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1. 发明授权

US08024033B2 Iontophoretic electrode 有权
标题翻译：离子电渗电极
公开(公告)号：US08024033B2
公开(公告)日：2011-09-20
申请号：US10587429
申请日：2005-02-28
申请人： Ralph Koschinsky , James D. Isaacson , Robert F. Hause, Jr.
发明人： Ralph Koschinsky , James D. Isaacson , Robert F. Hause, Jr.
IPC分类号： A61N1/30
CPC分类号： A61N1/0428 , A61N1/044 , A61N1/0448
摘要： An electrode for an iontophoretic drug delivery system includes a retainer having a malleable characteristic. The retainer and a conductor are connected to a platform. The conductor and a dose controller are electrically coupled to the iontophoretic drug delivery system. A drug delivery matrix is operably connected to the platform and proximate the conductor wherein the conductor, the drug delivery matrix, and the dose controller cooperate to deliver a drug to a user when the electrode is affixed to the user and operably connected to the iontophoretic drug delivery system.
摘要翻译：用于离子电渗药物递送系统的电极包括具有可延展特征的保持器。保持器和导体连接到平台。导体和剂量控制器电耦合到离子电渗药物递送系统。药物递送基质可操作地连接到平台并且靠近导体，其中当电极固定到使用者并且可操作地连接到离子电渗药物时，导体，药物递送基质和剂量控制器协同将药物递送给使用者输送系统。

2. 发明申请

US20110295188A1 IONTOPHORETIC ELECTRODE 有权
标题翻译：绝缘电极
公开(公告)号：US20110295188A1
公开(公告)日：2011-12-01
申请号：US13204113
申请日：2011-08-05
申请人： Ralph Koschinsky , James D. Isaacson , Robert F. Hause, JR.
发明人： Ralph Koschinsky , James D. Isaacson , Robert F. Hause, JR.
IPC分类号： A61N1/30
CPC分类号： A61N1/0428 , A61N1/044 , A61N1/0448
摘要： An electrode for an iontophoretic drug delivery system includes a retainer having a malleable characteristic. The retainer and a conductor are connected to a platform. The conductor and a dose controller are electrically coupled to the iontophoretic drug delivery system. A drug delivery matrix is operably connected to the platform and proximate the conductor wherein the conductor, the drug delivery matrix, and the dose controller cooperate to deliver a drug to a user when the electrode is affixed to the user and operably connected to the iontophoretic drug delivery system.
摘要翻译：用于离子电渗药物递送系统的电极包括具有可延展特征的保持器。保持器和导体连接到平台。导体和剂量控制器电耦合到离子电渗药物递送系统。药物递送基质可操作地连接到平台并且靠近导体，其中当电极固定到使用者并且可操作地连接到离子电渗药物时，导体，药物递送基质和剂量控制器协同将药物递送给使用者输送系统。

3. 发明申请

US20080058698A1 Iontophoretic Electrode 有权
标题翻译：离子电渗电极
公开(公告)号：US20080058698A1
公开(公告)日：2008-03-06
申请号：US10587429
申请日：2005-02-28
申请人： Ralph Koschinsky , James D. Isaacson , Robert F. Hause
发明人： Ralph Koschinsky , James D. Isaacson , Robert F. Hause
IPC分类号： A61N1/30
CPC分类号： A61N1/0428 , A61N1/044 , A61N1/0448
摘要： An electrode for an iontophoretic drug delivery system includes a retainer having a malleable characteristic. The retainer and a conductor are connected to a platform. The conductor and a dose controller are electrically coupled to the iontophoretic drug delivery system. A drug delivery matrix is operably connected to the platform and proximate the conductor wherein the conductor, the drug delivery matrix, and the dose controller cooperate to deliver a drug to a user when the electrode is affixed to the user and operably connected to the iontophoretic drug delivery system.
摘要翻译：用于离子电渗药物递送系统的电极包括具有可延展特征的保持器。保持器和导体连接到平台。导体和剂量控制器电耦合到离子电渗药物递送系统。药物递送基质可操作地连接到平台并且靠近导体，其中当电极固定到使用者并且可操作地连接到离子电渗药物时，导体，药物递送基质和剂量控制器协同将药物递送给使用者输送系统。

4. 发明申请

US20130253412A1 ROLLER-BALL APPLICATOR FOR TRANSDERMAL IONTOPHORETIC DELIVERY 审中-公开
标题翻译：用于超声波输送的滚轮应用器
公开(公告)号：US20130253412A1
公开(公告)日：2013-09-26
申请号：US13430313
申请日：2012-03-26
申请人： Jamal Yanaki , Ralph Koschinsky
发明人： Jamal Yanaki , Ralph Koschinsky
IPC分类号： A61N1/30
CPC分类号： A61N1/303 , A61N1/0428
摘要： Embodiments of iontophoretic devices are disclosed which may include a reservoir; a roller-ball applicator coupled to the reservoir and configured to dispense contents of the reservoir; a power supply; a first electrode electrically coupled to a pole of the power supply; and a second electrode coupled to the other pole of the power supply. The devices may be configured such that a current travels between the first electrode and the second electrode through the skin of a subject when the device is used.
摘要翻译：公开了可包括储存器的离子电渗装置的实施方案; 滚珠球施加器，其联接到所述储存器并且构造成分配所述储存器的内容物; 电源; 电耦合到所述电源的极的第一电极; 以及耦合到电源的另一极的第二电极。这些装置可以被配置为使得当使用该装置时，电流在第一电极和第二电极之间穿过被检体的皮肤。

5. 发明授权

US08447393B2 Iontophoretic electrode 有权
公开(公告)号：US08447393B2
公开(公告)日：2013-05-21
申请号：US13204113
申请日：2011-08-05
申请人： Ralph Koschinsky , Jim Isaacson , Robert F. Hause
发明人： Ralph Koschinsky , Jim Isaacson , Robert F. Hause
IPC分类号： A61N1/30
CPC分类号： A61N1/0428 , A61N1/044 , A61N1/0448
摘要： An electrode for an iontophoretic drug delivery system includes a retainer having a malleable characteristic. The retainer and a conductor are connected to a platform. The conductor and a dose controller are electrically coupled to the iontophoretic drug delivery system. A drug delivery matrix is operably connected to the platform and proximate the conductor wherein the conductor, the drug delivery matrix, and the dose controller cooperate to deliver a drug to a user when the electrode is affixed to the user and operably connected to the iontophoretic drug delivery system.

6. 发明授权

US6062915A Nondeforming electrode connector 失效
标题翻译：非变形电极连接器
公开(公告)号：US6062915A
公开(公告)日：2000-05-16
申请号：US244734
申请日：1999-02-05
申请人： Michael Costello , Ralph Koschinsky
发明人： Michael Costello , Ralph Koschinsky
IPC分类号： H01R11/24 , H01R13/627 , H01R4/48
CPC分类号： H01R11/24 , H01R13/6278 , Y10S439/909
摘要： An electrode connector for securely holding a thin flexible electrode. The electrode connector includes a bottom jaw member and an upper jaw member that are selectively movable between an open position and a closed position. The upper jaw member and the bottom jaw member are biased into a closed position. The electrode connector includes an electrical contact assembly configured to provide electrical contact with the flexible electrode. The electrical contact assembly comprises a contact platform and a contact pin attached thereto. The contact platform is configured to form an electrical contact with the contact area of the flexible electrode. The contact pin is sized and configured to be at least partially disposed in the aperture formed in the flexible electrode such that upon the upperjaw member and the lower jaw member moving to the closed position electrical contact is formed and maintained with the contact area of the flexible electrode without permanently deforming the contact area thereof. The electrical contact assembly further comprises a recess formed opposite the contact pin that is sized and configured to receive both the contact pin disposed in the aperture of the flexible electrode and a portion of the contact area of the flexible electrode. The contact assembly is configured such that disposing the contact pin in the aperture in the flexible electrode provides a visual indicator to medical personnel that the contact assembly and the flexible electrode are correctly aligned so as to form an electrical contact. A visual access opening is in communication with the recess to enhance the ability of the medical personnel to determine that the contact pin is disposed in the aperture of the flexible electrode. In addition, disposing the contact pin in the aperture in the flexible electrode positively locks the connector to the flexible electrode and prevents accidental disengagement.
摘要翻译：一种用于牢固地保持薄柔性电极的电极连接器。电极连接器包括可以在打开位置和关闭位置之间选择性地移动的底部钳口构件和上部钳口构件。上钳口构件和下钳口构件被偏压到关闭位置。电极连接器包括被配置为提供与柔性电极的电接触的电接触组件。电接触组件包括接触平台和连接到其上的接触销。接触平台构造成与柔性电极的接触区域形成电接触。接触销的尺寸和构造至少部分地设置在形成在柔性电极中的孔中，使得在上爪部件和下钳口构件移动到闭合位置时，电接触被形成并保持在柔性电极的接触面积电极，而不会使其接触面积永久变形。电接触组件还包括与接触针相对形成的凹部，其尺寸和构造被设计成接收设置在柔性电极的孔中的接触针和柔性电极的接触区域的一部分。接触组件被配置成使得将接触销设置在柔性电极的孔中为医务人员提供视觉指示器，使得接触组件和柔性电极被正确对准以便形成电接触。视觉进入开口与凹部连通，以增强医务人员确定接触销设置在柔性电极的孔中的能力。此外，将接触销设置在柔性电极的孔中，将连接器牢固地锁定到柔性电极上，并防止意外脱开。

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