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1. 发明申请

US20070281964A1 Novel Crystalline Polymorphs of Clopidogrel 有权
标题翻译：氯吡格雷的新型结晶多晶型物
公开(公告)号：US20070281964A1
公开(公告)日：2007-12-06
申请号：US10571419
申请日：2004-09-09
申请人： Ramakrishnan Arul , Ajay Rawat , Maheshkumar Gadakar , Rajesh Rao , Abhinay Pise , Jason Gray
发明人： Ramakrishnan Arul , Ajay Rawat , Maheshkumar Gadakar , Rajesh Rao , Abhinay Pise , Jason Gray
IPC分类号： A61K31/4365 , A61P7/02 , C07D495/04
CPC分类号： C07D495/04
摘要： The present invention relates to novel crystalline forms of the platelet aggregation inhibitor (+)-(S)-methyl-2-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetate, clopidogrel (1), in the form of hydrogen bromide salts, identified as polymorph forms 1, 2 and 3. The present invention further relates to processes for preparing such forms, pharmaceutical compositions comprising such forms, and uses for such forms and compositions. The pharmaceutical compositions may be used, in particular, for inhibiting platelet aggregation or for treating, preventing or managing thrombosis, atherothrombosis, an atherothrombotic event, ischaemic stroke, myocardial infarction, non-Q-wave myocardial infarction, atherosclerosis, peripheral arterial disease, or unstable angina. The present invention also relates to methods of treating said disorders. Formula (1).
摘要翻译：本发明涉及血小板聚集抑制剂（+） - （S） - 甲基-2-（2-氯苯基） - （6,7-二氢-4H-噻吩并[3,2-c]吡啶-3-基）（1），以溴化氢的形式，被鉴定为多晶型形式1,2和3.本发明还涉及制备这些形式的方法，包含这些形式的药物组合物和用于这种形式和组成。药物组合物可特别用于抑制血小板聚集或治疗，预防或控制血栓形成，动脉粥样硬化血栓形成，动脉粥样硬化血栓形成事件，缺血性卒中，心肌梗死，非Q波心肌梗塞，动脉粥样硬化，外周动脉疾病或不稳定型心绞痛本发明还涉及治疗所述疾病的方法。公式1）。

2. 发明授权

US07897613B2 Crystalline polymorphs of clopidogrel 有权
标题翻译：氯吡格雷的结晶多晶型物
公开(公告)号：US07897613B2
公开(公告)日：2011-03-01
申请号：US10571419
申请日：2004-09-09
申请人： Ramakrishnan Arul , Ajay Singh Rawat , Maheshkumar Gadakar , Rajesh Rao , Abhinay Pise , Jason Gray
发明人： Ramakrishnan Arul , Ajay Singh Rawat , Maheshkumar Gadakar , Rajesh Rao , Abhinay Pise , Jason Gray
IPC分类号： C07D495/04 , A61K31/4365 , A61P7/02
CPC分类号： C07D495/04
摘要： The present invention relates to novel crystalline forms of the platelet aggregation inhibitor (+)-(S)-methyl-2-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetate, clopidogrel (1), in the form of hydrogen bromide salts, identified as polymorph forms 1, 2 and 3. The present invention further relates to processes for preparing such forms, pharmaceutical compositions comprising such forms, and uses for such forms and compositions. The pharmaceutical compositions may be used, in particular, for inhibiting platelet aggregation or for treating, preventing or managing thrombosis, atherothrombosis, an atherothrombotic event, ischaemic stroke, myocardial infarction, non-Q-wave myocardial infarction, atherosclerosis, peripheral arterial disease, or unstable angina. The present invention also relates to methods of treating said disorders. Formula (1).
摘要翻译：本发明涉及血小板聚集抑制剂（+） - （S） - 甲基-2-（2-氯苯基） - （6,7-二氢-4H-噻吩并[3,2-c]吡啶-3-基）（1），以溴化氢的形式，被鉴定为多晶型形式1,2和3.本发明还涉及制备这些形式的方法，包含这些形式的药物组合物和用于这种形式和组成。药物组合物可特别用于抑制血小板聚集或治疗，预防或控制血栓形成，动脉粥样硬化血栓形成，动脉粥样硬化血栓形成事件，缺血性中风，心肌梗塞，非Q波心肌梗塞，动脉粥样硬化，外周动脉疾病或不稳定型心绞痛本发明还涉及治疗所述疾病的方法。公式1）。

3. 发明授权

US09808349B2 Expandable vertebral implant 有权
公开(公告)号：US09808349B2
公开(公告)日：2017-11-07
申请号：US13606625
申请日：2012-09-07
申请人： Colm McLaughlin , Jason Gray , James Himmelberger
发明人： Colm McLaughlin , Jason Gray , James Himmelberger
IPC分类号： A61F2/44 , A61F2/46 , A61F2/30
CPC分类号： A61F2/44 , A61F2/4455 , A61F2/4465 , A61F2/4611 , A61F2002/3008 , A61F2002/30383 , A61F2002/30393 , A61F2002/30395 , A61F2002/30477 , A61F2002/30495 , A61F2002/30504 , A61F2002/30505 , A61F2002/30512 , A61F2002/30523 , A61F2002/3055 , A61F2002/30571 , A61F2002/30578 , A61F2002/30579 , A61F2002/30601 , A61F2002/30604 , A61F2002/30828 , A61F2002/30843 , A61F2002/30846 , A61F2002/4475 , A61F2002/4625 , A61F2002/4627 , A61F2002/4629 , A61F2310/00011 , A61F2310/00023 , A61F2310/00131
摘要： The present invention relates to an expandable implant for engagement between vertebrae generally comprising an inner member, outer member, and gear member positioned coaxial with respect to each other such that the inner and outer members are moveable relative to each other along an axis. The gear member is axially fixed to the outer member and freely rotatable with respect to the outer member and the gear member threadedly engages a threaded portion of the inner member to translate inner member along the axis. The implant is configured to engage the vertebrae in a predetermined alignment and the gear member includes gear teeth exposed to the exterior and configured to be accessible by a tool member at a plurality of angular positions around the perimeter of the implant device.

4. 发明授权

US08814270B2 Folding headrest closeout member 有权
标题翻译：折叠头枕关闭成员
公开(公告)号：US08814270B2
公开(公告)日：2014-08-26
申请号：US13524860
申请日：2012-06-15
申请人： Grant Adams , Randy Eschelbach , Jason Gray , Dale Jung , Anthony Spagnuolo
发明人： Grant Adams , Randy Eschelbach , Jason Gray , Dale Jung , Anthony Spagnuolo
IPC分类号： A47C1/10
CPC分类号： B60N2/859
摘要： Folding assemblies for vehicles are described. In one aspect, a folding headrest assembly for a vehicle seat comprises a headrest having a frame. A pivot joint is coupled to the frame for rotatably supporting the headrest with respect to the vehicle seat between an upright position and a folded position. A support rod extends from the pivot joint and is configured for coupling to the vehicle seat. The headrest receives the pivot joint and a portion of the support rod, and the headrest defines an opening configured to provide clearance for the support rod as the headrest is rotated about the pivot joint relative to the support rod. A closeout member coupled to the support rod circumscribes at least an exposed portion of the pivot joint that is aligned with the opening of the headrest.
摘要翻译：描述车辆的折叠组件。一方面，一种用于车辆座椅的折叠头枕组件包括具有框架的头枕。枢转接头联接到框架，用于在直立位置和折叠位置之间相对于车辆座椅可旋转地支撑头枕。支撑杆从枢转接头延伸并且构造成用于联接到车辆座椅。头枕接收枢转接头和支撑杆的一部分，并且头枕限定了一个开口，该开口构造成当头枕相对于支撑杆围绕枢转接头旋转时为支撑杆提供间隙。耦合到支撑杆的闭合构件至少围绕与头枕的开口对准的枢转接头的暴露部分。

5. 发明申请

US20130073046A1 Multi-piece Intervertebral Implants 有权
公开(公告)号：US20130073046A1
公开(公告)日：2013-03-21
申请号：US13267119
申请日：2011-10-06
申请人： Jillian Zaveloff , Shairali Rao , Michael Lee Boyer, II , Christopher Angelucci , Jason Gray , Matthew Hansell , Daniel Laskowitz , Jody L. Seifert
发明人： Jillian Zaveloff , Shairali Rao , Michael Lee Boyer, II , Christopher Angelucci , Jason Gray , Matthew Hansell , Daniel Laskowitz , Jody L. Seifert
IPC分类号： A61F2/44
CPC分类号： A61F2/4455 , A61F2/442 , A61F2/447 , A61F2002/30131 , A61F2002/30332 , A61F2002/30354 , A61F2002/30359 , A61F2002/30383 , A61F2002/30385 , A61F2002/30387 , A61F2002/3039 , A61F2002/30405 , A61F2002/30418 , A61F2002/30433 , A61F2002/30448 , A61F2002/30472 , A61F2002/30487 , A61F2002/30604 , A61F2002/30607 , A61F2002/30785 , A61F2002/30787 , A61F2002/30808 , A61F2002/3081 , A61F2002/30828 , A61F2002/30836 , A61F2002/30841 , A61F2002/30843 , A61F2002/30904 , A61F2002/4475 , A61F2310/00017 , A61F2310/00023 , A61F2310/00359
摘要： Intervertebral implants for implanting into an intervertebral space are provided. The implants can comprise one or more layers that are operably attached to one another. An implant can comprise a first layer having a first mating surface that mates with a second mating surface of a second layer. The first mating surface and the second mating surface can have features that allow them to complement each other. The implants can include one or more bore holes for receiving a fixation member. The bore holes can be horizontal, vertical or diagonal. In some cases, the bore holes will be blind bore holes.

6. 发明授权

US08282683B2 Expandable vertebral implant 有权
标题翻译：可扩展椎体植入物
公开(公告)号：US08282683B2
公开(公告)日：2012-10-09
申请号：US12758529
申请日：2010-04-12
申请人： Colm McLaughlin , Jason Gray , James Himmelberger
发明人： Colm McLaughlin , Jason Gray , James Himmelberger
IPC分类号： A61F2/44
CPC分类号： A61F2/44 , A61F2/4455 , A61F2/4465 , A61F2/4611 , A61F2002/3008 , A61F2002/30383 , A61F2002/30393 , A61F2002/30395 , A61F2002/30477 , A61F2002/30495 , A61F2002/30504 , A61F2002/30505 , A61F2002/30512 , A61F2002/30523 , A61F2002/3055 , A61F2002/30571 , A61F2002/30578 , A61F2002/30579 , A61F2002/30601 , A61F2002/30604 , A61F2002/30828 , A61F2002/30843 , A61F2002/30846 , A61F2002/4475 , A61F2002/4625 , A61F2002/4627 , A61F2002/4629 , A61F2310/00011 , A61F2310/00023 , A61F2310/00131
摘要： The present invention relates to an expandable implant for engagement between vertebrae generally comprising an inner member, outer member, and gear member positioned coaxial with respect to each other such that the inner and outer members are moveable relative to each other along an axis. The gear member is axially fixed to the outer member and freely rotatable with respect to the outer member and the gear member threadedly engages a threaded portion of the inner member to translate inner member along the axis. The implant is configured to engage the vertebrae in a predetermined alignment and the gear member includes gear teeth exposed to the exterior and configured to be accessible by a tool member at a plurality of angular positions around the perimeter of the implant device.
摘要翻译：本发明涉及一种用于在通常包括内部构件，外部构件和相对于彼此同轴设置的齿轮构件的椎骨之间接合的可膨胀植入物，使得内部构件和外部构件能够相对于彼此沿轴线移动。齿轮构件轴向地固定到外部构件并且可相对于外部构件自由旋转，并且齿轮构件螺纹地接合内部构件的螺纹部分以沿着轴线平移内部构件。植入物被构造成以预定的对准接合椎骨，并且齿轮构件包括暴露于外部的齿轮齿，并且构造成可以在围绕植入装置的周边的多个角位置处由工具构件接近。

7. 发明申请

US20110264152A1 Insertion Tool Assembly 有权
标题翻译：插入工具装配
公开(公告)号：US20110264152A1
公开(公告)日：2011-10-27
申请号：US12764682
申请日：2010-04-21
申请人： Mark Weiman , Christopher Angelucci , Jason Gray , Noah Hansell , Jeff Bennett , Cameron Salzberger , Edward Dwyer
发明人： Mark Weiman , Christopher Angelucci , Jason Gray , Noah Hansell , Jeff Bennett , Cameron Salzberger , Edward Dwyer
IPC分类号： A61B17/56
CPC分类号： A61F2/4611 , A61B17/1757 , A61F2/4425 , A61F2/4455 , A61F2002/30596 , A61F2002/3082 , A61F2002/30884 , A61F2002/4629
摘要： Insertion tool assemblies for positioning an implant at a target location in a patient. Insertion tool assemblies that comprise first and second jaw portions configured to engage an implant; a sleeve assembly coupled to the first and second jaw portions; and a handle coupled to the sleeve assembly.
摘要翻译：用于将植入物定位在患者的目标位置的插入工具组件。插入工具组件，其包括构造成接合植入物的第一和第二钳口部分; 联接到所述第一和第二钳口部分的套筒组件; 以及联接到所述套筒组件的手柄。

8. 发明申请

US20140277471A1 Expandable Intervertebral Implant 有权
公开(公告)号：US20140277471A1
公开(公告)日：2014-09-18
申请号：US13968849
申请日：2013-08-16
申请人： Jason Gray , Daniel Davenport , Chad Glerum , Duncan Sibson , Jason Pastor , Derek Martzall
发明人： Jason Gray , Daniel Davenport , Chad Glerum , Duncan Sibson , Jason Pastor , Derek Martzall
IPC分类号： A61F2/44
CPC分类号： A61F2/447 , A61F2/442 , A61F2/4455 , A61F2/4465 , A61F2/4601 , A61F2/4611 , A61F2/4684 , A61F2002/30062 , A61F2002/3008 , A61F2002/30161 , A61F2002/30176 , A61F2002/30181 , A61F2002/30187 , A61F2002/30266 , A61F2002/30281 , A61F2002/30387 , A61F2002/30398 , A61F2002/30405 , A61F2002/30448 , A61F2002/30476 , A61F2002/30556 , A61F2002/30579 , A61F2002/30607 , A61F2002/30616 , A61F2002/30677 , A61F2002/30787 , A61F2002/4475 , A61F2230/0082 , A61F2230/0086 , A61F2250/0009 , A61F2250/0067 , A61F2310/00023 , A61F2310/00029 , A61F2310/00059 , A61F2310/00101 , A61F2310/00359
摘要： An implant for therapeutically separating bones of a joint has two endplates each having an opening through the endplate, and at least one ramped surface on a side opposite a bone engaging side. A frame is slideably connected to the endplates to enable the endplates to move relative to each other at an angle with respect to the longitudinal axis of the implant, in sliding connection with the frame. An actuator screw is rotatably connected to the frame. A carriage forms an open area aligned with the openings in the endplates. The openings in the endplates pass through the carriage to form an unimpeded passage from bone to bone of the joint. The carriage has ramps which mate with the ramped surfaces of the endplates, wherein when the carriage is moved by rotation of the actuator screw, the endplates move closer or farther apart.

9. 发明授权

US08808304B2 Insertion tool assembly 有权
标题翻译：插入工具组合
公开(公告)号：US08808304B2
公开(公告)日：2014-08-19
申请号：US12764682
申请日：2010-04-21
申请人： Mark Weiman , Christopher Angelucci , Jason Gray , Noah Hansell , Jeff Bennett , Cameron Salzberger , Edward Dwyer
发明人： Mark Weiman , Christopher Angelucci , Jason Gray , Noah Hansell , Jeff Bennett , Cameron Salzberger , Edward Dwyer
IPC分类号： A61B17/58 , A61B17/60 , A61F2/00
CPC分类号： A61F2/4611 , A61B17/1757 , A61F2/4425 , A61F2/4455 , A61F2002/30596 , A61F2002/3082 , A61F2002/30884 , A61F2002/4629
摘要： Insertion tool assemblies for positioning an implant at a target location in a patient. Insertion tool assemblies that comprise first and second jaw portions configured to engage an implant; a sleeve assembly coupled to the first and second jaw portions; and a handle coupled to the sleeve assembly.
摘要翻译：用于将植入物定位在患者的目标位置的插入工具组件。插入工具组件，其包括构造成接合植入物的第一和第二钳口部分; 联接到所述第一和第二钳口部分的套筒组件; 以及联接到所述套筒组件的手柄。

10. 发明授权

US08591585B2 Expandable vertebral implant 有权
标题翻译：可扩展椎体植入物
公开(公告)号：US08591585B2
公开(公告)日：2013-11-26
申请号：US13333227
申请日：2011-12-21
申请人： Colm McLaughlin , Jason Gray , James Himmelberger , Thomas Shinn , Mark Adams
发明人： Colm McLaughlin , Jason Gray , James Himmelberger , Thomas Shinn , Mark Adams
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61F2/44 , A61F2/4455 , A61F2/4465 , A61F2/4611 , A61F2002/3008 , A61F2002/30383 , A61F2002/30393 , A61F2002/30395 , A61F2002/30477 , A61F2002/30495 , A61F2002/305 , A61F2002/30504 , A61F2002/30505 , A61F2002/30512 , A61F2002/30523 , A61F2002/3055 , A61F2002/30571 , A61F2002/30578 , A61F2002/30579 , A61F2002/30596 , A61F2002/30598 , A61F2002/30601 , A61F2002/30604 , A61F2002/3071 , A61F2002/30714 , A61F2002/30828 , A61F2002/30843 , A61F2002/30846 , A61F2002/4475 , A61F2002/4625 , A61F2002/4627 , A61F2002/4629 , A61F2310/00011 , A61F2310/00023 , A61F2310/00131
摘要： The present invention relates to an expandable implant for engagement between vertebrae generally comprising an inner member, outer member, and gear member positioned coaxial with respect to each other such that the inner and outer members are moveable relative to each other along an axis. The gear member is axially fixed to the outer member and freely rotatable with respect to the outer member and the gear member threadedly engages a threaded portion of the inner member to translate inner member along the axis. The implant is configured to engage the vertebrae in a predetermined alignment and the gear member includes gear teeth exposed to the exterior and configured to be accessible by a tool member at a plurality of angular positions around the perimeter of the implant device.
摘要翻译：本发明涉及一种用于在通常包括内部构件，外部构件和相对于彼此同轴设置的齿轮构件的椎骨之间接合的可膨胀植入物，使得内部构件和外部构件能够相对于彼此沿轴线移动。齿轮构件轴向地固定到外部构件并且可相对于外部构件自由旋转，并且齿轮构件螺纹地接合内部构件的螺纹部分以沿着轴线平移内部构件。植入物被构造成以预定的对准接合椎骨，并且齿轮构件包括暴露于外部的齿轮齿，并且构造成可以在围绕植入装置的周边的多个角位置处由工具构件接近。

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