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1. 发明申请

US20090215876A1 Mitotic Progression Genes and Methods of Modulating Mitosis 审中-公开
标题翻译：有丝分裂进展基因和调节有丝分裂的方法
公开(公告)号：US20090215876A1
公开(公告)日：2009-08-27
申请号：US12223836
申请日：2007-02-14
申请人： Randall W. King , Susan K. Lyman , Eunah Chung , Sridaran Natesan , Charles B. Epstein
发明人： Randall W. King , Susan K. Lyman , Eunah Chung , Sridaran Natesan , Charles B. Epstein
IPC分类号： A61K31/7088 , C12Q1/48 , G01N33/53 , C12Q1/37 , C12Q1/68 , C40B30/04
CPC分类号： G01N33/5011 , C12N9/1205 , C12Q1/37 , C12Q1/485 , C12Y207/11001 , C12Y301/02015
摘要： The invention features methods of identifying candidate therapeutic compounds for the treatment of proliferative disorder. The invention also features methods for treating a proliferative disorder.
摘要翻译：本发明的特征在于鉴定用于治疗增殖性疾病的候选治疗化合物的方法。本发明还涉及治疗增殖性疾病的方法。

2. 发明申请

US20110319277A1 PRPK-TPRKB MODULATORS AND USES THEREOF 有权
标题翻译： PRPK-TPRKB调节剂及其用途
公开(公告)号：US20110319277A1
公开(公告)日：2011-12-29
申请号：US13163192
申请日：2011-06-17
申请人： Eun Sun Park , Henry E. Pelish , Astrid S. Clarke , Grace L. Williams , Maria Paola Castaldi , Alexander Arefolov , Jennifer E. Ring , Matthew D. Shair , Randall W. King
发明人： Eun Sun Park , Henry E. Pelish , Astrid S. Clarke , Grace L. Williams , Maria Paola Castaldi , Alexander Arefolov , Jennifer E. Ring , Matthew D. Shair , Randall W. King
IPC分类号： C12Q1/48 , C40B30/00 , G01N33/577
CPC分类号： C12Q1/485 , G01N2500/02
摘要： The present invention provides methods of identifying an agent that modulates PRPK, TPRKB, OSGEP, LAGE3 and its homologs, PRPK/TPRKB complex, and/or KEOPS complex. The present invention also provides compositions of such agents and methods of treating a disease, disorder, or condition associated with PRPK, TPRKB, OSGEP, LAGE3 and its homologs family (CT antigens), PRPK/TPRKB complex, and/or KEOPS complex using such an agent or composition.
摘要翻译：本发明提供鉴定调节PRPK，TPRKB，OSGEP，LAGE3及其同源物，PRPK / TPRKB复合物和/或KEOPS复合物的试剂的方法。本发明还提供了这样的药剂组合物和治疗与PRPK，TPRKB，OSGEP，LAGE3及其同系物家族（CT抗原），PRPK / TPRKB复合物和/或KEOPS复合物相关的疾病，病症或病症的方法代理或组合。

3. 发明授权

US06490620B1 Integrated proxy interface for web based broadband telecommunications management 有权
标题翻译：基于Web的宽带电信管理的集成代理接口
公开(公告)号：US06490620B1
公开(公告)日：2002-12-03
申请号：US09159407
申请日：1998-09-24
申请人： Christine M. Ditmer , Randall W. King , W. Russell Kennington , Patrick W. Pirtle , Diane J. Wells
发明人： Christine M. Ditmer , Randall W. King , W. Russell Kennington , Patrick W. Pirtle , Diane J. Wells
IPC分类号： G06F15173
CPC分类号： H04L63/02 , G06F11/0709 , G06F11/0757 , G06F11/0769 , G06F11/0775 , G06F11/0781 , G06F11/0784 , G06F11/202 , G06F11/32 , G06F11/324 , G06F11/327 , G06F11/328 , G06F11/3495 , G06F17/30893 , G06F21/00 , G06F21/41 , G06F21/552 , G06F2201/81 , G06F2201/86 , G06F2201/875 , G06F2221/2137 , G06F2221/2149 , G06Q10/10 , G06Q10/107 , G06Q20/102 , G06Q20/382 , G06Q30/02 , G06Q30/06 , G06Q30/0601 , G06Q30/0609 , G06Q30/0635 , G06Q99/00 , H04L12/14 , H04L12/1428 , H04L29/06027 , H04L41/0213 , H04L41/0233 , H04L41/024 , H04L41/0253 , H04L41/06 , H04L41/0681 , H04L41/08 , H04L41/0803 , H04L41/0879 , H04L41/142 , H04L41/18 , H04L41/22 , H04L41/28 , H04L41/5009 , H04L41/5022 , H04L41/5029 , H04L41/5032 , H04L41/5035 , H04L41/5061 , H04L41/5064 , H04L41/5067 , H04L41/5074 , H04L41/5083 , H04L41/5096 , H04L43/00 , H04L43/024 , H04L43/045 , H04L43/06 , H04L43/062 , H04L43/065 , H04L43/067 , H04L43/0805 , H04L43/0811 , H04L43/0817 , H04L43/0829 , H04L43/0847 , H04L43/0852 , H04L43/0876 , H04L43/0888 , H04L43/0894 , H04L43/10 , H04L43/106 , H04L43/16 , H04L51/00 , H04L63/0209 , H04L63/0218 , H04L63/0236 , H04L63/0272 , H04L63/0281 , H04L63/0428 , H04L63/0442 , H04L63/0464 , H04L63/08 , H04L63/0807 , H04L63/0815 , H04L63/0823 , H04L63/083 , H04L63/162 , H04L63/166 , H04L63/168 , H04L63/18 , H04L65/4007 , H04L65/80 , H04M3/5175 , H04M3/5191 , H04M15/00 , H04M15/41 , H04M15/43 , H04M15/44 , H04M15/49 , H04M15/51 , H04M15/58 , H04M15/705 , H04M15/721 , H04M15/745 , H04M15/80 , H04M15/8044 , H04M15/83 , H04M15/8351 , H04M15/84 , H04M2215/0104 , H04M2215/0108 , H04M2215/0152 , H04M2215/0164 , H04M2215/0168 , H04M2215/0176 , H04M2215/018 , H04M2215/0188 , H04M2215/42 , H04M2215/46 , H04M2215/54 , H04M2215/7009 , H04M2215/7045 , H04M2215/745 , H04M2215/81 , H04M2215/8108 , H04M2215/8129 , H04M2215/82 , Y10S379/90 , Y10S707/99931 , Y10S707/99937 , Y10S707/99938 , Y10S707/99939 , Y10S707/99944 , Y10S715/969
摘要： A Web/Internet-based performance reporting and trouble shooting tool that enables customers to understand the performance of their broadband telecommunications data networks via a graphical user interface. The tool is an object-oriented client server application that provides customers Web/Internet access to real-time SNMP alarms, real-time events, and near real-time performance statistics and configuration reports pertaining to their virtual transport networks including ATM, Frame-Relay and other broadband networks. Messaging is employed to enable specific report option presentation, ad-hoc report customization and report execution options. A Web/Internet-based reporting system infrastructure is provided that enables the secure initiation, acquisition, and presentation of customer reports to via a Web browser.
摘要翻译：基于网络/互联网的性能报告和故障排除工具，使客户能够通过图形用户界面了解其宽带电信数据网络的性能。该工具是一种面向对象的客户端服务器应用程序，可为客户提供Web / Internet访问实时SNMP警报，实时事件以及与其虚拟传输网络有关的近实时性能统计信息和配置报告，包括ATM，中继等宽带网络。消息传递用于启用特定报告选项表示，特别报告定制和报告执行选项。提供基于Web / Internet的报告系统基础设施，可通过Web浏览器安全地启动，获取和呈现客户报告。

4. 发明申请

US20130045992A1 Compositions and Methods for Enhancing Proteasome Activity 审中-公开
标题翻译：增强蛋白酶体活性的组合物和方法
公开(公告)号：US20130045992A1
公开(公告)日：2013-02-21
申请号：US13575812
申请日：2011-01-28
申请人： Daniel J. Finley , Randall W. King , Byung-Hoon Lee , Min J. Lee , Timothy C. Gahman
发明人： Daniel J. Finley , Randall W. King , Byung-Hoon Lee , Min J. Lee , Timothy C. Gahman
IPC分类号： A61K31/454 , C12N5/071 , A61P43/00 , C40B30/08 , C12N9/50 , C07D401/06 , C12N9/99 , C12N9/96
CPC分类号： C07D487/04 , C07D207/333 , C07D207/335 , C07D209/08 , C07D209/44 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D471/04 , G01N33/573 , G01N2333/948 , G01N2500/04
摘要： Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp 14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies.
摘要翻译：由蛋白酶体引起的蛋白酶体不能有效地消除有害蛋白质并阻止病原性聚集体的形成。如本文所述，抑制蛋白酶体相关的去泛素酶Usp14导致蛋白酶体效率增加。因此，本发明提供抑制Usp14，蛋白酶体活性增强和蛋白质病症治疗的新型组合物和方法。

5. 发明授权

US08933087B2 Tricyclic proteasome activity enhancing compounds 有权
标题翻译：三环蛋白酶体活性增强化合物
公开(公告)号：US08933087B2
公开(公告)日：2015-01-13
申请号：US13811129
申请日：2011-07-22
申请人： Daniel J. Finley , Randall W. King , Byung-Hoon Lee , Min J. Lee , Timothy C. Gahman
发明人： Daniel J. Finley , Randall W. King , Byung-Hoon Lee , Min J. Lee , Timothy C. Gahman
IPC分类号： A61K31/505 , C07D491/048 , C07D495/04 , C07D487/04
CPC分类号： C07D495/04 , C07D487/04
摘要： Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies.
摘要翻译：由蛋白酶体引起的蛋白酶体不能有效地消除有害蛋白质并阻止病原性聚集体的形成。如本文所述，蛋白酶体相关的去泛素酶Usp14的抑制导致蛋白酶体效率的增加。因此，本发明提供抑制Usp14，蛋白酶体活性增强和蛋白质病症治疗的新型组合物和方法。

6. 发明授权

US5726025A Assay and reagents for detecting inhibitors of ubiquitin-dependent degradation of cell cycle regulatory proteins 失效
标题翻译：用于检测细胞周期调节蛋白泛素依赖性降解抑制剂的测定和试剂
公开(公告)号：US5726025A
公开(公告)日：1998-03-10
申请号：US425299
申请日：1995-04-20
申请人： Marc W. Kirschner , Randall W. King , Jan-Michael Peters
发明人： Marc W. Kirschner , Randall W. King , Jan-Michael Peters
IPC分类号： C12Q1/25 , G01N33/68 , C12Q1/48 , G01N33/567
CPC分类号： G01N33/6842 , C12Q1/25 , G01N33/68
摘要： The present invention provides a systematic and practical approach for the identification of candidate agents able to inhibit ubiquitin-mediated degradation of a cell-cycle regulatory protein, such as cyclins. One aspect of the present invention relates to a method for identifying an inhibitor of ubiquitin-mediated proteolysis of a cell-cycle regulatory protein by (i) providing a ubiquitin-conjugating system that includes the regulatory protein and ubiquitin under conditions which promote the ubiquitination of the target protein, and (ii) measuring the level of ubiquitination of the subject protein brought about by the system in the presence and absence of a candidate agent. A decrease in the level of ubiquitin conjugation is indicative of an inhibitory activity for the candidate agent. The level of ubiquitination of the regulatory protein can be measured by determining the actual concentration of protein:ubiquitin conjugates formed; or inferred by detecting some other quality of the subject protein affected by ubiquitination, including the proteolytic degradation of the protein.
摘要翻译：本发明提供了一种用于鉴定能够抑制泛素介导的细胞周期调节蛋白如细胞周期蛋白降解的候选试剂的系统和实用的方法。本发明的一个方面涉及通过（i）在促进泛素化的条件下提供包含调节蛋白和泛素的泛素缀合系统来鉴定泛素介导的细胞周期调节蛋白的蛋白水解抑制剂的方法目标蛋白质，以及（ii）测量在存在和不存在候选药剂的情况下由系统产生的受试蛋白质的泛素化水平。泛素缀合水平的降低表明候选试剂的抑制活性。调节蛋白的泛素化水平可以通过测定蛋白质的实际浓度来测量：泛素缀合物的形成; 或通过检测受泛素化影响的受试蛋白的一些其他质量，包括蛋白质的蛋白水解降解来推断。

7. 发明申请

US20130210845A1 Tricyclic Proteasome Activity Enhancing Compounds 有权
标题翻译：三环蛋白酶体活性增强化合物
公开(公告)号：US20130210845A1
公开(公告)日：2013-08-15
申请号：US13811129
申请日：2011-07-22
申请人： Daniel J. Finley , Randall W. King , Byung-Hoon Lee , Min J. Lee , Timothy C. Gahman
发明人： Daniel J. Finley , Randall W. King , Byung-Hoon Lee , Min J. Lee , Timothy C. Gahman
IPC分类号： C07D495/04
CPC分类号： C07D495/04 , C07D487/04
摘要： Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies.
摘要翻译：由蛋白酶体引起的蛋白酶体不能有效地消除有害蛋白质并阻止病原性聚集体的形成。如本文所述，蛋白酶体相关的去泛素酶Usp14的抑制导致蛋白酶体效率的增加。因此，本发明提供抑制Usp14，蛋白酶体活性增强和蛋白质病症治疗的新型组合物和方法。

8. 发明授权

US06473407B1 Integrated proxy interface for web based alarm management tools 有权
标题翻译：集成代理接口，用于基于Web的报警管理工具
公开(公告)号：US06473407B1
公开(公告)日：2002-10-29
申请号：US09159517
申请日：1998-09-24
申请人： Christine M. Ditmer , James DeGraf-Johnson , Paul Glenn Franklin , William C. Holford , Randall W. King , Patrick W. Pirtle , Kenneth Joseph Qualls , Diane J. Wells , Edward Ronald Zack, Jr.
发明人： Christine M. Ditmer , James DeGraf-Johnson , Paul Glenn Franklin , William C. Holford , Randall W. King , Patrick W. Pirtle , Kenneth Joseph Qualls , Diane J. Wells , Edward Ronald Zack, Jr.
IPC分类号： H04J302
CPC分类号： H04L12/14 , G06F11/0709 , G06F11/0757 , G06F11/0769 , G06F11/0781 , G06F11/0784 , G06F11/327 , G06F11/328 , G06F11/3495 , G06F17/30893 , G06F21/41 , G06F21/552 , G06F2201/81 , G06F2201/86 , G06F2201/875 , G06F2221/2137 , G06F2221/2149 , G06Q10/10 , G06Q10/107 , G06Q30/02 , G06Q30/06 , G06Q99/00 , H04L12/1428 , H04L29/06027 , H04L41/0213 , H04L41/0233 , H04L41/024 , H04L41/0253 , H04L41/026 , H04L41/0681 , H04L41/08 , H04L41/142 , H04L41/18 , H04L41/22 , H04L41/28 , H04L41/5032 , H04L41/5064 , H04L41/5077 , H04L41/5087 , H04L43/00 , H04L43/067 , H04L43/0817 , H04L43/0852 , H04L43/0876 , H04L43/16 , H04L51/00 , H04L63/0815 , H04L65/80 , H04L67/1008 , H04L67/1029 , H04L67/142 , H04L67/22 , H04L67/26 , H04L67/306 , H04L67/322 , H04L67/325 , H04L67/327 , H04L69/08 , H04L69/16 , H04L69/162 , H04L69/329 , H04M15/00 , H04M15/41 , H04M15/43 , H04M15/44 , H04M15/49 , H04M15/51 , H04M15/58 , H04M15/745 , H04M15/80 , H04M15/8044 , H04M15/83 , H04M15/8351 , H04M15/84 , H04M2215/0104 , H04M2215/0108 , H04M2215/0152 , H04M2215/0164 , H04M2215/0168 , H04M2215/0176 , H04M2215/018 , H04M2215/0188 , H04M2215/42 , H04M2215/46 , H04M2215/54 , H04M2215/745 , H04M2215/81 , H04M2215/8108 , H04M2215/8129 , H04M2215/82 , H04Q3/0075
摘要： A Web-based fault and alarm management tool that enables customers to monitor and analyze the performance of their voice and data network via a graphical user interface is provided. The tool provides customers an Internet/Intranet access to near real-time alarms, events, and performance statistics and configuration reports corresponding to their switched network, including voice network, broadband, dedicated point-to-point circuits, and signaling services, for enabling customers to make informed network management decisions. A Web-based fault and alarm management infrastructure which enables the secure initiation, acquisition, and presentation of customer reports relating to network management via a Web browser on any computer is also provided.
摘要翻译：提供了一种基于Web的故障和警报管理工具，使客户能够通过图形用户界面监控和分析其语音和数据网络的性能。该工具为客户提供互联网/内联网访问近乎实时的报警，事件和性能统计以及与其交换网络相对应的配置报告，包括语音网络，宽带，专用点对点电路和信令服务，以实现客户做出明智的网络管理决策。还提供了一种基于Web的故障和警报管理基础设施，其能够通过任何计算机上的Web浏览器安全地启动，获取和呈现与网络管理有关的客户报告。

9. 发明授权

US6127158A Ubiquitin conjugating enzymes 失效
标题翻译：泛素缀合酶
公开(公告)号：US6127158A
公开(公告)日：2000-10-03
申请号：US350468
申请日：1994-12-07
申请人： Stefan Jentsch , Marc W. Kirschner , Randall W. King , P. Renee Yew
发明人： Stefan Jentsch , Marc W. Kirschner , Randall W. King , P. Renee Yew
IPC分类号： C12N9/00 , C12N15/54 , C12N9/10
CPC分类号： C12N9/93
摘要： Disclosed herein are novel ubiquitin-conjugating enzymes and methods for using same. More specifically, disclosed are nucleic acid sequences encoding the UBC9 protease.
摘要翻译：本文公开了新的泛素缀合酶及其使用方法。更具体地，公开了编码UBC9蛋白酶的核酸序列。

10. 发明授权

US5654150A Method of expression cloning 失效
标题翻译：表达克隆方法
公开(公告)号：US5654150A
公开(公告)日：1997-08-05
申请号：US475219
申请日：1995-06-07
申请人： Randall W. King , Kevin D. Lustig , P. Todd Stukenberg , Marc W. Kirschner
发明人： Randall W. King , Kevin D. Lustig , P. Todd Stukenberg , Marc W. Kirschner
IPC分类号： C12N9/12 , C12N15/10 , C12P21/02 , C12Q1/68 , C12P21/06
CPC分类号： C12N15/1086 , C12N9/12 , C12P21/02
摘要： The present invention provides improvements in the expression cloning method for isolating novel cDNA clones. In particular, in the expression cloning method comprising the steps of preparing a cDNA library from a cell that expresses a desired protein; inserting the cDNA library into an expression vector; inserting the cDNA library into bacterial cells and culturing the bacterial cells to produce individual bacterial colonies; collecting pools of a predetermined number of individual bacterial colonies; isolating the cDNAs contained in the pools; expressing proteins encoded by the cDNAs; and detecting the desired protein, positive clones may be efficiently and cost-effectively obtained by collecting pools of about 100 individual bacterial colonies and expressing proteins encoded by the cDNAs in the pools in vitro.
摘要翻译：本发明提供了用于分离新的cDNA克隆的表达克隆方法的改进。具体地，在表达克隆方法中，包括从表达所需蛋白质的细胞制备cDNA文库的步骤; 将cDNA文库插入表达载体; 将cDNA文库插入细菌细胞并培养细菌细胞以产生单独的细菌菌落; 收集预定数量的个体细菌菌落的池; 分离池中包含的cDNA; 表达由cDNA编码的蛋白质; 并检测所需的蛋白质，可以通过在体外收集约100个单独的细菌菌落的池并且在池中表达由cDNA编码的蛋白质的蛋白质来高效且经济地获得阳性克隆。

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