专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5434040A Photographic elements containing particular color couplers in combination with metal complex stabilizers 失效
标题翻译：含有特定颜色耦合器与金属络合物稳定剂组合的照相元件
公开(公告)号：US5434040A
公开(公告)日：1995-07-18
申请号：US42197
申请日：1993-04-02
申请人： Rakesh Jain , Thomas H. Jozefiak , Sundaram Krishnamurthy , John L. Pawlak , Hugh M. Williamson
发明人： Rakesh Jain , Thomas H. Jozefiak , Sundaram Krishnamurthy , John L. Pawlak , Hugh M. Williamson
IPC分类号： G03C7/30 , G03C7/36 , G03C7/392 , G03C7/32
CPC分类号： G03C7/36 , G03C7/3013
摘要： A photographic element having at least one photosensitive silver halide layer and associated therewith both a particular type of color coupler and a particular type of stabilizer. The color coupler is of the general formula (1) or (2): ##STR1## wherein A and B represent the same or different electron-withdrawing group,X is H or a group which splits off on coupling with oxidized color developer,R is an alkyl, cycloalkyl, aryl or heterocyclic which may be substituted, --COR.sup.1, --CSR.sup.1, SOR.sup.1, SO.sub.2 R.sup.1, --NHCOR.sup.1, --CONHR.sup.1, --COOR.sup.1, --COSR.sup.1, --NHSO.sub.2 R.sup.1 wherein R.sup.1 is an alkyl, cycloalkyl, or aryl group any of which are optionally substituted, and wherein two or more of A, B, R, and X optionally form part of a ring,Link is a linking group andn is 0, 1 or 2.The stabilizer is of the general formula (I) below: ##STR2## wherein: M is Cu, Co, Ni, Pd or Pt;W.sup.2, W.sup.3, W.sup.4 and W.sup.5 are defined in the specification.
摘要翻译：具有至少一个光敏卤化银层并与其相关联的特定类型的彩色耦合器和特定类型的稳定器的照相元件。（1）或（2）的成色剂：其中A和B表示相同或不同的吸电子基团，X是H或分开的基团与氧化显色剂偶联时，R为可被取代的烷基，环烷基，芳基或杂环，-COR1，-CSR1，SOR1，SO2R1，-NHCOR1，-CONHR1，-COOR1，-COSR1，-NHSO2R1，其中R1为任何一个烷基，环烷基或芳基任选被取代，并且其中A，B，R和X中的两个或更多个任选地形成环的一部分，Link是连接基团，n是0,1或2。稳定剂具有以下通式（I）：其中：M为Cu，Co，Ni，Pd或Pt; W2，W3，W4和W5在说明书中定义。

2. 发明授权

US5436124A Photographic elements containing particular color couplers in combination with polymeric stabilizers 失效
标题翻译：包含特定色耦合器与聚合物稳定剂的照相元件
公开(公告)号：US5436124A
公开(公告)日：1995-07-25
申请号：US42369
申请日：1993-04-02
申请人： Rakesh Jain , Thomas H. Jozefiak , Hugh M. Williamson
发明人： Rakesh Jain , Thomas H. Jozefiak , Hugh M. Williamson
IPC分类号： G03C7/30 , G03C7/36 , G03C7/392 , G03C7/396
CPC分类号： G03C7/36 , G03C7/3013 , G03C7/396
摘要： A photographic element comprising a support, at least one photosensitive silver halide layer and associated therewith a color coupler and a stabilizer therefor which stabilizer is an acrylate or acrylamide homopolymer or copolymer of low water solubility, the color coupler being of the general formula (1) or (2): ##STR1## wherein A and B represent the same or different electron-withdrawing group,X is H or a group which splits off on coupling with oxidised color developer,R is an alkyl, cycloalkyl, aryl or heterocyclic which may be substituted, --COR.sup.1, --CSR.sup.1, SOR.sup.1, SO.sub.2 R.sup.1, --NHCOR.sup.1, --CONHR.sup.1, --COOR.sup.1, --COSR.sup.1, --NHSO.sub.2 R.sup.1 wherein R.sup.1 is an alkyl, cycloalkyl, or aryl group any of which are optionally substituted, and wherein two or more of A, B, R, and X optionally form part of a ring,Link is a linking group andn is 0, 1 or 2.
摘要翻译：一种照相元件，其特征在于，包含支持体，至少一个感光卤化银层，并与其相配合的着色剂及其稳定剂，其中稳定剂是具有低水溶性的丙烯酸酯或丙烯酰胺均聚物或共聚物，所述着色剂为通式（1）或（2）：其中A和B表示相同或不同的吸电子基团，X为H或与氧化显色剂偶联时分裂的基团，R为可被取代的烷基，环烷基，芳基或杂环，-COR 1，-CSR 1，SOR 1，SO 2 R 1，-NHCOR 1，-CONHR 1，-COOR 1，-COSR 1，-NHSO 2 R 1，其中R 1是烷基，环烷基或芳基，任选地被取代，并且其中A，B，R和X中的两个或更多个任选地形成环的一部分，Link是连接基团，n是0,1或2。

3. 发明授权

US5434041A Photographic elements containing particular color couplers in combination with hydroquinone type stabilizers 失效
标题翻译：含有特定色耦合剂与氢醌类稳定剂的照相元件
公开(公告)号：US5434041A
公开(公告)日：1995-07-18
申请号：US042370
申请日：1993-04-02
申请人： Rakesh Jain , Thomas H. Jozefiak , Hugh M. Williamson
发明人： Rakesh Jain , Thomas H. Jozefiak , Hugh M. Williamson
IPC分类号： G03C7/30 , G03C7/36 , G03C7/392 , G03C7/32
CPC分类号： G03C7/36 , G03C7/3013
摘要： A photographic element having at least one photosensitive silver halide layer and associated therewith both a particular type of color coupler and a particular type of stabilizer. The color coupler is of the general formula (1) or (2): ##STR1## wherein A and B represent the same or different electron-withdrawing group,X is H or a group which splits off on coupling with oxidized color developer,R is an alkyl, cycloalkyl, aryl or heterocyclic which may be substituted, --COR.sup.1, --CSR.sup.1, SOR.sup.1, SO.sub.2 R.sup.1, --NHCOR.sup.1, --CONHR.sup.1, --COOR.sup.1, --COSR.sup.1, --NHSO.sub.2 R.sup.1 wherein R.sup.1 is an alkyl, cycloalkyl, or aryl group any of which are optionally substituted, and wherein two or more of A, B, R, and X optionally form part of a ring,Link is a linking group andn is 0, 1 or 2.The stabilizer is of the general formula: ##STR2## wherein: E.sup.1, E.sup.2, W.sup.2 and W.sup.3 may independently be a hydrogen atom, a substituted or unsubstituted aliphatic group, a substituted or unsubstituted aromatic group, an acylamino group, a mono or dialkylamino group, an aliphatic or aromatic thio group, an aliphatic or aromatic oxycarbonyl group, or W.sup.2 and W.sup.3 in combination with the benzene ring may independently represent the atoms necessary to complete a fused ring system, or E.sup.1 and W.sup.3 together, and E.sup.2 and W.sup.2 together, may independently form a heterocyclic ring with an O.
摘要翻译：具有至少一个光敏卤化银层并与其相关联的特定类型的彩色耦合器和特定类型的稳定器的照相元件。（1）或（2）的成色剂：其中A和B表示相同或不同的吸电子基团，X是H或分开的基团与氧化显色剂偶联时，R为可被取代的烷基，环烷基，芳基或杂环，-COR1，-CSR1，SOR1，SO2R1，-NHCOR1，-CONHR1，-COOR1，-COSR1，-NHSO2R1，其中R1为任何一个烷基，环烷基或芳基任选被取代，并且其中A，B，R和X中的两个或更多个任选地形成环的一部分，Link是连接基团，n是0,1或2。稳定剂具有以下通式：其中：E1，E2，W2和W3可以独立地为氢原子，取代或未取代的脂族基团，取代或未取代的芳基，酰氨基，单或二烷基氨基，脂族或芳族硫基，脂族或芳族氧基羰基，或W2和W3与苯环的组合可以独立地代表完成稠环系统或E1和W3一起必需的原子，E2和W2一起可以独立地形成具有O.的杂环。

4. 发明授权

US5437962A Photographic elements containing particular color couplers in combination with particular stabilizers 失效
标题翻译：包含特定色耦合器的特定稳定器的照相元件
公开(公告)号：US5437962A
公开(公告)日：1995-08-01
申请号：US42194
申请日：1993-04-02
申请人： Rakesh Jain , Thomas H. Jozefiak , Hugh M. Williamson
发明人： Rakesh Jain , Thomas H. Jozefiak , Hugh M. Williamson
IPC分类号： G03C7/30 , G03C7/36 , G03C7/392 , G03C7/32
CPC分类号： G03C7/36 , G03C7/3013
摘要： A photographic element having at least one photosensitive silver halide layer and associated therewith both a particular type of color coupler and a particular type of stabilizer. The color coupler is of the general formula (1) or (2): ##STR1## wherein A and B represent the same or different electron-withdrawing group,X is H or a group which splits off on coupling with oxidized color developer,R is an alkyl, cycloalkyl, aryl or heterocyclic which may be substituted, --COR.sup.1, --CSR.sup.1, SOR.sup.1, SO.sub.2 R.sup.1, --NHCOR.sup.1, --CONHR.sup.1, --COOR.sup.1, --COSR.sup.1, --NHSO.sub.2 R.sup.1 wherein R.sup.1 is an alkyl, cycloalkyl, or aryl group any of which are optionally substituted, and wherein two or more of A, B, R, and X optionally form part of a ring,Link is a linking group andn is 0, 1 or 2.The stabilizer is of the general formula (II), (III) or (IV): ##STR2## wherein the substituents of (II), (III) and (IV) are as defined in the specification.
摘要翻译：具有至少一个光敏卤化银层并与其相关联的特定类型的彩色耦合器和特定类型的稳定器的照相元件。彩色成色剂具有通式（1）或（2）：其中A和B表示相同或不同的吸电子基团，X为H或与氧化显色剂偶联时分裂的基团R 是可以被取代的烷基，环烷基，芳基或杂环，-COR1，-CSR1，SOR1，SO2R1，-NHCOR1，-CONHR1，-COOR1，-COSR1，-NHSO2R1，其中R1是烷基，环烷基或芳基，其中任选被取代，并且其中两个或多个A，B，R和X任选地形成环的一部分，Link是连接基团，n是0,1或2.稳定剂具有通式（II （II），（III）和（IV）的取代基如说明书中所定义。

5. 发明授权

US07754200B2 Phosphate transport inhibitors 有权
标题翻译：磷酸盐转运抑制剂
公开(公告)号：US07754200B2
公开(公告)日：2010-07-13
申请号：US11438679
申请日：2006-05-22
申请人： Thomas H. Jozefiak , Cecilia M. Bastos , Chad C. Huval
发明人： Thomas H. Jozefiak , Cecilia M. Bastos , Chad C. Huval
IPC分类号： A61K31/74
CPC分类号： C07F9/65502 , C07F9/3821 , C07F9/4012 , C07F9/5537 , C08F8/40 , C08F30/02 , Y02P20/55
摘要： Disclosed is a phosphate transport inhibiting compound represented by Structural Formula (I): R1 and R2 are independently —H, an electron withdrawing group or a C1-C10 alkyl group. Y is a covalent bond, a substituted methylene group, an unsubstituted methylene group or —CR1R2P(O)(OH)—. R3 is a hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups, a substituted hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups, a heteroaryl group, a substituted heteroaryl group or a phenyl group substituted with one or more groups selected from —Cl, —Br, —F, —CN, —NO2, —ORa, —N(Ra)2, —COORa, —CON(Ra)2, —CORa, —S(O)Ra, —S(O)2Ra, —S(O)2N(Ra)2, —NRaS(O)2Ra, —NRaCORa, a halogenated lower alkyl group, an aryl group, a substituted aryl group, or a halogenated alkoxy group. Each Ra is independently —H, lower alkyl, substituted lower alkyl, aryl or substituted aryl.Each Rb is independently —H, a lower alkyl group, or a phosphate protecting group.
摘要翻译：公开了由结构式（I）表示的磷酸盐转运抑制化合物：R1和R2独立地为-H，吸电子基团或C1-C10烷基。 Y是共价键，取代亚甲基，未取代的亚甲基或-CR 1 R 2 P（O）（OH） - 。 R3是任选地包含一个或多个胺，铵，醚，硫醚或亚苯基连接基团的烃基，任选地包含一个或多个胺，铵，醚，硫醚或亚苯基连接基团的取代的烃基，杂芳基，取代的杂芳基被一个或多个选自-Cl，-Br，-F，-CN，-NO 2，-OR a，-N（R a）2，-COOR a，-CON（R a）2，-COR a ，-S（O）R a，-S（O）2 R a，-S（O）2 N（R a）2，-NR a（O）2 R a，-NR a COR a，卤代低级烷基，芳基，取代的芳基，或卤代烷氧基。每个R a独立地为-H，低级烷基，取代的低级烷基，芳基或取代的芳基。每个R b独立地是-H，低级烷基或磷酸酯保护基。

6. 发明授权

US5476757A Photographic element containing a novel cyan dye forming coupler and process for its use 失效
标题翻译：含有新型青色染料成色剂的摄影元件及其使用方法
公开(公告)号：US5476757A
公开(公告)日：1995-12-19
申请号：US359134
申请日：1994-12-19
申请人： Philip T. S. Lau , Thomas H. Jozefiak , Thomas R. Welter
发明人： Philip T. S. Lau , Thomas H. Jozefiak , Thomas R. Welter
IPC分类号： G03C7/00 , G03C7/32 , G03C7/34
CPC分类号： G03C7/344 , G03C7/3212
摘要： A photographic element comprises a light sensitive silver halide emulsion layer having associated therewith a cyan dye-forming coupler dispersed in an organic solvent, the coupler having the formula: ##STR1## wherein A, B, and C are hydrogen or fluorine;X is selected from the group consisting of halogen, alkoxy and methyl groups;R is a straight chain aliphatic group which is unsubstituted or substituted with one or members selected from the group consisting of --F, --R", --OR", --SO.sub.2 R", --SO.sub.2 NHR", --CONHR", --COOR", --NHCOR", --NHSO.sub.2 R", and --OCOR" where R" is a primary or secondary alkyl group;R' is a substituent group and m is from 0 to 4;COG is hydrogen or a coupling-off group capable of being split-off by an oxidized color developer; andwherein the substituent groups X, R, and R' are selected so as to ballast the coupler and prevent it from wandering within the photographic coatings.The invention also encompasses a process for forming an image in an element as described after it has been exposed.
摘要翻译：照相元件包括光敏卤化银乳剂层，其具有分散在有机溶剂中的形成青色染料的成色剂，所述成色剂具有下式：尿素; X选自卤素，烷氧基和甲基; R是未取代的或被选自-F，-R“，-OR”，-SO 2 R“，-SO 2 NHR”，-CONHR“的一个或多个成员取代的直链脂族基团， -COOR“，-NHCOR”，-NHSO 2 R“和-OCOR”，其中R“是伯或仲烷基; R'为取代基，m为0〜4; COG是氢或能够被氧化的显色剂分离的偶合离去基团; 并且其中选择取代基X，R和R'，以便使耦合剂镇定并防止其在照相涂层内漂浮。本发明还包括用于在已经暴露之后描述的元件中形成图像的方法。

7. 发明申请

US20120322787A1 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS 有权
标题翻译： 2-乙酰氨基酚类型葡萄糖苷合成酶抑制剂
公开(公告)号：US20120322787A1
公开(公告)日：2012-12-20
申请号：US13595349
申请日：2012-08-27
申请人： Craig Siegel , Cecilia M. Bastos , David J. Harris , Angeles Dios , Edward Lee , Richard Silva , Lisa M. Cuff , Mikaela Levine , Cassandra A. Celatka , Frederic Vinick , Thomas H. Jozefiak , Yibin Xiang , John Kane , Junkai Liao
发明人： Craig Siegel , Cecilia M. Bastos , David J. Harris , Angeles Dios , Edward Lee , Richard Silva , Lisa M. Cuff , Mikaela Levine , Cassandra A. Celatka , Frederic Vinick , Thomas H. Jozefiak , Yibin Xiang , John Kane , Junkai Liao
IPC分类号： A61K31/4025 , A61P3/10 , A61P13/12 , C07D409/14 , A61K31/4439 , A61K31/397 , A61K31/422 , C07D417/14 , A61K31/428 , A61K31/4245 , A61K31/444 , A61K31/5377 , C07D405/10 , C07D413/14
CPC分类号： C07D417/14 , C07D295/125 , C07D319/18 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D411/12 , C07D413/12 , C07D413/14
摘要： A compound is represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating a subject in need thereof comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. The subject has type 2 diabetes; renal hypertrophy or hyperplasia associated with diabetic nephropathy; Tay-Sachs; Gaucher's; or Fabry's disease. Methods of decreasing plasma TNF-α, lowering blood glucose levels, decreasing glycated hemoglobin levels, inhibiting glucosylceramide synthase, and lowering glycosphingolipid concentrations in a subject in need thereof respectively comprise administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译：化合物由结构式（I）表示：或其药学上可接受的盐。药物组合物包含由结构式（I）表示的化合物或其药学上可接受的盐。治疗有需要的受试者的方法包括向受试者施用治疗有效量的由结构式（I）表示的化合物或其药学上可接受的盐。受试者患有2型糖尿病; 肾脏肥大或与糖尿病肾病相关的增生; 泰撒戈谢的或法布里氏病。分别在有需要的受试者中降低血浆TNF-α，降低血糖水平，降低糖化血红蛋白水平，抑制葡萄糖神经酰胺合成酶和降低糖鞘醇浓度的方法包括向受试者施用治疗有效量的由结构式（ I）或其药学上可接受的盐。

8. 发明授权

US07109184B2 Phosphate transport inhibitors 有权
公开(公告)号：US07109184B2
公开(公告)日：2006-09-19
申请号：US10392280
申请日：2003-03-19
申请人： Thomas H. Jozefiak , Cecilia M. Bastos , Chad C. Huval
发明人： Thomas H. Jozefiak , Cecilia M. Bastos , Chad C. Huval
IPC分类号： A10N57/00 , A61K31/675
CPC分类号： C07F9/65502 , C07F9/3821 , C07F9/4012 , C07F9/5537 , C08F8/40 , C08F30/02 , Y02P20/55
摘要： Disclosed is a phosphate transport inhibiting compound represented by Structural Formula (I): R1 and R2 are independently —H, an electron withdrawing group or a C1–C10 alkyl group. Y is a covalent bond, a substituted methylene group, an unsubstituted methylene group or —CR1R2P(O)(OH)—. R3 is a hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups, a substituted hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups, a heteroaryl group, a substituted heteroaryl group or a phenyl group substituted with one or more groups selected from —Cl, —Br, —F, —CN, —NO2, —ORa, —N(Ra)2, —COORa, —CON(Ra)2, —CORa, —S(O)Ra, —S(O)2Ra, —S(O)2N(Ra)2, —NRaS(O)2Ra, —NRaCORa, a halogenated lower alkyl group, an aryl group, a substituted aryl group, or a halogenated alkoxy group. Each Ra is independently —H, lower alkyl, substituted lower alkyl, aryl or substituted aryl. Each Rb is independently —H, a lower alkyl group, or a phosphate protecting group.

9. 发明授权

US09272996B2 2-acylaminopropoanol-type glucosylceramide synthase inhibitors 有权
标题翻译： 2-酰基氨基丙醇型葡萄糖神经酰胺合成酶抑制剂
公开(公告)号：US09272996B2
公开(公告)日：2016-03-01
申请号：US13595251
申请日：2012-08-27
申请人： Craig Siegel , Cecilia M. Bastos , David J. Harris , Angeles Dios , Edward Lee , Richard Silva , Lisa M. Cuff , Mikaela Levine , Cassandra A. Celatka , Thomas H. Jozefiak , Frederic Vinick , Yibin Xiang , John Kane , Junkai Liao
发明人： Craig Siegel , Cecilia M. Bastos , David J. Harris , Angeles Dios , Edward Lee , Richard Silva , Lisa M. Cuff , Mikaela Levine , Cassandra A. Celatka , Thomas H. Jozefiak , Frederic Vinick , Yibin Xiang , John Kane , Junkai Liao
IPC分类号： A61K31/397 , A61K31/5377 , A61K31/44 , A61K31/325 , A61K31/42 , A61K31/40 , C07D207/12 , C07D271/12 , C07D317/60 , C07D319/18 , C07D333/16 , C07D407/12 , C07D409/04 , C07D413/04 , C07D417/12 , C07C271/12 , C07D319/20 , C07D407/06
CPC分类号： A61K31/4025 , C07C271/12 , C07D207/12 , C07D317/60 , C07D319/18 , C07D319/20 , C07D333/16 , C07D407/06 , C07D407/12 , C07D409/04 , C07D413/04 , C07D417/12
摘要： A compound for use in treating polycystic kidney disease is represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating polycystic kidney disease in a subject in need thereof comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. Methods of treating in polycystic kidney disease in a subject in need thereof respectively comprise administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译：用于治疗多囊肾病的化合物由结构式（I）表示：或其药学上可接受的盐。药物组合物包含由结构式（I）表示的化合物或其药学上可接受的盐。在有需要的受试者中治疗多囊肾病的方法包括向受试者施用治疗有效量的由结构式（I）表示的化合物或其药学上可接受的盐。分别在有需要的受试者中治疗多囊肾病的方法包括向受试者施用治疗有效量的由结构式（I）表示的化合物或其药学上可接受的盐。

10. 发明授权

US08304447B2 2-acylaminopropoanol-type glucosylceramide synthase inhibitors 有权
标题翻译： 2-酰基氨基丙醇型葡萄糖神经酰胺合成酶抑制剂
公开(公告)号：US08304447B2
公开(公告)日：2012-11-06
申请号：US12601871
申请日：2008-05-30
申请人： Craig Siegel , Cecilia M. Bastos , David J. Harris , Angeles Dios , Edward Lee , Richard Silva , Lisa M. Cuff , Mikaela Levine , Cassandra A. Celatka , Frederic Vinick , Thomas H. Jozefiak , Yibin Xiang , John Kane , Junkai Liao
发明人： Craig Siegel , Cecilia M. Bastos , David J. Harris , Angeles Dios , Edward Lee , Richard Silva , Lisa M. Cuff , Mikaela Levine , Cassandra A. Celatka , Frederic Vinick , Thomas H. Jozefiak , Yibin Xiang , John Kane , Junkai Liao
IPC分类号： A61K31/40 , A61K31/4025 , C07D207/04 , C07D405/02
CPC分类号： C07D417/14 , C07D295/125 , C07D319/18 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D411/12 , C07D413/12 , C07D413/14
摘要： A compound is represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. A method of treating a subject in need thereof comprises administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. The subject has type 2 diabetes; renal hypertrophy or hyperplasia associated with diabetic nephropathy; Tay-Sachs; Gaucher's; or Fabry's disease. Methods of decreasing plasma TNF-α, lowering blood glucose levels, decreasing glycated hemoglobin levels, inhibiting glucosylceramide synthase, and lowering glycosphingolipid concentrations in a subject in need thereof respectively comprise administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译：化合物由结构式（I）表示：或其药学上可接受的盐。药物组合物包含由结构式（I）表示的化合物或其药学上可接受的盐。治疗有需要的受试者的方法包括向受试者施用治疗有效量的由结构式（I）表示的化合物或其药学上可接受的盐。受试者患有2型糖尿病; 肾脏肥大或与糖尿病肾病相关的增生; 泰撒戈谢的或法布里氏病。分别在有需要的受试者中降低血浆TNF-α，降低血糖水平，降低糖化血红蛋白水平，抑制葡萄糖神经酰胺合成酶和降低糖鞘醇浓度的方法包括向受试者施用治疗有效量的由结构式（ I）或其药学上可接受的盐。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式