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1. 发明授权

US06730795B2 Process for the preparation of phenylene-bis-benzimidazole-tetrasulfonic acid disodium salt 有权
标题翻译：亚苯基 - 双 - 苯并咪唑 - 四磺酸二钠盐的制备方法
公开(公告)号：US06730795B2
公开(公告)日：2004-05-04
申请号：US09995328
申请日：2001-11-27
申请人： Ralf Bertram , Stephan Hillers , Oskar Koch , Harry Erfurt , Gerald Reinders
发明人： Ralf Bertram , Stephan Hillers , Oskar Koch , Harry Erfurt , Gerald Reinders
IPC分类号： C07D40310
CPC分类号： A61K8/49 , A61K8/4946 , A61Q17/04 , C07D235/20
摘要： Phenylene-bis-benzimidazole-tetrasulfonic acid disodium salt which is largely free from impurities can be prepared by reacting o-phenylenediamine with terephthalic acid and chlorosulfonic acid in the presence of strong acids with a reaction time of 10 to 15 hours.
摘要翻译：大部分不含杂质的亚苯基 - 双 - 苯并咪唑 - 四磺酸二钠盐可以通过邻苯二胺与对苯二甲酸和氯磺酸在强酸存在下反应10至15小时的反应时间来制备。

2. 发明授权

US06547172B2 Chewing apparatus 失效
标题翻译：咀嚼器具
公开(公告)号：US06547172B2
公开(公告)日：2003-04-15
申请号：US09838431
申请日：2001-04-19
申请人： Gerald Reinders , Harry Erfurt , Horst Boos , Rainer Wellmann
发明人： Gerald Reinders , Harry Erfurt , Horst Boos , Rainer Wellmann
IPC分类号： B02C1900
CPC分类号： G09B23/28
摘要： A novel apparatus can be used to simulate the chewing process, wherein the wherein the apparatus comprises a thermostattable kneading space comprising an upper portion and lower portion, wherein the lower portion comprises at least two kneading paddles for comminuting and kneading the test material and the upper portion comprising an air space for connecting the volatile components released during the comminution and kneading, wherein said apparatus comprises an inlet in which saliva is introduced into the kneading space and a second inlet in which air is passed into the kneading space, wherein air is passed together with the volatile components of the comminution and kneading process through an outlet of the kneading space to a detector system.
摘要翻译：可以使用新颖的装置来模拟咀嚼过程，其中所述装置包括包含上部和下部的可热调混合空间，其中所述下部包括至少两个用于粉碎和揉捏测试材料和上部其包括用于连接在粉碎和捏合期间释放的挥发性组分的空气空间，其中所述装置包括将唾液引入捏合空间的入口和空气进入捏合空间的第二入口，其中空气通过以及通过捏合空间的出口将粉碎和捏合过程的挥发性组分连同检测器系统。

3. 发明授权

US08828469B2 Use of alkamides for masking an unpleasant flavor 有权
标题翻译：使用烷酰胺掩蔽不愉快的味道
公开(公告)号：US08828469B2
公开(公告)日：2014-09-09
申请号：US12266209
申请日：2008-11-06
申请人： Kathrin Langer , Jakob Ley , Gerald Reinders , Günter Kindel , Gerhard Krammer
发明人： Kathrin Langer , Jakob Ley , Gerald Reinders , Günter Kindel , Gerhard Krammer
IPC分类号： A23L1/22 , A23L2/56 , A61K8/18 , A61Q13/00 , A23G9/32 , A23G1/32 , A21D2/24 , A23C9/13 , A23C11/10
CPC分类号： A23L1/22075 , A21D2/24 , A23C9/1307 , A23C11/103 , A23G1/32 , A23G9/32 , A23L27/84 , A23L27/86
摘要： An individual alkamide and/or a mixture having two or more different alkamides, is disclosed for changing, masking or reducing the unpleasant flavor impression of an unpleasant-tasting substance or mixture of substances. The alkamide can be trans-pellitorine; cis-pellitorine; 2Z,4Z- or 2Z,4E-decadienoic acid-N-isobutylamide; 2E,4E-decadienoic acid-N-([2S]-2-methylbutyl)amide; 2E,4E-decadienoic acid-N-([2R]-2-methylbutylamide); 2E,4Z-decadienoic acid-N-(2-methylbutyl)amide; achilleamide; sarmentine; 2E- or 3E-decenoic acid-N-isobutylamide; 3E-nonenoic acid-N-isobutylamide; spilanthol; homospilanthol; 2E,6Z,8E-decatrienoic acid-N-([2R]-2-methylbutyl)amide; 2E- or 2Z-decen-4-oic acid-N-isobutylamide; α-sanshool; α-hydroxysanshool; γ-hydroxysanshool; γ-hydroxysanshool; γ-hydroxyisosanshool; γ-dehydrosanshool; γ-sanshool; bungeanool; isobungeanool; dihydrobungeanool; or tetrahydrobungeanool, or combinations thereof.
摘要翻译：公开了具有两种或更多种不同的烷酰胺的单独的烷酰胺和/或混合物，用于改变，掩蔽或减少不愉快的味道物质或物质混合物的不愉快的风味印象。烷酰胺可以是反式蝶呤; 顺式丝氨酸 2Z，4Z-或2Z，4E-癸二烯酸-N-异丁酰胺; 2E，4E-癸二烯酸-N - （[2S] -2-甲基丁基）酰胺; 2E，4E-癸二烯酸-N - （[2R] -2-甲基丁酰胺）; 2E，4Z-癸二烯酸-N-（2-甲基丁基）酰胺; 甲酰胺 sarmentine; 2E-或3E-癸烯酸-N-异丁酰胺; 3E-壬烯酸-N-异丁酰胺; 皮兰替康同型六醇 2E，6Z，8E-十二碳烯酸-N - （[2R] -2-甲基丁基）酰胺; 2E-或2Z-癸-4-酸酸-N-异丁酰胺; α-sans学校 α-羟基蛋白 γ-羟基辛酸 γ-羟基辛酸 γ-羟基异黄酮 γ-脱水师 γ-sans学校皮卡诺异丁腈二氢胆碱; 或四氢胆甾醇，或其组合。

4. 发明申请

US20080242740A1 AROMA COMPOSITIONS OF ALKAMIDES WITH HESPERETIN AND/OR 4-HYDROXYDIHYDROCHALCONES AND SALTS THEREOF FOR ENHANCING SWEET SENSORY IMPRESSIONS 审中-公开
标题翻译：含有HESPERETIN和/或4-羟基二氢吲哚的碱金属组合物及其盐，用于增强甜味剂的敏感性
公开(公告)号：US20080242740A1
公开(公告)日：2008-10-02
申请号：US12058088
申请日：2008-03-28
申请人： Jakob Ley , Kathrin Freiherr , Gerhard Krammer , Gerald Reinders
发明人： Jakob Ley , Kathrin Freiherr , Gerhard Krammer , Gerald Reinders
IPC分类号： A23L1/236 , A61K47/16
CPC分类号： C07C49/83 , A23C9/1307 , A23C9/156 , A23C11/103 , A23L2/56 , A23L7/139 , A23L27/2028 , A23L27/204 , A23L27/2052 , A23L27/30 , A23L27/63 , A23V2002/00 , C07C49/84 , A23V2200/16 , A23V2250/25 , A23V2250/21164 , A23V2250/5114 , A23V2250/5028
摘要： The invention primarily relates to aroma compositions of (i) certain saliva-stimulating alkamides having a tingling, pungent and/or hot flavor (such as for example pellitorines, spilanthol) with (ii) hesperetin (5,7-dihydroxy-3-(3-hydroxy-4-methoxyphenyl)-chroman-4-one) or the enantiomers and/or salts thereof and/or (iii) 4-hydroxydihydrochalcones (3-(4-hydroxyphenyl)-1-phenylpropan-1-ones) and/or the salts thereof, the use thereof to enhance the sweet flavor of sweet-tasting substances or the sweet odor impression of aroma substances which give rise to a sweet odor impression, but in particular to enhance the sweet initial flavor or odor (initial sweetness). The invention thus relates to the use of said aroma compositions as general sweetness enhancers and enhancers of initial sweetness. The invention further relates to certain preparations which contain an effective amount of said aroma compositions of (i) alkamides (such as in particular pellitorines, spilanthol) with (ii) hesperetin or the enantiomers and/or salts thereof and/or (iii) 4-hydroxydihydrochalcones and/or the salts thereof and methods for enhancing the sweet flavor or initial sweetness of a sweet-tasting substance or the sweet odor impression or initial sweetness of an aroma substance which gives rise to a sweet odor impression. The invention also relates to the use of certain alkamides (i) to enhance the initial sweetness of a preparation comprising (ii) hesperetin or the enantiomers and/or salts thereof and/or (iii) 4-hydroxydihydrochalcones and/or the salts thereof and (b) sweet-tasting substances and/or (c) aroma substances which give rise to a sweet odor impression.
摘要翻译：本发明主要涉及（i）具有刺痛，刺鼻和/或热风味的某些唾液刺激性烷酰胺（例如，扑地酮，滑液甾醇）与（ii）橙皮素（5,7-二羟基-3-（ 3-羟基-4-甲氧基苯基） - 苯并二氢吡喃-4-酮）或其对映异构体和/或盐和/或（iii）4-羟基二氢鲸蜡酮（3-（4-羟基苯基）-1-苯基丙-1-酮）和 /或其盐，其用于增强甜味物质的甜味或芳香物质的甜味气味，产生甜味气味，特别是增强甜味初始风味或气味（初始甜度）。因此，本发明涉及所述芳香组合物作为初始甜味的一般甜味增强剂和增强剂的用途。本发明进一步涉及含有有效量的所述芳香组合物的（i）烷酰胺（如特别是pellitorine，spantanthol）与（ii）橙皮素或其对映异构体和/或盐和/或（iii）4 - 羟基二氢鲸脑酯和/或其盐，以及用于增强甜味物质的甜味或初始甜味或芳香物质的甜味气味或初始甜度的方法，其产生甜味气味。本发明还涉及某些烷酰胺（i）增强包含（ii）橙皮素或其对映异构体和/或盐和/或（iii）4-羟基二氢樟脑和/或其盐的制剂的初始甜度的用途，以及（b）甜味物质和/或（c）产生甜味气味的香气物质。

5. 发明申请

US20090124701A1 USE OF ALKAMIDES FOR MASKING AN UNPLEASANT FLAVOR 有权
标题翻译：用于掩蔽不雅气味的碱性物质的使用
公开(公告)号：US20090124701A1
公开(公告)日：2009-05-14
申请号：US12266209
申请日：2008-11-06
申请人： Kathrin Langer , Jakob Ley , Gerald Reinders , Gunter Kindel , Gerhard Krammer
发明人： Kathrin Langer , Jakob Ley , Gerald Reinders , Gunter Kindel , Gerhard Krammer
IPC分类号： A61K31/16 , A23L1/226 , A61K8/18
CPC分类号： A23L1/22075 , A21D2/24 , A23C9/1307 , A23C11/103 , A23G1/32 , A23G9/32 , A23L27/84 , A23L27/86
摘要： An individual alkamide and/or a mixture having two or more different alkamides, is disclosed for changing, masking or reducing the unpleasant flavor impression of an unpleasant-tasting substance or mixture of substances. The alkamide can be trans-pellitorine; cis-pellitorine; 2Z,4Z- or 2Z,4E-decadienoic acid-N-isobutylamide; 2E,4E-decadienoic acid-N-([2S]-2-methylbutyl)amide; 2E,4E-decadienoic acid-N-([2R]-2-methylbutylamide); 2E,4Z-decadienoic acid-N-(2-methylbutyl)amide; achilleamide; sarmentine; 2E- or 3E-decenoic acid-N-isobutylamide; 3E-nonenoic acid-N-isobutylamide; spilanthol; homospilanthol; 2E,6Z,8E-decatrienoic acid-N-([2R]-2-methylbutyl)amide; 2E- or 2Z-decen-4-oic acid-N-isobutylamide; α-sanshool; α-hydroxysanshool; γ-hydroxysanshool; γ-hydroxysanshool; γ-hydroxyisosanshool; γ-dehydrosanshool; γ-sanshool; bungeanool; isobungeanool; dihydrobungeanool; or tetrahydrobungeanool, or combinations thereof.
摘要翻译：公开了具有两种或更多种不同的烷酰胺的单独的烷酰胺和/或混合物，用于改变，掩蔽或减少不愉快的味道物质或物质混合物的不愉快的风味印象。烷酰胺可以是反式蝶呤; 顺式丝氨酸 2Z，4Z-或2Z，4E-癸二烯酸-N-异丁酰胺; 2E，4E-癸二烯酸-N - （[2S] -2-甲基丁基）酰胺; 2E，4E-癸二烯酸-N - （[2R] -2-甲基丁酰胺）; 2E，4Z-癸二烯酸-N-（2-甲基丁基）酰胺; 甲酰胺 sarmentine 2E-或3E-癸烯酸-N-异丁酰胺; 3E-壬烯酸-N-异丁酰胺; 皮兰替康同型六醇 2E，6Z，8E-十二碳烯酸-N - （[2R] -2-甲基丁基）酰胺; 2E-或2Z-癸-4-酸酸-N-异丁酰胺; 阿尔卑斯山 α-羟基异黄酮 γ-羟基乙酸 γ-羟基乙酸 γ-羟基异黄酮 γ-脱水师伽马学校皮卡诺异丁腈二氢胆碱; 或四氢胆甾醇，或其组合。

6. 发明申请

US20080317923A1 AROMA COMPOSITION FOR REDUCING OR SUPPRESSING AN UNDESIRED BITTER, ASTRINGENT IMPRESSION 审中-公开
标题翻译： AROMA组合物，用于减少或抑制未受影响的叮咬，ASTRING IMPRESSION
公开(公告)号：US20080317923A1
公开(公告)日：2008-12-25
申请号：US12141982
申请日：2008-06-19
申请人： Jakob Ley , Kathrin Langer , Gerhard Krammer , Gerald Reinders , Gunter Kindel , Christian Nolte
发明人： Jakob Ley , Kathrin Langer , Gerhard Krammer , Gerald Reinders , Gunter Kindel , Christian Nolte
IPC分类号： A23L1/22
CPC分类号： A23L27/86 , A23L27/00 , A23L27/84
摘要： The invention relates to an aroma composition for reducing or suppressing a bitter, astringent impression in the oral cavity, comprising (i) one or more salivatory aroma substances and/or flavorings and (ii) one or more particular bitterness-masking aroma substances and/or flavorings and optionally (iii) one or more further aroma substances, wherein preferably at least one aroma substance is an aroma substance which suppresses malodors and optionally (iv) one or more auxiliary substances or carriers.
摘要翻译：本发明涉及用于减少或抑制口腔中的苦味，收敛印象的香味组合物，其包含（i）一种或多种唾液香味物质和/或调味剂和（ii）一种或多种特定的苦味掩蔽香味物质和/ 或调味剂，以及任选地（iii）一种或多种其它芳香物质，其中优选至少一种芳香物质是抑制恶臭的芳香物质，和任选地（iv）一种或多种辅助物质或载体。

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