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1. 发明授权

US5981243A Purified myceliophthora laccases and nucleic acids encoding same 失效
标题翻译：纯化的丝裂霉菌和编码相同的核酸
公开(公告)号：US5981243A
公开(公告)日：1999-11-09
申请号：US939218
申请日：1997-09-29
申请人： Randy Michael Berka , Stephen H. Brown , Feng Xu , Palle Schneider , Karen M. Oxenb.o slashed.ll , Dorrit A. Aaslyng
发明人： Randy Michael Berka , Stephen H. Brown , Feng Xu , Palle Schneider , Karen M. Oxenb.o slashed.ll , Dorrit A. Aaslyng
IPC分类号： C12N15/09 , A61K8/00 , A61K8/33 , A61K8/41 , A61K8/66 , A61K8/99 , A61Q5/10 , C12N1/15 , C12N9/02 , C12N15/53 , C12N15/63 , C12R1/69 , D21C5/02 , D21C9/10 , C09B69/00
CPC分类号： A61K8/66 , A61Q5/10 , C12N9/0061
摘要： The present invention relates to isolated nucleic acid constructs containing a sequence encoding a Myceliophthora laccase, and the laccase proteins encoded thereby.
摘要翻译：本发明涉及含有编码丝霉菌漆酶的序列的分离的核酸构建体和由其编码的漆酶蛋白质。

2. 发明授权

US5795760A Purified Myceliophthora laccases and nucleic acids encoding same 失效
标题翻译：纯化的菌丝霉菌和编码相同的核酸
公开(公告)号：US5795760A
公开(公告)日：1998-08-18
申请号：US940661
申请日：1997-09-29
申请人： Randy Michael Berka , Stephen H. Brown , Feng Xu , Palle Schneider , Karen M. Oxenb.o slashed.ll , Dorrit A. Aaslyng
发明人： Randy Michael Berka , Stephen H. Brown , Feng Xu , Palle Schneider , Karen M. Oxenb.o slashed.ll , Dorrit A. Aaslyng
IPC分类号： C12N15/09 , A61K8/00 , A61K8/33 , A61K8/41 , A61K8/66 , A61K8/99 , A61Q5/10 , C12N1/15 , C12N9/02 , C12N15/53 , C12N15/63 , C12R1/69 , D21C5/02 , D21C9/10
CPC分类号： A61K8/66 , A61Q5/10 , C12N9/0061
摘要： The present invention relates to isolated nucleic acid constructs containing a sequence encoding a Myceliophthora laccase, and the laccase proteins encoded thereby.
摘要翻译：本发明涉及含有编码丝霉菌漆酶的序列的分离的核酸构建体和由其编码的漆酶蛋白质。

3. 发明授权

US5843745A Purified scytalidium laccases and nucleic acids encoding same 失效
公开(公告)号：US5843745A
公开(公告)日：1998-12-01
申请号：US539134
申请日：1995-10-04
申请人： Randy Michael Berka , Sheryl Ann Thompson , Feng Xu
发明人： Randy Michael Berka , Sheryl Ann Thompson , Feng Xu
IPC分类号： A61K8/66 , A61Q5/10 , C12N1/15 , C12N9/02 , C12N15/53 , C12N1/00
CPC分类号： C12N9/0061 , A61K8/66 , A61Q5/10 , C12Y110/03002 , Y10S435/911
摘要： The present invention relates to isolated nucleic acid constructs containing a sequence encoding a Scytalidium laccase, and the laccase proteins encoded thereby.

4. 发明授权

US5750388A Purified scytalidium laccases and nucleic acids encoding same 失效
标题翻译：纯化的scytalidium laccases和编码相同的核酸
公开(公告)号：US5750388A
公开(公告)日：1998-05-12
申请号：US749882
申请日：1996-11-15
申请人： Randy Michael Berka , Sheryl Ann Thompson , Feng Xu
发明人： Randy Michael Berka , Sheryl Ann Thompson , Feng Xu
IPC分类号： A61K8/66 , A61Q5/10 , C12N1/15 , C12N9/02 , C12N15/53
CPC分类号： C12N9/0061 , A61K8/66 , A61Q5/10 , C12Y110/03002 , Y10S435/911
摘要： The present invention relates to isolated nucleic acid constructs containing a sequence encoding a Scytalidium laccase, and the laccase proteins encoded thereby.
摘要翻译：本发明涉及含有编码Scytalidium漆酶的序列的分离的核酸构建体和由此编码的漆酶蛋白。

5. 发明授权

US06379928B1 Heterologous polypeptides expressed in filamentous fungi, processes for making same, and vectors for making same 有权
标题翻译：在丝状真菌中表达的异源多肽，其制备方法和用于制备其的载体
公开(公告)号：US06379928B1
公开(公告)日：2002-04-30
申请号：US09468265
申请日：1999-12-10
申请人： Randy Michael Berka , Daniel Cullen , Gregory Lawrence Gray , Kirk James Hayenga , Virgil Bryan Lawlis
发明人： Randy Michael Berka , Daniel Cullen , Gregory Lawrence Gray , Kirk James Hayenga , Virgil Bryan Lawlis
IPC分类号： C12P2100
CPC分类号： C12N9/2428 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C07K2319/61 , C12N9/58 , C12N9/6481 , C12N15/62 , C12N15/80
摘要： Novel vectors are disclosed for expressing and secreting heterologous polypeptides from filamentous fungi. Such vectors are used in novel processes to express and secrete such heterologous polypeptides. The vectors used for transforming a filamentous fungus to express and secrete a heterologous polypeptide include a DNA sequence encoding a heterologous polypeptide and a DNA sequence encoding a signal sequence which is functional in a secretory system in a given filamentous fungus and which is operably linked to the sequence encoding the heterologous polypeptide. Such signal sequences may be the signal sequence normally associated with the heterologous polypeptides or may be derived from other sources. The vector may also contain DNA sequences encoding a promoter sequence which is functionally recognized by the filamentous fungus and which is operably linked to the DNA sequence encoding the signal sequence. Preferably functional polyadenylation sequences are operably linked to the 3′ terminus of the DNA sequence encoding the heterologous polypeptides. Each of the above described vectors are used in novel processes to transform a filamentous fungus wherein the DNA sequences encoding the signal sequence and heterologous polypeptide are expressed. The thus synthesized polypeptide is thereafter secreted from the filamentous fungus.
摘要翻译：公开了用于从丝状真菌表达和分泌异源多肽的新型载体。这些载体用于表达和分泌这些异源多肽的新方法中。用于转化丝状真菌以表达和分泌异源多肽的载体包括编码异源多肽的DNA序列和编码在给定丝状真菌中在分泌系统中有功能的信号序列的DNA序列，并且其与编码异源多肽的序列。这样的信号序列可以是通常与异源多肽相关的信号序列，或者可以来自其他来源。载体还可以含有编码启动子序列的DNA序列，其由丝状真菌功能识别，并且可操作地连接于编码信号序列的DNA序列。优选地，功能性多腺苷酸化序列可操作地连接到编码异源多肽的DNA序列的3'末端。上述载体中的每一种用于转化丝状真菌的新方法，其中表达编码信号序列和异源多肽的DNA序列。由此合成的多肽此后由丝状真菌分泌。

6. 发明授权

US06171817B2 Heterologous polypeptides expressed in filamentous fungi, process for making same, and vectors for making same 失效
标题翻译：在丝状真菌中表达的异源多肽，其制备方法和用于制备其的载体
公开(公告)号：US06171817B2
公开(公告)日：2001-01-09
申请号：US08976967
申请日：1997-11-24
申请人： Randy Michael Berka , Daniel Cullen , Gregory Lawrence Gray , Kirk James Hayenga , Virgil Bryan Lawlis
发明人： Randy Michael Berka , Daniel Cullen , Gregory Lawrence Gray , Kirk James Hayenga , Virgil Bryan Lawlis
IPC分类号： C12N1500
CPC分类号： C12N9/2428 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C07K2319/61 , C12N9/58 , C12N9/6481 , C12N15/62 , C12N15/80
摘要： Novel vectors are disclosed for expressing and secreting heterologous polypeptides from filamentous fungi. Such vectors are used in novel processes to express and secrete such heterologous polypeptides. The vectors used for transforming a filamentous fungus to express and secrete a heterologous polypeptide include a DNA sequence encoding a heterologous polypeptide and a DNA sequence encoding a signal sequence which is functional in a secretory system in a given filamentous fungus and which is operably linked to the sequence encoding the heterologous polypeptide. Such signal sequences may be the signal sequence normally associated with the heterologous polypeptides or may be derived from other sources. The vector may also contain DNA sequences encoding a promoter sequence which is functionally recognized by the filamentous fungus and which is operably linked to the DNA sequence encoding the signal sequence. Preferably functional polyadenylation sequences are operably linked to the 3′ terminus of the DNA sequence encoding the heterologous polypeptides. Each of the above described vectors are used in novel processes to transform a filamentous fungus wherein the DNA sequences encoding the signal sequence and heterologous polypeptide are expressed. The thus synthesized polypeptide is thereafter secreted from the filamentous fungus.
摘要翻译：公开了用于从丝状真菌表达和分泌异源多肽的新型载体。这些载体用于表达和分泌这些异源多肽的新方法中。用于转化丝状真菌以表达和分泌异源多肽的载体包括编码异源多肽的DNA序列和编码在给定丝状真菌中在分泌系统中有功能的信号序列的DNA序列，并且可操作地连接到编码异源多肽的序列。这样的信号序列可以是通常与异源多肽相关的信号序列，或者可以来自其他来源。载体还可以含有编码启动子序列的DNA序列，其由丝状真菌功能识别，并且可操作地连接于编码信号序列的DNA序列。优选地，功能性多腺苷酸化序列可操作地连接到编码异源多肽的DNA序列的3'末端。上述载体中的每一种用于转化丝状真菌的新方法，其中表达编码信号序列和异源多肽的DNA序列。由此合成的多肽此后由丝状真菌分泌。

7. 发明授权

US6103490A Heterologous polypeptides expressed in filamentous fungi, processes for making same, and vectors for making same 失效
公开(公告)号：US6103490A
公开(公告)日：2000-08-15
申请号：US261989
申请日：1994-06-17
申请人： Randy Michael Berka , Daniel Cullen , Gregory Lawrence Gray , Kirk James Hayenga , Virgil Bryan Lawlis
发明人： Randy Michael Berka , Daniel Cullen , Gregory Lawrence Gray , Kirk James Hayenga , Virgil Bryan Lawlis
IPC分类号： C12N1/15 , C12N1/19 , C12N9/34 , C12N9/58 , C12N9/64 , C12N15/62 , C12N15/80 , C12N15/00 , C12N15/11 , C12N15/63
CPC分类号： C12N9/2428 , C12N15/62 , C12N15/80 , C12N9/58 , C12N9/6481 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C07K2319/61
摘要： Novel vectors are disclosed for expressing and secreting heterologous polypeptides from filamentous fungi. Such vectors are used in novel processes to express and secrete such heterologous polypeptides. The vectors used for transforming a filamentous fungus to express and secrete a heterologous polypeptide include a DNA sequence encoding a heterologous polypeptide and a DNA sequence encoding a signal sequence which is functional in a secretory system in a given filamentous fungus and which is operably linked to the sequence encoding the heterologous polypeptide. Such signal sequences may be the signal sequence normally associated with the heterologous polypeptides or may be derived from other sources. The vector may also contain DNA sequences encoding a promoter sequence which is functionally recognized by the filamentous fungus and which is operably linked to the DNA sequence encoding the signal sequence. Preferably functional polyadenylation sequences are operably linked to the 3' terminus of the DNA sequence encoding the heterologous polypeptides. Each of the above described vectors are used in novel processes to transform a filamentous fungus wherein the DNA sequences encoding the signal sequence and heterologous polypeptide are expressed. The thus synthesized polypeptide is thereafter secreted from the filamentous fungus.

8. 发明授权

US6004785A Heterologous polypeptides expressed in filamentous fungi, processes for making same, and vectors for making same 失效
公开(公告)号：US6004785A
公开(公告)日：1999-12-21
申请号：US484384
申请日：1995-06-07
申请人： Randy Michael Berka , Daniel Cullen , Gregory Lawrence Gray , Kirk James Hayenga , Virgil Bryan Lawlis
发明人： Randy Michael Berka , Daniel Cullen , Gregory Lawrence Gray , Kirk James Hayenga , Virgil Bryan Lawlis
IPC分类号： C12N1/15 , C12N9/34 , C12N9/58 , C12N9/64 , C12N15/62 , C12N15/80
CPC分类号： C12N9/2428 , C12N15/62 , C12N15/80 , C12N9/58 , C12N9/6481 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C07K2319/61
摘要： Novel vectors are disclosed for expressing and secreting heterologous polypeptides from filamentous fungi. Such vectors are used in novel processes to express and secrete such heterologous polypeptides. The vectors used for transforming a filamentous fungus to express and secrete a heterologous polypeptide include a DNA sequence encoding a heterologous polypeptide and a DNA sequence encoding a signal sequence which is functional in a secretory system in a given filamentous fungus and which is operably linked to the sequence encoding the heterologous polypeptide. Such signal sequences may be the signal sequence normally associated with the heterologous polypeptides or may be derived from other sources. The vector may also contain DNA sequences encoding a promoter sequence which is functionally recognized by the filamentous fungus and which is operably linked to the DNA sequence encoding the signal sequence. Preferably functional polyadenylation sequences are operably linked to the 3' terminus of the DNA sequence encoding the heterologous polypeptides. Each of the above described vectors are used in novel processes to transform a filamentous fungus wherein the DNA sequences encoding the signal sequence and heterologous polypeptide are expressed. The thus synthesized polypeptide is thereafter secreted from the filamentous fungus.

9. 发明授权

US5667990A Aspergillus expression system 失效
标题翻译：曲霉表达系统
公开(公告)号：US5667990A
公开(公告)日：1997-09-16
申请号：US458023
申请日：1995-06-01
申请人： Randy Michael Berka , Wendy Yoder , Shinobu Takagi , Karuppan Chettier Boominathan
发明人： Randy Michael Berka , Wendy Yoder , Shinobu Takagi , Karuppan Chettier Boominathan
IPC分类号： C12N15/09 , C12N1/15 , C12N9/00 , C12N9/08 , C12N9/20 , C12N9/30 , C12N15/80 , C12P21/02 , C12R1/66 , C07H21/04 , C12N15/11
CPC分类号： C12N9/0065 , C12N15/80 , C12N9/20 , C12N9/242
摘要： The present invention relates to a novel expression system in which A. japonicus-type species are used as host cells for expression of heterologous proteins.
摘要翻译：本发明涉及一种新型的表达系统，其中日本粳稻型物种用作表达异源蛋白质的宿主细胞。

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