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1. 发明专利

IL179545A VIRAL AND VIRAL ASSOCIATED MIRNAS AND USES THEREOF 未知
公开(公告)号：IL179545A
公开(公告)日：2010-12-30
申请号：IL17954506
申请日：2006-11-23
申请人： KAROV YAEL , ROSETTA GENOMICS LTD , BENTWICH ITZHAK , AVNIEL AMIR , AHARONOV RANIT
发明人： KAROV YAEL , BENTWICH ITZHAK , AVNIEL AMIR , AHARONOV RANIT
IPC分类号： C12N15/11 , C12Q1/68 , C12Q1/70

2. 发明申请

WO2005116250A8 VIRAL AND VIRAL ASSOCIATED MIRNAS AND USES THEREOF 审中-公开
标题翻译：病毒和病毒相关的MIRNAS及其用途
公开(公告)号：WO2005116250A8
公开(公告)日：2007-07-05
申请号：PCT/IB2005002352
申请日：2005-05-26
申请人： ROSETTA GENOMICS LTD , BENTWICH ITZHAK , AVNIEL AMIR
发明人： BENTWICH ITZHAK , AVNIEL AMIR
IPC分类号： C12Q1/68 , C12N15/11 , C12Q1/70
CPC分类号： C12N7/00 , C12N15/111 , C12N2310/14 , C12N2320/10 , C12N2330/10 , C12N2710/16221 , C12Q1/701
摘要： Described herein are novel polynucleotides associated with viral infections. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of viral infections.
摘要翻译：本文描述的是与病毒感染相关的新型多核苷酸。多核苷酸是miRNA和miRNA前体。公开了可用于诊断，预后和治疗这些医疗条件的相关方法和组合物。本文还描述了可用于鉴定病毒感染调节剂的方法。

3. 发明申请

WO2006126040A8 BACTERIAL AND BACTERIAL ASSOCIATED MIRNAS AND USES THEREOF 审中-公开
标题翻译：细菌和细菌相关的MIRNAS及其用途
公开(公告)号：WO2006126040A8
公开(公告)日：2007-02-15
申请号：PCT/IB2005002702
申请日：2005-05-25
申请人： ROSETTA GENOMICS LTD , BENTWICH ITZHAK , AVNIEL AMIR
发明人： BENTWICH ITZHAK , AVNIEL AMIR
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to a first group of novel bacterial and human associated oligonucleotides, here identified as "Genomic Address Messenger" or "GAM" oligonucleotide, and a second group of novel operon-like bacterial and human polynucleotides, here identified as "Genomic Record" or "GR" polynucleotide. GAM oligonucleotides selectively inhibit translation of known "target" genes, many of which are known to be involved in various bacterial infections. Nucleic acid molecules are provided respectively encoding 21,916 bacterial and 6,100 human GAM precursor oligonucleotides, and 6,056 bacterial and 430 human GR polynucleotides, as are vectors and probes both comprising the nucleic acid molecules, and methods and systems for detecting GAM oligonucleotides and GR polynucleotides and specific functions and utilities thereof, for detecting expression of GAM oligonucleotides and GR polynucleotides, and for selectively enhancing and selectively inhibiting translation of the respective target genes thereof.
摘要翻译：本发明涉及第一组新的细菌和人类相关寡核苷酸，这里被鉴定为“基因组地址信使”或“GAM”寡核苷酸，以及第二组新的操纵子样细菌和人多核苷酸，这里被鉴定为“基因组记录 “或”GR“多核苷酸。 GAM寡核苷酸选择性地抑制已知的“靶”基因的翻译，其中许多已知涉及各种细菌感染。分别提供核酸分子，编码21,916个细菌和6,100个人GAM前体寡核苷酸，以及6,056个细菌和430个人GR多核苷酸，以及包含核酸分子的载体和探针，以及用于检测GAM寡核苷酸和GR多核苷酸的方法和系统功能和用途，用于检测GAM寡核苷酸和GR多核苷酸的表达，并用于选择性增强和选择性抑制其各自靶基因的翻译。

4. 发明申请

WO2005111211A8 MICRONAS AND USES THEREOF 审中-公开
标题翻译： MICRONAS及其用途
公开(公告)号：WO2005111211A8
公开(公告)日：2007-07-05
申请号：PCT/IB2005002383
申请日：2005-05-14
申请人： ROSETTA GENOMICS LTD , BENTWICH ITZHAK , AVNIEL AMIR , KAROV YAEL , AHARONOV RANIT
发明人： BENTWICH ITZHAK , AVNIEL AMIR , KAROV YAEL , AHARONOV RANIT
IPC分类号： C12Q1/68 , C12N15/11
CPC分类号： C12N15/113 , A61K38/00 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2320/10 , C12N2320/11 , C12N2320/30 , C12N2330/10 , C12Q1/6809 , C12Q1/6876 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , Y02A90/26
摘要： Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.
摘要翻译：本文描述了与前列腺和肺癌相关的新型多核苷酸。多核苷酸是miRNA和miRNA前体。公开了可用于诊断，预后和治疗这些医疗条件的相关方法和组合物。本文还描述了可用于鉴定前列腺和肺癌调节剂的方法。

5. 发明申请

WO2006092738A8 MICRORNAS AND RELATED NUCLEIC ACIDS 审中-公开
标题翻译：微生物和相关核酸
公开(公告)号：WO2006092738A8
公开(公告)日：2006-10-26
申请号：PCT/IB2006001400
申请日：2006-02-07
申请人： ROSETTA GENOMICS LTD , BENTWICH ITZHAK , AVNIEL AMIR , KAROV YAEL , AHARONOV RANIT
发明人： BENTWICH ITZHAK , AVNIEL AMIR , KAROV YAEL , AHARONOV RANIT
IPC分类号： C12N15/11
CPC分类号： C12N15/111 , C12N2310/14 , C12N2320/10 , C12N2330/10
摘要： Described herein are novel polynucleotides associated with disease. The polynucleotides are miRNAs, miRNA precursors, and associated nucleic acids. Methods and compositions are described that can be used for diagnosis, prognosis, and treatment of disease. Also described herein are methods that can be used to identify modulators of the disease-associated polynucleotides. Also described herein are methods and compositions for linear amplification and labeling of a targeted nucleic acid. The amplified targeted molecules may be used in hybridization techniques like Luminex and Microarray analysis.
摘要翻译：本文描述的是与疾病相关的新型多核苷酸。多核苷酸是miRNA，miRNA前体和相关核酸。描述了可用于诊断，预后和治疗疾病的方法和组合物。本文还描述了可用于鉴定疾病相关多核苷酸的调节剂的方法。本文还描述了用于靶向核酸的线性扩增和标记的方法和组合物。扩增的靶向分子可用于杂交技术，如Luminex和Microarray分析。

6. 发明申请

WO2006092738A2 MICRORNAS AND RELATED NUCLEIC ACIDS 审中-公开
标题翻译：微RNA和相关的核酸
公开(公告)号：WO2006092738A2
公开(公告)日：2006-09-08
申请号：PCT/IB2006001400
申请日：2006-02-07
申请人： ROSETTA GENOMICS LTD , BENTWICH ITZHAK , AVNIEL AMIR , KAROV YAEL , AHARONOV RANIT
发明人： BENTWICH ITZHAK , AVNIEL AMIR , KAROV YAEL , AHARONOV RANIT
IPC分类号： C12N15/11
CPC分类号： C12N15/111 , C12N2310/14 , C12N2320/10 , C12N2330/10
摘要： Described herein are novel polynucleotides associated with disease. The polynucleotides are miRNAs, miRNA precursors, and associated nucleic acids. Methods and compositions are described that can be used for diagnosis, prognosis, and treatment of disease. Also described herein are methods that can be used to identify modulators of the disease-associated polynucleotides. Also described herein are methods and compositions for linear amplification and labeling of a targeted nucleic acid. The amplified targeted molecules may be used in hybridization techniques like Luminex and Microarray analysis.
摘要翻译：本文描述了与疾病相关的新型多核苷酸。多核苷酸是miRNA，miRNA前体和相关核酸。描述了可用于疾病的诊断，预后和治疗的方法和组合物。本文还描述了可用于鉴定疾病相关多核苷酸的调节剂的方法。本文还描述了用于靶向核酸的线性扩增和标记的方法和组合物。扩增的靶向分子可用于杂交技术如Luminex和微阵列分析。

7. 发明申请

WO2005116250A2 VIRAL AND VIRAL ASSOCIATED MIRNAS AND USES THEREOF 审中-公开
标题翻译：病毒和病毒相关的MIRNAS及其用途
公开(公告)号：WO2005116250A2
公开(公告)日：2005-12-08
申请号：PCT/IB2005002352
申请日：2005-05-26
申请人： ROSETTA GENOMICS LTD , BENTWICH ITZHAK , AVNIEL AMIR
发明人： BENTWICH ITZHAK , AVNIEL AMIR
IPC分类号： C12N15/11 , C12Q1/68 , C12Q1/70
CPC分类号： C12N7/00 , C12N15/111 , C12N2310/14 , C12N2320/10 , C12N2330/10 , C12N2710/16221 , C12Q1/701
摘要： Described herein are novel polynucleotides associated with viral infections. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of viral infections.
摘要翻译：本文描述的是与病毒感染相关的新型多核苷酸。多核苷酸是miRNA和miRNA前体。公开了可用于诊断，预后和治疗这些医疗条件的相关方法和组合物。本文还描述了可用于鉴定病毒感染调节剂的方法。

8. 发明申请

WO2005111211A2 MICRONAS AND USES THEREOF 审中-公开
标题翻译： MICRONAS及其用途
公开(公告)号：WO2005111211A2
公开(公告)日：2005-11-24
申请号：PCT/IB2005002383
申请日：2005-05-14
申请人： ROSETTA GENOMICS LTD , BENTWICH ITZHAK , AVNIEL AMIR , KAROV YAEL , AHARONOV RANIT
发明人： BENTWICH ITZHAK , AVNIEL AMIR , KAROV YAEL , AHARONOV RANIT
IPC分类号： C12N15/11 , C12Q1/68
CPC分类号： C12N15/113 , A61K38/00 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2320/10 , C12N2320/11 , C12N2320/30 , C12N2330/10 , C12Q1/6809 , C12Q1/6876 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , Y02A90/26
摘要： Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.
摘要翻译：本文描述了与前列腺和肺癌相关的新型多核苷酸。多核苷酸是miRNA和miRNA前体。公开了可用于诊断，预后和治疗这些医疗条件的相关方法和组合物。本文还描述了可用于鉴定前列腺和肺癌调节剂的方法。

9. 发明申请

WO2004044123A9 BIOINFORMATICALLY DETECTABLE GROUP OF NOVEL REGULATORY GENES AND USES THEREOF 审中-公开
标题翻译：生物检测的新型法规基因组及其用途
公开(公告)号：WO2004044123A9
公开(公告)日：2010-06-10
申请号：PCT/IL0300970
申请日：2003-11-16
申请人： ROSETTA GENOMICS LTD , BENTWICH ITZHAK
发明人： BENTWICH ITZHAK
IPC分类号： C12N20060101 , C12N1/00 , C12N15/00 , C12N15/113 , C12N15/12 , C12Q1/68 , G06F19/00
CPC分类号： C12N15/113 , C12N2310/14 , C12N2330/10 , G06F19/16 , G06F19/18
摘要： The present invention relates to a first group of novel genes, here identified as "genomic address messenger" or "GAM" genes, and a second group of novel operon-like genes, here identified as "genomic record" or "GR" genes. GAM genes selectively inhibit translation of known 'target' genes, many of which are known to be involved in various diseases. Nucleic acid molecules are provided respectively encoding 20600 GAM genes, and 6635 GR genes, as are vectors and probes both comprising the nucleic acid molecules, and methods and systems for detecting GAM and GR genes and specific functions and utilities thereof, for detecting expression of GAM and GR genes, and for selectively enhancing and selectively inhibiting translation of the respective target genes thereof.

10. 发明申请

WO2004048511A2 BIOINFORMATICALLY DETECTABLE GROUP OF NOVEL VIRAL REGULATORY GENES AND USES THEREOF 审中-公开
标题翻译：生物检测的新型病毒基因组及其用途
公开(公告)号：WO2004048511A2
公开(公告)日：2004-06-10
申请号：PCT/IL0300998
申请日：2003-11-26
申请人： ROSETTA GENOMICS LTD , BENTWICH ITZHAK
发明人： BENTWICH ITZHAK
IPC分类号： C07H21/04 , C12N15/11 , C12N15/113 , C12Q1/70 , C12N
CPC分类号： C12N15/1132 , C07K14/005 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2320/11 , C12N2330/10 , C12N2740/16022 , Y02A90/26
摘要： The present invention relates to a first group of novel genes, here identified as genomic address messenger or VGAM genes, and a second group of novel operon-like genes, here identified as viral genomic record or VGR genes. VGAM genes selectively inhibit translation of known `target' genes, many of which are known to be involved in various diseases. Nucleic acid molecules are provided respectively encoding 1560 VGAM genes, and 205 VGR genes, as are vectors and probes both comprising the nucleic acid molecules, and methods and systems for detecting VGAM and VGR genes and specific functions and utilities thereof, for detecting expression of VGAM and VGR genes, and for selectively enhancing and selectively inhibiting translation of the respective target genes thereof.
摘要翻译：本发明涉及第一组新基因，这里被鉴定为基因组地址信使或VGAM基因，第二组新的操纵子样基因，这里被鉴定为病毒基因组记录或VGR基因。 VGAM基因选择性地抑制已知的“靶”基因的翻译，其中许多已知涉及各种疾病。提供分别编码1560个VGAM基因和205个VGR基因的核酸分子，以及包含核酸分子的载体和探针，以及用于检测VGAM和VGR基因的方法和系统及其具体功能和用途，用于检测VGAM的表达和VGR基因，并且用于选择性增强和选择性抑制其各自靶基因的翻译。

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