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1. 发明申请

WO2023046837A1 ANALYTICAL SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2023046837A1
公开(公告)日：2023-03-30
申请号：PCT/EP2022/076382
申请日：2022-09-22
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC. , HITACHI HIGH-TECH CORPORATION
发明人： LANG, Robert , MITRA, Indranil , HASHIMOTO, Yuichiro , SUGAWARA, Yuka
IPC分类号： H01J49/04 , G01N30/40 , G01N1/38 , G01N2030/402 , G01N30/7233 , H01J49/0431
摘要： An analytical system (100, 100') comprising a mass spectrometer (60) and an ionization source (61) coupled to the mass spectrometer (60) is herein disclosed. The analytical system (100, 100') further comprises an analytical fluidic system (10, 10') connectable to the ionization source (61) via a downstream valve (20) for infusing samples into the mass spectrometer (60) via the ionization source (61), a downstream pump (40) fluidically connectable to the ionization source (61) via the downstream valve (20), where the downstream pump (40) is fluidically connected to a plurality of fluid containers comprising respective fluids (41, 42, 43, 44), the fluids comprising at least one concentrated composition (44) for calibrating the mass spectrometer (60) and at least one diluent (42, 43) for diluting the at least one concentrated composition (44). The analytical system(100, 100') further comprises a controller (90) configured to control the downstream pump (40) in order to obtain at least one diluted composition (45) by automatically mixing at least one concentrated composition (44) with at least one diluent (42, 43) with a predetermined dilution factor, to infuse the at least one diluted composition (45) into the ionization source (61), to obtain a mass spectrum (62) of the at least one diluted composition (45) and to execute a calibration (63) of the mass spectrometer (60) based on an assessment (64) of the mass spectrum (62). A respective automated analytical method comprising calibration of a mass spectrometer (60), like mass axis check and/or adjustment, with selected chemical compositions is herein also disclosed.

2. 发明申请

WO2023031447A1 METHOD FOR AUTOMATED QUALITY CHECK OF CHROMATOGRAPHIC AND/OR MASS SPECTRAL DATA 审中-公开
公开(公告)号：WO2023031447A1
公开(公告)日：2023-03-09
申请号：PCT/EP2022/074552
申请日：2022-09-05
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： TARASOV, Kirill , REICHERT, Andreas , HUMMEL, Manuela , LANG, Robert , WAGNER, Marius
IPC分类号： G01N30/86
摘要： A computer implemented method for automated quality check of chromatographic and/or mass spectral data is disclosed. The method comprises the following steps: a) (110) providing processed chromatographic and/or mass spectral data obtained by at least one mass spectrometry device (112); b) (114) classifying quality of the chromatographic and/or mass spectral data by applying at least one trained machine learning model on the chromatographic and/or mass spectral data, wherein the trained machine learning model uses at least one regression model (116), wherein the trained machine learning model is trained on at least one training dataset comprising historical and/or semi- synthetic chromatographic and/or mass spectral data, wherein the trained machine learning model is an analyte-specific trained machine learning model.

3. 发明申请

WO2018077783A1 IMMOBILIZED ANALYTES 审中-公开
标题翻译：固定化分析
公开(公告)号：WO2018077783A1
公开(公告)日：2018-05-03
申请号：PCT/EP2017/076961
申请日：2017-10-23
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： KOBOLD, Uwe , LANG, Robert , LEINENBACH, Andreas
IPC分类号： G01N33/543 , G01N33/68
摘要： The present invention relates to a method for detecting an analyte comprising a) contacting said analyte, a capture agent and a solid surface to form a capture complex attached to a solid surface, b) cleaving at least one covalent bond within said analyte and/or within said capture agent comprised in said capture complex and, thereby, releasing said analyte or a fragment thereof from said capture complex, and c) detecting said at least one fragment of said analyte and, thereby, detecting said analyte. The present invention further relates to a kit comprising i) a capture agent binding, in an embodiment specifically binding, to an analyte; and ii) an agent cleaving at least one covalent bond within said analyte and/or within said capture agent; and to a use of a protease for releasing fragments of an analyte for detecting said analyte, wherein said analyte is bound to a solid surface via a capture agent.
摘要翻译：本发明涉及用于检测分析物的方法，其包括a）使所述分析物，捕获剂和固体表面接触以形成附着于固体表面的捕获复合物，b）将至少一个在所述捕获复合物中包含的所述分析物内和/或所述捕获剂内的共价键，从而从所述捕获复合物释放所述分析物或其片段，以及c）检测所述分析物的所述至少一个片段，从而检测所述分析物。本发明进一步涉及一种试剂盒，其包含：i）在分析物中结合特定结合的捕获剂; 和ii）切割所述分析物内和/或所述捕获剂内的至少一个共价键的试剂; 并涉及蛋白酶用于释放分析物片段以检测所述分析物的用途，其中所述分析物通过捕获剂结合到固体表面。

4. 发明申请

WO2023046716A1 REAGENT FORMULATION FOR MASS AXIS CHECK AND ADJUSTMENT 审中-公开
公开(公告)号：WO2023046716A1
公开(公告)日：2023-03-30
申请号：PCT/EP2022/076160
申请日：2022-09-21
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： LANG, Robert
IPC分类号： H01J49/00
摘要： The present invention relates to a composition comprising (i) cesium iodide, (ii) ethylamine and/or formic acid, and (iii) methanol and/or water. The present invention further relates to a method for calibrating a mass spectrometry (MS) device comprising (I) determining a mass spectrum of a composition as specified; and (II) calibrating the MS device based on the mass spectrum determined in step (I). The present invention further relates to devices, kits, uses, and methods related thereto.

5. 发明公开

EP4405998A1 REAGENT FORMULATION FOR MASS AXIS CHECK AND ADJUSTMENT 审中-实审
公开(公告)号：EP4405998A1
公开(公告)日：2024-07-31
申请号：EP22785727.3
申请日：2022-09-21
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： LANG, Robert
IPC分类号： H01J49/00
CPC分类号： H01J49/0009

6. 发明公开

EP4006952A1 ANOMALY DETECTION OF GAS FLOW PARAMETERS IN MASS SPECTROMETRY 审中-公开
公开(公告)号：EP4006952A1
公开(公告)日：2022-06-01
申请号：EP20209866.1
申请日：2020-11-25
申请人： F. Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： LANG, Robert , PUNZMANN, Gabriele , QUINT, Stefan
IPC分类号： H01J49/00 , H01J49/04 , H01J49/10
摘要： In one general aspect, the present disclosure relates to a mass spectrometry (MS) apparatus. The MS apparatus includes a mass spectrometer, an ionization source coupled to the mass spectrometer and a flow injection system (FIS) coupled to the ionization source. The ionization source is configured to provide an ionized gas flow of an analyte towards an entrance of the mass spectrometer. The ionization source is further configured to provide a second gas flow of a second gas. The MS apparatus is configured to measure a mass spectrometer (MS) signal of the analyte. The MS apparatus is further configured to analyze a dependency of the MS signal of the analyte versus a parameter of the second gas flow or a state of the second gas flow and to determine a condition of the apparatus based on the analyzed dependency.

7. 发明公开

EP3529617A1 IMMOBILIZED ANALYTES 有权
公开(公告)号：EP3529617A1
公开(公告)日：2019-08-28
申请号：EP17794920.3
申请日：2017-10-23
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： KOBOLD, Uwe , LANG, Robert , LEINENBACH, Andreas
IPC分类号： G01N33/543 , G01N33/68

8. 发明公开

EP4399518A1 METHOD FOR AUTOMATED QUALITY CHECK OF CHROMATOGRAPHIC AND/OR MASS SPECTRAL DATA 审中-实审
公开(公告)号：EP4399518A1
公开(公告)日：2024-07-17
申请号：EP22782461.2
申请日：2022-09-05
申请人： F. Hoffmann-La Roche AG , Roche Diagnostics GmbH
发明人： TARASOV, Kirill , REICHERT, Andreas , HUMMEL, Manuela , LANG, Robert , WAGNER, Marius
IPC分类号： G01N30/86
CPC分类号： G01N30/8634 , G01N30/8682

9. 发明公开

EP4156228A1 ANALYTICAL SYSTEM AND METHOD 审中-实审
公开(公告)号：EP4156228A1
公开(公告)日：2023-03-29
申请号：EP21198491.9
申请日：2021-09-23
申请人： F. Hoffmann-La Roche AG , Roche Diagnostics GmbH , HITACHI HIGH-TECH CORPORATION
发明人： LANG, Robert , MITRA, Indranil , HASHIMOTO, Yuichiro , SUGAWARA, Yuka
IPC分类号： H01J49/04 , G01N35/00 , G01N1/38 , G01N30/40 , G01N30/72
摘要： An analytical system (100, 100') comprising a mass spectrometer (60) and an ionization source (61) coupled to the mass spectrometer (60) is herein disclosed. The analytical system (100, 100') further comprises an analytical fluidic system (10, 10') connectable to the ionization source (61) via a downstream valve (20) for infusing samples into the mass spectrometer (60) via the ionization source (61), a downstream pump (40) fluidically connectable to the ionization source (61) via the downstream valve (20), where the downstream pump (40) is fluidically connected to a plurality of fluid containers comprising respective fluids (41, 42, 43, 44), the fluids comprising at least one concentrated composition (44) for calibrating the mass spectrometer (60) and at least one diluent (42, 43) for diluting the at least one concentrated composition (44). The analytical system(100, 100') further comprises a controller (90) configured to control the downstream pump (40) in order to obtain at least one diluted composition (45) by automatically mixing at least one concentrated composition (44) with at least one diluent (42, 43) with a predetermined dilution factor, to infuse the at least one diluted composition (45) into the ionization source (61), to obtain a mass spectrum (62) of the at least one diluted composition (45) and to execute a calibration (63) of the mass spectrometer (60) based on an assessment (64) of the mass spectrum (62). A respective automated analytical method comprising calibration of a mass spectrometer (60), like mass axis check and/or adjustment, with selected chemical compositions is herein also disclosed.

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