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1. 发明申请

WO2005070480A1 APPARATUS AND METHODS FOR ENZYMATIC DEBRIDEMENT OF SKIN LESIONS 审中-公开
标题翻译：装置和方法进行皮肤脱落的脱发
公开(公告)号：WO2005070480A1
公开(公告)日：2005-08-04
申请号：PCT/IL2005/000101
申请日：2005-01-27
申请人： RAMOT AT TEL-AVIV UNIVERSITY LTD. , ENZYSURGE LTD. , FREEMAN, Amihay , HIRSZOWICZ, Eran , BE'ERI-LIPPERMAN, Michal
发明人： FREEMAN, Amihay , HIRSZOWICZ, Eran , BE'ERI-LIPPERMAN, Michal
IPC分类号： A61M3/02
CPC分类号： A61M3/0258 , A61B10/0035 , A61B10/02 , A61B17/545 , A61B2017/00761 , A61B2017/00769 , A61B2017/00774 , A61B2017/22082 , A61B2017/3411 , A61K38/48 , A61K38/4886 , A61M1/0088 , A61M3/0241 , A61M3/0283 , A61M3/0287 , A61M27/00 , C12M45/09 , C12N5/0629 , C12N2509/00
摘要： The present invention relates to apparatus for debridement of devitalized tissue in skin lesions, comprising a plurality of height- and angle-adjustable inlet tubes (204) and at least one outlet tube (206) and means (230) to form an occlusive seal around a skin lesion. The plurality of inlet tubes is adapted for directing a continuous stream of enzymatic solution to the surface and into the entire volume of the wound bed of the lesion and the at least one outlet is adapted for removing the enzymatic solution, fluids draining from the lesion and tissue debris from the occluded skin lesion.
摘要翻译：本发明涉及用于在皮肤病变中清创失活的组织的装置，包括多个高度和角度可调的入口管（204）和至少一个出口管（206）和用于形成封闭密封件的装置（230）皮肤病变。所述多个入口管适于将连续的酶溶液流引导到所述表面并进入所述损伤的所述伤口床的整个体积，并且所述至少一个出口适于去除所述酶溶液，从所述病变排出的流体和来自闭塞的皮肤损伤的组织碎片。

2. 发明授权

EP1720586B8 APPARATUS FOR DEBRIDEMENT OF SKIN LESIONS 失效转让
标题翻译：装置脱除皮肤伤害
公开(公告)号：EP1720586B8
公开(公告)日：2012-10-03
申请号：EP05703144.5
申请日：2005-01-27
申请人： Ramot at Tel-Aviv University Ltd. , Enzysurge Ltd.
发明人： FREEMAN, Amihay , HIRSZOWICZ, Eran , BE'ERI-LIPPERMAN, Michal
IPC分类号： A61M1/00 , A61K38/48
CPC分类号： A61M3/0258 , A61B10/0035 , A61B10/02 , A61B17/545 , A61B2017/00761 , A61B2017/00769 , A61B2017/00774 , A61B2017/22082 , A61B2017/3411 , A61K38/48 , A61K38/4886 , A61M1/0088 , A61M3/0241 , A61M3/0283 , A61M3/0287 , A61M27/00 , C12M45/09 , C12N5/0629 , C12N2509/00

3. 发明授权

EP1720586B1 APPARATUS FOR DEBRIDEMENT OF SKIN LESIONS 失效转让
标题翻译：装置脱除皮肤伤害
公开(公告)号：EP1720586B1
公开(公告)日：2012-08-29
申请号：EP05703144.5
申请日：2005-01-27
申请人： Ramot at Tel-Aviv University Ltd. , Enzysurge Ltd.
发明人： FREEMAN, Amihay , HIRSZOWICZ, Eran , BE'ERI-LIPPERMAN, Michal
IPC分类号： A61M1/00 , A61K38/48
CPC分类号： A61M3/0258 , A61B10/0035 , A61B10/02 , A61B17/545 , A61B2017/00761 , A61B2017/00769 , A61B2017/00774 , A61B2017/22082 , A61B2017/3411 , A61K38/48 , A61K38/4886 , A61M1/0088 , A61M3/0241 , A61M3/0283 , A61M3/0287 , A61M27/00 , C12M45/09 , C12N5/0629 , C12N2509/00

4. 发明公开

EP1720586A1 APPARATUS AND METHODS FOR ENZYMATIC DEBRIDEMENT OF SKIN LESIONS 失效转让
标题翻译：装置脱除皮肤伤害
公开(公告)号：EP1720586A1
公开(公告)日：2006-11-15
申请号：EP05703144.5
申请日：2005-01-27
申请人： Ramot at Tel-Aviv University Ltd. , Enzysurge Ltd.
发明人： FREEMAN, Amihay , HIRSZOWICZ, Eran , BE'ERI-LIPPERMAN, Michal
IPC分类号： A61M3/02 , A61M27/00 , A61K38/48 , A61M35/00
CPC分类号： A61M3/0258 , A61B10/0035 , A61B10/02 , A61B17/545 , A61B2017/00761 , A61B2017/00769 , A61B2017/00774 , A61B2017/22082 , A61B2017/3411 , A61K38/48 , A61K38/4886 , A61M1/0088 , A61M3/0241 , A61M3/0283 , A61M3/0287 , A61M27/00 , C12M45/09 , C12N5/0629 , C12N2509/00
摘要： The present invention relates to apparatus for debridement of devitalized tissue in skin lesions, comprising a plurality of height- and angle-adjustable inlet tubes (204) and at least one outlet tube (206) and means (230) to form an occlusive seal around a skin lesion. The plurality of inlet tubes is adapted for directing a continuous stream of enzymatic solution to the surface and into the entire volume of the wound bed of the lesion and the at least one outlet is adapted for removing the enzymatic solution, fluids draining from the lesion and tissue debris from the occluded skin lesion.

5. 发明申请

WO2013011513A9 METHODS OF DETERMINING ENZYME ACTIVITY IN PRESERVED CELL SAMPLES 审中-公开
公开(公告)号：WO2013011513A9
公开(公告)日：2013-01-24
申请号：PCT/IL2012/050258
申请日：2012-07-18
申请人： RAMOT AT TEL-AVIV UNIVERSITY LTD. , SHACHAM-DIAMAND, Yosi , VERNICK, Sefi , NIV, Yaron , RISHPON, Judith , FREEMAN, Amihay
发明人： SHACHAM-DIAMAND, Yosi , VERNICK, Sefi , NIV, Yaron , RISHPON, Judith , FREEMAN, Amihay
IPC分类号： C12Q1/42 , G01N33/574
摘要： A method of determining enzyme activity in preserved cells is disclosed. The method comprises: (a) contacting preserved cells with a substrate for an enzyme under conditions wherein the enzyme catalyzes a reaction of the cells with the substrate, so as to generate a product capable of producing an electrical signal; and (b) measuring a level of the electrical signal, wherein a level of the electrical signal correlates with enzyme activity. Uses of same for diagnosing diseases are also disclosed.

6. 发明申请

WO2010092578A1 ANTISEPTIC COMPOSITIONS COMPRISING SILVER IONS AND MENTHOL AND USES THEREOF 审中-公开
标题翻译：包含银离子和精液的抗菌组合物及其用途
公开(公告)号：WO2010092578A1
公开(公告)日：2010-08-19
申请号：PCT/IL2010/000128
申请日：2010-02-11
申请人： RAMOT AT TEL AVIV UNIVERSITY LTD. , HADAR, Noa , FREEMAN, Amihay
发明人： HADAR, Noa , FREEMAN, Amihay
IPC分类号： A61K31/045 , A61K33/38
CPC分类号： A61K31/045 , A61K9/0014 , A61K33/38 , A61K45/06 , A61K2300/00
摘要： Antiseptic compositions and kits containing a source of silver ions and menthol, which act in synergy such that a concentration of silver ions in the composition is substantially reduced, are disclosed. Further disclosed are uses of the antiseptic compositions as disinfectants and in the treatment of wounds.
摘要翻译：公开了包含银离子和薄荷醇源的防腐组合物和试剂盒，其协同作用使得组合物中银离子的浓度显着降低。进一步公开了防腐组合物作为消毒剂和伤口治疗的用途。

7. 发明申请

WO2007074454A2 STABLE ENZYMATIC PREPARATIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：稳定的酶制剂及其使用方法
公开(公告)号：WO2007074454A2
公开(公告)日：2007-07-05
申请号：PCT/IL2006/001492
申请日：2006-12-27
申请人： RAMOT AT TEL-AVIV UNIVERSITY LTD. , FREEMAN, Amihay , HADAR, Noa
发明人： FREEMAN, Amihay , HADAR, Noa
CPC分类号： A61K9/0019 , A61K9/0014 , A61K9/08
摘要： The present invention relates to stable concentrated enzymatic compositions suitable for storage under ambient conditions, while maintaining their intended enzymatic activity. The invention further relate to kits comprising concentrated enzymatic compositions, methods for preparing debriding solutions from said concentrated enzymatic compositions and methods of using the diluted debriding solutions.
摘要翻译：本发明涉及适于在环境条件下储存的稳定的浓缩酶组合物，同时保持其预期的酶活性。本发明还涉及包含浓缩酶组合物的试剂盒，从所述浓缩酶组合物制备清创溶液的方法和使用稀释的清创溶液的方法。

8. 发明申请

WO2006080017A2 BIOLOGICALLY ACTIVE SILVER-COATED PROTEINS 审中-公开
标题翻译：生物活性银包衣蛋白
公开(公告)号：WO2006080017A2
公开(公告)日：2006-08-03
申请号：PCT/IL2006/000115
申请日：2006-01-26
申请人： RAMOT AT TEL AVIV UNIVERSITY LTD. , FREEMAN, Amihay , SHACHAM-DIAMAND, Yosi , MOSCOVICH-DAGAN, Hila , HADAR, Noa
发明人： FREEMAN, Amihay , SHACHAM-DIAMAND, Yosi , MOSCOVICH-DAGAN, Hila , HADAR, Noa
IPC分类号： G01N33/532 , G01N33/543 , C07K14/00 , A61K38/16 , A61K31/28
CPC分类号： C12Q1/006 , C07K14/00 , C12Q1/001
摘要： Silver-coated proteins, being dissolvable or suspendable in aqueous media and/or retaining a biological activity of the protein and a process for preparing same are disclosed. Further disclosed are modified proteins which have a reducing moiety attached to the surface thereof and a process for preparing same. The modified proteins can be utilized for obtaining the silver-coated proteins. Further disclosed are a pharmaceutical composition containing and a method of treating bacterial and fungal infections utilizing biologically active silver-coated hydrogen peroxide producing enzymes such as glucose oxidase. Further disclosed are conductive elements that comprise the silver-coated proteins disclosed herein and electronic circuits containing same. Further disclosed are electrodes having the silver-coated proteins deposited thereon and biosensor systems utilizing same for determining a level of an analyte in a liquid sample.
摘要翻译：公开了可溶解或可悬浮于水性介质中和/或保持蛋白质的生物学活性的银包覆蛋白质及其制备方法。还公开了具有连接到其表面上的还原部分的修饰蛋白及其制备方法。修饰的蛋白质可用于获得银包被的蛋白质。本发明还公开了一种药物组合物，其含有利用生物活性的涂有银的过氧化氢产生酶例如葡萄糖氧化酶来治疗细菌和真菌感染的方法。还公开了包含本文公开的涂银蛋白质和包含其的电子电路的导电元件。还公开了具有沉积在其上的银涂覆蛋白质的电极和利用它们的生物传感器系统来测定液体样品中分析物的水平。

9. 发明申请

WO2015104713A1 COLORING COMPOSITIONS AND METHODS 审中-公开
标题翻译：着色组合物和方法
公开(公告)号：WO2015104713A1
公开(公告)日：2015-07-16
申请号：PCT/IL2015/050039
申请日：2015-01-11
申请人： RAMOT AT TEL- AVIV UNIVERSITY LTD.
发明人： FREEMAN, Amihay , HADAR, Noa
IPC分类号： A61Q5/10 , A61K8/64 , A61K8/72 , A45D19/00
CPC分类号： A61K8/64 , A45D2019/0066 , A61K2800/884 , A61Q5/10
摘要： Methods of coloring a surface such as hair, utilizing a dye composition comprising a macromolecule having at least one dye molecule associated therewith, are disclosed herein. The method may further comprise applying a priming composition comprising a cationic polymer to the surface, such that the dye composition selectively colors the cationic polymer applied on the surface. Further disclosed are compositions- of-matter comprising a macromolecule and at least one oxidative dye associated therewith, as well as processes for preparing a composition-of-matter which comprises a macromolecule and at least one dye molecule associated therewith. Kits comprising a priming composition and at least one dye composition, as well as applicators configured for applying a priming composition and/or at least one dye composition, are further disclosed.
摘要翻译：本文公开了使用包含具有至少一个与其相关联的染料分子的大分子的染料组合物使头发等表面着色的方法。所述方法可以进一步包括将包含阳离子聚合物的底漆组合物施用于所述表面，使得所述染料组合物选择性地着色施加在所述表面上的阳离子聚合物。还公开了包含大分子和与其相关的至少一种氧化染料的物质组合物，以及包含大分子和至少一种与其相关联的染料分子的物质组合物的方法。进一步公开了包含起始组合物和至少一种染料组合物的试剂盒，以及配置用于施用起泡组合物和/或至少一种染料组合物的施用器。

10. 发明申请

WO2014024187A1 PLACEABLE SENSOR AND METHOD OF USING SAME 审中-公开
标题翻译：可放置传感器及其使用方法
公开(公告)号：WO2014024187A1
公开(公告)日：2014-02-13
申请号：PCT/IL2013/050666
申请日：2013-08-05
申请人： RAMOT AT TEL-AVIV UNIVERSITY LTD.
发明人： SHACHAM-DIAMAND, Yosi , RAGONES, Heftsi , FREEMAN, Amihay , SCHREIBER, David
IPC分类号： G01N27/403 , G01N27/28 , G01N27/416 , A61B5/05 , A61B5/1473
CPC分类号： A61B5/1473 , A61B1/3132 , A61B5/00 , A61B5/1477 , A61B17/3423 , G01N27/286 , G01N27/327 , Y10T29/49117
摘要： A sensor system is disclosed. The system comprises: a solid substrate having a front side and a back side, a sensing assembly formed on the front side and being configured to provide electrochemical sensing, a plurality of electrical contacts, formed on the back side and being in electrical communication with the sensing assembly via a plurality of interconnects passing through the substrate and extending at least from the front side to the back side, and a mounting member configured for mounting the back side onto a tip of a movable device.
摘要翻译：公开了一种传感器系统。该系统包括：具有前侧和后侧的固体基板，形成在前侧上并且被配置为提供电化学感测的感测组件，形成在背侧并与其相连通的多个电触头通过穿过基板并且至少从前侧延伸到后侧的多个互连件的感测组件和被配置为将背面安装到可移动装置的尖端上的安装构件。

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