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1. 发明专利

JP2004135678A Magnetic particle for refining nucleic acid 有权
公开(公告)号：JP2004135678A
公开(公告)日：2004-05-13
申请号：JP2003429949
申请日：2003-12-25
申请人： Roche Diagnostics Gmbh , ロシュダイアグノスティクスゲゼルシャフトミットベシュレンクテルハフツング
发明人： HARTTIG HERBERT , RIEDLING MICHAEL , MENNIG MARTIN , SCHMIDT HELMUT
IPC分类号： C12N15/00 , B01D15/08 , B01J2/00 , B03C1/00 , B03C1/01 , B22F1/02 , C03B8/02 , C03C3/091 , C03C3/093 , C04B35/653 , C12M1/00 , C12N15/09 , C12N15/10 , C12Q1/68 , H01F1/00 , H01F1/11 , H01F1/24
CPC分类号： B82Y25/00 , B03C1/01 , C12N15/1006 , C12N15/1013 , C12Q1/6806 , H01F1/11 , H01F1/112 , Y10T428/2989 , Y10T428/2993 , Y10T428/2996
摘要： PROBLEM TO BE SOLVED: To provide a new glass-surface particle preparation effective for purifying nucleic acid. SOLUTION: The preparation comprises particles having a glass surface, wherein >75 wt.% of the particles have 5-15 μm particle size, the glass surface comprises 2-6 mol% oxide of SiO 2 , B 2 O 3 , K 2 O, CaO, Al 2 O 3 and ZnO and the preparation is extremely efficient in a method for purifying the nucleic acid. The preparation increases nucleic acid yield. COPYRIGHT: (C)2004,JPO

2. 发明专利

JP2001245684A SYSTEM FOR SIMPLE NUCLEIC ACID ANALYSIS 失效
公开(公告)号：JP2001245684A
公开(公告)日：2001-09-11
申请号：JP2001034732
申请日：2001-02-09
申请人： ROCHE DIAGNOSTICS GMBH
发明人： FRITZ MICHAEL , HARTTIG HERBERT , STEINBISS JOACHIM , GERSTLE VOLKER , SCHWAB JUERGEN , RAUSCHER ANDREAS
IPC分类号： C12N15/09 , B01L7/00 , C12M1/00 , C12M1/34 , C12M1/38 , C12N15/10 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a method for the analysis of nucleic acid having high sensitivity, decreasing the technological complexity and necessary time for the analysis and free from the defects of conventional method. SOLUTION: The method for detecting a nucleic acid in a specimen contains (a) a step to purify the nucleic acid by immobilizing the nucleic acid in a bonding space and separating impurities, (b) a step to dissolve the immobilized nucleic acid, (c) a step to amplify the purified nucleic acid in an amplification space and (d) a step to detect the amplification product in a detection space. The amplification space contains at least a part of the bonding space.

3. 发明专利

JP2008134239A Magnetic pigment 有权
标题翻译：磁性颜料
公开(公告)号：JP2008134239A
公开(公告)日：2008-06-12
申请号：JP2007280179
申请日：2007-10-29
申请人： Roche Diagnostics Gmbh , ロシュダイアグノスティックスゲーエムベーハー
发明人： KLEIBER JOERG , MARKERT-HAHN CHRISTINE , HARTTIG HERBERT
IPC分类号： G01N33/50 , G01N33/552 , B01D43/00 , B03C1/00 , B03C1/01 , C03C14/00 , C12M1/00 , C12N15/09 , C12N15/10 , C12Q1/68 , G01N1/28 , G01N33/553 , G01N35/00 , H01F1/11
CPC分类号： H01F1/112 , B03C1/01 , C03C14/004 , C07H1/08 , C12N15/1006 , C12N15/1013 , C12Q1/6806 , G01N35/0098 , G01N35/0099
摘要： PROBLEM TO BE SOLVED: To provide a new magnetic pigment capable of being used for a method which enables the easy detection of an object to be inspected which exists under a very low concentration, a method that easily eliminates many other matters capable of interfering separation or measurement of the object; and a method which eliminates risks such as carry-over and contamination when a nucleic acid is extracted from a biological sample.
SOLUTION: A magnetic glass particle includes a magnetic core and SiO
2 , B
2 O
3 , and a glass coat containing alkali metal oxides.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够用于能够容易地检测以非常低的浓度存在的待检查对象的方法的新的磁性颜料，可以容易地消除许多其它能够物体的干扰分离或测量; 以及当从生物样品中提取核酸时，消除诸如携带和污染等风险的方法。解决方案：磁性玻璃颗粒包括磁芯和SiO 2 SBB，B 2 O 3 和含有碱金属的玻璃涂层氧化物。版权所有（C）2008，JPO＆INPIT

4. 发明专利

JP2007175060A Apparatus for isolation of analyte in biological sample 审中-公开
标题翻译：分离生物样品分析仪的设备
公开(公告)号：JP2007175060A
公开(公告)日：2007-07-12
申请号：JP2007047875
申请日：2007-02-27
申请人： Roche Diagnostics Gmbh , ロシュダイアグノスティックスゲーエムベーハー
发明人： KLEIBER JOERG , MARKERT-HAHN CHRISTINE , HARTTIG HERBERT
IPC分类号： C12M1/00 , G01N33/50 , B01D43/00 , B03C1/00 , B03C1/01 , C03C14/00 , C12N15/09 , C12N15/10 , C12Q1/68 , G01N1/28 , G01N35/00 , H01F1/11
CPC分类号： H01F1/112 , B03C1/01 , C03C14/004 , C07H1/08 , C12N15/1006 , C12N15/1013 , C12Q1/6806 , G01N35/0098 , G01N35/0099
摘要： PROBLEM TO BE SOLVED: To provide a new apparatus for preparing biological samples for subsequent detection of an analyte in the biological samples, especially a nucleic acid.
SOLUTION: The apparatus for isolating a nucleic acid analyte from a biological sample comprises a sample preparing apparatus (1), a sample holding apparatus (2), a first holding device (3) equipping operation temperature of ≤70°C, especially ≤40°C and for a sample-preparing reaction vessel, second holding devices (4a, 4b, 4c) optionally containing a cooling means and/or a heating means and for the reactor vessel, and a robot tool device (5).
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于制备生物样品以用于随后检测生物样品中的分析物，特别是核酸的新装置。解决方案：用于从生物样品中分离核酸分析物的装置包括样品制备装置（1），样品保持装置（2），装备操作温度≤70℃的第一保持装置（3）特别是≤40℃，对于样品制备反应容器，任选地包含冷却装置和/或加热装置和用于反应容器的第二保持装置（4a，4b，4c）和机器人工具装置（5）。版权所有（C）2007，JPO＆INPIT

5. 发明申请

WO2006058654A3 PRICKING DEVICE FOR TAKING BLOOD 审中-公开
标题翻译： HOLLY设备收集的血液
公开(公告)号：WO2006058654A3
公开(公告)日：2006-09-21
申请号：PCT/EP2005012569
申请日：2005-11-24
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , WINHEIM SVEN , DECK FRANK , HARTTIG HERBERT
发明人： WINHEIM SVEN , DECK FRANK , HARTTIG HERBERT
IPC分类号： A61B5/151
CPC分类号： A61B5/150893 , A61B5/150022 , A61B5/150297 , A61B5/150412 , A61B5/150465 , A61B5/150519 , A61B5/150916 , A61B5/15105 , A61B5/15128 , A61B5/15142 , A61B5/15144
摘要： The invention relates to a pricking device for taking blood, comprising an element (1, 100, 200) for contacting an extraction surface, an actuating element (3, 103, 202) for manually actuating the pricking device, and a pricking element (4, 102, 204) that is movable relative to the contacting element (1, 100, 200) substantially perpendicular to the extraction surface and is used for perforating the extraction surface. The pricking element (4, 102, 204) is disposed in the contacting element (1, 100, 200) so as not to protrude from the contacting element (1, 100, 200) before the pricking process is initiated while obtaining a defined pricking depth during the pricking process. The inventive pricking device further comprises a return spring (6, 106, 207) for automatically retracting the pricking element (4, 102, 204) into the contacting element (1, 100, 200) once the pricking process has been completed as well as a mechanism (7, 109) for locking the pricking device following a single pricking process. Said locking mechanism (7, 109) is embodied such that a bolt (11, 110, 208) slides across a switch (10, 112) along a first guiding area (24, 117, 211) when the pricking process is initiated while sliding across said switch (10, 112) along a second guiding area (27, 121, 215) into a locking position when the pricking element (4, 102, 204) is retracted by means of the return spring (6, 106, 207) once the pricking process has been completed.
摘要翻译：本发明涉及一种刺血装置用于与接触元件（1，100，200），用于提取表面接触，以及一个致动元件（3，103，202），用于手动操作所述柳叶刀切开装置，收集血液相对（与接触元件1，100 ，200）基本上垂直地移动的用于将用于产生采样表面的穿孔，其特征在于，所述穿刺件（4，102，204）在所述接触元件（1，100，200）中除去表面刺穿构件（4，102，204）被布置成之前Einstechvorgangs的开始不从所述接触元件（1，100，200）突出，并且在其刺穿定义穿刺深度达到，在复位弹簧（6，106，207），用于将穿透构件的自动回缩（4，102，204）完成穿孔后接触元件（1，100，200），以及锁定机构（7，109）根据一个独特的用于锁定柳叶刀切开装置由刺穿，其中，所述锁定机构（7，109）被形成为使得通过开关沿着第一引导面（24，117，211）的螺栓（11，110，208）在所述Einstechvorgangs开始（10，112）滑动并在通过沿着第二导向表面（27，121，215）的开关（10，112）刺穿的完成之后由复位弹簧（6，106，207）的穿透构件（4，102，204）的缩回滑动到锁定位置中。

6. 发明申请

WO2009036986A2 JOINING FOILS WITH LASER FOR STERILE LANCETS 审中-公开
标题翻译：加入无菌激光用于无菌LANCETS
公开(公告)号：WO2009036986A2
公开(公告)日：2009-03-26
申请号：PCT/EP2008007875
申请日：2008-09-19
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , ROEPER JOSEF , FINKE WERNER , HARTTIG HERBERT , HILLER BERND , LIST HANS
发明人： ROEPER JOSEF , FINKE WERNER , HARTTIG HERBERT , HILLER BERND , LIST HANS
IPC分类号： A61B5/00 , B65B9/06 , B65B11/48 , B65B51/10
CPC分类号： B65B9/06 , A61B5/150022 , A61B5/150213 , A61B5/150282 , A61B5/15032 , A61B5/150328 , A61B5/150335 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150572 , A61B5/15123 , A61B5/1519 , A61B5/15194 , A61B2562/242 , B29C65/16 , B29C65/1619 , B29C65/1654 , B29C65/1674 , B29C65/48 , B29C65/4815 , B29C65/7473 , B29C66/1122 , B29C66/24244 , B29C66/43 , B29C66/4332 , B29C66/71 , B29C66/836 , B29L2031/753 , B65B11/48 , B65B15/04 , B65B51/22 , B65B55/00 , Y10T29/49799 , Y10T29/49885 , Y10T29/49966 , Y10T29/49968 , Y10T29/4997 , Y10T436/110833 , B29K2067/00 , B29K2023/12 , B29K2023/06 , B29K2033/12 , B29K2031/04 , B29K2077/00 , B29K2067/003 , B29K2023/38
摘要： A process for manufacturing packaged lancets, comprising the steps: providing a tape comprising a plurality of lancets comprising a lancet tip and a lancet body, enveloping at least the lancet tip with at least one foil, whereby the at least one foil build a first and a second portion that overlap at least partly, sealing the at least one foil with a laser beam at least at the edges of the first and second portion of the overlapping parts.
摘要翻译：一种用于制造包装的刺血针的方法，包括以下步骤：提供包括多个刺针的胶带，所述刺针包括刺血针尖端和刺血针本体，至少用至少一个箔片包封刺血针尖端，由此所述至少一个箔片构成第一和至少部分重叠的第二部分，至少在重叠部分的第一部分和第二部分的边缘用激光束密封至少一个箔。

7. 发明申请

WO2006092309A3 PIERCING SYSTEM FOR REMOVING A BODILY FLUID 审中-公开
标题翻译：用于去除身体流体的PEG系统
公开(公告)号：WO2006092309A3
公开(公告)日：2006-12-21
申请号：PCT/EP2006001922
申请日：2006-03-02
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , DECK FRANK , QUARDER ORTRUD , WEISS THOMAS , HOERAUF CHRISTIAN , KISTNER MICHAEL , KONYA AHMET , HARTTIG HERBERT , BAADER FELIX , LIST HANS , EBERT KARL-PETER
发明人： DECK FRANK , QUARDER ORTRUD , WEISS THOMAS , HOERAUF CHRISTIAN , KISTNER MICHAEL , KONYA AHMET , HARTTIG HERBERT , BAADER FELIX , LIST HANS , EBERT KARL-PETER
IPC分类号： A61B5/151
CPC分类号： A61B5/15148 , A61B5/150022 , A61B5/15019 , A61B5/150198 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150572 , A61B5/150832 , A61B5/150916 , A61B5/15113 , A61B5/15117 , A61B5/15128 , A61B5/1519 , A61B5/15194 , A61B5/15196
摘要： The invention relates to a piercing system for removing bodily fluid from the skin of a human or animal. Said system comprises a disposable piercing unit (1), which contains a needle element (6) for puncturing the skin, a piercing device (2), which encompasses a piercing drive (4), said drive propelling a piercing displacement of the piercing unit (1), which is coupled to the piercing drive (4) by means of a coupling mechanism (3), a predefined value of the piercing depth being guaranteed using a piercing depth reference element (10), which comprises a skin contact surface (11) and the predefined value of the piercing depth being determined by the distance in the piercing direction between the skin contact surface (11) and the position of the needle tip at the inversion point of the piercing displacement. The piercing depth reference element (10) is connected to the needle element (6) and coupled to the drive in such a way that it is displaced together with the needle element (1) during at least one part of the propulsion phase and has a defined longitudinal position in the piercing direction in relation to the needle element (6), at least at the inverse point of the piercing displacement.
摘要翻译：用于收集体液从人或动物的皮肤上，用一次性采血部的柳叶刀切开系统（1）具有针构件（6），用于刺穿皮肤，穿刺装置（2），其包括穿刺驱动器（4），由通过联接机构的装置连接到所述切缝驱动件的穿刺单元（1）的穿刺移动（3）（4）耦合，被驱动，由此，穿刺深度的由穿刺深度参考元件的装置的预定值（10）得到保证，其具有皮肤接触面（11），和穿刺深度的预定值.The通过在皮肤接触表面（11），并且在刺入运动穿刺深度参考元件的反转点的针尖（10）被连接在与所述针元件（6）这样的方式以及与所述驱动器的位置之间的穿刺方向的距离来确定，在推进阶段的至少一部分期间它至少与针元件（1）一起移动 s在刺穿运动的反向点处具有相对于针元件（6）在穿刺方向上限定的纵向位置。

8. 发明申请

WO2005034740A3 MANUAL DEVICE FOR EXAMINING A BODY FLUID 审中-公开
标题翻译：这款针对分析体液
公开(公告)号：WO2005034740A3
公开(公告)日：2005-07-21
申请号：PCT/EP2004011311
申请日：2004-10-09
申请人： HOFFMANN LA ROCHE , ROCHE DIAGNOSTICS GMBH , HARTTIG HERBERT , LIST HANS
发明人： HARTTIG HERBERT , LIST HANS
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B2562/0295
摘要： The invention relates to a portable blood sugar measuring device comprising a band device (12) for sectionally pre-winding a test band (14), a detection unit (16) for detecting measurement on the test band sections impinged with blood in the region of a reception point (44) and a housing (10) for receiving the band unit (1é) and detection unit (16). According to the invention, the band unit (12) and/or the detection unit (16) can be moved from working position in relation to the housing counter to an elastic restoring element (18) when impacted.
摘要翻译：本发明涉及一种具有Bandein单元（12），用于测试条（14），解tektionseinheit（16），用于在以向上接管点（44）与所述范围数据获取的截面方向快进的便携式血糖仪，但施加测试条部和壳体（10），用于接收所述带单元（12）和检测部（16）。根据本发明，所述带单元（12）和/或所述检测单元（16），当针对一个由-giebiges恢复从相对于所述壳体（10）中的工作位置元件（18）可被偏转，提出了一种冲击载荷。

9. 发明申请

WO9916781A3 AUTOMATABLE METHOD FOR PREPARING SAMPLES WHICH CAN BE UNIVERSALLY APPLIED 审中-公开
标题翻译：自动化的普及应用样方法
公开(公告)号：WO9916781A3
公开(公告)日：1999-09-16
申请号：PCT/EP9806196
申请日：1998-09-29
申请人： ROCHE DIAGNOSTICS GMBH , KLEIBER JOERG , MARKERT HAHN CHRISTINE , HARTTIG HERBERT
发明人： KLEIBER JOERG , MARKERT-HAHN CHRISTINE , HARTTIG HERBERT
IPC分类号： G01N33/50 , B01D43/00 , B03C1/00 , B03C1/01 , C03C14/00 , C12M1/00 , C12N15/09 , C12N15/10 , C12Q1/68 , G01N1/28 , G01N35/00 , H01F1/11 , C07H1/08 , C03C17/30
CPC分类号： H01F1/112 , B03C1/01 , C03C14/004 , C07H1/08 , C12N15/1006 , C12N15/1013 , C12Q1/6806 , G01N35/0098 , G01N35/0099
摘要： The invention relates to a method for preparing biological samples for a subsequent detection of an analyte, especially of a nucleic acid, in said sample. The invention also relates to the preparation of reagent kits, novel devices for preparing samples and novel magnetic pigments.
摘要翻译：本发明涉及一种用于制备生物样品用于分析物的后续检测，尤其是核酸的所述样品中。此外，提供的试剂盒和用于样品制备和新的磁性颜料的新设备。

10. 发明申请

WO2011038839A8 METHOD FOR CONTROLLING A PHOTOMETRIC MEASURING UNIT OF A MEASURING DEVICE FOR OBTAINING AND EXAMINING A BODILY FLUID SAMPLE AND MEASURING SYSTEM 审中-公开
标题翻译：一种用于控制仪的光度测量单元，用于获得与体液样本和测量系统的研究
公开(公告)号：WO2011038839A8
公开(公告)日：2011-09-29
申请号：PCT/EP2010005679
申请日：2010-09-16
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , WEHOWSKI FREDERICH , HARTTIG HERBERT , HOENES JOACHIM
发明人： WEHOWSKI FREDERICH , HARTTIG HERBERT , HOENES JOACHIM
IPC分类号： G01N21/86
CPC分类号： G01N21/8483
摘要： The invention relates to a method for controlling a photometric measuring unit of a measuring device for obtaining and examining a human or animal bodily fluid sample, wherein a test field (1) partially wetted with a bodily fluid sample is illuminated and light from a measuring surface (3) that covers a part of the test field (1) is fed to a detector of the measuring unit, and the measuring surface (3) is slid relative to the test field (1) to a partial surface (2) wetted by the fluid sample and beyond the partial surface (2). According to the invention, the intensity of a detector signal is detected during the sliding, an extreme is determined in the course of the detector signal, the measuring surface (3) is brought back to the position in which an extreme detector signal was previously measured, and the position of the measuring surface (3) in which the detector signal is extreme is used for a photometric determination of concentration.
摘要翻译：本发明涉及一种方法，用于控制测量装置的测光测量单元，用于人或动物的体液样品的回收和分析，其特征在于，与体液样品部分润湿测试场（1）进行照明和测量单元的一个检测器，光从测量表面（3）形成的一部分覆盖的测试场（1），供给到测定表面（3）相对于所述测试场（1）移位到一个随液体试样的部分表面（2）朝向和在局部区域（2）除了润湿。根据本发明，它提供了一种被检测到的检测信号的强度的位移期间，在检测器信号的过程中已经检测到一个极值，测量区域（3）被带回到其极值检测器信号被前测得的位置，和的位置测量表面（3），其中检测器信号是极值，用于光度浓度测定。

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