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    • 4. 发明申请
    • Pharmaceutical composition for the treatment of rhinitis
    • 用于治疗鼻炎的药物组合物
    • US20050107330A1
    • 2005-05-19
    • US10984628
    • 2004-11-08
    • Harald GreveRainer Greve
    • Harald GreveRainer Greve
    • A61K45/00A61K9/00A61K31/137A61K31/164A61K31/197A61K31/4164A61K31/4168A61K31/4174A61K31/726A61K31/728A61K45/06A61K47/36A61P11/02A61P37/08A61P43/00
    • A61K45/06A61K31/137A61K31/4174A61K31/728A61K2300/00
    • The present invention relates to a pharmaceutical composition suitable for the prophylactic and/or curative topical treatment of rhinitis, said composition containing in combination and in each case in pharmaceutically efficacious amounts: (a) at least one sympathomimetic suitable for topical application and having vasoconstrictor action and/or detumescent action on the mucous membrane or its physiologically acceptable salts or derivatives; and (b) at least one preferably acidic glycosaminoglycan or its physiologically acceptable salts or derivatives, in particular hyaluronic acid or its salts. On account of a synergistic combined action of the glycosaminoglycan with the sympathomimetic, drying out and inflammatory irritation of the nasal mucous membranes caused by the sympathomimetic on topical application of the pharmaceutical composition are avoided and a detumescence of the mucous membrane in the nasal cavity and an inhibition of secretion are simultaneously achieved, which leads to an efficient alleviation of rhinitis.
    • 本发明涉及适用于预防性和/或局部治疗鼻炎的药物组合物,所述组合物组合含有药学有效量,每种情况下均含有:(a)至少一种适于局部应用并具有血管收缩作用的拟交感神经元 和/或对粘膜或其生理上可接受的盐或衍生物的起泡作用; 和(b)至少一种优选的酸性糖胺聚糖或其生理上可接受的盐或衍生物,特别是透明质酸或其盐。 考虑到糖胺聚糖与拟交感神经的协同联合作用,避免了由局部应用药物组合物的拟交感神经造成的鼻粘膜的干燥和炎症刺激,并且避免了粘膜在鼻腔中的消退, 同时实现抑制分泌,从而有效缓解鼻炎。
    • 5. 发明申请
    • PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF RHINITIS
    • 用于治疗RHINITIS的药物组合物
    • US20110245202A1
    • 2011-10-06
    • US13157702
    • 2011-06-10
    • Harald GreveRainer Greve
    • Harald GreveRainer Greve
    • A61K31/7008A61P37/08A61P29/00
    • A61K45/06A61K31/137A61K31/4174A61K31/728A61K2300/00
    • The present invention relates to a pharmaceutical composition suitable for the prophylactic and/or curative topical treatment of rhinitis, said composition containing in combination and in each case in pharmaceutically efficacious amounts:(a) at least one sympathomimetic suitable for topical application and having vasoconstrictor action and/or detumescent action on the mucous membrane or its physiologically acceptable salts or derivatives; and(b) at least one preferably acidic glycosaminoglycan or its physiologically acceptable salts or derivatives, in particular hyaluronic acid or its salts.On account of a synergistic combined action of the glycosaminoglycan with the sympathomimetic, drying out and inflammatory irritation of the nasal mucous membranes caused by the sympathomimetic on topical application of the pharmaceutical composition are avoided and a detumescence of the mucous membrane in the nasal cavity and an inhibition of secretion are simultaneously achieved, which leads to an efficient alleviation of rhinitis.
    • 本发明涉及适用于预防性和/或局部治疗鼻炎的药物组合物,所述组合物组合含有药学有效量,每种情况下均含有:(a)至少一种适于局部应用并具有血管收缩作用的拟交感神经元 和/或对粘膜或其生理上可接受的盐或衍生物的起泡作用; 和(b)至少一种优选的酸性糖胺聚糖或其生理上可接受的盐或衍生物,特别是透明质酸或其盐。 考虑到糖胺聚糖与拟交感神经的协同联合作用,避免了由局部应用药物组合物的拟交感神经造成的鼻粘膜的干燥和炎症刺激,并且避免了粘膜在鼻腔中的消退, 同时实现抑制分泌,从而有效缓解鼻炎。