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1. 发明授权

US5994351A Arylsulfonylamino hydroxamic acid derivatives 失效
公开(公告)号：US5994351A
公开(公告)日：1999-11-30
申请号：US122920
申请日：1998-07-27
申请人： Ralph P. Robinson , James P. Rizzi
发明人： Ralph P. Robinson , James P. Rizzi
IPC分类号： A61P19/02 , A61P35/00 , C07C311/29 , C07D213/40 , C07D295/13 , C07D295/15 , C07D295/185 , A61K31/495 , A61K31/535 , C07D295/192
CPC分类号： C07D213/40 , C07C311/29 , C07D295/13 , C07D295/15 , C07D295/185
摘要： A compound of the formula ##STR1## wherein n, X, R.sup.3, R.sup.4 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, restenosis, periodontal disease, epidermolysis bullosa, scleritis and other diseases characterized by matrix metalloproteinase activity, AIDS, sepsis, septic shock and other diseases involving the production of TNF.

2. 发明授权

US06380219B1 Arylsulfonylamino hydroxamic acid derivatives 失效
标题翻译：芳基磺酰氨基异羟肟酸衍生物
公开(公告)号：US06380219B1
公开(公告)日：2002-04-30
申请号：US09635186
申请日：2000-08-08
申请人： Ralph P. Robinson , James P. Rizzi
发明人： Ralph P. Robinson , James P. Rizzi
IPC分类号： A61K314468
CPC分类号： C07D213/40 , C07C311/29 , C07D295/13 , C07D295/15 , C07D295/185
摘要： A compound of the formula wherein n, X, R3, R4 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, restenosis, periodontal disease, epidermolysis bullosa, scleritis and other diseases characterized by matrix metalloproteinase activity, AIDS, sepsis, septic shock and other diseases involving the production of TNF.
摘要翻译：化合物n，X，R 3，R 4和Ar如上所定义，可用于治疗选自关节炎，癌症，组织溃疡，再狭窄，牙周病，大疱性表皮松解症，巩膜炎等的病症以基质金属蛋白酶活性为特征的疾病，艾滋病，败血症，败血性休克和涉及TNF产生的其他疾病。

3. 发明授权

US6147074A Arylsulfonylamino hydroxamic acid derivatives 失效
标题翻译：芳基磺酰氨基异羟肟酸衍生物
公开(公告)号：US6147074A
公开(公告)日：2000-11-14
申请号：US406522
申请日：1999-09-28
申请人： Ralph P. Robinson , James P. Rizzi
发明人： Ralph P. Robinson , James P. Rizzi
IPC分类号： A61P19/02 , A61P35/00 , C07C311/29 , C07D213/40 , C07D295/13 , C07D295/15 , C07D295/185 , A61K31/192 , A61K31/5375
CPC分类号： C07D213/40 , C07C311/29 , C07D295/13 , C07D295/15 , C07D295/185
摘要： A compound of the formula ##STR1## wherein n, X, R.sup.3, R.sup.4 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, restenosis, periodontal disease, epidermolysis bullosa, scleritis and other diseases characterized by matrix metalloproteinase activity, AIDS, sepsis, septic shock and other diseases involving the production of TNF.
摘要翻译：下式的化合物其中n，X，R 3，R 4和Ar如上定义，可用于治疗选自以下的病症：选自由关节炎，癌症，组织溃疡，再狭窄，牙周病，大疱性表皮松解症，巩膜炎和以基质金属蛋白酶活性为特征的其他疾病，AIDS，败血症，败血性休克等涉及TNF产生的疾病。

4. 发明授权

US5863949A Arylsulfonylamino hydroxamic acid derivatives 失效
标题翻译：芳基磺酰氨基异羟肟酸衍生物
公开(公告)号：US5863949A
公开(公告)日：1999-01-26
申请号：US894873
申请日：1997-08-04
申请人： Ralph P. Robinson , James P. Rizzi
发明人： Ralph P. Robinson , James P. Rizzi
IPC分类号： C07D295/18 , A61K31/18 , A61K31/40 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/5375 , A61P1/02 , A61P9/00 , A61P17/00 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/04 , A61P43/00 , C07C311/29 , C07D207/12 , C07D213/40 , C07D213/56 , C07D213/75 , C07D241/08 , C07D295/185 , A61K31/185 , C07C311/18
CPC分类号： C07D213/40 , C07C311/29 , C07D207/12 , C07D241/08 , C07D295/185
摘要： A compound of formula (I), wherein n, X, R.sup.3, R.sup.4 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, restenosis, periodontal disease, epidermolysis bullosa, scleritis and other diseases characterized by matrix metalloproteinase activity, AIDS, sepsis, septic shock and other diseases involving the production of TNF. ##STR1##
摘要翻译： PCT No.PCT / US96 / 02679 Sec。 371日期：1997年8月4日 102（e）日期1997年8月4日PCT 1995年3月7日PCT PCT。公开号WO96 / 27583 日期1996年9月12日一种式（I）化合物，其中n，X，R 3，R 4和Ar如上所定义，可用于治疗选自以下的病症：关节炎，癌症，组织溃疡，再狭窄，牙周病，大疱性表皮松解症，巩膜炎等特征为基质金属蛋白酶活性的疾病，艾滋病，败血症，败血性休克等涉及TNF产生的疾病。（一）

5. 发明授权

US08635860B1 Internal combustion engine heat transfer system 失效
标题翻译：内燃机传热系统
公开(公告)号：US08635860B1
公开(公告)日：2014-01-28
申请号：US13358726
申请日：2012-01-26
申请人： Ralph P. Robinson
发明人： Ralph P. Robinson
IPC分类号： F01N3/00
CPC分类号： F02B77/11 , F01N2260/20
摘要： A system for reversing heat transfer from an exhaust system assembly on a vehicle comprising an engine block assembly and transaxle assembly operatively connected and located in an engine compartment of an automobile. The system comprises a number one exhaust manifold stay mount, a number two exhaust manifold stay mount, and a front exhaust collector pipe bracket and stay mount. The system comprises an exhaust system with a front exhaust collector pipe located beneath the engine block assembly. The system comprises an engine block assembly heat shield with a cross-section generally comprising the shape of a “U” that is located next to the surface of the engine block assembly. The engine block assembly heat shield is located over and overlays the front exhaust collector pipe bracket and stay mount, the number one exhaust manifold stay mount, and the number two exhaust manifold stay mount.
摘要翻译：一种用于反转来自车辆上的排气系统组件的热传递的系统，包括可操作地连接并位于汽车的发动机室中的发动机缸体组件和变速驱动桥组件。该系统包括一个排气歧管支架，两个排气歧管支架和一个前排气收集管支架，并支撑。该系统包括具有位于发动机缸体组件下方的前排气收集管的排气系统。该系统包括具有通常包括邻近发动机缸体组件的表面的“U”形状的横截面的发动机缸体组件隔热罩。发动机机组组合隔热罩位于前排气收集管支架和支架上，排气歧管支架一号和排气歧管两座支架上。

6. 发明授权

US07368573B2 Triamide-substituted heterobicyclic compounds 失效
标题翻译：三酰胺取代的杂双环化合物
公开(公告)号：US07368573B2
公开(公告)日：2008-05-06
申请号：US11424488
申请日：2006-06-15
申请人： Peter Bertinato , Michel A. Couturier , Ernest S. Hamanaka , Marcus D. Ewing , Ralph P. Robinson , Derek L. Tickner
发明人： Peter Bertinato , Michel A. Couturier , Ernest S. Hamanaka , Marcus D. Ewing , Ralph P. Robinson , Derek L. Tickner
IPC分类号： C07D215/38 , C07D215/46 , A61K31/47
CPC分类号： C07D215/48 , C07D401/12
摘要： This invention relates to MTP/Apo-B secretion inhibitors of Formula (I) wherein R1-R7, X1, m and n are as defined in the specification, as well as pharmaceutical compositions comprising the compounds, and methods of use of the compounds and compositions. The compounds of the invention are useful in treating obesity and associated diseases, conditions or disorders.
摘要翻译：本发明涉及式（I）的MTP / Apo-B分泌抑制剂，其中R 1〜R 7，X 1，m和n 如本说明书中所定义，以及包含该化合物的药物组合物，以及该化合物和组合物的使用方法。本发明的化合物可用于治疗肥胖症和相关疾病，病症或病症。

7. 发明授权

US07138406B2 Modulators of the glucocorticoid receptor 有权
标题翻译：糖皮质激素受体的调节剂
公开(公告)号：US07138406B2
公开(公告)日：2006-11-21
申请号：US10615126
申请日：2003-07-08
申请人： Yves A. Chantigny , Edward F. Kleinman , Ralph P. Robinson
发明人： Yves A. Chantigny , Edward F. Kleinman , Ralph P. Robinson
IPC分类号： A61K31/435 , A61K31/44 , C07D211/04
CPC分类号： C07D213/30 , C07C35/42 , C07C39/17 , C07C39/23 , C07C39/42 , C07C43/23 , C07C49/747 , C07C49/755 , C07C49/83 , C07C59/72 , C07C69/712 , C07C205/57 , C07C215/64 , C07C235/20 , C07C255/13 , C07C255/29 , C07C255/53 , C07C271/52 , C07C2603/26 , C07D213/40 , C07D257/04 , C07D271/06 , C07D277/24 , C07D295/088 , C07D295/185 , C07D413/06 , C07D413/12
摘要： The present invention provides compounds of the formula wherein A is of the formula and X, Y, n, R1–R25 are as described in the specification which are modulators of the glucocorticoid receptor and are thus useful for the treatment of animals requiring glucocorticoid receptor agonist therapy. Glucocorticoid receptor modulators are useful in the treatment of certain inflammatory conditions.
摘要翻译：本发明提供下式的化合物其中A为下式且X，Y，n，R 1 -R 25如说明书中所述，其为糖皮质激素受体，因此可用于治疗需要糖皮质激素受体激动剂治疗的动物。糖皮质激素受体调节剂可用于治疗某些炎性疾病。

8. 发明申请

US20110020460A1 GPR 119 MODULATORS 审中-公开
标题翻译： GPR 119调制器
公开(公告)号：US20110020460A1
公开(公告)日：2011-01-27
申请号：US12793938
申请日：2010-06-04
申请人： Vincent Mascitti , Kim F. McClure , Michael J. Munchhof , Ralph P. Robinson
发明人： Vincent Mascitti , Kim F. McClure , Michael J. Munchhof , Ralph P. Robinson
IPC分类号： A61K31/454 , C07D401/04 , C07D401/14 , C07F9/40 , A61K31/4545 , A61K31/675 , A61K31/55 , A61K31/536 , A61K31/485 , A61K31/566 , A61K38/22 , A61K31/46 , A61K31/473 , A61K31/4965 , A61K31/472 , A61K31/702 , A61K38/16 , A61K35/56 , A61K31/4985 , A61P3/10 , A61P3/04 , A61P3/00 , A61P3/06 , A61P9/10 , A61P1/00 , A61P1/04
CPC分类号： C07D401/04 , C07D401/14
摘要： Compounds of Formula I that modulate the activity of the G-protein-coupled receptor GPR119 and their uses in the treatment of diseases linked to the modulation of the G-protein-coupled receptor GPR119 in animals are described herein.
摘要翻译：本文描述了调节G-蛋白偶联受体GPR119的活性的式I化合物及其用于治疗与动物中G-蛋白偶联受体GPR119调节相关的疾病的用途。

9. 发明授权

US6114361A 5-oxo-pyrrolidine-2-carboxylic acid hydroxamide derivatives 失效
标题翻译： 5-氧代 - 吡咯烷-2-甲酸羟基酰胺衍生物
公开(公告)号：US6114361A
公开(公告)日：2000-09-05
申请号：US429937
申请日：1999-10-29
申请人： Ralph P. Robinson , Ellen R. Laird
发明人： Ralph P. Robinson , Ellen R. Laird
IPC分类号： C07D207/277 , A61K31/4015 , A61K31/4439 , A61P1/00 , A61P1/02 , A61P1/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/06 , A61P25/16 , A61P25/24 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P35/04 , A61P37/02 , A61P37/08 , A61P43/00 , C07D207/12 , C07D207/16 , C07D207/28 , C07D401/04
CPC分类号： C07D207/28 , Y02P20/55
摘要： The present invention relates to a compound of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 are as defined above, to pharmaceutical compositions and methods of treatment.
摘要翻译：本发明涉及药物组合物和治疗方法，其中R1，R2，R3如上定义。

10. 发明授权

US6107337A Arylsulfonylamino hydroxamic acid derivatives 失效
标题翻译：芳基磺酰氨基异羟肟酸衍生物
公开(公告)号：US6107337A
公开(公告)日：2000-08-22
申请号：US130922
申请日：1998-08-06
申请人： Ralph P. Robinson
发明人： Ralph P. Robinson
IPC分类号： C07C311/19 , C07C311/20 , A61K31/35 , A61K31/216 , A61K31/50 , A61K31/5375
CPC分类号： C07C311/19 , C07C311/20 , C07C2101/08 , Y10S514/824 , Y10S514/921
摘要： A compound of the formula ##STR1## wherein n, X, R.sup.3, R.sup.4 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, restenosis, periodontal disease, epidermolysis bullosa, scleritis, bone resorption, loosening of artificial joint implants, atherosclerosis, multiple sclerosis, occular angiogenisis and other diseases characterized by matrix metalloproteinase activity, AIDS, sepsis, septic shock and other diseases involving the production of TNF.
摘要翻译：下式的化合物其中n，X，R 3，R 4和Ar如上定义，可用于治疗选自以下的病症：选自由关节炎，癌症，组织溃疡，再狭窄，牙周病，大疱性表皮松解症，巩膜炎，骨吸收，人工关节植入物的松动，动脉粥样硬化，多发性硬化，眼部血管生成和其他以基质金属蛋白酶活性为特征的疾病，艾滋病，败血症，败血症休克等涉及TNF产生的疾病。

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