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1. 发明申请

WO2010004562A3 METHODS AND COMPOSITIONS FOR DETECTING COLORECTAL CANCER 审中-公开
公开(公告)号：WO2010004562A3
公开(公告)日：2010-01-14
申请号：PCT/IL2009/000683
申请日：2009-07-08
申请人： ROSETTA GENOMICS LTD. , MOR RESEARCH APPLICATIONS LTD. , BRENNER, Baruch , GILAD, Shlomit , GOREN, Yaron , CHAJUT, Ayelet
发明人： BRENNER, Baruch , GILAD, Shlomit , GOREN, Yaron , CHAJUT, Ayelet
IPC分类号： C12Q1/68
摘要： The invention provides a method for conducting minimally-invasive early detection of colorectal cancer and/or of colorectal cancer precursor cells, by using microRNA molecules associated with colorectal cancer, as well as various nucleic acid molecules relating thereto or derived thereof.

2. 发明申请

WO2009093254A2 METHODS AND COMPOSITIONS FOR DIAGNOSING COMPLICATIONS OF PREGNANCY 审中-公开
标题翻译：用于诊断孕妇综合征的方法和组合
公开(公告)号：WO2009093254A2
公开(公告)日：2009-07-30
申请号：PCT/IL2009/000101
申请日：2009-01-26
申请人： ROSETTA GENOMICS LTD. , MOR RESEARCH APPLICATIONS , GOREN, Yaron , GILAD, Shlomit , HOD, Moshe , YOGEV, Yariv
发明人： GOREN, Yaron , GILAD, Shlomit , HOD, Moshe , YOGEV, Yariv
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158 , C12Q2600/178
摘要： The present invention provides methods and compositions for identifying subjects at risk of developing a complication of pregnancy, such as preeclampsia or preterm labor. The compositions are microRNAs and associated nucleic acids.
摘要翻译：本发明提供了用于鉴定发生怀孕并发症风险的受试者的方法和组合物，例如先兆子痫或早产。组合物是微小RNA和相关核酸。

3. 发明申请

WO2010103522A1 METHOD FOR DETECTION OF NUCLEIC ACID SEQUENCES 审中-公开
标题翻译：检测核酸序列的方法
公开(公告)号：WO2010103522A1
公开(公告)日：2010-09-16
申请号：PCT/IL2010/000206
申请日：2010-03-10
申请人： ROSETTA GENOMICS LTD. , BEN GURION UNIVERSITY OF THE NEGEV , GILAD, Shlomit , SHEMER AVNI, Yonat
发明人： GILAD, Shlomit , SHEMER AVNI, Yonat
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6813 , C12Q2525/207
摘要： The present invention provides a method to detect and quantify RNAs with high sensitivity and specificity. The method makes use of polyadenylation, primers, and general probes for the detection of RNA sequences including mRNAs and short RNA sequences such as miRNA.
摘要翻译：本发明提供了一种以高灵敏度和特异性检测和定量RNA的方法。该方法利用多聚腺苷酸化，引物和一般探针检测RNA序列，包括mRNA和短RNA序列，如miRNA。

4. 发明申请

WO2003025203A2 PREDICTION OF CANCER BY DETECTION OF ATM MUTATIONS 审中-公开
标题翻译：通过检测ATM突变预测癌症
公开(公告)号：WO2003025203A2
公开(公告)日：2003-03-27
申请号：PCT/US2002/030015
申请日：2002-09-20
申请人： QUARK BIOTECH, INC. , GILAD, Shlomit , YAHALOM, Joachim
发明人： GILAD, Shlomit , YAHALOM, Joachim
IPC分类号： C12Q
CPC分类号： C12Q1/6827 , C12Q1/6886 , C12Q2600/156
摘要： There is provided a method of testing a subject to determine if the subject has a predisposition for developing a cancer, a cancer of epithelial origin such as lung cancer, colon cancer, prostate cancer, ovarian cancer, bladder cancer, and cancer of the pancreas, and also a lymphoproliferative malignancy such as Hodgkin's disease and non-Hodgkin's lymphoma. This method includes the steps of detecting a mutation in the open reading frame of the ATM gene (SEQ.ID.NO:1) in a cDNA sample or a genomic DNA sample from the subject, which mutation is selected from the group consisting of the mutations set forth in Table 3 and Table 4; or, detecting a mutation in the mRNA corresponding to the open reading frame of the ATM gene (SEQ.ID.NO:1) in a mRNA sample from the subject, which mutation is selected from the group consisting of RNA complementary to the mutations set forth in Table 3 and Table 4, wherein the presence of such a mutation indicates that the subject has a predisposition for developing cancer. Also provided is an isolated cDNA molecule having a nucleotide sequence which differs from the sequence set forth in SEQ.ID.NO:1 by a mutation selected from the group consisting of mutations 378 T→A, 3383 A→G, 1636 C→G, 2614 C→T, 6437 G→C, 2932 T→C, 2289 T→A, 6096 A→T, 6176 C→T, 6919 C→T, 2442 C→A, 3925 G→A, 6067 G→A, 2119 T→C, 1810 C→T, and 4388 T→G. An oligonucleotide probe which is capable of detecting a mutation in the open reading frame of the ATM gene is also provided. Additionally, kits for detection and prediction of cancer are provided.
摘要翻译：提供了一种测试受试者以确定受试者是否具有发展癌症，上皮来源癌症如肺癌，结肠癌，前列腺癌，卵巢癌，膀胱癌和胰腺癌的倾向的方法，以及淋巴增生性恶性肿瘤如霍奇金病和非霍奇金淋巴瘤。该方法包括检测cDNA样品中的ATM基因（SEQ ID NO：1）的开放阅读框中的突变或来自受试者的基因组DNA样品中的突变，所述突变选自表3和表4所示的突变; 或者检测来自受试者的mRNA样品中与ATM基因（SEQ ID NO：1）的开放阅读框相对应的mRNA的突变，该突变选自与突变组互补的RNA 在表3和表4中，其中存在这样的突变表明受试者具有发生癌症的倾向。还提供了具有与SEQ.ID.NO:1所示序列不同的核苷酸序列的分离的cDNA分子，其选自突变378T} A，3383A} G，1636C} G ，2614 C} T，6437 G} C，2932 T} C，2289 T} A，6096 A} T，6176 C} T，6919 C} T，2442 C} A，3925 G} A，6067 G} A ，2119 T} C，1810 C} T和4388 T} G。还提供了能够检测ATM基因的开放阅读框中的突变的寡核苷酸探针。此外，还提供了用于癌症检测和预测的试剂盒。

5. 发明申请

WO2004111182A2 METHODS FOR CLONING NUCLEIC ACIDS IN A DESIRED ORIENTATION 审中-公开
标题翻译：在想要的方位克隆核酸的方法
公开(公告)号：WO2004111182A2
公开(公告)日：2004-12-23
申请号：PCT/IL2004/000515
申请日：2004-06-15
申请人： QUARK BIOTECH, INC. , EINAT, Paz , ZEVIN-SONKIN, Dina , GILAD, Shlomit
发明人： EINAT, Paz , ZEVIN-SONKIN, Dina , GILAD, Shlomit
IPC分类号： C12N
CPC分类号： C12N15/64 , C12N15/10 , C12N15/66
摘要： The present invention provides highly accurate methods for cloning nucleic acids in a desired, pre-defined orientation, and additionally provides for a library of cloned oriented nucleic acids. The ability to control the orientation of a nucleic acid being cloned is highly important in various molecular biology applications.
摘要翻译：本发明提供用于以期望的预定义取向克隆核酸的高度精确的方法，并另外提供克隆的定向核酸文库。控制被克隆的核酸取向的能力在各种分子生物学应用中是非常重要的。

6. 发明公开

EP2234483A2 METHODS AND COMPOSITIONS FOR DIAGNOSING COMPLICATIONS OF PREGNANCY 审中-公开
标题翻译：方法和组合物诊断妊娠并发症
公开(公告)号：EP2234483A2
公开(公告)日：2010-10-06
申请号：EP09703376.5
申请日：2009-01-26
申请人： Rosetta Genomics Ltd , MOR Research Applications
发明人： GOREN, Yaron , GILAD, Shlomit , HOD, Moshe , YOGEV, Yariv
IPC分类号： A01N43/04 , A61K31/70 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158 , C12Q2600/178
摘要： The present invention provides methods and compositions for identifying subjects at risk of developing a complication of pregnancy, such as preeclampsia or preterm labor. The compositions are microRNAs and associated nucleic acids.

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