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1. 发明申请

US20140178901A1 Molecular Analysis of Tumor Samples 审中-公开
标题翻译：肿瘤样品的分子分析
公开(公告)号：US20140178901A1
公开(公告)日：2014-06-26
申请号：US14005986
申请日：2012-03-21
申请人： Ralph Weissleder , Hakho Lee , Cesar Castro
发明人： Ralph Weissleder , Hakho Lee , Cesar Castro
IPC分类号： G01N33/574
CPC分类号： G01N33/574 , G01N21/6428 , G01N24/088 , G01N33/54326 , G01N33/57484 , G01N33/57492 , G01N33/587 , G01N2333/4725 , G01N2333/485 , G01N2333/70596 , G01N2333/71 , G01R33/1269
摘要： This invention relates to methods for diagnosing cancer, e.g., cancer of epithelial origin, by detecting the presence of tumor cells in a sample, based (at least in some embodiments) on the quantification of levels of four biomarkers, MUC1, EGFR, EpCAM, and HER2. In some embodiments, the methods are performed using diagnostic magnetic resonance (DMR), e.g., with a portable relaxometer or MR imager.
摘要翻译：本发明涉及通过基于（至少在一些实施方案中）基于四个生物标志物MUC1，EGFR，EpCAM等级的量化来检测样品中肿瘤细胞的存在来检测癌症的方法，例如上皮起源的癌症。和HER2。在一些实施例中，使用诊断磁共振（DMR），例如使用便携式放大器或MR成像仪来执行所述方法。

2. 发明授权

US09532729B2 Self-assembled magnetic arrays 有权
标题翻译：自组装磁阵列
公开(公告)号：US09532729B2
公开(公告)日：2017-01-03
申请号：US13825762
申请日：2011-09-27
申请人： Ralph Weissleder , Hakho Lee , David Issadore
发明人： Ralph Weissleder , Hakho Lee , David Issadore
IPC分类号： H01F1/06 , A61B5/055 , B03C1/033 , B03C1/28 , G01R33/383 , H01F1/00
CPC分类号： G01N1/4077 , A61B5/055 , B03C1/0332 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N33/4833 , G01N2001/4088 , G01N2610/00 , G01R33/383 , H01F1/009 , H01F1/047 , H01F1/068 , H01F10/007
摘要： A magnetic device includes a substrate and an array including a plurality of magnetic particles, in which a magnetic dipole moment direction of each magnetic particle in a majority of the magnetic particles in the array alternates with respect to a magnetic dipole direction of a directly adjacent magnetic particle or directly adjacent magnetic particles in the array.
摘要翻译：磁性装置包括基板和包括多个磁性颗粒的阵列，其中阵列中大部分磁性颗粒中的每个磁性颗粒的磁偶极矩方向相对于直接相邻的磁体的磁偶极方向交替颗粒或直接相邻的磁性颗粒。

3. 发明申请

US20130271250A1 Self-Assembled Magnetic Arrays 有权
标题翻译：自组装磁阵列
公开(公告)号：US20130271250A1
公开(公告)日：2013-10-17
申请号：US13825762
申请日：2011-09-27
申请人： Ralph Weissleder , Hakho Lee , David Issadore
发明人： Ralph Weissleder , Hakho Lee , David Issadore
IPC分类号： A61B5/055
CPC分类号： G01N1/4077 , A61B5/055 , B03C1/0332 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N33/4833 , G01N2001/4088 , G01N2610/00 , G01R33/383 , H01F1/009 , H01F1/047 , H01F1/068 , H01F10/007
摘要： A magnetic device includes a substrate and an array including a plurality of magnetic particles, in which a magnetic dipole moment direction of each magnetic particle in a majority of the magnetic particles in the array alternates with respect to a magnetic dipole direction of a directly adjacent magnetic particle or directly adjacent magnetic particles in the array.
摘要翻译：磁性装置包括基板和包括多个磁性颗粒的阵列，其中阵列中大部分磁性颗粒中的每个磁性颗粒的磁偶极矩方向相对于直接相邻的磁体的磁偶极方向交替颗粒或直接相邻的磁性颗粒。

4. 发明授权

US09874564B2 Detection of targets using magnetic resonance 有权
公开(公告)号：US09874564B2
公开(公告)日：2018-01-23
申请号：US14006389
申请日：2012-03-21
申请人： Ralph Weissleder , Hakho Lee , David Issadore
发明人： Ralph Weissleder , Hakho Lee , David Issadore
IPC分类号： G01V3/00 , G01N33/574 , G01N24/08
CPC分类号： G01N33/574 , G01N21/6428 , G01N24/088 , G01N33/54326 , G01N33/57484 , G01N33/57492 , G01N33/587 , G01N2333/4725 , G01N2333/485 , G01N2333/70596 , G01N2333/71 , G01R33/1269
摘要： A portable magnetic resonance system includes a permanent magnet, a nuclear magnetic resonance probe, and control electronics. The control electronics are configured to transmit to the probe a magnetic resonance excitation signal having an excitation frequency f, receive from the probe a magnetic resonance measurement signal, detect in the magnetic resonance measurement signal a magnetic resonance frequency f0, and automatically adjust the excitation frequency f until the difference between the excitation frequency and the magnetic resonance frequency is approximately equal to a target offset.

5. 发明申请

US20130195767A1 Magnetic Nanoparticles 有权
公开(公告)号：US20130195767A1
公开(公告)日：2013-08-01
申请号：US13699378
申请日：2011-05-26
申请人： Ralph Weissleder , Hakho Lee , Tae-Jong Yoon
发明人： Ralph Weissleder , Hakho Lee , Tae-Jong Yoon
IPC分类号： A61K49/18 , A61N2/02 , B22F1/02 , A61K41/00
CPC分类号： A61K49/1824 , A61K9/5094 , A61K9/5115 , A61K33/24 , A61K33/26 , A61K33/30 , A61K41/0052 , A61K49/08 , A61K49/10 , A61K49/126 , A61K49/1827 , A61K49/183 , A61K49/1836 , A61K2800/47 , A61N2/02 , B22F1/025 , A61K2300/00
摘要： A magnetic nanoparticle includes a magnetic core and a superparamagnetic outer shell, in which the outer shell enhances magnetic properties of the nanoparticle. The enhanced magnetic properties of the magnetic nanoparticle allow for highly sensitive detection as well as diminished non-specific aggregation of nanoparticles.

6. 发明授权

US08945628B2 Magnetic nanoparticles 有权
标题翻译：磁性纳米颗粒
公开(公告)号：US08945628B2
公开(公告)日：2015-02-03
申请号：US13699378
申请日：2011-05-26
申请人： Ralph Weissleder , Hakho Lee , Tae-Jong Yoon
发明人： Ralph Weissleder , Hakho Lee , Tae-Jong Yoon
IPC分类号： A61K9/14 , A61K49/18 , A61K9/50 , A61K9/51 , A61K33/24 , A61K33/26 , A61K33/30 , A61K41/00 , A61N2/02 , B22F1/02
CPC分类号： A61K49/1824 , A61K9/5094 , A61K9/5115 , A61K33/24 , A61K33/26 , A61K33/30 , A61K41/0052 , A61K49/08 , A61K49/10 , A61K49/126 , A61K49/1827 , A61K49/183 , A61K49/1836 , A61K2800/47 , A61N2/02 , B22F1/025 , A61K2300/00
摘要： A magnetic nanoparticle includes a magnetic core and a superparamagnetic outer shell, in which the outer shell enhances magnetic properties of the nanoparticle. The enhanced magnetic properties of the magnetic nanoparticle allow for highly sensitive detection as well as diminished non-specific aggregation of nanoparticles.
摘要翻译：磁性纳米颗粒包括磁芯和超顺磁性外壳，其中外壳增强纳米颗粒的磁性能。磁性纳米颗粒的增强的磁性能允许高度敏感的检测以及纳米颗粒的非特异性聚集减少。

7. 发明申请

US20140011217A1 Detection of Targets Using Magnetic Resonance 有权
标题翻译：使用磁共振检测目标
公开(公告)号：US20140011217A1
公开(公告)日：2014-01-09
申请号：US14006389
申请日：2012-03-21
申请人： Ralph Weissleder , Hakho Lee , David Issadore
发明人： Ralph Weissleder , Hakho Lee , David Issadore
IPC分类号： G01N24/08
CPC分类号： G01N33/574 , G01N21/6428 , G01N24/088 , G01N33/54326 , G01N33/57484 , G01N33/57492 , G01N33/587 , G01N2333/4725 , G01N2333/485 , G01N2333/70596 , G01N2333/71 , G01R33/1269
摘要： A portable magnetic resonance system includes a permanent magnet, a nuclear magnetic resonance probe, and control electronics. The control electronics are configured to transmit to the probe a magnetic resonance excitation signal having an excitation frequency f, receive from the probe a magnetic resonance measurement signal, detect in the magnetic resonance measurement signal a magnetic resonance frequency f0, and automatically adjust the excitation frequency f until the difference between the excitation frequency and the magnetic resonance frequency is approximately equal to a target offset.
摘要翻译：便携式磁共振系统包括永磁体，核磁共振探针和控制电子装置。控制电子设备被配置为向探头发送具有激励频率f的磁共振激励信号，从探头接收磁共振测量信号，在磁共振测量信号中检测磁共振频率f0，并自动调节激励频率直到激励频率和磁共振频率之间的差近似等于目标偏移。

8. 发明申请

US20110091987A1 Miniaturized Magnetic Resonance Systems and Methods 审中-公开
标题翻译：小型化磁共振系统与方法
公开(公告)号：US20110091987A1
公开(公告)日：2011-04-21
申请号：US12681303
申请日：2008-10-06
申请人： Ralph Weissleder , Hakho Lee , Donhee Ham , Nan Sun , Yong Liu
发明人： Ralph Weissleder , Hakho Lee , Donhee Ham , Nan Sun , Yong Liu
IPC分类号： G01N24/08 , B01J19/00
CPC分类号： G01R33/302 , G01R33/307 , G01R33/34092 , G01R33/383 , G01R33/465 , G01R33/50 , G01R33/5601 , G01R33/5617 , Y10T436/24
摘要： The present application describes devices, systems, and techniques related to a chip-based, miniaturized NMR diagnostic platform for rapid, quantitative and multi-channeled detection of biological targets.
摘要翻译：本申请描述了与用于快速，定量和多通道检测生物靶标的基于芯片的小型化NMR诊断平台相关的装置，系统和技术。

9. 发明申请

US20100006439A1 METHODS AND APPARATUS FOR MANIPULATION AND/OR DETECTION OF BIOLOGICAL SAMPLES AND OTHER OBJECTS 审中-公开
标题翻译：用于操纵和/或检测生物样本和其他对象的方法和装置
公开(公告)号：US20100006439A1
公开(公告)日：2010-01-14
申请号：US12559895
申请日：2009-09-15
申请人： Donhee Ham , Robert Westervelt , Thomas Hunt , Yong Liu , Hakho Lee
发明人： Donhee Ham , Robert Westervelt , Thomas Hunt , Yong Liu , Hakho Lee
IPC分类号： B03C5/02
CPC分类号： G01R33/302 , B01L3/502761 , B01L2200/0668 , B01L2200/147 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/1822 , B01L2300/1827 , B01L2400/043 , G01N15/1031 , G01N24/08 , G01N24/10 , G01R33/307 , G01R33/34092 , G01R33/3415 , G01R33/465 , G01R33/4808 , G01R33/5604
摘要： Methods and apparatus for manipulation, detection, imaging, characterization, sorting and/or assembly of biological or other materials, involving an integration of CMOS or other semiconductor-based technology and microfluidics. In one implementation, various components relating to the generation of electric and/or magnetic fields are implemented on an IC chip that is fabricated using standard protocols. The generated electric and/or magnetic fields are used to manipulate and/or detect one or more dielectric and/or magnetic particles and distinguish different types of particles. A microfluidic system is fabricated either directly on top of the IC chip, or as a separate entity that is then appropriately bonded to the IC chip, to facilitate the introduction and removal of cells in a biocompatible environment, or other particles/objects of interest suspended in a fluid. The patterned electric and/or magnetic fields generated by the IC chip can trap and move biological cells or other objects inside the microfluidic system. Electric and/or magnetic field generating components also may be controlled using signals of various frequencies so as to detect one or more cells, particles or objects of interest, and even the type of particle or object of interest, by measuring resonance characteristics associated with interactions between samples and one or more of the field-generating devices. Such systems may be employed in a variety of biological and medical related applications, including cell sorting and tissue assembly.
摘要翻译：用于操作，检测，成像，表征，分选和/或组装生物或其他材料的方法和装置，涉及CMOS或其他基于半导体的技术和微流体的集成。在一个实现中，与使用标准协议制造的IC芯片上实现与电场和/或磁场的产生有关的各种组件。产生的电场和/或磁场用于操纵和/或检测一个或多个电介质和/或磁性颗粒并区分不同类型的颗粒。微流体系统直接制造在IC芯片的顶部上，或者作为独立的实体，然后适当地结合到IC芯片，以便于在生物相容性环境或其他感兴趣的其它颗粒/物体中引入和去除细胞悬浮在流体中。由IC芯片产生的图案化电场和/或磁场可以捕获并移动微流体系统内的生物细胞或其它物体。可以使用各种频率的信号来控制电场和/或磁场产生组件，以便通过测量与相互作用相关联的共振特性来检测一个或多个感兴趣的细胞，颗粒或感兴趣的物体，甚至是感兴趣的粒子或物体的类型样本和一个或多个场产生装置之间。这样的系统可以用于各种生物和医学相关应用，包括细胞分选和组织组装。

10. 发明申请

US20090168162A1 Microscopy Methods And Apparatus For Manipulation And/Or Detection of Biological Samples And Other Objects 审中-公开
标题翻译：用于操纵和/或检测生物样品和其他物体的显微镜方法和装置
公开(公告)号：US20090168162A1
公开(公告)日：2009-07-02
申请号：US12087532
申请日：2007-01-12
申请人： Donhee Ham , Robert Westervelt , Thomas Hunt , Yong Liu , Hakho Lee
发明人： Donhee Ham , Robert Westervelt , Thomas Hunt , Yong Liu , Hakho Lee
IPC分类号： G02B21/26 , G02B21/32
CPC分类号： G02B21/34 , B01J2219/00653 , B01J2219/00655 , B01J2219/00659 , B01J2219/00702 , B01L3/502761 , B01L2200/0668 , B01L2300/0819 , B01L2300/0877 , B01L2300/1822 , B01L2400/0415 , B01L2400/043 , G01N15/1463 , G02B21/32
摘要： Microscopy methods and apparatus for manipulation, detection, imaging, characterization, sorting and/or assembly of biological or other materials, involving an integration of CMOS or other semiconductor-based technology and microfluidics in connection with a microscope. In one implementation, a microscope including optics and a stage is outfitted with various components relating to the generation of electric and/or magnetic fields, which are implemented on an IC chip. A microfluidic system is fabricated either directly on top of the IC chip, or as a separate entity that is then appropriately bonded to the IC chip, to facilitate the introduction and removal of cells in a biocompatible environment, or other particles/objects of interest suspended in a fluid. The patterned electric and/or magnetic fields generated by the IC chip can trap and move biological cells or other objects inside the microfluidic system to facilitate viewing via the microscope.
摘要翻译：显微镜方法和用于操纵，检测，成像，表征，分选和/或组装生物或其他材料的装置，涉及CMOS或其他基于半导体的技术和与显微镜相结合的微流体的集成。在一个实施方式中，包括光学器件和阶段的显微镜配备有与在IC芯片上实现的电场和/或磁场的产生相关的各种组件。微流体系统直接制造在IC芯片的顶部上，或者作为独立的实体，然后适当地结合到IC芯片，以便于在生物相容性环境或其他感兴趣的其它颗粒/物体中引入和去除细胞悬浮在流体中。由IC芯片产生的图案化电场和/或磁场可捕获和移动微流体系统内的生物细胞或其它物体，以便于通过显微镜观察。

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