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1. 发明授权

US06312692B1 Method of treating graft-versus-host disease with anti-GP39 antibodies and bone marrow cells 失效
标题翻译：用抗GP39抗体和骨髓细胞治疗移植物抗宿主病的方法
公开(公告)号：US06312692B1
公开(公告)日：2001-11-06
申请号：US09069871
申请日：1998-04-30
申请人： Randolph J. Noelle , Teresa M. Foy , Alejandro Aruffo , Jeffrey A. Ledbetter
发明人： Randolph J. Noelle , Teresa M. Foy , Alejandro Aruffo , Jeffrey A. Ledbetter
IPC分类号： A61K39395
CPC分类号： C07K14/70578 , A61K38/00 , A61K2039/505 , A61K2039/57 , C07K16/2875 , C07K19/00 , C07K2317/24 , C07K2317/73 , C07K2319/00 , G01N33/6854
摘要： A method of treating graft-vs-host diseases by administration of bone marrow and an anti-gp39 antibody specific to human gp39 is provided.
摘要翻译：提供了一种通过施用骨髓治疗移植物抗宿主病的方法和针对人gp39特异的抗gp39抗体。

2. 发明授权

US5876718A Methods of inducing T cell non-responsiveness to transplanted tissues and of treating graft-versus-host-disease with anti-gp39 antibodies 失效
标题翻译：诱导T细胞对移植组织无反应性和用抗gp39抗体治疗移植物抗宿主病的方法
公开(公告)号：US5876718A
公开(公告)日：1999-03-02
申请号：US49043
申请日：1998-03-27
申请人： Randolph J. Noelle , Teresa M. Foy , Alejandro Aruffo , Jeffrey A. Ledbetter
发明人： Randolph J. Noelle , Teresa M. Foy , Alejandro Aruffo , Jeffrey A. Ledbetter
IPC分类号： A61K39/395 , A61K31/00 , A61K35/14 , A61K35/28 , A61K38/00 , A61K38/17 , A61K39/00 , A61P37/00 , A61P37/06 , C07K14/705 , C07K16/28 , C07K19/00 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/68 , C12N5/12
CPC分类号： C07K14/70578 , C07K16/2875 , C07K19/00 , G01N33/6854 , A61K2039/505 , A61K2039/57 , A61K38/00 , C07K2317/24 , C07K2317/73 , C07K2319/00
摘要： Antibodies that bind a protein gp39 (also referred to as CD40 ligand) are disclosed. Preferably, the antibodies are monoclonal antibodies of an IgG1 isotype and bind human gp39. In a preferred embodiment, an antibody of the invention binds an epitope recognized by a monoclonal antibody 24-31, produced by a hybridoma 24-31 (ATTC Accession No. HB11712) or binds an epitope recognized by a monoclonal antibody 89-76, produced by a hybridoma 89-76 (ATCC Accession No. HB 11713). Pharmaceutical compositions comprising the antibodies of the invention are also disclosed. The antibodies of the invention are useful for inhibiting B cell proliferation and differentiation, T cell responses and for inducing T cell tolerance. Nucleic acid molecules encoding anti-gp39 antibodies, or portions thereof, as well as expression vectors and host cells incorporating said nucleic acid molecules, are also encompassed by the invention.
摘要翻译：公开了结合蛋白质gp39（也称为CD40配体）的抗体。优选地，抗体是IgG1同种型的单克隆抗体并结合人gp39。在优选的实施方案中，本发明的抗体结合由杂交瘤24-31（ATTC登录号HB11712）产生的单克隆抗体24-31识别的表位或结合由单克隆抗体89-76识别的表位，产生通过杂交瘤89-76（ATCC登录号HB 11713）。还公开了包含本发明抗体的药物组合物。本发明的抗体可用于抑制B细胞增殖和分化，T细胞应答和诱导T细胞耐受。编码抗gp39抗体或其部分的核酸分子以及掺入所述核酸分子的表达载体和宿主细胞也包括在本发明中。

3. 发明授权

US5747037A Anti-GP39 antibodies 失效
标题翻译：抗GP39抗体
公开(公告)号：US5747037A
公开(公告)日：1998-05-05
申请号：US475847
申请日：1995-06-07
申请人： Randolph J. Noelle , Teresa M. Foy , Alejandro Aruffo , Jeffrey A. Ledbetter
发明人： Randolph J. Noelle , Teresa M. Foy , Alejandro Aruffo , Jeffrey A. Ledbetter
IPC分类号： A61K39/395 , A61K31/00 , A61K35/14 , A61K35/28 , A61K38/00 , A61K38/17 , A61K39/00 , A61P37/00 , A61P37/06 , C07K14/705 , C07K16/28 , C07K19/00 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/68 , C12N5/12
CPC分类号： C07K14/70578 , C07K16/2875 , C07K19/00 , G01N33/6854 , A61K2039/505 , A61K2039/57 , A61K38/00 , C07K2317/24 , C07K2317/73 , C07K2319/00
摘要： Antibodies that bind a protein gp39 (also referred to as CD40 ligand) are disclosed. Preferably, the antibodies are monoclonal antibodies of an IgG1 isotype and bind human gp39. In a preferred embodiment, an antibody of the invention binds an epitope recognized by a monoclonal antibody 24-31, produced by a hybridoma 24-31 (ATTC Accession No. HB11712) or binds an epitope recognized by a monoclonal antibody 89-76, produced by a hybridoma 89-76 (ATCC Accession No.HB11713). Pharmaceutical compositions comprising the antibodies of the invention are also disclosed. The antibodies of the invention are useful for inhibiting B cell proliferation and differentiation, T cell responses and for inducing T cell tolerance. Nucleic acid molecules encoding anti-gp39 antibodies, or portions thereof, as well as expression vectors and host cells incorporating said nucleic acid molecules, are also encompassed by the invention.
摘要翻译：公开了结合蛋白质gp39（也称为CD40配体）的抗体。优选地，抗体是IgG1同种型的单克隆抗体并结合人gp39。在优选的实施方案中，本发明的抗体结合由杂交瘤24-31（ATTC登录号HB11712）产生的单克隆抗体24-31识别的表位或结合由单克隆抗体89-76识别的表位，产生通过杂交瘤89-76（ATCC登录号HB11713）。还公开了包含本发明抗体的药物组合物。本发明的抗体可用于抑制B细胞增殖和分化，T细胞应答和诱导T细胞耐受。编码抗gp39抗体或其部分的核酸分子以及掺入所述核酸分子的表达载体和宿主细胞也包括在本发明中。

4. 发明授权

US07722874B2 Methods for reducing T cell responsiveness to an autoantigen with anti-gp39 antibodies and antigen presenting cells 有权
标题翻译：用抗Gp39抗体和抗原呈递细胞降低T细胞对自身抗原反应性的方法
公开(公告)号：US07722874B2
公开(公告)日：2010-05-25
申请号：US09164568
申请日：1998-10-01
申请人： Randolph J. Noelle , Teresa M. Foy , Fiona H. Durie
发明人： Randolph J. Noelle , Teresa M. Foy , Fiona H. Durie
IPC分类号： A61K39/395 , A61K35/26 , A61K35/28
CPC分类号： C07K14/70578 , A61K38/00 , A61K2039/505 , A61K2039/57 , C07K16/2875 , C07K19/00 , C07K2317/24 , C07K2317/73 , C07K2319/00 , G01N33/6854
摘要： Methods for inducing antigen-specific T cell tolerance are disclosed. The methods involve contacting a T cell with: 1) a cell which presents antigen to the T cell, wherein a ligand on the cell interacts with a receptor on the surface of the T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor on the surface of the T cell which inhibits interaction of the ligand on the antigen presenting cell with the receptor on the T cell. In a preferred embodiment, the cell which presents antigen to the T cell is a B cell and the receptor on the surface of the T cell which mediates contact-dependent helper effector function is gp39. Preferably, the antagonist is an anti-gp39 antibody or a soluble gp39 ligand (e.g., soluble CD40). The methods of the invention can be used to induce T cell tolerance to a soluble antigen or to an allogeneic cell. The methods of the invention can also be used to induce tolerance in cases of bone marrow transplantation and other organ transplants and to inhibit graft-versus-host disease.
摘要翻译：公开了诱导抗原特异性T细胞耐受性的方法。所述方法包括使T细胞接触：1）向T细胞呈递抗原的细胞，其中细胞上的配体与介导接触依赖性辅助效应子功能的T细胞表面上的受体相互作用; 和2）T细胞表面上的受体拮抗剂，其抑制抗原呈递细胞上的配体与T细胞上的受体的相互作用。在优选的实施方案中，向T细胞呈递抗原的细胞是B细胞，介导接触依赖性辅助效应子功能的T细胞表面上的受体是gp39。优选地，拮抗剂是抗gp39抗体或可溶性gp39配体（例如可溶性CD40）。本发明的方法可用于诱导对可溶性抗原或同种异体细胞的T细胞耐受性。本发明的方法还可用于在骨髓移植和其他器官移植的情况下诱导耐受性并抑制移植物抗宿主病。

5. 发明授权

US5942229A Method for prolonged suppression of humoral immune response to a thymus-dependent antigen therapeutic agent 失效
标题翻译：延长抑制对胸腺依赖性抗原治疗剂的体液免疫应答的方法
公开(公告)号：US5942229A
公开(公告)日：1999-08-24
申请号：US475873
申请日：1995-06-07
申请人： Randolph J. Noelle , Teresa M. Foy
发明人： Randolph J. Noelle , Teresa M. Foy
IPC分类号： A61K35/14 , A61K35/28 , A61K38/00 , A61K38/17 , A61P37/06 , C07K14/705 , C07K16/28 , C07K19/00 , G01N33/68 , A61K39/395 , A61K35/12
CPC分类号： C07K14/70575 , C07K14/70578 , C07K16/2875 , C07K19/00 , G01N33/6854 , A61K2039/505 , A61K2039/57 , A61K38/00 , C07K2317/24 , C07K2319/00 , Y10S514/885
摘要： Methods of suppressing a humoral immune response to a thymus-dependent (TD) antigen are disclosed. The methods involve administering to a subject a TD antigen with an antagonist of a molecule which mediates contact-dependent helper effector functions. In a preferred embodiment, the antagonist is an antagonist of gp39. Primary and secondary humoral immune responses can be suppressed and suppression is prolonged.
摘要翻译：公开了抑制对胸腺依赖（TD）抗原的体液免疫应答的方法。所述方法包括用受体介导接触依赖性辅助效应子功能的分子的拮抗剂向受试者施用TD抗原。在优选的实施方案中，拮抗剂是gp39的拮抗剂。初级和次级体液免疫应答可以被抑制并且抑制被延长。

6. 发明授权

US5869049A Methods of inducing T cell unresponsiveness to bone marrow with gp39 antagonists 失效
标题翻译：用gp39拮抗剂诱导T细胞对骨髓无反应的方法
公开(公告)号：US5869049A
公开(公告)日：1999-02-09
申请号：US232929
申请日：1994-04-25
申请人： Randolph J. Noelle , Teresa M. Foy , Fiona H. Durie , David C. Parker , Dale L. Greiner , Aldo A. Rossini , John P. Mordes
发明人： Randolph J. Noelle , Teresa M. Foy , Fiona H. Durie , David C. Parker , Dale L. Greiner , Aldo A. Rossini , John P. Mordes
IPC分类号： A61K35/14 , A61K35/28 , A61K38/00 , A61P37/06 , C07K14/705 , C07K16/28 , C07K19/00 , G01N33/68 , A61K39/395 , A61K38/16
CPC分类号： C07K14/70578 , A61K35/28 , C07K16/2875 , C07K19/00 , G01N33/6854 , A61K2039/57 , A61K38/00 , C07K2317/24 , C07K2317/73 , C07K2319/00
摘要： Methods for inducing antigen-specific T cell tolerance are disclosed. The methods involve contacting a T cell with: 1) a cell which presents antigen to the T cell, wherein a ligand on the cell interacts with a receptor on the surface of the T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor on the surface of the T cell which inhibits interaction of the ligand on the antigen presenting cell with the receptor on the T cell. In a preferred embodiment, the cell which presents antigen to the T cell is a B cell and the receptor on the surface of the T cell which mediates contact-dependent helper effector function is gp39. Preferably, the antagonist is an anti-gp39 antibody or a soluble gp39 ligand (e.g., soluble CD40). The methods of the invention can be used to induce T cell tolerance to a soluble antigen or to an allogeneic cell. The methods of the invention can also be used to induce tolerance in cases of bone marrow transplantation and other organ transplants and to inhibit graft-versus-host disease.
摘要翻译：公开了诱导抗原特异性T细胞耐受性的方法。所述方法包括使T细胞接触：1）向T细胞呈递抗原的细胞，其中细胞上的配体与介导接触依赖性辅助效应子功能的T细胞表面上的受体相互作用; 和2）T细胞表面上的受体拮抗剂，其抑制抗原呈递细胞上的配体与T细胞上的受体的相互作用。在优选的实施方案中，向T细胞呈递抗原的细胞是B细胞，介导接触依赖性辅助效应子功能的T细胞表面上的受体是gp39。优选地，拮抗剂是抗gp39抗体或可溶性gp39配体（例如可溶性CD40）。本发明的方法可用于诱导对可溶性抗原或同种异体细胞的T细胞耐受性。本发明的方法还可用于在骨髓移植和其他器官移植的情况下诱导耐受性并抑制移植物抗宿主病。

7. 发明授权

US07476385B2 Methods of inhibiting IgE responses to thymus-dependent antigens with the anti-gp39 antibody MR1 失效
标题翻译：用抗gp39抗体MR1抑制对胸腺依赖性抗原的IgE反应的方法
公开(公告)号：US07476385B2
公开(公告)日：2009-01-13
申请号：US11029868
申请日：2005-01-04
申请人： Randolph J. Noelle , Teresa M. Foy
发明人： Randolph J. Noelle , Teresa M. Foy
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K14/70575 , A61K38/00 , A61K2039/505 , A61K2039/57 , C07K14/70578 , C07K16/2875 , C07K19/00 , C07K2317/24 , C07K2319/00 , G01N33/6854 , Y10S514/885
摘要： Methods of suppressing a humoral immune response to a thymus-dependent (TD) antigen are disclosed. The methods involve administering to a subject a TD antigen with an antagonist of a molecule which mediates contact-dependent helper effector functions. In a preferred embodiment, the antagonist is an antagonist of gp39. Primary and secondary humoral immune responses can be suppressed and suppression is prolonged.
摘要翻译：公开了抑制对胸腺依赖（TD）抗原的体液免疫应答的方法。所述方法包括用受体介导接触依赖性辅助效应子功能的分子的拮抗剂向受试者施用TD抗原。在优选的实施方案中，拮抗剂是gp39的拮抗剂。初级和次级体液免疫应答可以被抑制并且抑制被延长。

8. 发明申请

US20080219982A1 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF BREAST CANCER 审中-公开
公开(公告)号：US20080219982A1
公开(公告)日：2008-09-11
申请号：US11930068
申请日：2007-10-30
申请人： Gary R. Fanger , Shannon Kathleen Hirst , Davin C. Dillon , Teresa M. Foy , Raymond L. Houghton , David H. Persing , Michael D. Kalos
发明人： Gary R. Fanger , Shannon Kathleen Hirst , Davin C. Dillon , Teresa M. Foy , Raymond L. Houghton , David H. Persing , Michael D. Kalos
IPC分类号： A61K39/395 , C12N15/11 , C07K14/00 , C12N15/00 , A61K35/12 , A61P43/00 , C12N5/06 , C07K16/18 , C12Q1/68
CPC分类号： C07K14/4748 , A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , A61K2039/5154 , A61K2039/5156 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/47 , C07K14/82 , C07K16/3015 , C07K2317/21 , C07K2319/00 , C12N2710/14143 , C12N2710/24143 , C12N2740/10022 , C12N2740/14022 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

9. 发明申请

US20110150883A1 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF BREAST CANCER 审中-公开
公开(公告)号：US20110150883A1
公开(公告)日：2011-06-23
申请号：US11930084
申请日：2007-10-30
申请人： Gary R. Fanger , Shannon Kathleen Hirst , Davin C. Dillon , Teresa M. Foy , Raymond L. Houghton , David H. Persing , Michael D. Kalos
发明人： Gary R. Fanger , Shannon Kathleen Hirst , Davin C. Dillon , Teresa M. Foy , Raymond L. Houghton , David H. Persing , Michael D. Kalos
IPC分类号： A61K39/395 , A61K39/00 , A61K35/26 , C12Q1/68 , G01N33/53 , C12N5/10 , C12N5/02 , C12N15/63 , A61K38/00 , A61P35/00 , A61K31/7088 , C07K14/00 , C07K16/00 , C07H21/04 , C12N5/0783
CPC分类号： C07K14/4748 , A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , A61K2039/5154 , A61K2039/5156 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/47 , C07K14/82 , C07K16/3015 , C07K2317/21 , C07K2319/00 , C12N2710/14143 , C12N2710/24143 , C12N2740/10022 , C12N2740/14022 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

10. 发明授权

US07585506B2 Compositions and methods for the therapy and diagnosis of lung cancer 失效
公开(公告)号：US07585506B2
公开(公告)日：2009-09-08
申请号：US11603929
申请日：2006-11-22
申请人： Tongtong Wang , Robert A. Henderson , Teresa M. Foy
发明人： Tongtong Wang , Robert A. Henderson , Teresa M. Foy
IPC分类号： A61K39/00
CPC分类号： G01N33/57411 , A61K39/00 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , A61K2039/545 , C07K14/47 , C07K14/4748 , C07K16/3023 , C07K2317/21 , C07K2317/34 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/40 , C12N15/86 , C12N2710/10343 , C12N2710/10371 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , G01N33/5088 , G01N33/57423
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

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