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1. 发明申请

US20050165231A1 Process for making triazine UV absorbers using Lewis acids and reaction promoters 审中-公开
标题翻译：使用路易斯酸和反应促进剂制备三嗪紫外线吸收剂的方法
公开(公告)号：US20050165231A1
公开(公告)日：2005-07-28
申请号：US11089289
申请日：2005-03-24
申请人： Ram Gupta , Dennis Jakiela , Sampath Venimadhavan , Russell Cappadona , Venkatrao Pai
发明人： Ram Gupta , Dennis Jakiela , Sampath Venimadhavan , Russell Cappadona , Venkatrao Pai
IPC分类号： C07D251/14 , C07B61/00 , C07D251/22 , C07D251/24 , C07D251/00
CPC分类号： C07D251/24 , C07D251/22
摘要： It has been now surprisingly discovered after extensive research that 2-halo-4,6-bisaryl-1,3,5-triazine can be prepared with unprecedented selectivity, efficiency, mild conditions, and in high yield by the reaction of cyanuric halide with aromatics in the presence of at least one Lewis acid and at least one reaction promoter. This reaction is also unprecedently general as a variety of aromatics can be used to produce a wide selection of 2-halo-4,6-bisaryl-1,3,5-triazines. The novel approach includes the use of the reaction promoters in combination with at least one Lewis acid under certain reaction conditions to promote the formation of 2-halo-4,6-bisaryl-1,3,5-triazine compounds from cyanuric halide. Preferably, the Lewis acids and reaction promoters are combined to form a complex. 2-Halo-4,6-bisaryl-1,3,5-triazines are key intermediates for making 2-(2-oxyaryl)-4,6-bisaryl-1,3,5-triazine class of UV absorbers.
摘要翻译：现在已经广泛研究出人意料地发现，2-卤代-4,6-二芳基-1,3,5-三嗪可以以前所未有的选择性，效率，温和条件制备，并且通过氰尿酰卤与芳族化合物在至少一种路易斯酸和至少一种反应促进剂的存在下进行。该反应也是前所未有的，因为各种芳族化合物可用于产生广泛选择的2-卤代-4,6-二芳基-1,3,5-三嗪。该新方法包括在某些反应条件下使用反应促进剂与至少一种路易斯酸组合以促进由氰尿酰卤形成2-卤代-4,6-二芳基-1,3,5-三嗪化合物。优选将路易斯酸和反应促进剂组合以形成络合物。 2-卤代-4,6-二芳基-1,3,5-三嗪是制备2-（2-氧芳基）-4,6-双芳基-1,3,5-三嗪类UV吸收剂的关键中间体。

2. 发明申请

US20070015920A1 Process for Making Trisaryl Triazine UV Absorbers Using Lewis Acids and Reaction Promoters 有权
标题翻译：使用路易斯酸和反应促进剂制备三芳基三嗪紫外线吸收剂的方法
公开(公告)号：US20070015920A1
公开(公告)日：2007-01-18
申请号：US11531932
申请日：2006-09-14
申请人： Ram Gupta , Dennis Jakiela , Sampath Venimadhavan , Russell Cappadona , Venkatrao Pai
发明人： Ram Gupta , Dennis Jakiela , Sampath Venimadhavan , Russell Cappadona , Venkatrao Pai
IPC分类号： C07D251/18
CPC分类号： C07D251/24 , C07D251/22
摘要： It has been now surprisingly discovered after extensive research that 2-halo-4,6-bisaryl-1,3,5-triazine can be prepared with unprecedented selectivity, efficiency, mild conditions, and in high yield by the reaction of cyanuric halide with aromatics in the presence of at least one Lewis acid and at least one reaction promoter. This reaction is also unprecedently general as a variety of aromatics can be used to produce a wide selection of 2-halo-4,6-bisaryl-1,3,5-triazines. The novel approach includes the use of the reaction promoters in combination with at least one Lewis acid under certain reaction conditions to promote the formation of 2-halo-4,6-bisaryl-1,3,5-triazine compounds from cyanuric halide. Preferably, the Lewis acids and reaction promoter's are combined to form a complex 2-Halo-4,6-bisaryl-1,3,5-triazines are key intermediates for making 2-(2-oxyaryl)-4,6-bisaryl-1,3,5-triazine class of UV absorbers.
摘要翻译：现在已经广泛研究出人意料地发现，2-卤代-4,6-二芳基-1,3,5-三嗪可以以前所未有的选择性，效率，温和条件制备，并且通过氰尿酰卤与芳族化合物在至少一种路易斯酸和至少一种反应促进剂的存在下进行。该反应也是前所未有的，因为各种芳族化合物可用于产生广泛选择的2-卤代-4,6-二芳基-1,3,5-三嗪。该新方法包括在某些反应条件下使用反应促进剂与至少一种路易斯酸组合以促进由氰尿酰卤形成2-卤代-4,6-二芳基-1,3,5-三嗪化合物。优选将路易斯酸和反应促进剂组合以形成络合物2-卤代-4,6-二芳基-1,3,5-三嗪是制备2-（2-氧芳基）-4,6-二芳基-1,3,5-三嗪的关键中间体， 1,3,5-三嗪类紫外线吸收剂。

3. 发明申请

US20110034378A1 Pharmaceutical Combinations Comprising Specified Age Breaker and Further Drugs, I.A. Antihypertensive Drugs, Antidiabetic Drugs Etc. 审中-公开
标题翻译：药物组合包括特定的破碎者和其他药物，I.A. 抗高血压药物，抗糖尿病药物等
公开(公告)号：US20110034378A1
公开(公告)日：2011-02-10
申请号：US12735472
申请日：2009-01-21
申请人： Chaitanya Dutt , Deepa Joshi , Ram Gupta , Kumarprafull Chandra
发明人： Chaitanya Dutt , Deepa Joshi , Ram Gupta , Kumarprafull Chandra
IPC分类号： A61K31/4425 , A61K31/4545 , A61K31/4439 , A61K31/4436 , A61K31/55 , A61K31/472 , A61K31/675 , A61K31/549 , A61K31/397 , A61K38/26 , A61K38/28 , A61K31/704 , A61P9/04 , A61P9/12 , A61P9/10 , A61P9/00 , A61P13/12 , A61P3/10 , A61P3/04 , A61P7/02 , C07D213/86 , C07D213/87 , C07D405/14 , C07D401/12 , C07D401/06 , C07D409/06 , C07D417/06
CPC分类号： A61K31/155 , A61K31/00 , A61K31/40 , A61K31/44 , A61K31/4422 , A61K31/4436 , A61K31/4439 , A61K31/7048 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a combination, such as a combined preparation or pharmaceutical composition comprising: (a) compound of formula (I), and/or (II) or a pharmaceutically acceptable salt thereof; (b) at least one therapeutic agent selected from the group consisting of: an antihypertensive agent; an antidiabetics agent; a hypolipidemic agent; an antiplatelet agent; an antiobesity agent; an antithrombotic agent; an agent for diabetic vascular complications; and an agent for treatment of heart failure; or a pharmaceutically acceptable salts thereof, optionally in presence of a pharmaceutically acceptable carrier for separate, simultaneous or sequential use. The present invention also relates to a use of such combination for the treatment of mammal including human being. R1, R2, R3, R1, R2, R3, R4, R5, X, Y, A and B and m are as defined in the specification.
摘要翻译：本发明涉及组合，例如组合制剂或药物组合物，其包含：（a）式（I）和/或（II）化合物或其药学上可接受的盐; （b）至少一种选自以下的治疗剂：抗高血压药; 抗糖尿病药; 降血脂药; 抗血小板药; 抗生素; 抗血栓剂; 糖尿病血管并发症的药剂; 和治疗心力衰竭的药剂; 或其药学上可接受的盐，任选地在用于分离，同时或顺序使用的药学上可接受的载体的存在下。本发明还涉及这种组合用于治疗包括人的哺乳动物的用途。 R1，R2，R3，R1，R2，R3，R4，R5，X，Y，A和B和m如说明书中所定义。

4. 发明授权

US07133933B2 Content synchronization frameworks using dynamic attributes and file bundles for connected devices 有权
标题翻译：内容同步框架使用连接设备的动态属性和文件包
公开(公告)号：US07133933B2
公开(公告)日：2006-11-07
申请号：US10229677
申请日：2002-08-28
申请人： Samir Shah , Binh Truong , Ram Gupta
发明人： Samir Shah , Binh Truong , Ram Gupta
IPC分类号： G06F15/16
CPC分类号： G06F17/30174 , H04L67/1095 , H04L69/329
摘要： A content synchronization method for connected devices comprises accepting, by a central reference point, context from a connected client device, constructing, by the central reference point, at least one response in a semantic compatible with the connected device and compatible with a user of the connected device the response comprising at least one file description bundle, prioritizing, by the central reference point, download order of files described in the at least one response bundle, downloading the files described in the at least one response bundle, to the connected device in the download order, confirming complete download of the files described in the at least one response bundle, and rejecting incompletely downloaded bundles of files.
摘要翻译：用于连接的设备的内容同步方法包括：通过中央参考点接收来自连接的客户端设备的上下文，由中央参考点构建与连接的设备兼容的语义中的至少一个响应，并且与所连接的设备的用户兼容连接设备，响应包括至少一个文件描述束，通过中央参考点将在该至少一个响应束中描述的文件的下载顺序排列在下列位置中，将在该至少一个响应束中描述的文件下载到所连接的设备下载顺序，确认至少一个响应包中描述的文件的完全下载，以及拒绝不完全下载的文件包。

5. 发明授权

US07043010B2 Smart phonebook search 失效
标题翻译：智能手机搜索
公开(公告)号：US07043010B2
公开(公告)日：2006-05-09
申请号：US10229698
申请日：2002-08-28
申请人： Samir Shah , Binh Truong , Ram Gupta
发明人： Samir Shah , Binh Truong , Ram Gupta
IPC分类号： H04M1/26
CPC分类号： H04M1/274566
摘要： A smart phonebook search method comprises collecting, from a customer, a phone number to use for a dial-up connection, filtering any national direct dialing prefix from the collected number, obtaining a country code from an operating system of the smart phonebook search, matching a pattern of a prefix of the collected number with area codes for a country of the customer to provide a closest entry for said connection, and selecting a phone number for said dial-up connection, the phone number having a customer provided area code and the operating system provided country code.
摘要翻译：智能电话簿搜索方法包括从客户收集用于拨号连接的电话号码，从收集的号码过滤任何国家直拨电话前缀，从智能电话簿搜索的操作系统获得国家代码，匹配收集的号码的前缀的模式与客户的国家的区域代码的模式以提供用于所述连接的最接近的条目，并且为所述拨号连接选择电话号码，具有客户提供的区域代码的电话号码和操作系统提供国家代码。

6. 发明授权

US10174219B2 Non-etherified reaction product of a cyclic urea and a multifunctional aldehyde 有权
公开(公告)号：US10174219B2
公开(公告)日：2019-01-08
申请号：US13876545
申请日：2011-09-23
申请人： Ram Gupta , Lawrence Flood , Urvee Treasurer , Barry Lawless , Colin Brogan
发明人： Ram Gupta , Lawrence Flood , Urvee Treasurer , Barry Lawless , Colin Brogan
IPC分类号： C08G12/36 , C09D133/02 , C08G12/12 , C09D161/24
摘要： The invention relates to a coating composition comprising a reaction product UA of at least one multifunctional aldehyde A with at least one cyclic urea U, and a crosslinkable resin having at least one kind of functional groups selected from the group consisting of hydroxyl functional groups, acid functional groups, amide functional groups, amino functional groups, imino functional groups, mercaptan functional groups, phosphine functional groups, and carbamate functional groups, characterized in that the degree of etherification, measured as the ratio

7. 发明授权

US09475780B2 Process for the synthesis of cyclic alkylene ureas 有权
标题翻译：用于合成环状亚烷基脲的方法
公开(公告)号：US09475780B2
公开(公告)日：2016-10-25
申请号：US14233302
申请日：2012-07-19
申请人： Ram Gupta , Irina Kobylanska , Urvee Treasurer , Lawrence Flood
发明人： Ram Gupta , Irina Kobylanska , Urvee Treasurer , Lawrence Flood
IPC分类号： C07C275/00 , C07D243/04 , C07D233/34 , C07D239/10
CPC分类号： C07D243/04 , C07D233/34 , C07D239/10
摘要： The invention relates to a process for the synthesis of cyclic alkylene ureas comprising reacting in the presence of a basic catalyst, a difunctional amine A having two primary amino groups, and an aliphatic organic carbonate component C selected from the group consisting of dialkyl carbonates CD and of alkylene carbonates CA, wherein the ratio of the amount of substance Ji(—NH2) of primary amino groups —NH2 in the difunctional amine A to the sum M(C) of the amount of substance n(CD) of carbonate groups of a dialkyl carbonate CD and the amount of substance n(CA) of carbonate groups in an alkylene carbonate CA, is at least more than 2, and to the product obtained by this process.
摘要翻译：本发明涉及一种合成环状亚烷基脲的方法，包括在碱性催化剂，具有两个伯氨基的双官能胺A和选自碳酸二烷基酯CD和的碳酸亚烷基酯CA，其中二官能胺A中的伯氨基-NH 2的物质Ji（-NH 2）的量与碳酸酯基的物质n（CD）的量的总和M（C）的比率碳酸二烷基碳酸酯CD和碳酸亚烷基碳酸酯CA中的碳酸酯基团的物质n（CA）的量至少大于2，以及通过该方法得到的产物。

8. 发明申请

US20140179931A1 Process for the Synthesis of N-Substituted Cyclic Alkylene Ureas 有权
标题翻译： N-取代的环状亚烷基脲的合成方法
公开(公告)号：US20140179931A1
公开(公告)日：2014-06-26
申请号：US14233307
申请日：2012-07-19
申请人： Ram Gupta , Irina Kobylanska , Urvee Treasurer , Lawrence Flood
发明人： Ram Gupta , Irina Kobylanska , Urvee Treasurer , Lawrence Flood
IPC分类号： C07D233/36 , C07D233/32
CPC分类号： C07D233/36 , C07D233/32 , C07D233/34
摘要： The invention relates to a process for the synthesis of N-substituted cyclic alkylene ureas by reacting a multifunctional aliphatic amine A having at least two amino groups which may be primary or secondary, at least one of which is a primary amino group, —NH2, and at least one of which is a secondary amino group, >NH, the other hydrogen group whereof having been substituted by a hydrocarbyl group which in turn may be substituted by a hydroxyl group, or an amino group, or a carboxyl group, or a ketone carbonyl group, or a hydrazide or hydrazone group, or a mercaptan group, and at least one further functional group selected from the group consisting of primary or secondary amino groups and hydroxyl groups, and an aliphatic organic carbonate component C selected from the group consisting of dialkyl carbonates CD and of alkylene carbonates CA.
摘要翻译：本发明涉及一种合成N-取代的环状亚烷基脲的方法，该方法是使具有至少两个可以是伯或仲的氨基的多官能脂族胺A，其中至少一个是伯氨基，-NH 2，并且其中至少一个是仲氨基，NH，另一个氢基团被烃基取代，烃基又可以被羟基，氨基或羧基取代，或酮羰基或酰肼或腙基或硫醇基，以及至少一种选自伯或仲氨基和羟基的另外的官能团，和选自以下的脂族有机碳酸酯组分C：的碳酸二烷基酯CD和碳酸亚烷基酯CA。

9. 发明申请

US20130217824A1 NON-ETHERIFIED REACTION PRODUCT OF A CYCLIC UREA AND A MULTIFUNCTIONAL ALDEHYDE 审中-公开
标题翻译：循环尿素和多功能阿尔德黑的非特异性反应产物
公开(公告)号：US20130217824A1
公开(公告)日：2013-08-22
申请号：US13876545
申请日：2011-09-23
申请人： Ram Gupta , Lawrence Flood , Urvee Treasurer , Barry Lawless , Colin Brogan
发明人： Ram Gupta , Lawrence Flood , Urvee Treasurer , Barry Lawless , Colin Brogan
IPC分类号： C09D133/02 , C08G12/12
CPC分类号： C09D133/02 , C08G12/12 , C08G12/36 , C09D161/24
摘要： The invention relates to a coating composition comprising a reaction product UA of at least one multifunctional aldehyde A with at least one cyclic urea U, and a crosslinkable resin having at least one kind of functional groups selected from the group consisting of hydroxyl functional groups, acid functional groups, amide functional groups, amino functional groups, imino functional groups, mercaptan functional groups, phosphine functional groups, and carbamate functional groups, characterised in that the degree of etherification, measured as the ratio
摘要翻译：本发明涉及一种涂料组合物，其包含至少一种多官能醛A与至少一种环状脲U的反应产物UA和具有至少一种选自羟基官能团，酸性的官能团的交联性树脂官能团，酰胺官能团，氨基官能团，亚氨基官能团，硫醇官能团，膦官能团和氨基甲酸酯官能团，其特征在于醚化度以“（ - 0-R）/ 作为在反应产物UA中化学键合的多官能醛的醛碳原子作为取代基的烷氧基的量的（U）的量<（U））与化合物U的物质“（U）”U 在反应产物中结合，小于0.01mol / mol，以及制备反应产物UA的方法。

10. 发明申请

US20060073561A1 157 human secreted proteins 审中-公开
标题翻译： 157人分泌蛋白
公开(公告)号：US20060073561A1
公开(公告)日：2006-04-06
申请号：US10986405
申请日：2004-11-12
申请人： Craig Rosen , Steven Ruben , Henrik Olsen , Kevin Baker , Michele Fiscella , Ping Wei , Charles Birse , George Komatsoulis , Gil Choi , Paul Moore , Ram Gupta , Yanggu Shi
发明人： Craig Rosen , Steven Ruben , Henrik Olsen , Kevin Baker , Michele Fiscella , Ping Wei , Charles Birse , George Komatsoulis , Gil Choi , Paul Moore , Ram Gupta , Yanggu Shi
IPC分类号： A61K38/17 , C07K14/47 , C07H21/04 , C12P21/06
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗与所述人分泌蛋白相关的疾病，病症和/或病症。结合这些多肽的抗体也包括在本发明中。本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

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