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1. 发明申请

US20090294303A1 method for identifying compounds that affect a transport of a protein through menbrane trafficking pathway 审中-公开
标题翻译：用于鉴定影响蛋白质通过menbula运输途径运输的化合物的方法
公开(公告)号：US20090294303A1
公开(公告)日：2009-12-03
申请号：US11665219
申请日：2005-10-12
申请人： Rainer Fischer , Neil Emans , Stefano Di Fiore , Carlo Jochems , Kurt Herrenknecht , Stephan Hurling
发明人： Rainer Fischer , Neil Emans , Stefano Di Fiore , Carlo Jochems , Kurt Herrenknecht , Stephan Hurling
IPC分类号： G01N27/403 , B29C41/20
CPC分类号： G01N27/127 , B01J2219/00653 , B01J2219/00722 , B01J2219/00731 , B01J2219/00736 , B01L3/5027 , B82Y15/00 , G01N27/126
摘要： Resistive-sensors are provided wherein networks or nanoframeworks of conducting polymer nanowires are electrochemically grown from pre-polymer solutions in the junction gap located between electrode pairs.
摘要翻译：提供电阻传感器，其中导电聚合物纳米线的网络或纳米框架在位于电极对之间的接合间隙中从预聚物溶液电化学生长。

2. 发明申请

US20090117598A1 Method for identifying compounds that affect a transport of a protein through a membrane trafficking pathway 审中-公开
标题翻译：用于鉴定影响蛋白质通过膜运输途径运输的化合物的方法
公开(公告)号：US20090117598A1
公开(公告)日：2009-05-07
申请号：US11665184
申请日：2005-10-13
申请人： Rainer Fischer , Neil Emans , Stefano Di Fiore , Carlo Jochems , Kurt Herrenknecht , Stephan Hurling
发明人： Rainer Fischer , Neil Emans , Stefano Di Fiore , Carlo Jochems , Kurt Herrenknecht , Stephan Hurling
IPC分类号： C12Q1/48 , C12Q1/34 , C12Q1/00
CPC分类号： G01N33/5008 , G01N33/5035 , G01N33/5041 , G01N33/566 , G01N33/68 , G01N2333/726
摘要： The present invention relates to a method for identifying compounds that affect a transport of a receptor of interest through a specific membrane trafficking pathway mediated by said receptor within the context of a generic membrane trafficking pathway, which generic pathway is not mediated by said receptor, characterised by the following steps: d) monitoring the transport of the receptor of interest in a cell in the presence of the compound, wherein the receptor is labelled with a first marker, e) monitoring the transport of a second marker through the generic membrane trafficking pathway in a cell in the presence of the compound, f) comparing the results obtained from steps a) and b) and thereby identifying a compound affecting the specific membrane trafficking pathway. Furthermore it relates to the generation of a compound database using the method according to the invention as well as to the compound database itself.
摘要翻译：本发明涉及通过在通用膜运输途径的上下文中由所述受体介导的特异性膜运送途径鉴定影响感兴趣的受体的化合物的方法，该通用途径不是由所述受体介导的，其特征在于通过以下步骤：d）在所述化合物存在下监测细胞中感兴趣的受体的转运，其中所述受体用第一标记物标记，e）通过所述通用膜运送途径监测第二标志物的转运在化合物存在下在细胞中，f）比较从步骤a）和b）获得的结果，从而鉴定影响特异性膜转运途径的化合物。此外，它涉及使用根据本发明的方法以及复合数据库本身生成复合数据库。

3. 发明申请

US20050037420A1 Immunoglobulin having particular framework scaffold and methods of making and using 审中-公开
标题翻译：具有特定骨架支架的免疫球蛋白和制造和使用方法
公开(公告)号：US20050037420A1
公开(公告)日：2005-02-17
申请号：US10489328
申请日：2002-09-13
申请人： Mei-Yun Zhang , Stefan Schillberg , Sabine Zimmermann , Stefano Fiore , Neil Emans , Rainer Fischer
发明人： Mei-Yun Zhang , Stefan Schillberg , Sabine Zimmermann , Stefano Fiore , Neil Emans , Rainer Fischer
IPC分类号： C07K16/00 , C07K16/08 , G01N33/53 , C07K16/44
CPC分类号： C07K16/081 , A01K2217/05 , C07K16/00 , C07K2317/13 , C07K2317/23 , C07K2317/24 , C07K2317/567 , C07K2317/622
摘要： This invention relates to immunoglobulin molecules comprising light chain (VL) chimeric variable domains, heavy chain (VH) chimeric variable domains, e.g., scFv antibodies that are expressed at high levels within a host cell, preferably within particular cellular compartments such as, e.g., cytosol or apoplast. The VL, VH and scFv antibody molecules comprise framework scaffolds of particularly preferred framework regions. This invention also relates to nucleic acid molecules encoding the immunoglobulin molecules of this invention, vectors expressing the immunoglobulin molecules, hosts transformed with the nucleic acid molecules and vectors, and methods of using the immunoglobulin molecules. Also described are immunoglobulin libraries as well as host cells, including transgenic plants, expressing the VL, VH or scFv antibody molecules of this invention.
摘要翻译：本发明涉及包含轻链（VL）嵌合可变域，重链（VH）嵌合可变结构域的免疫球蛋白分子，例如在宿主细胞内，优选在特定细胞区室内以高水平表达的scFv抗体，例如，胞质或质外体。 VL，VH和scFv抗体分子包括特别优选的框架区的框架支架。本发明还涉及编码本发明的免疫球蛋白分子的核酸分子，表达免疫球蛋白分子的载体，用核酸分子和载体转化的宿主，以及使用免疫球蛋白分子的方法。还描述了免疫球蛋白文库以及表达本发明的VL，VH或scFv抗体分子的宿主细胞，包括转基因植物。

4. 发明授权

US06825325B1 Molecular pathogenicide mediated plant disease resistance 有权
标题翻译：分子致病因子介导植物病害抗性
公开(公告)号：US06825325B1
公开(公告)日：2004-11-30
申请号：US09419788
申请日：1999-10-18
申请人： Rainer Fischer , Stefan Schillberg , Jörg Nähring , Markus Sack , Michael Monecke , Yu-Cai Liao , Holger Spiegel , Sabine Zimmerman , Neil Emans
发明人： Rainer Fischer , Stefan Schillberg , Jörg Nähring , Markus Sack , Michael Monecke , Yu-Cai Liao , Holger Spiegel , Sabine Zimmerman , Neil Emans
IPC分类号： C12P2108
CPC分类号： C12N15/8283 , C07K14/21 , C07K14/415 , C07K14/7051 , C07K16/10 , C07K2317/13 , C07K2317/34 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C12N15/8258
摘要： The present invention is drawn to a fusion protein containing at least one binding domain that specifically recognizes an eptitope of a plant pathogen and at least one additional domain made from a protein or peptide sequence which is toxic to the pathogen or detrimental the replication, transmission or life cycle of the pathogen. The present invention is further drawn to a pathogenocide made from the binding domain, a cellular targeting sequence and/or membrane localization sequence that leads to membrane anchoring. The present invention is further drawn to nucleotide sequences encoding fusion proteins and pathogenocides and to vectors containing the nucleotide sequences; as well as methods of making the fusion proteins and pathogencides and methods of making pathogen resistant plants, plant cells, or plant tissues with the fusion proteins and pathogenocides.
摘要翻译：本发明涉及一种融合蛋白，其含有特异性识别植物病原体的视角的至少一个结合结构域和由对病原体有毒的蛋白质或肽序列制成的至少一个另外的结构域，或不利于复制，传播或病原体的生命周期。本发明进一步涉及由结合域制成的致病性杀伤剂，导致膜锚定的细胞靶向序列和/或膜定位序列。本发明进一步涉及编码融合蛋白和病原菌的核苷酸序列和含有该核苷酸序列的载体; 以及制备融合蛋白和病原体的方法以及用融合蛋白和病原体杀伤剂制备具有抗病性的植物，植物细胞或植物组织的方法。

5. 发明授权

US10480001B2 Method for the generation of a monoclonal plant cell line 有权
公开(公告)号：US10480001B2
公开(公告)日：2019-11-19
申请号：US14115629
申请日：2011-06-07
申请人： Janina Kirchhoff , Stefan Schillberg , Andreas Schiermeyer , Helga Schinkel , Rainer Fischer
发明人： Janina Kirchhoff , Stefan Schillberg , Andreas Schiermeyer , Helga Schinkel , Rainer Fischer
IPC分类号： C12N15/82 , A01H4/00
摘要： The invention provides a method for the generation of a monoclonal plant cell line from a heterologous population of plant cells, comprising the following steps: (a) provision of a heterologous population of plant cells; (b) preparation of protoplasts from said heterologous population of plant cells; (c) separation of single protoplasts by subjecting the preparation of protoplasts to flow cytometric sorting; (d) regeneration of a separated single transformed protoplast until the formation of a microcolony by co-cultivation in the presence of feeder cell material; (e) removal of the microcolony from the feeder cell material and cultivation of the microcolony until the formation of a monoclonal plant cell line.

6. 发明授权

US08752521B2 Piston 有权
标题翻译：活塞
公开(公告)号：US08752521B2
公开(公告)日：2014-06-17
申请号：US13221498
申请日：2011-08-30
申请人： Ralf Braig , Rainer Fischer , Thomas Hettich , Peter Kleinle , Michael Marquardt
发明人： Ralf Braig , Rainer Fischer , Thomas Hettich , Peter Kleinle , Michael Marquardt
IPC分类号： F02F3/00
CPC分类号： F02F3/02
摘要： A piston for an internal combustion engine may include a piston head and a piston shaft. The piston shaft may have two shaft walls, one arranged on a pressure side and the other arranged on a counter-pressure side. Two box walls may have pin bosses and connect the shaft walls. Each of the box walls may have a first partial wall section and a second partial wall section. The first partial wall section may extend between the pin boss and the shaft wall arranged on the pressure side. The second partial wall section may extend between the pin boss and the shaft wall arranged on the counter-pressure side. A first longitudinal center line of the first partial wall section is may be convergent to a second longitudinal center line of the second partial wall section, wherein the first and second longitudinal center lines—intersect each other outside the piston.
摘要翻译：用于内燃机的活塞可以包括活塞头和活塞轴。活塞轴可以具有两个轴壁，一个布置在压力侧，另一个布置在反压侧。两个箱壁可以具有销凸起并连接轴壁。每个箱壁可以具有第一部分壁部分和第二部分壁部分。第一部分壁部分可以在销凸台和布置在压力侧的轴壁之间延伸。第二部分壁部分可以在销凸台和布置在反压侧的轴壁之间延伸。第一部分壁部分的第一纵向中心线可以会聚到第二部分壁部分的第二纵向中心线，其中第一和第二纵向中心线在活塞外部彼此相交。

7. 发明授权

US08605210B2 Optical module for a cellular phone 有权
标题翻译：用于蜂窝电话的光模块
公开(公告)号：US08605210B2
公开(公告)日：2013-12-10
申请号：US12996909
申请日：2009-09-10
申请人： Sebastien Fabre , Rainer Fischer , Mathias Schulz
发明人： Sebastien Fabre , Rainer Fischer , Mathias Schulz
IPC分类号： H04N5/225
CPC分类号： H04N5/335 , H04N5/2253 , H04N5/2257 , H05K1/182
摘要： The invention relates to an optical module for a cellular phone having an image sensor comprising a light sensitive upper side for detecting and converting optical signals into electrical signals, an imaging device for imaging the optical signals on the image sensor, and a circuit board comprising an upper side and a lower side electrically and mechanically connected to the image sensor. In order to create a particularly flat optical module, for example for integration into a cellular phone, the invention provides that the circuit board has a recess in which the image sensor is disposed such that a lower side of the image sensor is substantially located at the same height as the lower side of the circuit board.
摘要翻译：本发明涉及一种用于蜂窝电话的光学模块，其具有图像传感器，该图像传感器包括用于检测和将光信号转换为电信号的光敏上侧，用于对图像传感器上的光信号进行成像的成像装置，以及包括上侧和下侧电气地和机械地连接到图像传感器。为了创建特别平坦的光学模块，例如用于集成到蜂窝电话中，本发明提供了电路板具有凹部，图像传感器设置在该凹部中，使得图像传感器的下侧基本上位于与电路板下侧相同的高度。

8. 发明申请

US20130036997A1 PISTON 有权
标题翻译：活塞
公开(公告)号：US20130036997A1
公开(公告)日：2013-02-14
申请号：US13221498
申请日：2011-08-30
申请人： Ralf Braig , Rainer Fischer , Thomas Hettich , Peter Kleine , Michael Marquardt
发明人： Ralf Braig , Rainer Fischer , Thomas Hettich , Peter Kleine , Michael Marquardt
IPC分类号： F02F3/00
CPC分类号： F02F3/02
摘要： A piston for an internal combustion engine may include a piston head and a piston shaft. The piston shaft may have two shaft walls, one arranged on a pressure side and the other arranged on a counter-pressure side. Two box walls may have pin bosses and connect the shaft walls. Each of the box walls may have a first partial wall section and a second partial wall section. The first partial wall section may extend between the pin boss and the shaft wall arranged on the pressure side. The second partial wall section may extend between the pin boss and the shaft wall arranged on the counter-pressure side. A first longitudinal centre line of the first partial wall section is may be convergent to a second longitudinal centre line of the second partial wall section, wherein the first and second longitudinal centre lines—intersect each other outside the piston.
摘要翻译：用于内燃机的活塞可以包括活塞头和活塞轴。活塞轴可以具有两个轴壁，一个布置在压力侧，另一个布置在反压侧。两个箱壁可以具有销凸起并连接轴壁。每个箱壁可以具有第一部分壁部分和第二部分壁部分。第一部分壁部分可以在销凸台和布置在压力侧的轴壁之间延伸。第二部分壁部分可以在销凸台和布置在反压侧的轴壁之间延伸。第一部分壁部分的第一纵向中心线可以会聚到第二部分壁部分的第二纵向中心线，其中第一和第二纵向中心线在活塞外部彼此相交。

9. 发明申请

US20110086669A1 OPTICAL MODULE FOR A CELLULAR PHONE 有权
标题翻译：蜂窝电话的光模块
公开(公告)号：US20110086669A1
公开(公告)日：2011-04-14
申请号：US12996909
申请日：2009-09-10
申请人： Sebastien Fabre , Mathias Schulz , Rainer Fischer
发明人： Sebastien Fabre , Mathias Schulz , Rainer Fischer
IPC分类号： H04M1/00
CPC分类号： H04N5/335 , H04N5/2253 , H04N5/2257 , H05K1/182
摘要： The invention relates to an optical module for a cellular phone having an image sensor comprising a light sensitive upper side for detecting and converting optical signals into electrical signals, an imaging device for imaging the optical signals on the image sensor, and a circuit board comprising an upper side and a lower side electrically and mechanically connected to the image sensor. In order to create a particularly flat optical module, for example for integration into a cellular phone, the invention provides that the circuit board has a recess in which the image sensor is disposed such that a lower side of the image sensor is substantially located at the same height as the lower side of the circuit board.
摘要翻译：本发明涉及一种用于蜂窝电话的光学模块，其具有图像传感器，该图像传感器包括用于检测和将光信号转换为电信号的光敏上侧，用于对图像传感器上的光信号进行成像的成像装置，以及包括上侧和下侧电气地和机械地连接到图像传感器。为了创建特别平坦的光学模块，例如用于集成到蜂窝电话中，本发明提供了电路板具有凹部，图像传感器设置在该凹部中，使得图像传感器的下侧基本上位于与电路板下侧相同的高度。

10. 发明申请

US20070231321A1 Diabody which Specifically Binds Streptococcus Surface Antigen I/II and Methods of Use Thereof 有权
标题翻译：具体绑定链球菌表面抗原I / II的双抗体及其使用方法
公开(公告)号：US20070231321A1
公开(公告)日：2007-10-04
申请号：US11578641
申请日：2005-04-21
申请人： Ricarda Finnern , Rainer Fischer
发明人： Ricarda Finnern , Rainer Fischer
IPC分类号： A61K39/395 , C07K16/18 , C12N15/63 , C12N5/06
CPC分类号： C07K16/1275 , C07K2317/21 , C07K2317/622 , C07K2317/626
摘要： Common oral diseases such as periodontitis and dental caries can be prevented effectively by passive immunization. The present invention provides human single chain Fv (scFv) and diabody antibody fragments based on the binding characteristics of the murine monoclonal antibody Guy's 13. Like the parent antibody, these derivatives bind specifically to SAI/II, the surface adhesin of Streptococcus and the human diabody derivative is capable of aggregating streptococcal cells, making it a useful candidate therapeutic agent for passive immunization against oral diseases.
摘要翻译：普通口腔疾病如牙周炎和龋齿可以通过被动免疫有效的预防。本发明基于鼠单克隆抗体Guy's 13的结合特征提供人单链Fv（scFv）和双抗体抗体片段。与母体抗体相似，这些衍生物特异性结合SAI / II，链球菌和人类的表面粘附素双抗体衍生物能够聚集链球菌细胞，使其成为针对口腔疾病的被动免疫的有用的候选治疗剂。

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