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1. 发明申请

WO2010004562A2 METHODS AND COMPOSITIONS FOR DETECTING COLORECTAL CANCER 审中-公开
标题翻译：检测大肠癌的方法和组合物
公开(公告)号：WO2010004562A2
公开(公告)日：2010-01-14
申请号：PCT/IL2009000683
申请日：2009-07-08
申请人： ROSETTA GENOMICS LTD , MOR RESEARCH APPLIC LTD , BRENNER BARUCH , GILAD SHLOMIT , GOREN YARON , CHAJUT AYELET
发明人： BRENNER BARUCH , GILAD SHLOMIT , GOREN YARON , CHAJUT AYELET
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6809 , C12Q2600/158 , C12Q2600/178 , C12Q2525/207
摘要： The invention provides a method for conducting minimally-invasive early detection of colorectal cancer and/or of colorectal cancer precursor cells, by using microRNA molecules associated with colorectal cancer, as well as various nucleic acid molecules relating thereto or derived thereof.
摘要翻译：本发明提供了通过使用与结肠直肠癌相关的微RNA分子以及与其相关或其衍生的各种核酸分子进行结肠直肠癌和/或结肠直肠癌前体细胞的微创早期检测的方法。

2. 发明申请

WO2009093254A3 METHODS AND COMPOSITIONS FOR DIAGNOSING COMPLICATIONS OF PREGNANCY 审中-公开
标题翻译：用于诊断孕妇综合征的方法和组合
公开(公告)号：WO2009093254A3
公开(公告)日：2010-03-11
申请号：PCT/IL2009000101
申请日：2009-01-26
申请人： ROSETTA GENOMICS LTD , MOR RES APPLIC , GOREN YARON , GILAD SHLOMIT , HOD MOSHE , YOGEV YARIV
发明人： GOREN YARON , GILAD SHLOMIT , HOD MOSHE , YOGEV YARIV
IPC分类号： A01N43/04 , A61K31/70 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158 , C12Q2600/178
摘要： The present invention provides methods and compositions for identifying subjects at risk of developing a complication of pregnancy, such as preeclampsia or preterm labor. The compositions are microRNAs and associated nucleic acids.
摘要翻译：本发明提供了用于鉴定发生怀孕并发症风险的受试者的方法和组合物，例如先兆子痫或早产。组合物是微小RNA和相关核酸。

3. 发明专利

CA2708661A1 METHODS AND COMPOSITIONS FOR DIAGNOSING COMPLICATIONS OF PREGNANCY 未知
公开(公告)号：CA2708661A1
公开(公告)日：2009-07-30
申请号：CA2708661
申请日：2009-01-26
申请人： ROSETTA GENOMICS LTD , MOR RES APPLIC
发明人： GOREN YARON , GILAD SHLOMIT , HOD MOSHE , YOGEV YARIV
IPC分类号： A01N43/04 , A61K31/70 , C12Q1/68
摘要： The present invention provides methods and compositions for identifying subjects at risk of developing a complication of pregnancy, such as preeclampsia or preterm labor. The compositions are microRNAs and associated nucleic acids.

4. 发明专利

AU2009207291B2 Methods and compositions for diagnosing complications of pregnancy 未知
公开(公告)号：AU2009207291B2
公开(公告)日：2014-11-06
申请号：AU2009207291
申请日：2009-01-26
申请人： MOR RES APPLICATIONS , ROSETTA GENOMICS LTD
发明人： HOD MOSHE , GILAD SHLOMIT , YOGEV YARIV , GOREN YARON
IPC分类号： A61K31/70 , A01N43/04 , C12Q1/68
摘要： The present invention provides methods and compositions for identifying subjects at risk of developing a complication of pregnancy, such as preeclampsia or preterm labor. The compositions are microRNAs and associated nucleic acids.

5. 发明专利

AU2009207291A1 Methods and compositions for diagnosing complications of pregnancy 未知
公开(公告)号：AU2009207291A1
公开(公告)日：2009-07-30
申请号：AU2009207291
申请日：2009-01-26
申请人： ROSETTA GENOMICS LTD , MOR RES APPLIC
发明人： HOD MOSHE , GILAD SHLOMIT , YOGEV YARIV , GOREN YARON
IPC分类号： A01N43/04 , A61K31/70 , C12Q1/68

6. 发明申请

WO03025203A3 PREDICTION OF CANCER BY DETECTION OF ATM MUTATIONS 审中-公开
标题翻译：通过检测ATM突变预测癌症
公开(公告)号：WO03025203A3
公开(公告)日：2003-05-22
申请号：PCT/US0230015
申请日：2002-09-20
申请人： QUARK BIOTECH INC , GILAD SHLOMIT , YAHALOM JOACHIM
发明人： GILAD SHLOMIT , YAHALOM JOACHIM
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6827 , C12Q1/6886 , C12Q2600/156
摘要： There is provided a method of testing a subject to determine if the subject has a predisposition for developing a cancer, a cancer of epithelial origin such as lung cancer, colon cancer, prostate cancer, ovarian cancer, bladder cancer, and cancer of the pancreas, and also a lymphoproliferative malignancy such as Hodgkin's disease and non-Hodgkin's lymphoma. This method includes the steps of detecting a mutation in the open reading frame of the ATM gene SEQ.ID.NO:1 in a cDNA sample or a genomic DNA sample from the subject, which mutation is selected from the group consisting of the mutations set forth in Table 3 and Table 4 or, detecting a mutation in the mRNA corresponding to the open reading frame of the ATM gene SEQ.ID.NO:1 in a mRNA sample from the subject, which mutation is selected from the group consisting of RNA complementary to the mutations set forth in Table 3 and Table 4, wherein the presence of such a mutation indicates that the subject has a predisposition for developing cancer. Also provided is an isolated cDNA molecules, oligonucleotide probes, and kits for detection and prediction of cancer.
摘要翻译：提供了一种测试受试者以确定受试者是否具有发展癌症，上皮来源癌症如肺癌，结肠癌，前列腺癌，卵巢癌，膀胱癌和胰腺癌的倾向的方法，以及淋巴增生性恶性肿瘤如霍奇金病和非霍奇金淋巴瘤。该方法包括检测cDNA样品中的ATM基因SEQ.ID.NO:1的开放阅读框中的突变或来自受试者的基因组DNA样品中的突变，该突变选自突变组在表3和表4中，或者检测来自受试者的mRNA样品中与ATM基因SEQ ID NO：1的开放阅读框相对应的mRNA的突变，该突变选自RNA 与表3和表4所示的突变互补，其中这种突变的存在表明受试者具有发生癌症的倾向。还提供了分离的cDNA分子，寡核苷酸探针和用于癌症的检测和预测的试剂盒。

7. 发明公开

EP2234483A4 METHODS AND COMPOSITIONS FOR DIAGNOSING COMPLICATIONS OF PREGNANCY 审中-公开
标题翻译：方法和组合物诊断妊娠并发症
公开(公告)号：EP2234483A4
公开(公告)日：2011-04-27
申请号：EP09703376
申请日：2009-01-26
申请人： ROSETTA GENOMICS LTD , MOR RES APPLIC
发明人： GOREN YARON , GILAD SHLOMIT , HOD MOSHE , YOGEV YARIV
IPC分类号： A01N43/04 , A61K31/70 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158 , C12Q2600/178

8. 发明申请

WO2004111182A3 METHODS FOR CLONING NUCLEIC ACIDS IN A DESIRED ORIENTATION 审中-公开
标题翻译：在想要的方位克隆核酸的方法
公开(公告)号：WO2004111182A3
公开(公告)日：2005-02-24
申请号：PCT/IL2004000515
申请日：2004-06-15
申请人： QUARK BIOTECH INC , EINAT PAZ , ZEVIN-SONKIN DINA , GILAD SHLOMIT
发明人： EINAT PAZ , ZEVIN-SONKIN DINA , GILAD SHLOMIT
IPC分类号： C12N15/10 , C12N15/64 , C12N15/66 , C12P19/34 , C07H21/04
CPC分类号： C12N15/64 , C12N15/10 , C12N15/66
摘要： The present invention provides highly accurate methods for cloning nucleic acids in a desired, pre-defined orientation, and additionally provides for a library of cloned oriented nucleic acids. The ability to control the orientation of a nucleic acid being cloned is highly important in various molecular biology applications.
摘要翻译：本发明提供用于以期望的预定义取向克隆核酸的高度精确的方法，并另外提供克隆的定向核酸文库。控制被克隆的核酸取向的能力在各种分子生物学应用中是非常重要的。

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