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1. 发明授权

US11226328B2 Method of detecting the presence or absence of a clot in a liquid sample analyzer 有权
公开(公告)号：US11226328B2
公开(公告)日：2022-01-18
申请号：US16064707
申请日：2016-12-19
申请人： Radiometer Medical ApS
发明人： Peter Aage Frischauf , Michael Taagaard , Flemming Aas
IPC分类号： G01N33/49 , A61B5/1495 , G01N27/416
摘要： A method of detecting a clot in a measurement chamber of a liquid sample analyzer, the liquid sample analyzer comprising one or more analyte sensors, each one of the one or more analyte sensors being arranged for measuring a physical parameter for a respective analyte in a liquid sample in the measurement chamber, wherein detection is performed after conclusion of a rinsing procedure with a primary solution (Cal2) having a pre-determined primary composition with a primary level of the analyte, the method comprising the steps of: (a) at least partly filling the measurement chamber with a secondary solution (Rinse/Cal1) having a pre-determined secondary composition with a respective secondary level for each of the analytes, wherein the respective secondary level is different from the respective primary level; (b) immediately after filling the measurement chamber with the secondary solution (Rinse/Cal1), obtaining an initial measurement result by each of the one or more analyte sensors; (c) flushing the measurement chamber with the secondary solution (Rinse/Cal1); (d) after a time delay with respect to the initial measurement result, obtaining a subsequent measurement result by each of the one or more analyte sensors; (e) comparing the respective initial and subsequent measurement results; and (f) determining presence or absence of a clot in the measurement chamber based on the comparison.

2. 发明授权

US11169141B2 Method of detecting presence or absence of a clot in a liquid sample analyzer 有权
公开(公告)号：US11169141B2
公开(公告)日：2021-11-09
申请号：US16064742
申请日：2016-12-19
申请人： Radiometer Medical ApS
发明人： Michael Taagaard , Peter Aage Frischauf , Flemming Aas
IPC分类号： G01N33/49 , A61B5/1495 , A61B5/145 , G01N27/327 , G01N33/00
摘要： The invention relates to a method of detecting a clot in a measurement chamber of a liquid sample analyzer, wherein the liquid sample analyzer comprises at least two analyte sensors, a first analyte sensor, for measuring a first analyte in a liquid sample, and one or more second analyte sensors, for measuring one or more second analytes in the liquid sample in the measurement chamber, the method comprising the steps of, (a) at least partly filling the measurement chamber with a known solution having a composition comprising the first analyte at a pre-determined level, and the second one or more analytes at pre-determined levels, (b) obtaining a first sequence of measurement results by the first analyte sensor, and simultaneously obtaining a second sequence of measurement results by the second, one or more analyte sensors, (c) determining a change of the first sequence of measurement results, (d) determining a change of the second one or more sequence of measurement results, (e) comparing the change of the first sequence of measurement results with the second sequence of measurement results, (f) determining presence or absence of a clot in the measurement chamber based on said comparison.

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