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1. 发明申请

WO2011049414A2 METHOD FOR INDUCING MIGRATION OF ADULT STEM CELLS DERIVED FROM ADIPOSE TISSUE 审中-公开
标题翻译：诱导脂肪组织来源的成年干细胞迁移的方法
公开(公告)号：WO2011049414A2
公开(公告)日：2011-04-28
申请号：PCT/KR2010007329
申请日：2010-10-25
申请人： RNL BIO CO LTD , RA JEONG CHAN , KANG SUNG KEUN , BAEK SUN JIN
发明人： RA JEONG CHAN , KANG SUNG KEUN , BAEK SUN JIN
IPC分类号： C12N5/02 , C12N5/071 , C12Q1/02
CPC分类号： C12N5/0667 , A61K35/12 , C12N2501/21
摘要： The present invention relates to cell migration capacity of adult stem cells derived from adipose tissue, and more specifically, to treatment of adipose-derived, adult stem cells with cellular protein secretions. In particular, the present invention is a new use for adipose stem cells, whereby pretreatment of adipose-derived, adult stem cells with a specific chemokine or growth factor induces a more effective migration to diseased parts of the body. Adipose-derived adult stem cells, pretreated with specific chemokine or growth factor may be intravenously administered as a simple way to target stem cells (targetting) to the site of the disease and represents potential for cell therapy.
摘要翻译：本发明涉及源自脂肪组织的成体干细胞的细胞迁移能力，更具体地涉及用细胞蛋白质分泌物处理源自脂肪的成体干细胞。具体而言，本发明是脂肪干细胞的新用途，由此用特定的趋化因子或生长因子预处理脂肪来源的成体干细胞诱导更有效地迁移至患病部位。用特异性趋化因子或生长因子预处理的脂肪衍生的成体干细胞可作为将干细胞（靶向）靶向疾病部位的简单方法静脉给药，并代表细胞疗法的可能性。

2. 发明申请

WO2010082798A2 COMPOSITION CONTAINING EXTRACTS OF FUSCOPORIA OBLIQUA, GANODERMA LUCIDUM AND PHELLINUS LINTEUS FOR PROMOTING THE PROLIFERATION OF HEMATOPOIETIC STEM CELLS 审中-公开
标题翻译：含有FUSCOPORIA OBLIQUA，GANODERMA LUCIDUM和PHELLINUS LINTEUS提取HEMATOPOIETIC STEM细胞增殖的组合物
公开(公告)号：WO2010082798A2
公开(公告)日：2010-07-22
申请号：PCT/KR2010000310
申请日：2010-01-18
申请人： RNL BIO CO LTD , BAE HYUNG SUK , KANG SUNG KEUN , SHIN IL SEOB , WOO SANG KYU , KIM YUN JUNG , KIM MI AE , RA JEONG CHAN
发明人： BAE HYUNG SUK , KANG SUNG KEUN , SHIN IL SEOB , WOO SANG KYU , KIM YUN JUNG , KIM MI AE , RA JEONG CHAN
IPC分类号： A61K36/074 , A61K36/07 , A61K36/258 , A61P37/00
CPC分类号： A61K36/07 , A61K36/074
摘要： The present invention relates to a composition containing mushroom extracts for promoting the proliferation of hematopoietic stem cells, and more specifically to a composition having a proliferation-promotive effect on hematopoietic stem cells, wherein the composition contains active ingredients composed of extracts of fuscoporia obliqua, ganoderma lucidum and phellinus linteus and plant extracts for improving immune activities thereof, and to functional foods. The composition and functional foods according to the present invention substantially increase the proliferation of hematopoietic stem cells to help immune activities, and the proliferation of hematopoietic stem cells together with the improved immune activity create anticancer and anti-inflammatory effects, promote cell activities, regenerate damaged tissues and prevent cardiovascular diseases, all in a positive way.
摘要翻译：本发明涉及含有用于促进造血干细胞增殖的蘑菇提取物的组合物，更具体地说涉及对造血干细胞具有增殖促进作用的组合物，其中，所述组合物含有活性成分，所述活性成分由禾本科植物提取物，灵芝灵芝和桑黄以及用于提高其免疫活性的植物提取物和功能性食品。根据本发明的组合物和功能性食物显着增加造血干细胞的增殖以帮助免疫活性，并且造血干细胞的增殖以及改善的免疫活性产生抗癌和抗炎作用，促进细胞活性，再生损伤组织和预防心血管疾病，都以积极的方式。

3. 发明申请

WO2012008813A3 CULTURE MEDIUM COMPOSITION FOR CULTURING AMNION-DERIVED MESENCHYMAL STEM CELL, AND METHOD FOR CULTURING AMNION-DERIVED MESENCHYMAL STEM CELL BY USING SAME 审中-公开
标题翻译：培养羊膜来源的间质干细胞的培养基培养基组合物以及使用相同培养方法培养羊膜来源的间质干细胞的方法
公开(公告)号：WO2012008813A3
公开(公告)日：2012-05-03
申请号：PCT/KR2011005258
申请日：2011-07-18
申请人： RNL BIO CO LTD , RA JEONG CHAN , KANG SUNG KEUN , SEO JU YEON , KIM HYOEUN
发明人： RA JEONG CHAN , KANG SUNG KEUN , SEO JU YEON , KIM HYOEUN
IPC分类号： C12N5/0775 , C12N5/02
CPC分类号： C12N5/0605 , C12N5/0668 , C12N2500/14 , C12N2500/32 , C12N2501/115 , C12N2501/33 , C12N2501/39
摘要： The present invention relates to a culture medium for culturing a mesenchymal stem cell, and more specifically, to a culture medium composition for culturing a mesenchymal stem cell, comprising a basic culture medium, L-ascorbic acid 2-phosphate, fetal bovine serum, basic fibroblast growth factor (b-FGF), non-essential amino acids (NEAA), insulin, N-acetyl-L-cysteine, calcium chloride and hydrocortisone,and a method for culturing a mesenchymal stem cell by using the same. According to the present invention, it is possible to obtain the number of mesenchymal stem cells necessary for stem cell treatment within a short time and the differentiation of mesenchymal stem cells is improved, and is useful for the treatment of cells using a stem cell.
摘要翻译：本发明涉及用于培养间充质干细胞的培养基，更具体地涉及用于培养间充质干细胞的培养基组合物，其包含碱性培养基，L-抗坏血酸2-磷酸，胎牛血清，碱性成纤维细胞生长因子（b-FGF），非必需氨基酸（NEAA），胰岛素，N-乙酰-L-半胱氨酸，氯化钙和氢化可的松，以及使用其培养间充质干细胞的方法。根据本发明，可以在短时间内获得干细胞治疗所需的间充质干细胞的数量，并且间充质干细胞的分化得到改善，并且可用于使用干细胞处理细胞。

4. 发明申请

WO2011056017A3 MASS PROPAGATION METHOD FOR HAIR FOLLICLE STEM CELLS 审中-公开
标题翻译：毛囊干细胞的质量传播方法
公开(公告)号：WO2011056017A3
公开(公告)日：2011-11-03
申请号：PCT/KR2010007794
申请日：2010-11-05
申请人： RNL BIO CO LTD , RA JEONG CHAN , KANG SUNG KEUN , WOO SANG KYU , KIM MI AE , YOON EUN JI
发明人： RA JEONG CHAN , KANG SUNG KEUN , WOO SANG KYU , KIM MI AE , YOON EUN JI
IPC分类号： C12N5/02 , A61K35/36 , A61P17/14 , C12N5/071
CPC分类号： C12N5/0628 , A61K35/12 , C12N2501/70
摘要： The present invention relates to a method for propagating hair follicle stem cells with a high yield rate, and more particularly, to a method which uses a specific culture medium with a Rho-associated kinase (ROCK) inhibitor at a specific concentration during the cultivation of hair follicle stem cells, in order to mass-produce hair follicle stem cells. The present invention also relates to the culture medium used for the method. The culture medium for culturing hair follicle stem cells according to the present invention can propagate hair follicle stem cells separated from scalp tissues in an amount sufficient for application to clinical treatment, and therefore the hair follicle stem cells can be effectively used as therapeutic agents for promoting hair growth for those with alopecia, atrichia, and the like.
摘要翻译：本发明涉及以高收率繁殖毛囊干细胞的方法，更具体地涉及在培养期间使用具有特定浓度的Rho相关激酶（ROCK）抑制剂的特定培养基的方法毛囊干细胞，以大量生产毛囊干细胞。本发明还涉及用于该方法的培养基。根据本发明的用于培养毛囊干细胞的培养基可以使从头皮组织分离的毛囊干细胞以足以用于临床治疗的量增殖，因此毛囊干细胞可以有效地用作促进剂的治疗剂头发生长用于脱发，无毛菌等。

5. 发明申请

WO2012074265A3 COMPOSITION FOR PROMOTING THE STABILITY OF STEM CELLS 审中-公开
标题翻译：促进干细胞稳定性的组合物
公开(公告)号：WO2012074265A3
公开(公告)日：2012-08-23
申请号：PCT/KR2011009140
申请日：2011-11-29
申请人： RNL BIO CO LTD , PARK HYEONG-GEUN , KANG SUNG KEUN , RA JEONG CHAN , YIM CHA-OK
发明人： PARK HYEONG-GEUN , KANG SUNG KEUN , RA JEONG CHAN , YIM CHA-OK
IPC分类号： C12N5/0775 , A61K35/12 , C07K14/475 , C12N5/02
CPC分类号： C12N5/0663 , A61K35/28
摘要： The present invention relates to a composition which can promote the stability of stem cells, and more specifically relates to a composition for promoting the stability of stem cells which contains a mesenchymal stem cell culture and base. The composition for promoting the stability of stem cells according to the present invention has the advantageous effect of promoting the stability of stem cells and maintaining a high survival rate, and, in injectable cell therapeutic agent products that contain the composition for promoting the stability of stem cells according to the present invention, the survival rate of the stem cells comprised in the cell therapeutic agent can be maintained at at least 80% for a long time (10 days), and thus the composition for promoting the stability of stem cells according to the present invention can be used in long-duration transportation of injectable cell therapeutic agent products and, as a consequence of the high survival rates of the stem cells comprised in the cell therapeutic agent, the advantages in cell therapy are outstanding and hence the invention can also be used to advantage in the production of high-quality injectable cell therapeutic agent products.
摘要翻译：本发明涉及能够促进干细胞稳定性的组合物，更具体而言，涉及含有间充质干细胞培养物和碱的用于促进干细胞稳定性的组合物。根据本发明的用于促进干细胞稳定性的组合物具有促进干细胞稳定性并维持高存活率的有利效果，并且在含有用于促进干细胞稳定性的组合物的注射用细胞治疗剂产品根据本发明的细胞，包含在细胞治疗剂中的干细胞的存活率可以长时间（10天）维持在至少80％，因此根据本发明的用于促进干细胞稳定性的组合物本发明可以用于可注射细胞治疗剂产品的长时间运输，并且由于细胞治疗剂中包含的干细胞的高存活率的结果，细胞疗法的优点是突出的，因此本发明可以也可用于生产高质量注射用细胞治疗剂产品。

6. 发明申请

WO2010008219A3 CULTURE OF MULTI-POTENTIAL STEM CELLS ORIGINATING IN ADIPOSE TISSUE AND A COSMETIC COMPOSITION CONTAINING PROTEIN EXTRACTED THEREFROM 审中-公开
标题翻译：多潜能干细胞在脂肪组织中的培养及其含有蛋白质的化妆品组合物的提取
公开(公告)号：WO2010008219A3
公开(公告)日：2010-04-22
申请号：PCT/KR2009003923
申请日：2009-07-16
申请人： RNL BIO CO LTD , RA JEONG CHAN , KANG SUNG KEUN , YIM CHA OK , KIM HYO EUN
发明人： RA JEONG CHAN , KANG SUNG KEUN , YIM CHA OK , KIM HYO EUN
IPC分类号： A61K8/89
CPC分类号： A61Q19/08 , A61K8/64
摘要： The present invention relates to an adult stem cell culture originating in adipose tissue and a cosmetic composition containing either protein extracted from said adult stem cells originating in adipose tissue, or peptide or amino acid hydrolysates of said protein as the active ingredient. As a result of the synergistic and reciprocal effects of improving wrinkles and preventing aging of said adult stem cell cultures originating in adipose tissue and proteins or amino acids extracted from said culture, the cosmetic composition of the present invention can be used for the manufacture of functional cosmetics.
摘要翻译：本发明涉及源自脂肪组织的成体干细胞培养物和含有从源于脂肪组织的所述成体干细胞提取的蛋白质或者所述蛋白质的肽或氨基酸水解产物作为活性成分的化妆品组合物。由于改善了起源于脂肪组织和由所述培养物提取的蛋白质或氨基酸的所述成体干细胞培养物的皱纹并防止老化的协同和相互作用，本发明的化妆品组合物可用于制造功能性化妆品。

7. 发明申请

WO2009148279A3 TRITERPENOID-BASED COMPOUND USED AS A VIRUS INHIBITOR 审中-公开
标题翻译：基于三萜类的化合物用作病毒抑制剂
公开(公告)号：WO2009148279A3
公开(公告)日：2010-03-11
申请号：PCT/KR2009002994
申请日：2009-06-04
申请人： RNL BIO CO LTD , RA JEONG CHAN , KIM YOUNG HO , KWON HYUK JOON , NGUYEN HUU TUNG
发明人： RA JEONG CHAN , KIM YOUNG HO , KWON HYUK JOON , NGUYEN HUU TUNG
IPC分类号： A61K31/56
CPC分类号： A61K31/11
摘要： The present invention relates to an application for a triterpenoid-based compound of Chemical formula (1), for suppressing viral activity. The triterpenoid-based compound according to the present invention is outstandingly effective in suppressing viral activity and can therefore be beneficially used as a therapeutic agent for medical conditions in which a virus is involved.
摘要翻译：本发明涉及化学式（1）的三萜类化合物用于抑制病毒活性的用途。本发明的三萜类化合物在抑制病毒活性方面非常有效，因此可以有利地用作涉及病毒的医学病症的治疗剂。

8. 发明申请

WO2009075488A3 ANTI-INFLUENZA VIRAL COMPOSITION CONTAINING BARK OR STEM EXTRACT OF ALNUS JAPONICA 审中-公开
标题翻译：含有日本榛子皮或茎提取物的抗流感病毒组合物
公开(公告)号：WO2009075488A3
公开(公告)日：2009-08-06
申请号：PCT/KR2008007172
申请日：2008-12-04
申请人： RNL BIO CO LTD , RA JEONG CHAN , KWON HYUK JOON , KIM BYEUNG GIE , YOU SEOK HYON
发明人： RA JEONG CHAN , KWON HYUK JOON , KIM BYEUNG GIE , YOU SEOK HYON
IPC分类号： A61K36/185
CPC分类号： A61K36/185
摘要： The present invention relates to an antiviral composition comprising an Alnus japonica extract, more specifically, relates to a method for preparing high activated anti-influenza viral composition, which comprises an extract of the bark or stem of Alnus japonica, and an anti-influenza viral composition comprising the extract. An extract of the bark or stem of Alnus japonica according to the present invention has low toxicity to normal cells, while having an excellent antiviral effect even when administered at low concentration and thus the composition comprising the Alnus japonica extract can be used effectively in preventing and treating influenza viral infection.
摘要翻译：本发明涉及包含Al木提取物的抗病毒组合物，更具体地涉及用于制备高活化的抗流感病毒组合物的方法，所述组合物包含Al木树皮或茎的提取物和抗流感病毒包含提取物的组合物。根据本发明的赤杨的树皮或茎的提取物对正常细胞具有低毒性，而即使以低浓度施用也具有优异的抗病毒效果，并且因此包含Al木提取物的组合物可有效用于预防和治疗流感病毒感染。

9. 发明申请

WO2009148282A3 NOVEL DIARYL HEPATONOID COMPOUND AND USE THEREOF 审中-公开
标题翻译：新型DIARYL HEPATONOID化合物及其用途
公开(公告)号：WO2009148282A3
公开(公告)日：2010-03-11
申请号：PCT/KR2009002997
申请日：2009-06-04
申请人： RNL BIO CO LTD , RA JEONG CHAN , KIM YOUNG HO , KWON HYUK JOON , NGUYEN HUU TUNG
发明人： RA JEONG CHAN , KIM YOUNG HO , KWON HYUK JOON , NGUYEN HUU TUNG
IPC分类号： C07D309/08
CPC分类号： C07D309/10
摘要： The present invention relates to a diaryl hepatonoid compound of chemical formula (1) having virus inhibitory activity; its pharmaceutically acceptable salts; its hydrates, solvates or prodrugs; and a pharmaceutical composition containing the compound and its use as a therapeutic agent. The diaryl hepatonoid compound according to the present invention has excellent inhibitory effects on virus activity, and can be used as a therapeutic agent for virus-related diseases.
摘要翻译：本发明涉及具有病毒抑制活性的化学式（1）的二芳基肝素类化合物; 其药学上可接受的盐; 其水合物，溶剂合物或前药; 以及含有该化合物的药物组合物及其作为治疗剂的用途。根据本发明的二芳基肝素类化合物对病毒活性具有优异的抑制作用，可用作病毒相关疾病的治疗剂。

10. 发明申请

WO2009148280A3 DIARYL HEPATONOID-BASED COMPOUND USEFUL AS VIRUS INHIBITOR 审中-公开
标题翻译：基于类胡萝卜素的化合物可用作病毒抑制剂
公开(公告)号：WO2009148280A3
公开(公告)日：2010-03-04
申请号：PCT/KR2009002995
申请日：2009-06-04
申请人： RNL BIO CO LTD , RA JEONG CHAN , KIM YOUNG HO , KWON HYUK JOON , NGUYEN HUU TUNG
发明人： RA JEONG CHAN , KIM YOUNG HO , KWON HYUK JOON , NGUYEN HUU TUNG
IPC分类号： A61K31/12
CPC分类号： A61K31/7032 , A61K31/12 , A61K31/7028
摘要： The present invention relates to use of a diaryl hepatonoid-based compound of the following chemical formula (1) for inhibiting virus activity. The diaryl hepatonoid-based compound according to the present invention has excellent inhibitory effects on virus activity, so it can be used as a therapeutic agent for virus-related diseases.
摘要翻译：本发明涉及以下化学式（1）的二芳基肝素类化合物用于抑制病毒活性的用途。根据本发明的二芳基肝素类化合物对病毒活性具有优异的抑制作用，因此可用作病毒相关疾病的治疗剂。

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