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1. 发明申请

WO2008120181A2 A METHOD OF PRODUCING FAST DISSOLVING TABLETS 审中-公开
标题翻译：生产快速溶解片的方法
公开(公告)号：WO2008120181A2
公开(公告)日：2008-10-09
申请号：PCT/IE2008/000036
申请日：2008-04-03
申请人： ROYAL COLLEGE OF SURGEONS IN IRELAND , RAMTOOLA, Zebunnissa , PABARI, Ritesh , KELLY, John
发明人： RAMTOOLA, Zebunnissa , PABARI, Ritesh , KELLY, John
IPC分类号： A61K9/00 , A61K9/20
CPC分类号： A61K9/2018 , A61K9/0056 , A61K9/1635 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2081 , A61K9/2095 , A61K9/5026
摘要： A method of producing a fast-melt tablet comprises the steps of forming a mixture of components, the mixture comprising at least one fast dissolving sugar alcohol, at least one disintegrant or osmotic agent, and at least one an active component, blending the mixture for a period of time, and directly compressing the blended mixture at a compression force of typically between 5 and 2OkN to form the fast-melt tablet. The process of the invention does not involve any granulation step, thereby making the process more energy efficient and cost effective. The fast dissolving sugar alcohol is selected from the group comprising: mannitol; sorbitol; erythritol; xylitol; lactose; dextrose; and sucrose, and comprises at least 50%, preferably at least 60%, and more preferably at least 70%, of the tablet (w/w). The active component is suitably provided in the form of microparticles or microcapsules having an average diameter of less than 125 microns. Also described are directly compressed fast dissolving type tablets obtainable by the process of the invention. The tablets typically are flat-faced.
摘要翻译：制备快速熔融片剂的方法包括以下步骤：形成组分的混合物，所述混合物包含至少一种快速溶解糖醇，至少一种崩解剂或渗透剂和至少一种活性组分，将该混合物混合一段时间，并以通常在5至20kN之间的压缩力直接压缩混合的混合物以形成快速熔融的片剂。本发明的方法不涉及任何造粒步骤，从而使得该方法更节能和成本有效。快溶糖醇选自：甘露醇; 山梨糖醇; 赤藓糖醇; 木糖醇; 乳糖; 葡萄糖; 和蔗糖，并且包含片剂（w / w）的至少50％，优选至少60％，更优选至少70％。活性组分合适地以平均直径小于125微米的微粒或微胶囊的形式提供。还描述了通过本发明的方法可获得的直接压缩的快速溶解型片剂。平板电脑通常是平面的。

2. 发明申请

WO2006013084A1 PHENYTOIN FORMULATIONS, AND USES THEREOF IN WOUND HEALING 审中-公开
标题翻译：苯妥英制剂及其在治疗中的应用
公开(公告)号：WO2006013084A1
公开(公告)日：2006-02-09
申请号：PCT/EP2005/008344
申请日：2005-08-02
申请人： ROYAL COLLEGE OF SURGEONS IN IRELAND , KELLY, John , KENNEDY, Cormac , MEANEY, Clare
发明人： KELLY, John , KENNEDY, Cormac , MEANEY, Clare
IPC分类号： A61K9/06
CPC分类号： A61K31/415 , A61K9/0014 , A61L15/44 , A61L15/60 , A61L26/0066 , A61L26/0076 , A61L2300/204 , A61L2300/802
摘要： A formulation of phenytoin suitable for topical application to a wound comprises a reservoir of phenytoin entrapped within a stabilising matrix, and an amount of dissolved phenytoin, wherein the dissolved phenytoin is in chemical equilibrium with the phenytoin entrapped within the stabilised matrix. The stabilised matrix may comprise a gel matrix, especially a gel matrix in which the polymer of the gel forms ion-pairs with the phenytoin. Also described are methods of treating a wound in diabetic and non-diabetic patients using a formulation according to the invention.
摘要翻译：适用于局部施用于伤口的苯妥英制剂包含截留在稳定基质内的苯妥英的储存器和一定量的溶解的苯妥英，其中溶解的苯妥英与截留在稳定化基质内的苯妥英化学平衡。稳定的基质可以包含凝胶基质，特别是凝胶基质，其中凝胶的聚合物与苯妥英形成离子对。还描述了使用根据本发明的制剂治疗糖尿病和非糖尿病患者的伤口的方法。

3. 发明公开

EP2142170A2 A METHOD OF PRODUCING FAST DISSOLVING TABLETS 无效
标题翻译：用于生产快速定义片剂
公开(公告)号：EP2142170A2
公开(公告)日：2010-01-13
申请号：EP08719894.1
申请日：2008-04-03
申请人： The Royal College of Surgeons in Ireland
发明人： RAMTOOLA, Zebunnissa , PABARI, Ritesh , KELLY, John
IPC分类号： A61K9/00 , A61K9/20 , A61K47/42 , A61K47/30
CPC分类号： A61K9/2018 , A61K9/0056 , A61K9/1635 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2081 , A61K9/2095 , A61K9/5026
摘要： A method of producing a fast-melt tablet comprises the steps of forming a mixture of components, the mixture comprising at least one fast dissolving sugar alcohol, at least one disintegrant or osmotic agent, and at least one an active component, blending the mixture for a period of time, and directly compressing the blended mixture at a compression force of typically between 5 and 2OkN to form the fast-melt tablet. The process of the invention does not involve any granulation step, thereby making the process more energy efficient and cost effective. The fast dissolving sugar alcohol is selected from the group comprising: mannitol; sorbitol; erythritol; xylitol; lactose; dextrose; and sucrose, and comprises at least 50%, preferably at least 60%, and more preferably at least 70%, of the tablet (w/w). The active component is suitably provided in the form of microparticles or microcapsules having an average diameter of less than 125 microns. Also described are directly compressed fast dissolving type tablets obtainable by the process of the invention. The tablets typically are flat-faced.

4. 发明公开

EP1786397A1 PHENYTOIN FORMULATIONS, AND USES THEREOF IN WOUND HEALING 有权
标题翻译： PHENYTOINFORMULIERUNGEN和用途伤口愈合
公开(公告)号：EP1786397A1
公开(公告)日：2007-05-23
申请号：EP05776796.4
申请日：2005-08-02
申请人： Royal College of Surgeons in Ireland
发明人： KELLY, John , KENNEDY, Cormac , MEANEY, Clare
IPC分类号： A61K9/06 , A61K9/00 , A61K31/415 , A61K47/38 , A61K47/40 , A61K47/42 , A61K9/12 , A61K9/107
CPC分类号： A61K31/415 , A61K9/0014 , A61L15/44 , A61L15/60 , A61L26/0066 , A61L26/0076 , A61L2300/204 , A61L2300/802
摘要： A formulation of phenytoin suitable for topical application to a wound comprises a reservoir of phenytoin entrapped within a stabilising matrix, and an amount of dissolved phenytoin, wherein the dissolved phenytoin is in chemical equilibrium with the phenytoin entrapped within the stabilised matrix. The stabilised matrix may comprise a gel matrix, especially a gel matrix in which the polymer of the gel forms ion-pairs with the phenytoin. Also described are methods of treating a wound in diabetic and non-diabetic patients using a formulation according to the invention.

5. 发明授权

EP2142170B1 A METHOD OF PRODUCING FAST DISSOLVING TABLETS 无效
标题翻译：用于生产快速定义片剂
公开(公告)号：EP2142170B1
公开(公告)日：2011-11-16
申请号：EP08719894.1
申请日：2008-04-03
申请人： Royal College of Surgeons in Ireland
发明人： RAMTOOLA, Zebunnissa , PABARI, Ritesh , KELLY, John
IPC分类号： A61K9/00 , A61K9/20 , A61K47/42 , A61K47/30
CPC分类号： A61K9/2018 , A61K9/0056 , A61K9/1635 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2081 , A61K9/2095 , A61K9/5026
摘要： A method of producing a fast-melt tablet comprises the steps of forming a mixture of components, the mixture comprising at least one fast dissolving sugar alcohol, at least one disintegrant or osmotic agent, and at least one an active component, blending the mixture for a period of time, and directly compressing the blended mixture at a compression force of typically between 5 and 20kN to form the fast-melt tablet. The process of the invention does not involve any granulation step, thereby making the process more energy efficient and cost effective. The fast dissolving sugar alcohol is selected from the group comprising: mannitol; sorbitol; erythritol; xylitol; lactose; dextrose; and sucrose, and comprises at least 50%, preferably at least 60%, and more preferably at least 70%, of the tablet (w/w). The active component is suitably provided in the form of microparticles or microcapsules having an average diameter of less than 125 microns. Also described are directly compressed fast dissolving type tablets obtainable by the process of the invention.

6. 发明授权

EP1786397B1 PHENYTOIN FORMULATIONS, AND USES THEREOF IN WOUND HEALING 有权
标题翻译： PHENYTOINFORMULIERUNGEN和用途伤口愈合
公开(公告)号：EP1786397B1
公开(公告)日：2011-05-18
申请号：EP05776796.4
申请日：2005-08-02
申请人： Royal College of Surgeons in Ireland
发明人： KELLY, John , KENNEDY, Cormac , MEANEY, Clare
IPC分类号： A61K9/06 , A61K9/00 , A61K31/415 , A61K47/38 , A61K47/40 , A61K47/42 , A61K9/12 , A61K9/107
CPC分类号： A61K31/415 , A61K9/0014 , A61L15/44 , A61L15/60 , A61L26/0066 , A61L26/0076 , A61L2300/204 , A61L2300/802
摘要： A formulation of phenyloin suitable for topical application to a wound comprises a reservoir of phenyloin entrapped within a stabilising matrix, and an amount of dissolved phenyloin, wherein the dissolved phenyloin is in chemical equilibrium with the phenyloin entrapped within the stabilised matrix. The stabilised matrix may comprise a gel matrix, especially a gel matrix in which the polymer of the gel forms ion-pairs with the phenyloin. Also described are methods of treating a wound in diabetic and non-diabetic patients using a formulation according to the invention.

7. 发明公开

EP2632364A1 NEUROMODULATION CRYOTHERAPEUTIC DEVICES AND ASSOCIATED SYSTEMS AND METHODS 有权转让
公开(公告)号：EP2632364A1
公开(公告)日：2013-09-04
申请号：EP11778763.0
申请日：2011-10-24
申请人： Buckley, Naomi , Clark, Benjamin J. , Cummins, Michael , Donovan, Danny , Gelfand, Mark , Hughes, Luke , Kelly, Brian , Kelly, Gary , Kelly, Grace , Kelly, John , Leung, Mark S. , McMullin, Gwenda , Mullins, Barry , Naga, Karun D. , Nash, Stephen , Ryba, Eric , Sweeney, Fiachra , Tilotta, Vicenzo , Woolley, Lana , Zarins, Denise , Medtronic Ardian Luxembourg S.à.r.l.
发明人： BUCKLEY, Naomi , CLARK, Benjamin J. , CUMMINS, Michael , DONOVAN, Danny , GELFAND, Mark , HUGHES, Luke , KELLY, Brian , KELLY, Gary , KELLY, Grace , KELLY, John , LEUNG, Mark S. , McMULLIN, Gwenda , MULLINS, Barry , NAGA, Karun D. , NAASH, Stephen , RYBA, Eric , SWEENEY, Fiachra , TILOTTA, Vincenzo , WOOLLEY, Lana , ZARINS, Denise
IPC分类号： A61B18/02
摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

8. 发明申请

WO2011095435A2 STAIN BLOCKING COMPOSITIONS INCLUDING AN ALKYL AMIDE 审中-公开
标题翻译：包含烷基酰胺的污渍组合物
公开(公告)号：WO2011095435A2
公开(公告)日：2011-08-11
申请号：PCT/EP2011/051198
申请日：2011-01-28
申请人： BASF SE , WILDESON, Jacob , KELLY, John
发明人： WILDESON, Jacob , KELLY, John
IPC分类号： C09D133/00
CPC分类号： C09D133/00 , C08K5/20 , C09D5/024 , C09D7/63
摘要： An aqueous coating composition for blocking stains and a method of using the coating composition are described. The coating composition includes an aqueous dispersion of a co- polymer that is derived from an emulsion polymerization of an ethylenically unsaturated non-ionic monomer, an ethylenically unsaturated monomer with a functional acid group having a pKa of 2 or greater or salt thereof, and an alkyl amide.
摘要翻译：描述了用于阻挡污渍的水性涂料组合物和使用该涂料组合物的方法。所述涂料组合物包含共聚物的水分散体，所述共聚物衍生自烯键式不饱和非离子单体，具有pKa为2或更大的官能酸基团的烯键式不饱和单体或其盐以及烷基酰胺。

9. 发明申请

WO2012059722A2 APPARATUS FOR IDENTIFYING INTERCONNECTIONS AND/OR DETERMINING THE PHYSICAL STATE OF CABLE LINES IN A NETWORK AND ASSOCIATED COMPONENTS 审中-公开
标题翻译：用于识别网络和相关组件中的互连和/或确定电缆线物理状态的装置
公开(公告)号：WO2012059722A2
公开(公告)日：2012-05-10
申请号：PCT/GB2011/001558
申请日：2011-11-03
申请人： CABLE SENSE LIMITED , PEYTON, Anthony , KELLY, John
发明人： PEYTON, Anthony , KELLY, John
IPC分类号： H04Q1/14
CPC分类号： H04L43/50 , H04Q1/136
摘要： An apparatus for identifying interconnections in a network. The apparatus comprises a plurality of transmitter coupling units, a plurality of receiver coupling units, and an interconnection identification means configured to identify interconnections between the transmitter coupling units and the receiver coupling units by cable lines in the network. In some embodiments, the interconnection identification means is configured to, if any one of the transmitter coupling units is coupled to the same cable line as a selected one of the receiver coupling units, identify the interconnection between the transmitter coupling unit and the selected receiver coupling unit according to by a binary tree search algorithm.
摘要翻译：一种用于识别网络中的互连的装置。该装置包括多个发射器耦合单元，多个接收器耦合单元以及配置成通过网络中的电缆线识别发射器耦合单元和接收器耦合单元之间的互连的互连识别装置。在一些实施例中，互连识别装置被配置为，如果发射器耦合单元中的任何一个耦合到与选定的一个接收器耦合单元相同的电缆线，则识别发射器耦合单元和选择的接收器耦合器之间的互连单位根据二叉树搜索算法。

10. 发明申请

WO2012058159A1 NEUROMODULATION CRYOTHERAPEUTIC DEVICES AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
公开(公告)号：WO2012058159A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/057502
申请日：2011-10-24
申请人： BUCKLEY, Naomi , CLARK, Benjamin, J. , CUMMINS, Michael , DONOVAN, Danny , GELFAND, Mark , HUGHES, Luke , KELLY, Brian , KELLY, Gary , KELLY, Grace , KELLY, John , LEDWITH, Seamus , LEUNG, Mark, S. , MCMULLIN, Gwenda , MULLINS, Barry , NAGA, Karun, D. , NASH, Stephen , PICCAGLI, Francesco , RYBA, Eric , SWEENEY, Fiachra , TILOTTA, Vicenzo , TUROVSKIY, Roman , WOOLLEY, Lana , ZARINS, Denise
发明人： BUCKLEY, Naomi , CLARK, Benjamin, J. , CUMMINS, Michael , DONOVAN, Danny , GELFAND, Mark , HUGHES, Luke , KELLY, Brian , KELLY, Gary , KELLY, Grace , KELLY, John , LEDWITH, Seamus , LEUNG, Mark, S. , MCMULLIN, Gwenda , MULLINS, Barry , NAGA, Karun, D. , NASH, Stephen , PICCAGLI, Francesco , RYBA, Eric , SWEENEY, Fiachra , TILOTTA, Vicenzo , TUROVSKIY, Roman , WOOLLEY, Lana , ZARINS, Denise
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/22054 , A61B2017/22067 , A61B2018/00023 , A61B2018/00166 , A61B2018/0022 , A61B2018/00232 , A61B2018/0025 , A61B2018/00261 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/0212 , A61B2018/0262
摘要： Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

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