专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08465484B2 Irreversible electroporation using nanoparticles 有权
标题翻译：使用纳米粒子的不可逆电穿孔
公开(公告)号：US08465484B2
公开(公告)日：2013-06-18
申请号：US12609779
申请日：2009-10-30
申请人： Rafael V. Davalos , Marissa N. Rylander , Christopher B. Arena
发明人： Rafael V. Davalos , Marissa N. Rylander , Christopher B. Arena
IPC分类号： A61B18/18
CPC分类号： A61B18/1477 , A61B18/1206 , A61B2018/00446 , A61B2018/00613 , A61N1/05 , A61N1/327 , C12N13/00
摘要： The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors. In embodiments, the methods comprise the use of high aspect ratio nanoparticles with or without modified surface chemistry.
摘要翻译：本发明提供用于体内治疗细胞增殖性疾病的方法，装置和系统。本发明可用于治疗诸如脑肿瘤的实体瘤。该方法依赖于非热不可逆电穿孔（IRE）在治疗的肿瘤中引起细胞死亡。在实施方案中，所述方法包括使用具有或不具有改性表面化学性质的高纵横比纳米颗粒。

2. 发明授权

US10471254B2 Selective modulation of intracellular effects of cells using pulsed electric fields 有权
公开(公告)号：US10471254B2
公开(公告)日：2019-11-12
申请号：US15310114
申请日：2015-05-12
申请人： Virginia Tech Intellectual Properties, Inc. , Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
发明人： Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
IPC分类号： A61B18/14 , A61N1/32 , A61N1/40 , A61B90/00 , A61B18/12 , A61N1/06 , A61N1/08 , A61B18/00 , A61B17/00
摘要： A system and method for selectively treating aberrant cells such as cancer cells through administration of a train of electrical pulses is described. The pulse length and delay between successive pulses is optimized to produce effects on intracellular membrane potentials. Therapies based on the system and method produce two treatment zones: an ablation zone surrounding the electrodes within which aberrant cells are non-selectively killed and a selective treatment zone surrounding the ablation zone within which target cells are selectively killed through effects on intracellular membrane potentials. As a result, infiltrating tumor cells within a tumor margin can be effectively treated while sparing healthy tissue. The system and method are useful for treating various cancers in which solid tumors form and have a chance of recurrence from microscopic disease surrounding the tumor.

3. 发明授权

US10448989B2 High-frequency electroporation for cancer therapy 有权
公开(公告)号：US10448989B2
公开(公告)日：2019-10-22
申请号：US13332133
申请日：2011-12-20
申请人： Christopher B. Arena , Rafael V. Davalos , Michael B. Sano
发明人： Christopher B. Arena , Rafael V. Davalos , Michael B. Sano
IPC分类号： A61B18/12 , A61B18/14 , A61N1/32 , A61B18/00
摘要： The present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.

4. 发明申请

US20120109122A1 HIGH-FREQUENCY ELECTROPORATION FOR CANCER THERAPY 审中-公开
标题翻译：用于癌症治疗的高频电泳
公开(公告)号：US20120109122A1
公开(公告)日：2012-05-03
申请号：US13332133
申请日：2011-12-20
申请人： Christopher B. ARENA , Rafael V. Davalos , Michael B. Sano
发明人： Christopher B. ARENA , Rafael V. Davalos , Michael B. Sano
IPC分类号： A61B18/00
CPC分类号： A61B18/14 , A61B2018/0016 , A61B2018/00577 , A61B2018/00613 , A61B2018/00761 , A61B2018/00767 , A61N1/327
摘要： The present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.
摘要翻译：本发明涉及疾病和病症的生物医学工程和医学治疗领域。提供了体内治疗细胞增殖性疾病的方法，装置和系统。在实施例中，这些方法包括输送高频脉冲串的双极脉冲以实现所需的细胞死亡模式。更具体地，本发明的实施例涉及使用高频双极电脉冲来破坏包括肿瘤组织的异常细胞的装置和方法，所述高频双极电脉冲具有微秒级的微秒级和单极性的持续时间，微秒至纳秒级。在实施方案中，所述方法依赖于常规电穿孔辅助药物或不可逆电穿孔以在治疗的肿瘤中引起细胞死亡。本发明可用于治疗诸如脑肿瘤的实体瘤。

5. 发明授权

US10702326B2 Device and method for electroporation based treatment of stenosis of a tubular body part 有权
公开(公告)号：US10702326B2
公开(公告)日：2020-07-07
申请号：US13550307
申请日：2012-07-16
申请人： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , Peter Callas
发明人： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , Peter Callas
IPC分类号： A61B18/18 , A61B18/00 , A61B18/14 , A61B90/00
摘要： The present invention relates to medical devices and methods for treating a lesion such as a vascular stenosis using non-thermal irreversible electroporation (NTIRE). Embodiments of the present invention provide a balloon catheter type NTIRE device for treating a target lesion comprising a plurality of electrodes positioned along the balloon that are electrically independent from each other so as to be individually selectable in order to more precisely treat an asymmetrical lesion in which the lesion extends only partially around the vessel.

6. 发明授权

US08992517B2 Irreversible electroporation to treat aberrant cell masses 有权
标题翻译：不可逆电穿孔治疗异常细胞团
公开(公告)号：US08992517B2
公开(公告)日：2015-03-31
申请号：US12491151
申请日：2009-06-24
申请人： Rafael V. Davalos , Paulo A. Garcia , John H. Rossmeisl , John L. Robertson , Robert E. Neal
发明人： Rafael V. Davalos , Paulo A. Garcia , John H. Rossmeisl , John L. Robertson , Robert E. Neal
IPC分类号： A61B18/14 , A61N1/32 , C12N13/00 , A61N1/05
CPC分类号： A61B18/1477 , A61B18/1206 , A61B2018/00446 , A61B2018/00613 , A61N1/05 , A61N1/327 , C12N13/00
摘要： The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.
摘要翻译：本发明提供用于体内治疗细胞增殖性疾病的方法，装置和系统。本发明可用于治疗诸如脑肿瘤的实体瘤。该方法依赖于非热不可逆电穿孔（IRE）在治疗的肿瘤中引起细胞死亡。

7. 发明申请

US20130253415A1 IRREVERSIBLE ELECTROPORATION USING TISSUE VASCULATURE TO TREAT ABERRANT CELL MASSES OR CREATE TISSUE SCAFFOLDS 有权
标题翻译：不可逆电气使用组织血管来治疗细胞质量或产生组织病变
公开(公告)号：US20130253415A1
公开(公告)日：2013-09-26
申请号：US13989175
申请日：2011-11-23
申请人： Michael B. Sano , Rafael V. Davalos , John L. Robertson , Paulo A. Garcia , Robert E. Neal
发明人： Michael B. Sano , Rafael V. Davalos , John L. Robertson , Paulo A. Garcia , Robert E. Neal
IPC分类号： A61B18/14 , A61M5/00
CPC分类号： A61B18/14 , A61B18/1492 , A61B2018/00613 , A61B2018/1472 , A61B2218/002 , A61K48/0075 , A61M5/00 , A61N1/327
摘要： The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.
摘要翻译：本发明涉及疾病和病症的医疗领域以及生物医学工程领域。本发明的实施方案涉及通过器官脉管系统递送不可逆电穿孔（IRE）以治疗深入组织或器官内的肿瘤，或者使现有动物组织脱细胞从而使现有的脉管系统完整地产生支架。特别地，提供了在体内施用非热不可逆电穿孔（IRE）的方法用于治疗位于血管化组织和器官中的肿瘤。本发明的实施方案进一步提供了使用IRE离体产生的来自天然来源的支架和组织，以去除细胞碎片，最大限度地获得细胞结合潜能，并使异物免疫应答最小化。工程组织可用于治疗受试者的方法，例如需要组织置换或增生的方法。

8. 发明申请

US20120190078A1 THREE-DIMENSIONAL BIOPRINTING OF BIOSYNTHETIC CELLULOSE (BC) IMPLANTS AND SCAFFOLDS FOR TISSUE ENGINEERING 有权
标题翻译：生物塑料纤维素（BC）植物和组织的组织工程三维生物学
公开(公告)号：US20120190078A1
公开(公告)日：2012-07-26
申请号：US13498657
申请日：2010-09-28
申请人： Paul Gatenholm , Henrik Backdahl , Theodore Jon Tzavaras , Rafael V. Davalos , Michael B. Sano
发明人： Paul Gatenholm , Henrik Backdahl , Theodore Jon Tzavaras , Rafael V. Davalos , Michael B. Sano
IPC分类号： C12P19/04 , C12N5/02 , C12N11/12
CPC分类号： C08B1/00 , A61L27/20 , A61L27/38 , A61L27/56 , A61L2400/12 , C12N5/0062 , C12N11/12 , C12N2533/78 , C12P19/04 , C08L1/02
摘要： A novel BC fermentation technique for controlling 3D shape, thickness and architecture of the entangled cellulose nano-fibril network is presented. The resultant nano-cellulose based structures are useful as biomedical implants and devices, are useful for tissue engineering and regenerative medicine, and for health care products. More particularly, embodiments of the present invention relate to systems and methods for the production and control of 3-D architecture and morphology of nano-cellulose biomaterials produced by bacteria using any biofabrication process, including the novel 3-D Bioprinting processes disclosed. Representative processes according to the invention involve control of the rate of production of biomaterial by bacteria achieved by meticulous control of the addition of fermentation media using a microfluidic system. In exemplary embodiments, the bacteria gradually grew up along the printed alginate structure that had been placed into the culture, incorporating it. After culture, the printed alginate structure was successfully removed revealing porosity where the alginate had been placed. Porosity and interconnectivity of pores in the resultant 3-D architecture can be achieved by porogen introduction using, e.g., ink-jet printer technology.
摘要翻译：提出了一种用于控制缠结纤维素纳米纤维网络的3D形状，厚度和结构的新型BC发酵技术。所得的纳米纤维素基结构可用作生物医学植入物和装置，可用于组织工程和再生医学以及保健产品。更具体地说，本发明的实施方案涉及使用任何生物制造方法生产和控制由细菌生产的纳米纤维素生物材料的三维结构和形态的系统和方法，包括所公开的新型3-D生物印迹方法。根据本发明的代表性方法涉及通过细微控制使用微流体系统添加发酵培养基来控制细菌生物材料的生产速率。在示例性实施方案中，细菌沿已经放入培养物中的印刷的藻酸盐结构逐渐长大，并入其中。培养后，成功去除了印刷的藻酸盐结构，显示了藻酸盐放置的孔隙度。所得3-D结构中孔隙的孔隙率和互连性可以通过使用例如喷墨打印机技术的致孔剂引入来实现。

9. 发明申请

US20110106221A1 TREATMENT PLANNING FOR ELECTROPORATION-BASED THERAPIES 有权
标题翻译：电子治疗治疗计划
公开(公告)号：US20110106221A1
公开(公告)日：2011-05-05
申请号：US12906923
申请日：2010-10-18
申请人： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
发明人： Robert E. Neal, II , Paulo A. Garcia , Rafael V. Davalos , John H. Rossmeisl , John L. Robertson
IPC分类号： A61N1/32 , A61N1/00 , G06F17/50
CPC分类号： C12N13/00 , A61B34/10 , A61B2018/00613 , A61B2034/104 , A61B2034/105 , A61N1/0412 , G16H50/50
摘要： The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.
摘要翻译：本发明提供了用于基于电穿孔的疗法（EBT）的系统，方法和装置。实施例提供了通过从组织拍摄的图像对目标组织进行3D重建的数值模拟得出的患者特异性治疗方案，并且可选地考虑物理约束或动态组织属性中的一种或多种。本发明还涉及用于递送用于不可逆电穿孔的双极电脉冲的系统，方法和装置，其显示对EBT诱导的递送至组织的过量电荷通常相关的组织的减少或不损伤。

10. 发明授权

US09867652B2 Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds 有权
公开(公告)号：US09867652B2
公开(公告)日：2018-01-16
申请号：US13989175
申请日：2011-11-23
申请人： Michael B. Sano , Rafael V. Davalos , John L. Robertson , Paulo A. Garcia , Robert E. Neal, II
发明人： Michael B. Sano , Rafael V. Davalos , John L. Robertson , Paulo A. Garcia , Robert E. Neal, II
IPC分类号： A61B18/14 , A61K48/00 , A61M5/00 , A61B18/00 , A61N1/32
CPC分类号： A61B18/14 , A61B18/1492 , A61B2018/00613 , A61B2018/1472 , A61B2218/002 , A61K48/0075 , A61M5/00 , A61N1/327
摘要： The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式