30/34
摘要： An apparatus and method for manufacturing an extruded cooked food product including use of an extruder having a barrel, at least one screw contained therein, a feed element at the discharge end of the screw, and a die head containing an expansion chamber. The discharge feed element is formed with a large pitch for pushing a large volume of cooked food mix into the expansion chamber. The large volume of cooked food mix is extruded as extrudate strands through relatively large orifices extending through the die plate of the die head to dimensionally expand upon exiting the orifices. The extrudate strands are conveyed over a sole support bar located a significant distance from the die head and then to a cutter. An air flow is applied to the extrudate strands for further cooling and drying before being cut. The cutter is located approximately 90 inches from the die head. The extruded food product is uniform in cross-section.
摘要翻译：一种用于制造挤压熟食品的设备和方法，包括使用具有桶的挤出机，其中容纳有至少一个螺杆的螺杆的排出端处的进料元件和包含膨胀室的模头。排出进料元件形成有大的间距，用于将大量的熟食料混合物推入膨胀室。大量的熟食混合物通过穿过模头的模板的相对较大的孔口挤出成挤出物股，在离开孔口时尺寸扩大。挤出物股线在位于与模具头相当远的位置上的鞋底支撑杆上传送，然后传送到切割器。将空气流施加到挤出物股线上，以便在切割之前进一步冷却和干燥。切割器距离模具头约90英寸。挤压食品的横截面均匀。

8. 发明授权

US4235967A Process for producing antibiotics by cultivation of Streptomyces flavogriseus 失效
标题翻译：通过种植黄曲霉生产抗生素的方法
公开(公告)号：US4235967A
公开(公告)日：1980-11-25
申请号：US27642
申请日：1979-04-06
申请人： Patrick J. Cassidy , Robert T. Goegelman , Edward O. Stapley , Sebastian Hernandez
发明人： Patrick J. Cassidy , Robert T. Goegelman , Edward O. Stapley , Sebastian Hernandez
IPC分类号： C12P17/18
CPC分类号： C12R1/465 , C12P17/184 , Y10S435/886
摘要： The antibiotics MSD 890A.sub.1 and MSD 890A.sub.3 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotics 890A.sub.1 and 890A.sub.3) are active against both gram-positive and gram-negative bacteria. The antibiotics are produced by growing species of Streptomyces on suitable fermentation media.
摘要翻译：抗生素MSD 890A1和MSD 890A3及其药学上可接受的盐（以下称为抗生素890A1和890A3）对革兰氏阳性菌和革兰氏阴性细菌均有活性。抗生素通过在合适的发酵培养基上种植链霉菌来生产。

9. 发明授权

US4168202A Process for producing antibiotics 失效
标题翻译：生产抗生素的方法
公开(公告)号：US4168202A
公开(公告)日：1979-09-18
申请号：US813908
申请日：1977-07-08
申请人： Patrick J. Cassidy , Robert T. Goegelman , Edward O. Stapley , Sebastian Hernandez
发明人： Patrick J. Cassidy , Robert T. Goegelman , Edward O. Stapley , Sebastian Hernandez
IPC分类号： C07D477/20 , C12P17/18 , C12D9/14
CPC分类号： C07D477/20 , C12P17/184
摘要： The antibiotics MSD 890A.sub.2 and MSD 890A.sub.5 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotics 890A.sub.2 and 890A.sub.5) are active against both gram-positive and gram-negative bacteria. The antibiotics are produced by growing species of Streptomyces on suitable fermentation media.
摘要翻译：抗生素MSD 890A2和MSD 890A5及其药学上可接受的盐（以下称为抗生素890A2和890A5）对革兰氏阳性菌和革兰氏阴性细菌均有活性。抗生素通过在合适的发酵培养基上种植链霉菌来生产。

10. 发明授权

US4141986A Antibiotics 890A.sub.2 and 890A.sub.5 失效
标题翻译：抗生素890A {HD 2 {B和890A {HD 5
公开(公告)号：US4141986A
公开(公告)日：1979-02-27
申请号：US823258
申请日：1977-08-05
申请人： Patrick J. Cassidy , Robert T. Goegelman , Edward O. Stapley , Sebastian Hernandez
发明人： Patrick J. Cassidy , Robert T. Goegelman , Edward O. Stapley , Sebastian Hernandez
IPC分类号： C07D477/00 , A61K31/397 , A61K31/40 , A61P31/04 , C07D477/20 , C07D487/04 , C12P17/18 , C12R1/485
CPC分类号： C07D477/20 , C12P17/184 , Y10S435/886
摘要： The antibiotics MSD 890A.sub.2 and MSD 890A.sub.5 and pharmaceutically acceptable salts thereof (hereinafter referred to as antibiotics 890A.sub.2 and 890A.sub.5) are active against both gram-positive and gram-negative bacteria. The antibiotics are produced by growing species of Streptomyces on suitable fermentation media.
摘要翻译：抗生素MSD 890A2和MSD 890A5及其药学上可接受的盐（以下称为抗生素890A2和890A5）对革兰氏阳性菌和革兰氏阴性细菌均有活性。抗生素通过在合适的发酵培养基上种植链霉菌来生产。

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