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1. 发明申请

WO0168901A3 IMPLANTABLE ANALYTE SENSOR 审中-公开
标题翻译：可植入分析传感器
公开(公告)号：WO0168901A3
公开(公告)日：2001-12-27
申请号：PCT/EP0103027
申请日：2001-03-16
申请人： ROCHE DIAGNOSTICS GMBH , UNIV CALIFORNIA , ESSENPREIS MATTHIAS , DESAI TEJAL A , FERRARI MAURO , HANSFORD DEREK J
发明人： ESSENPREIS MATTHIAS , DESAI TEJAL A , FERRARI MAURO , HANSFORD DEREK J
IPC分类号： G01N33/483 , A61B5/00 , A61B5/145 , A61B5/1473 , C12M1/34 , C12Q1/00 , G01N27/327 , G01N27/40 , G01N27/416 , G01N33/66 , G01N33/68
CPC分类号： A61B5/14865 , C12Q1/006
摘要： An implantable analyte sensor includes a substrate, electrodes on the substrate, and a membrane on the electrodes. The membrane can comprise elemental silicon and has a glucose diffusion test result of at least 1 mg/dl in 330 min., and an albumin diffusion test result of at most 0.1 g/dl in 420 min.
摘要翻译：可植入分析物传感器包括基底，基底上的电极以及电极上的膜。该膜可以包含元素硅，并且在330分钟内具有至少1mg / dl的葡萄糖扩散测试结果，并且在420分钟内具有至多0.1g / dl的白蛋白扩散测试结果。

2. 发明专利

AU3930401A Implantable analyte sensor 未知
公开(公告)号：AU3930401A
公开(公告)日：2001-09-24
申请号：AU3930401
申请日：2001-03-16
申请人： ROCHE DIAGNOSTICS GMBH , UNIV CALIFORNIA
发明人： ESSENPREIS MATTHIAS , DESAI TEJAL A , FERRARI MAURO , HANSFORD DEREK J
IPC分类号： G01N33/483 , A61B5/00 , A61B5/145 , A61B5/1473 , C12M1/34 , C12Q1/00 , G01N27/327 , G01N27/40 , G01N27/416 , G01N33/66 , G01N33/68
摘要： An implantable analyte sensor includes a substrate, electrodes on the substrate, and a membrane on the electrodes. The membrane can comprise elemental silicon and has a glucose diffusion test result of at least 1 mg/dl in 330 min., and an albumin diffusion test result of at most 0.1 g/dl in 420 min.

3. 发明专利

CA2406878A1 IMPLANTABLE ANALYTE SENSOR 未知
公开(公告)号：CA2406878A1
公开(公告)日：2001-09-20
申请号：CA2406878
申请日：2001-03-16
申请人： ROCHE DIAGNOSTICS GMBH , UNIV CALIFORNIA
发明人： FERRARI MAURO , ESSENPREIS MATTHIAS , HANSFORD DEREK J , DESAI TEJAL A
IPC分类号： G01N33/483 , A61B5/00 , A61B5/145 , A61B5/1473 , C12M1/34 , C12Q1/00 , G01N27/327 , G01N27/40 , G01N27/416 , G01N33/66 , G01N33/68
摘要： An implantable analyte sensor includes a substrate, electrodes on the substrate, and a membrane on the electrodes. The membrane can comprise elemental silicon and has a glucose diffusion test result of at least 1 mg/dl in 330 min., and an albumin diffusion test result of at most 0.1 g/dl in 420 min.

4. 发明申请

WO2011156028A2 POROUS AND NON-POROUS NANOSTRUCTURES 审中-公开
标题翻译：多孔和非多孔纳米结构
公开(公告)号：WO2011156028A2
公开(公告)日：2011-12-15
申请号：PCT/US2011027746
申请日：2011-03-09
申请人： UNIV TEXAS , FERRARI MAURO , LIU XUEWU , CHIAPPINI CIRO , FAKHOURY JEAN RAYMOND
发明人： FERRARI MAURO , LIU XUEWU , CHIAPPINI CIRO , FAKHOURY JEAN RAYMOND
IPC分类号： H01L29/06 , H01L21/306 , H01L23/48 , H01L23/532
CPC分类号： H01L29/0665 , B82Y10/00 , B82Y30/00 , B82Y40/00 , H01L2924/0002 , H01L2924/00
摘要： Disclosed are a variety of porous and non-porous wire-like structures of microscopic and nanoscopic scale. For instance, disclosed are structures that comprise a porous object that comprises: (i) a first region; and (ii) a second region adjacent to the first region along an axis of the object, where the first region has at least one porous property different from that of the second region. Also disclosed are structures that include: (i) a high resistivity silicon; and (ii) a cross-section that is substantially perpendicular to an axis of the object. Also disclosed are methods of making and using such structures. For instance, the present invention provides methods of making a porous object by: (i) obtaining an etchable substrate; (ii) forming on a surface of the substrate a patterned porosification assisting metal layer that has at least one opening; and (iii) subsequently exposing the substrate to a first etching solution and a second etching solution to form respectively a first region and a second region of a porous object.
摘要翻译：公开了各种微观和纳米尺度的多孔和无孔线状结构。例如，公开的是包括多孔物体的结构，其包括：（i）第一区域; 和（ii）沿所述物体的轴线邻近所述第一区域的第二区域，其中所述第一区域具有与所述第二区域不同的至少一个多孔性质。还公开了包括：（i）高电阻率硅; 和（ii）基本上垂直于物体轴线的横截面。还公开了制造和使用这种结构的方法。例如，本发明提供了通过以下步骤制造多孔物体的方法：（i）获得可蚀刻的基底; （ii）在所述基材的表面上形成具有至少一个开口的图案化的赋形金属层; 和（iii）随后将所述衬底暴露于第一蚀刻溶液和第二蚀刻溶液以分别形成多孔物体的第一区域和第二区域。

5. 发明申请

WO2010056986A8 NANOCHANNELED DEVICE AND RELATED METHODS 审中-公开
标题翻译：纳米通道装置和相关方法
公开(公告)号：WO2010056986A8
公开(公告)日：2010-08-05
申请号：PCT/US2009064376
申请日：2009-11-13
申请人： UNIV TEXAS , UNIV OHIO STATE RES FOUND , FERRARI MAURO , LIU XEUWU , GRATTONI ALESSANDRO , HOSALI SHARATH , GOODALL RANDY , MEDEMA RYAN , HUDSON LEE , FINE DANIEL
发明人： FERRARI MAURO , LIU XEUWU , GRATTONI ALESSANDRO , HOSALI SHARATH , GOODALL RANDY , MEDEMA RYAN , HUDSON LEE , FINE DANIEL
IPC分类号： A61M5/14 , A61M5/00 , A61M37/00
CPC分类号： A61M5/00 , A61K9/0097 , A61M5/14276 , A61M37/00 , B81B2201/058 , B81B2203/0338 , B81C1/00119 , B82Y5/00 , Y10T137/8593 , Y10T156/1064
摘要： A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device. The inlet and outlet may be in direct fluid communication with the nanochannel.
摘要翻译：纳米通道输送装置及其制造和使用方法。纳米通道递送装置包括入口，出口和纳米通道。纳米通道可以平行于纳米通道递送装置的主平面取向。入口和出口可以与纳米通道直接流体连通。

6. 发明申请

WO2008021908A3 MULTISTAGE DELIVERY OF ACTIVE AGENTS 审中-公开
标题翻译：有效代理的多个交付
公开(公告)号：WO2008021908A3
公开(公告)日：2008-08-14
申请号：PCT/US2007075516
申请日：2007-08-08
申请人： UNIV TEXAS , TASCIOTTI ENNIO , FERRARI MAURO
发明人： FERRARI MAURO
IPC分类号： A61K9/14
CPC分类号： A61K9/50 , A61K9/127 , A61K9/1271 , A61K9/51 , A61K31/165 , A61K31/704 , A61K31/7088
摘要： Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.
摘要翻译：公开了包括第一阶段颗粒和第二阶段颗粒的多阶段递送载体。第一级颗粒是含有第二级颗粒的微型或纳米颗粒。第二级粒子包括活性剂，例如治疗剂或成像剂。多级递送载体允许顺序克服或绕过生物屏障。作为包括多个车辆的组合物的一部分来管理多级输送车辆。还提供制造多级输送车辆的方法。

7. 发明申请

WO2013095736A2 GOLD-IN-SILICON NANOASSEMBLY FOR THERMAL THERAPY AND METHODS OF USE 审中-公开
标题翻译：用于热疗的金属硅纳米管及其使用方法
公开(公告)号：WO2013095736A2
公开(公告)日：2013-06-27
申请号：PCT/US2012057365
申请日：2012-09-26
申请人： METHODIST HOSPITAL RES INST , SHEN HAIFA , FERRARI MAURO , LI CHUN , YOU JIAN
发明人： SHEN HAIFA , FERRARI MAURO , LI CHUN , YOU JIAN
IPC分类号： A61K41/00 , A61P35/00
CPC分类号： A61K41/0052 , A61B18/18 , A61B2018/1807 , A61K9/143 , A61K33/00 , A61K41/00 , A61K45/06 , A61K47/6923 , A61K47/6927 , A61N5/0625 , A61N2005/0659
摘要： Disclosed are methods and compositions for nanotechnology-based therapy of mammalian diseases. Also disclosed is a gold-in-porous silicon nanoassembly that is effective in the targeted, localized, treatment of human hyperproliferative disorders, including, for example, cancer of the breast. Using systemic administration of the nanoassembly vector, direct thermal ablative therapy is facilitate upon localized application of near-infrared energy to the target site, wherein the gold nanoparticles release heat to destroy the cancer tissue.
摘要翻译：公开了用于哺乳动物疾病的基于纳米技术的治疗的方法和组合物。还公开了一种金多孔硅纳米组合物，其有效地靶向，局部化，治疗人类过度增殖性疾病，包括例如乳腺癌。使用纳米组装载体的全身施用，直接热消融治疗有利于将近红外能量局部应用于靶位点，其中金纳米颗粒释放热量以破坏癌组织。

8. 发明申请

WO2009134786A2 QUALITY CONTROL METHOD AND MICRO/NANO-CHANNELED DEVICES 审中-公开
标题翻译：质量控制方法和微/纳米通道设备
公开(公告)号：WO2009134786A2
公开(公告)日：2009-11-05
申请号：PCT/US2009041957
申请日：2009-04-28
申请人： UNIV TEXAS , GRATTONI ALESSANDRO , FERRARI MAURO , LIU XUEWU
发明人： GRATTONI ALESSANDRO , FERRARI MAURO , LIU XUEWU
IPC分类号： G01N3/12 , B81B7/00 , B82B3/00
CPC分类号： B81C99/005 , B81B2201/058 , B81B2203/0338 , G01N11/08 , G01N35/00663
摘要： Embodiments of the present invention comprise a quality control system and method for testing micro- or nano-channeled devices. The system and method can utilize a pressure- driven gas flow for the detection and quantification of structural defects. The test method and system are non-destructive and allow defects to be detected and classified quickly based on measured factors, such as mass flow rate for a given pressure differential.
摘要翻译：本发明的实施例包括用于测试微通道或纳米通道器件的质量控制系统和方法。该系统和方法可以利用压力驱动气流来检测和定量结构缺陷。测试方法和系统是非破坏性的，并且基于测量因素（例如给定压力差的质量流率）来快速检测和分类缺陷。

9. 发明申请

WO2006108054A2 DIFFUSION DELIVERY SYSTEM AND METHODS OF FABRICATION 审中-公开
标题翻译：扩散输送系统和制造方法
公开(公告)号：WO2006108054A2
公开(公告)日：2006-10-12
申请号：PCT/US2006012700
申请日：2006-04-05
申请人： UNIV OHIO STATE , FERRARI MAURO , LIU XUEWU , SINHA PIYUSH MOHAN , SMITH BRYAN , SHARMA SADHANA
发明人： FERRARI MAURO , LIU XUEWU , SINHA PIYUSH MOHAN , SMITH BRYAN , SHARMA SADHANA
IPC分类号： H01R13/648
CPC分类号： A61K9/0097 , A61F2/022 , A61M31/002 , A61N1/306 , B82Y30/00
摘要： The invention generally relates to diffusion delivery systems and more particularly to high precision nano engineered devices for therapeutic applications. The device contains diffusion areas that may be fabricated between bonded substrates, and the device can possess high mechanical strength. The invention further relates to capsules containing a diffusion delivery system. The present invention also relates to methods of fabricating the diffusion delivery systems.
摘要翻译：本发明一般涉及扩散递送系统，更具体地涉及用于治疗应用的高精度纳米工程装置。该器件包含可在接合的衬底之间制造的扩散区域，该器件可以具有高的机械强度。本发明还涉及含有扩散递送系统的胶囊。本发明还涉及制造扩散递送系统的方法。

10. 发明申请

WO2004047682A2 VASCULAR PROSTHESIS FOR THE TREATMENT OF ABDOMINAL AORTIC ANEURYSMS, USING A COMBINED LAPAROSCOPIC/OPEN AND ENDOVASCULAR TECHNIQUE, AND DELIVERY SYSTEM FOR RELEASING A PROSTHESIS FITTED WITH ANCHORING STENTS 审中-公开
标题翻译：用于治疗腹部动脉瘤的血管造影术，使用组合的LAPAROSCOPIC / OPEN和内镜技术，以及用于释放用锚固装置安装的假体的输送系统
公开(公告)号：WO2004047682A2
公开(公告)日：2004-06-10
申请号：PCT/IT0300781
申请日：2003-11-26
申请人： BOLTON MEDICAL INC , SERINO FRANCESCO , FERRARI MAURO
发明人： SERINO FRANCESCO , FERRARI MAURO
IPC分类号： A61F2/06 , A61F2/07 , A61F2/89 , A61F2/90 , A61F2/954
CPC分类号： A61F2/07 , A61F2/89 , A61F2/90 , A61F2/954 , A61F2002/065 , A61F2002/075 , A61M25/10182 , A61M25/10184
摘要： A bifurcated vascular prosthesis implanted using a combined laparoscopic/open and endovascular technique for curing aneurysms of the abdominal aorta includes two stents on distal arms of the prosthesis. A delivery system and surgical kit for the release of the vascular prosthesis includes a pair of balloon release catheters, to be inserted within each corresponding stent and to remain adhering thereto throughout the time prior to release until reinflated with an inflating syringe, and a pair of balloon guide catheters, each including a dilator and a sheath. A method for implanting the prosthesis is also provided.
摘要翻译：使用联合腹腔镜/开放和血管内技术植入用于治疗腹主动脉的动脉瘤的分叉血管假体包括在假体的远端臂上的两个支架。用于释放血管假体的输送系统和外科手术套件包括一对气囊释放导管，其将插入每个对应的支架内并且在释放之前的整个时间期间保持粘附，直到用充气式注射器重新充气，并且一对气囊引导导管，每个包括扩张器和护套。还提供了一种用于植入假体的方法。

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