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1. 发明申请

WO2003074007A3 MODULATORS OF LEUKOCYTE ACTIVATION, COMPOSITIONS, AND METHODS OF USE 审中-公开
公开(公告)号：WO2003074007A3
公开(公告)日：2003-09-12
申请号：PCT/US2003/006748
申请日：2003-03-03
申请人： RIGEL PHARMACEUTICALS, INC. , FRIERA, Annabelle, M. , VALLONE, Marcy, K. , WONG, Brian , MASUDA, Esteban , POWELL, Mark
发明人： FRIERA, Annabelle, M. , VALLONE, Marcy, K. , WONG, Brian , MASUDA, Esteban , POWELL, Mark
IPC分类号： C12N5/00
摘要： The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids and proteins which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.

2. 发明申请

WO2003074007A2 MODULATORS OF LEUKOCYTE ACTIVATION, COMPOSITIONS, AND METHODS OF USE 审中-公开
标题翻译：荧光素激活的调节剂，组合物和使用方法
公开(公告)号：WO2003074007A2
公开(公告)日：2003-09-12
申请号：PCT/US2003/006748
申请日：2003-03-03
申请人： RIGEL PHARMACEUTICALS, INC. , FRIERA, Annabelle, M. , VALLONE, Marcy, K. , WONG, Brian , MASUDA, Esteban , POWELL, Mark
发明人： FRIERA, Annabelle, M. , VALLONE, Marcy, K. , WONG, Brian , MASUDA, Esteban , POWELL, Mark
IPC分类号： A61K
CPC分类号： C07K14/47 , A61K38/00 , G01N33/5047
摘要： The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids and proteins which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.
摘要翻译：本发明提供了调节白细胞活化的组合物和方法。提供能够调节白细胞活化的核酸和蛋白质。还提供了用于治疗与白细胞功能障碍或失调相关的疾病的组合物和方法。还提供了预防和预防这种疾病的方法。还提供了用于诊断和预测这些疾病的组合物和方法。还提供了用于鉴定能够调节白细胞活化的生物活性剂的测定法。

3. 发明申请

WO2004009786A2 MODULATORS OF LEUKOCYTE ACTIVATION, BIC COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：荧光素激活剂的调节剂，BIC组合物和使用方法
公开(公告)号：WO2004009786A2
公开(公告)日：2004-01-29
申请号：PCT/US2003/022918
申请日：2003-07-22
申请人： RIGEL PHARMACEUTICALS, INC. , VALLONE, Marcy, K. , WONG, Brian , MASUDA, Esteban , POWELL, Mark
发明人： VALLONE, Marcy, K. , WONG, Brian , MASUDA, Esteban , POWELL, Mark
IPC分类号： C12N
CPC分类号： G01N33/6872 , C07K14/705 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.
摘要翻译：本发明提供了调节白细胞活化的组合物和方法。提供编码能够调节白细胞活化的蛋白质和蛋白质的核酸。还提供了用于治疗与白细胞功能障碍或失调相关的疾病的组合物和方法。还提供了预防和预防这种疾病的方法。还提供了用于这种障碍的诊断和预后测定的组合物和方法。还提供了用于鉴定能够调节白细胞活化的生物活性剂的测定法。

4. 发明申请

WO2004009791A2 MODULATORS OF B-LYMPHOCYTE ACTIVATION, MYOSIN-1F COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： B淋巴细胞活化调节剂，MYOSIN-1F组合物及其使用方法
公开(公告)号：WO2004009791A2
公开(公告)日：2004-01-29
申请号：PCT/US2003/023044
申请日：2003-07-22
申请人： RIGEL PHARMACEUTICALS, INC. , VALLONE, Marcy, K. , WONG, Brian, R. , MASUDA, Esteban , POWELL, Mark
发明人： VALLONE, Marcy, K. , WONG, Brian, R. , MASUDA, Esteban , POWELL, Mark
IPC分类号： C12N
CPC分类号： C12Q1/42 , C07K14/4716 , G01N33/5052 , G01N33/9493
摘要： The present invention provides compositions and methods for modulating B-lymphocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating B-lymphocyte activation are provided. Compositions and methods for the treatment of disorders related to dysfunction or dysregulation of B-lymphocyte activation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable for modulating B-lymphocyte activation.
摘要翻译：本发明提供用于调节B-淋巴细胞活化的组合物和方法。提供编码能够调节B淋巴细胞活化的蛋白质和蛋白质的核酸。还提供了用于治疗与B淋巴细胞活化的功能障碍或失调相关的疾病的组合物和方法。还提供了预防和预防这种疾病的方法。还提供了用于诊断和预测这些疾病的组合物和方法。还提供了用于鉴定能够调节B-淋巴细胞活化的生物活性剂的测定法。

5. 发明申请

WO2004004666A2 MODULATORS OF LEUKOCYTE ACTIVATION, HCK COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：低密度脂蛋白激活剂，HCK组合物的调节剂和使用方法
公开(公告)号：WO2004004666A2
公开(公告)日：2004-01-15
申请号：PCT/US2003/022243
申请日：2003-07-10
申请人： RIGEL PHARMACEUTICALS, INC. , FRIERA, AnnaBelle , WONG, Brian, R. , MASUDA, Esteban , POWELL, Mark
发明人： FRIERA, AnnaBelle , WONG, Brian, R. , MASUDA, Esteban , POWELL, Mark
IPC分类号： A61K
CPC分类号： C12Q1/485 , G01N33/5047 , G01N2500/02
摘要： The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.
摘要翻译：本发明提供了调节白细胞活化的组合物和方法。提供编码能够调节白细胞活化的蛋白质和蛋白质的核酸。还提供了用于治疗与白细胞功能障碍或失调相关的疾病的组合物和方法。还提供了预防和预防这种疾病的方法。还提供了用于诊断和预测这些疾病的组合物和方法。还提供了用于鉴定能够调节白细胞活化的生物活性剂的测定法。

6. 发明申请

WO2003023706A1 METHOD OF MAKING INTERACTIVE INFORMATION CLOSURE AND PACKAGE 审中-公开
标题翻译：制作交互式信息封闭和包装的方法
公开(公告)号：WO2003023706A1
公开(公告)日：2003-03-20
申请号：PCT/US2002/028922
申请日：2002-09-11
申请人： ALCOA CLOSURE SYSTEMS INTERNATIONAL, INC. , SMEYAK, Larry , CARR, Timothy , POWELL, Mark , ZIEGLER, John
发明人： SMEYAK, Larry , CARR, Timothy , POWELL, Mark , ZIEGLER, John
IPC分类号： G06K19/077
CPC分类号： H01Q1/2225 , G06K19/04 , G06K19/07749 , G06K19/07758 , H01Q1/22
摘要： A method of making an interactive information package (10), including an interactive information closure (1) including a ratio frequency identification device (16), contemplates that a microelectronics assembly be provided by formation on an inside surface of the top wall portion of the closure of the package. After formation of the assembly, it is contemplated that a sealing liner be positioned within the closure so that the microelectronics assembly is positioned between the top wall portion and the sealing liner.
摘要翻译：一种制造交互式信息包（10）的方法，包括包括比率频率识别装置（16）的交互信息关闭（1），预期通过形成微电子组件来形成微电子组件关闭包装。在组装形成之后，预期密封衬垫定位在封闭件内，使得微电子组件位于顶壁部分和密封衬里之间。

7. 发明申请

WO2003060818A2 METHOD OF MAKING INTERACTIVE INFORMATION CLOSURE AND PACKAGE 审中-公开
标题翻译：制作交互式信息封闭和包装的方法
公开(公告)号：WO2003060818A2
公开(公告)日：2003-07-24
申请号：PCT/US2003/000090
申请日：2003-01-02
申请人： ALCOA CLOSURE SYSTEMS INTERNATIONAL, INC. , SMEYAK, Larry , CARR, Timothy , POWELL, Mark , ZIEGLER, John
发明人： SMEYAK, Larry , CARR, Timothy , POWELL, Mark , ZIEGLER, John
IPC分类号： G06K19/00
CPC分类号： G06K19/07758 , B65D51/245 , B65D2203/10 , G06K19/041 , G06K19/07745 , G06K19/07749 , G06K19/07779 , G06K19/07783 , H01L2924/0002 , H01L2924/00
摘要： A method of making an interactive information package, including an interactive information closure including a radio frequency identification device, contemplates that a microelectronics assembly be positioned within a mold cavity within which a plastic closure is subsequently molded. The microelectronics assembly is thus integrated with the closure, such as by disposition on either the exterior or interior of a top wall portion of the closure. The closure can be provided with a sealing liner positioned adjacent an inside surface of the top wall portion.
摘要翻译：一种制作交互式信息包的方法，包括包括射频识别装置的交互式信息关闭，预期微电子组件定位在模腔内，随后模塑塑料封闭件。微电子组件因此与闭合件一体化，例如通过配置在封闭件的顶壁部分的外部或内部。封闭件可以设置有邻近顶壁部分的内表面定位的密封衬垫。

8. 发明申请

WO2011053507A1 2-AMINO-9-[4-(4-METHOXY-PHENOXY) - PIPERID IN -1-YL] -4-PHENYL-INDENO [1,2-D] PYRIMIDIN -5 -ONE AND ITS USE AS A HIGHLY SELECTIVE ADENOSINE A2A RECEPTOR ANTAGONIST 审中-公开
标题翻译： 2-氨基-9- [4-（4-甲氧基 - 苯氧基） - 哌嗪-1-基] -4-苯基 - 茚并[1,2-D]嘧啶-5-酮并且其作为高选择性腺苷 A2A受体拮抗剂
公开(公告)号：WO2011053507A1
公开(公告)日：2011-05-05
申请号：PCT/US2010/053568
申请日：2010-10-21
申请人： JANSSEN PHARMACEUTICA NV , JACKSON, Paul, F. , POWELL, Mark , SHOOK, Brian, Christopher , WANG, Aihua
发明人： JACKSON, Paul, F. , POWELL, Mark , SHOOK, Brian, Christopher , WANG, Aihua
IPC分类号： C07D401/04 , A61K31/517 , A61P25/16
CPC分类号： C07D401/04
摘要： This invention relates to a novel arylindenopyrimidine, A, and its therapeutic and prophylactic uses. Disorders treated and/or prevented include Parkinson's Disease.
摘要翻译：本发明涉及一种新颖的阿氮茚嘧啶A及其治疗和预防用途。治疗和/或预防的疾病包括帕金森病。

9. 发明申请

WO2009138316A1 ENCODER DEVICE AND GAPPING AND CENTRING DEVICE FOR AN ENCODER DEVICE 审中-公开
标题翻译：编码器装置和用于编码器装置的接口和中心装置
公开(公告)号：WO2009138316A1
公开(公告)日：2009-11-19
申请号：PCT/EP2009/054824
申请日：2009-04-22
申请人： DR. JOHANNES HEIDENHAIN GmbH , POWELL, Mark
发明人： POWELL, Mark
IPC分类号： G01D5/347
CPC分类号： G01D5/34707 , G01D5/34738 , Y10T74/1488
摘要： An encoder device (5, 6) includes: a housing (10); a hub (15) arranged in the housing (10), the hub (15) arranged to carry an encoder disc (20), the hub (15) rotatable in the housing (10); a cover (30, 31 ) that is axially movable between a first position and a second position; and a gapping and centring device (35) arranged to urge the hub (15) into a predetermined axial and radial position relative to a portion of the housing (10) when the cover (30, 31 ) is in the first position, the gapping and centring device (35) arranged to permit axial and radial movement of the hub (15) when the cover (30, 31 ) is in the second position.
摘要翻译：编码器装置（5,6）包括：壳体（10）; 布置在所述壳体（10）中的轮毂（15），所述轮毂（15）布置成承载编码器盘（20），所述轮毂（15）可在所述壳体（10）中旋转; 可在第一位置和第二位置之间轴向移动的盖子（30,31）; 以及间隙和定心装置（35），其布置成当所述盖（30,31）处于所述第一位置时相对于所述壳体（10）的一部分推动所述轮毂（15）进入预定的轴向和径向位置，所述间隙和定心装置（35），其布置成当盖（30,31）处于第二位置时允许轮毂（15）的轴向和径向移动。

10. 发明申请

WO2002095671A1 PACKAGE WITH INTEGRATED TRANSPONDER 审中-公开
标题翻译：包装与集成的TRANSPONDER
公开(公告)号：WO2002095671A1
公开(公告)日：2002-11-28
申请号：PCT/US2002/015508
申请日：2002-05-15
申请人： ALCOA CLOSURE SYSTEMS INTERNATIONAL, INC. , CARR, Timothy , LANDSKRONE, Siegfried , SMEYAK, Lawrence, M. , POWELL, Mark , GATLIN-CHAMBERS, Sharon, L. , ZIEGLER, John
发明人： CARR, Timothy , LANDSKRONE, Siegfried , SMEYAK, Lawrence, M. , POWELL, Mark , GATLIN-CHAMBERS, Sharon, L. , ZIEGLER, John
IPC分类号： G06K19/04
CPC分类号： B65D55/028 , B65D51/245 , B65D2203/10 , G06K19/041
摘要： A product package (10) embodying the principles of the present invention includes an integrated circuit device (16) which is configured for radio frequency interfacing with associated equipment. The package is configured such that the integrated circuit device is disposed within the package, thus assuring that the device remains associated with the package's contents. Notably, this arrangement facilitates use of the device for applications apart from product tracking and inventory control, including product promotions, storage, and dissemination of product information, and quality assurance including tamper-indication. A packaging machine for writing information on, and or reading information from, the integrated circuit device is also disclosed.
摘要翻译：体现本发明原理的产品包（10）包括集成电路装置（16），其被配置用于与相关设备的无线电频率接口。该封装构造成使得集成电路器件设置在封装内，从而确保该器件保持与封装的内容物相关联。值得注意的是，这种安排便于将设备用于除了产品跟踪和库存控制之外的应用，包括产品升级，存储和产品信息的传播以及包括篡改指示的质量保证。还公开了一种用于在集成电路器件上写入信息和从其读取信息的封装机。

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