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1. 发明授权

US4246349A Stabilization of immobilized bacteria 失效
标题翻译：固定化细菌的稳定
公开(公告)号：US4246349A
公开(公告)日：1981-01-20
申请号：US939176
申请日：1978-09-05
申请人： Ralph A. Messing , Robert A. Oppermann , William S. Ramsey , Milton M. Takeguchi
发明人： Ralph A. Messing , Robert A. Oppermann , William S. Ramsey , Milton M. Takeguchi
IPC分类号： C12N11/14
CPC分类号： C12N11/14
摘要： Bacteria immobilized by adsorption on an inorganic carrier are stabilized by carrying out the adsorption procedure in the presence of from about 1 to about 20% weight per volume of sucrose of nonfat dry milk solids and lyophilizing the adsorbed bacteria.
摘要翻译：通过吸附在无机载体上固定的细菌通过在约1至约20％重量/体积的脱脂干乳固体蔗糖的存在下进行吸附程序而稳定，并冻干吸附的细菌。

2. 发明授权

US4286061A Method for continuous culturing of microbes 失效
标题翻译：连续培养微生物的方法
公开(公告)号：US4286061A
公开(公告)日：1981-08-25
申请号：US162582
申请日：1980-06-23
申请人： Ralph A. Messing , Robert A. Oppermann , Lynn B. Simpson , Milton M. Takeguchi
发明人： Ralph A. Messing , Robert A. Oppermann , Lynn B. Simpson , Milton M. Takeguchi
IPC分类号： C12N1/00 , C12N1/16 , C12N1/20 , C12N11/14
CPC分类号： C12N11/14 , C12N1/00 , C12N1/16 , C12N1/20 , Y10S435/813 , Y10S435/839 , Y10S435/842 , Y10S435/849 , Y10S435/85 , Y10S435/871 , Y10S435/942
摘要： A method for the continuous culturing of microbes in a plug-flow reactor which comprises the steps of:A. supplying medium to microbes immobilized on a porous inorganic support at a rate sufficient to maintain such microbes substantially in a logarithmic growth stateandB. removing microbe-containing effluent from the immobilized microbes at a rate equal to the medium supply rate, wherein the microbes are selected from the group consisting of bacteria, yeasts, and fungus-like organisms; such reactor is operated continuously in a substantially plug-flow mode; the immobilized microbes are substantially covered by said medium; and such porous inorganic support has a controlled porosity such that at least 70% of the pores, on a pore size distribution basis, have a pore diameter,a. in the case of bacteria, at least as large as the smallest major dimension of the microbes but less than about five times the largest major dimension of the microbes;b. in the case of yeasts, at least as large as the smallest dimension of the microbes but less than about four times the largest dimension of the microbes; andc. in the case of fungus-like organisms, at least as large as the smallest major dimension of the microbes but less than about sixteen times the largest major dimension of the microbes.
摘要翻译：一种用于在活塞流反应器中连续培养微生物的方法，其包括以下步骤：A.以足以维持这种微生物基本上处于对数生长状态的速率向固定在多孔无机载体上的微生物供应培养基，以及B.去除来自固定化微生物的含微生物的流出物以等于中等供应速率的速率，其中微生物选自细菌，酵母和真菌样生物; 这样的反应器以大致的插塞模式连续运行; 固定的微生物基本上被所述培养基覆盖; 并且这种多孔无机载体具有受控的孔隙率，使得至少70％的孔在孔径分布的基础上具有孔径a。在细菌的情况下，至少与微生物的最小主要尺寸一样大，但小于微生物最大主要尺寸的约五倍; b。在酵母的情况下，至少与微生物的最小尺寸一样大，但小于微生物最大尺寸的四倍; 和c。在真菌样生物的情况下，至少与微生物的最小主要尺寸一样大，但小于微生物最大主要尺寸的约十六倍。

3. 发明授权

US4135981A Device for recognition and differentiation of group D streptococci 失效
标题翻译：用于识别和分组D组的设备
公开(公告)号：US4135981A
公开(公告)日：1979-01-23
申请号：US791549
申请日：1977-04-27
申请人： Lynn B. Simpson , Milton M. Takeguchi
发明人： Lynn B. Simpson , Milton M. Takeguchi
IPC分类号： C12M1/24 , C12Q1/14 , C12K1/06 , C12K1/10
CPC分类号： C12Q1/14 , G01N2333/315
摘要： Device for simultaneous recognition of group D streptococci and the differentiation of members of that group into enterococci and nonenterococci bacteria. Device comprises an elongated substantially cylindrical transparent tube having upper and lower chambers joined by a conduit having a smallest diameter smaller than either chamber. The upper chamber contains a semi-solid bile-esculin medium capable of indicating the presence of group D streptococci. The lower chamber contains a semi-solid enterococci distinguishing medium having a NaCl content of at least about 6.5%. Media in the two chambers are separated by a gas (e.g., air) within the conduit.

4. 发明授权

US4150950A Transport system for clinical specimens 失效
标题翻译：临床标本运输系统
公开(公告)号：US4150950A
公开(公告)日：1979-04-24
申请号：US837361
申请日：1977-09-28
申请人： Milton M. Takeguchi , Howard H. Weetall
发明人： Milton M. Takeguchi , Howard H. Weetall
IPC分类号： B01L3/14 , C12M1/30 , G01N33/483 , G01N33/16 , A61B10/00
CPC分类号： C12M45/22 , B01L3/5082 , C12M33/02 , Y10T436/2525
摘要： This invention relates to means for transporting clinical specimens wherein the activity thereof can be retained for relatively long periods of time. The crux of the invention resides in a liquid reagent capable of preserving or stabilizing the activity of a particular specimen. Where the clinical specimen is Neisseria gonorrhoeae, the preferred liquid reagent consists of an aqueous mixture of cysteine and TRIS (Trihydroxymethylaminomethane) buffer. A convenient type of specimen collector comprises a swab. Again, where the clinical specimen is Neisseria gonorrhoeae, the preferred swab consists of calcium alginate. An apparatus particularly useful for transporting specimens comprises a screw-capped container having a liquid reagent sealed into the bottom portion thereof capable of preserving the activity of a particular specimen, and a specimen collector attachable to the inside of said screw cap through a longitudinal element of sufficient length to immerse said collector into said liquid. After a specimen has been obtained, the collector, attached to the screw cap, is forced through the seal into the liquid preservative as the screw cap is fastened tightly onto the container.
摘要翻译：本发明涉及用于运输临床样品的方法，其中其活性可以保留相对较长的时间。本发明的关键在于能够保持或稳定特定样品的活性的液体试剂。当临床标本是淋病奈瑟氏球菌时，优选的液体试剂由半胱氨酸和TRIS（三羟甲基氨基甲烷）缓冲液的含水混合物组成。样本收集器的方便类型包括拭子。再次，临床标本是淋病奈瑟氏球菌，优选的棉签由海藻酸钙组成。特别可用于运输试样的装置包括：具有密封到其底部的能够保持特定样品的活性的液体试剂的螺旋盖容器，以及可通过纵向元件连接到所述螺帽的内部的试样收集器足够的长度将所述收集器浸入所述液体中。在获得样品后，当螺丝帽紧紧地紧固在容器上时，附接到螺帽的收集器被迫通过密封件进入液体防腐剂。

5. 发明授权

US4254218A Detecting Neisseria via immobilized antibody-enzyme complex 失效
标题翻译：通过固定的抗体 - 酶复合物检测奈瑟氏球菌
公开(公告)号：US4254218A
公开(公告)日：1981-03-03
申请号：US14294
申请日：1979-02-23
申请人： Hugh C. McDonald , Gerald Odstrchel , Milton M. Takeguchi
发明人： Hugh C. McDonald , Gerald Odstrchel , Milton M. Takeguchi
IPC分类号： C12Q1/12 , G01N33/571 , C12Q1/66 , C12N11/14
CPC分类号： C12Q1/12 , G01N33/571 , Y10S435/81
摘要： A method for detecting the presence of Neisseria bacteria in a fluid sample which comprises bringing immobilized antibody specific for the enzyme 1,2-propanediol dehydrogenase which is released from such bacteria upon lysis thereof, into contact with a lysed sample, isolating the immobilized antibody or resulting immobilized antibody-enzyme complex or mixture thereof, and then testing the isolated material for enzymatic activity.
摘要翻译：一种用于检测流体样品中奈瑟菌属细菌存在的方法，其包括将对此类细菌释放的1,2-丙二醇脱氢酶的特异性固定化的抗体裂解，与裂解的样品接触，分离固定的抗体或得到的固定化抗体 - 酶复合物或其混合物，然后测试分离的材料用于酶活性。

6. 发明授权

US4039387A Medium and method for distinguishing Neisseria gonorrhoeae and Neisseria meningitidis 失效
标题翻译：培养基和鉴别淋病奈瑟氏球菌{b和{脑膜炎奈瑟菌脑膜炎奈瑟氏球菌
公开(公告)号：US4039387A
公开(公告)日：1977-08-02
申请号：US701891
申请日：1976-07-01
申请人： Lynn B. Simpson , Milton M. Takeguchi
发明人： Lynn B. Simpson , Milton M. Takeguchi
IPC分类号： C12Q1/12 , C12K1/10 , C12K1/06
CPC分类号： C12Q1/12 , Y10S435/80 , Y10S435/848 , Y10S435/849 , Y10S435/852 , Y10S435/871 , Y10S435/873 , Y10S435/922
摘要： A microbial growth medium for distinguishing Neisseria gonorrhoeae from Neisseria meningitidis. The medium comprises a gonococci and meningococci specific medium having incorporated therein a quantity of 8-anilino-1-naphthalene-sulfonic acid (ANS) or a salt thereof, at a concentration sufficient to permit the growth of the meningococci and inhibit the growth of the gonococci.
摘要翻译：用于区分淋病奈瑟氏球菌和脑膜炎奈瑟球菌的微生物生长培养基。培养基包含淋球菌和脑膜炎球菌特异性培养基，其中以足以允许脑膜炎球菌生长并抑制脑膜炎球菌生长的浓度掺入量的8-苯胺基-1-萘磺酸（ANS）或其盐淋球菌

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