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1. 发明申请

WO2009065131A1 CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS 审中-公开
标题翻译：用于代谢障碍的羧酰胺，磺酰胺和胺化合物
公开(公告)号：WO2009065131A1
公开(公告)日：2009-05-22
申请号：PCT/US2008/083801
申请日：2008-11-17
申请人： RIGEL PHARMACEUTICALS, INC. , HONG, Hui , XU, Xiang , YU, Jiaxin , SINGH, Rajinder , DARWISH, Ihab, S. , THOTA, Sambaiah
发明人： HONG, Hui , XU, Xiang , YU, Jiaxin , SINGH, Rajinder , DARWISH, Ihab, S. , THOTA, Sambaiah
IPC分类号： C07D211/46 , C07D211/58 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , A61K31/4427 , A61K31/4523 , A61P3/00 , A61P9/00
CPC分类号： C07D401/14 , C07D211/46 , C07D211/58 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14
摘要： Disclosed are carboxamide, sulfonamide and amine compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R 1 , R 2 , R 4 , E, T, n and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.
摘要翻译：公开了羧酰胺，磺酰胺和胺化合物，以及药物组合物和使用方法。一个实施方案是具有其中R 1，R 2，R 4，E，T，n和x如本文所述的结构的化合物。在某些实施方案中，本文公开的化合物激活AMPK途径，并且可用于治疗与代谢有关的病症和病症。

2. 发明申请

WO2009076631A1 CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS 审中-公开
标题翻译：用于代谢障碍的羧酰胺，磺酰胺和胺化合物
公开(公告)号：WO2009076631A1
公开(公告)日：2009-06-18
申请号：PCT/US2008/086673
申请日：2008-12-12
申请人： RIGEL PHARMACEUTICALS, INC. , DARWISH, Ihab, S. , YU, Jiaxin , HONG, Hui , SINGH, Rajinder , THOTA, Sambaiah , XU, Xiang
发明人： DARWISH, Ihab, S. , YU, Jiaxin , HONG, Hui , SINGH, Rajinder , THOTA, Sambaiah , XU, Xiang
IPC分类号： C07D471/04 , C07D401/12 , C07D401/14 , A61K31/4427 , A61K31/4523 , A61P3/00 , A61P9/00 , C07D401/06
CPC分类号： C07D471/04 , C07D401/06 , C07D401/12 , C07D401/14
摘要： Disclosed are carboxamide, sulfonamide and amine compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R 1 , R 2 , R 4 , D, E, J, T, p, q and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.
摘要翻译：公开了羧酰胺，磺酰胺和胺化合物，以及药物组合物和使用方法。一个实施方案是具有其中R 1，R 2，R 4，D，E，J，T，p，q和x如本文所述的结构的化合物。在某些实施方案中，本文公开的化合物激活AMPK途径，并且可用于治疗与代谢有关的病症和病症。

3. 发明申请

WO2009132136A1 CARBOXAMIDE COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS 审中-公开
标题翻译：用于治疗代谢性疾病的羧酰胺化合物
公开(公告)号：WO2009132136A1
公开(公告)日：2009-10-29
申请号：PCT/US2009/041448
申请日：2009-04-22
申请人： RIGEL PHARMACEUTICALS, INC. , YU, Jiaxin , HONG, Hui , DARWISH, Ihab, S. , XU, Xiang , SINGH, Rajinder
发明人： YU, Jiaxin , HONG, Hui , DARWISH, Ihab, S. , XU, Xiang , SINGH, Rajinder
IPC分类号： C07D471/04 , C07D401/12 , C07D401/14 , A61K31/4427 , A61K31/4523 , A61P3/00 , A61P9/00 , C07D401/06 , C07D413/12 , C07D413/14 , C07D417/14 , C07D487/08 , C07D211/58
CPC分类号： C07D471/04 , A61K31/437 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/497 , C07D211/58 , C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D487/08
摘要： Disclosed are carboxamide compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R 1 , R 2 , R 3 , R 4 , D, J, Z, T, p, q, w and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.
摘要翻译：公开了羧酰胺化合物，以及药物组合物和使用方法。一个实施方案是具有其中R 1，R 2，R 3，R 4，D，J，Z，T，p，q，w和x如本文所述的结构的化合物。在某些实施方案中，本文公开的化合物激活AMPK途径，并且可用于治疗与代谢有关的病症和病症。

4. 发明申请

WO2008083124A1 N-SUBSTITUTED-HETEROCYCLOALKYLOXYBENZAMIDE COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译： N-取代的杂环基二茂铁基化合物及其使用方法
公开(公告)号：WO2008083124A1
公开(公告)日：2008-07-10
申请号：PCT/US2007/088742
申请日：2007-12-21
申请人： RIGEL PHARMACEUTICALS, INC. , SINGH, Rajinder , YU, Jiaxin , HONG, Hui , THOTA, Sambaiah , XU, Xiang
发明人： SINGH, Rajinder , YU, Jiaxin , HONG, Hui , THOTA, Sambaiah , XU, Xiang
IPC分类号： C07D211/58 , C07D211/96 , C07D401/14 , C07D405/14 , A61K31/4545 , A61P3/10 , A61P9/00 , C07D409/14
CPC分类号： C07D401/12 , C07D211/58 , C07D211/96 , C07D401/14 , C07D405/14 , C07D409/14
摘要： The present invention provides N-substituted-heterocycloalkyloxybenzamide compounds, as well as pharmaceutical compositions and methods of use. One embodiment of the invention is a compound having the structure (I), in which R 1 , R 2 , R 3 , R 4 , T, n, w and x are as described herein. In certain embodiments of the invention, a compound of the present invention activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.
摘要翻译：本发明提供N-取代的 - 杂环烷氧基苯甲酰胺化合物，以及药物组合物和使用方法。本发明的一个实施方案是具有结构（I）的化合物，其中R 1，R 2，R 3，R 3， > 4，T，n，w和x如本文所述。在本发明的某些实施方案中，本发明的化合物激活AMPK途径，并且可用于治疗与代谢相关的病症和病症。

5. 发明申请

WO2010088392A1 CARBOXAMIDE COMPOUNDS AND METHODS FOR USING THE SAME 审中-公开
标题翻译：羧酰胺化合物及其使用方法
公开(公告)号：WO2010088392A1
公开(公告)日：2010-08-05
申请号：PCT/US2010/022411
申请日：2010-01-28
申请人： RIGEL PHARMACEUTICALS, INC. , DARWISH, Ihab, S. , HONG, Hui , SINGH, Rajinder , XU, Xiang
发明人： DARWISH, Ihab, S. , HONG, Hui , SINGH, Rajinder , XU, Xiang
IPC分类号： C07D401/12 , A61K31/501 , A61P3/00 , A61P9/00
CPC分类号： C07D401/12 , C07D401/14
摘要： Disclosed are carboxamide compounds as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure (I) in which R 1 , R 2 , R 3 , R 4 , T, p, q, w and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.
摘要翻译：公开了羧酰胺化合物以及药物组合物和使用方法。一个实施方案是具有结构（I）的化合物，其中R 1，R 2，R 3，R 4，T，p，q，w和x如本文所述。在某些实施方案中，本文公开的化合物激活AMPK途径，并且可用于治疗与代谢有关的病症和病症。

6. 发明申请

WO2003040409A1 NOVEL GERMINAL CENTER KINASE PROTEINS, COMPOSITIONS, AND METHODS OF USE 审中-公开
标题翻译：新型终端中心激酶蛋白，组合物和使用方法
公开(公告)号：WO2003040409A1
公开(公告)日：2003-05-15
申请号：PCT/US2002/033845
申请日：2002-10-21
申请人： RIGEL PHARMACEUTICALS, INC. , LEO, Cindy , LUO, Ying , XU, Xiang , YU, Simon
发明人： LEO, Cindy , LUO, Ying , XU, Xiang , YU, Simon
IPC分类号： C12Q1/68
CPC分类号： C12N9/1205 , C12Q1/485 , G01N33/5041 , G01N2500/02
摘要： The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating proliferation, survival, morphology and migration in mammalian cells are provided. Compositions and methods for the treatment of disorders related to cell proliferation, survival, morphology and migration are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating proliferation, survival, morphology and migration in mammalian cells.
摘要翻译：本发明提供调节细胞增殖，存活，形态和迁移的组合物和方法。提供了编码能够调节哺乳动物细胞中增殖，存活，形态和迁移的蛋白质和蛋白质的核酸。还提供了用于治疗与细胞增殖，存活，形态和迁移相关的病症的组合物和方法。还提供了预防和预防这种疾病的方法。还提供了用于诊断和预测这些疾病的组合物和方法。还提供了用于鉴定能够调节哺乳动物细胞中增殖，存活，形态和迁移的生物活性剂的测定。

7. 发明申请

WO2001021799A1 TRAF4 ASSOCIATED CELL CYCLE PROTEINS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： TRAF4相关细胞周期蛋白，组合物和使用方法
公开(公告)号：WO2001021799A1
公开(公告)日：2001-03-29
申请号：PCT/US2000/040987
申请日：2000-09-25
申请人： RIGEL PHARMACEUTICALS, INC. , LUO, Ying , XU, Xiang
发明人： LUO, Ying , XU, Xiang
IPC分类号： C12N15/12
CPC分类号： C07K14/4738
摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
摘要翻译：本发明涉及对细胞周期有影响或与其有关的新型多肽，核酸和相关分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，结合本发明多肽的抗体以及产生本发明多肽的方法发明。本发明进一步提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的用途。

8. 发明申请

WO2001064913A3 CELL CYCLE PROTEINS ASSOCIATED WITH RAD9, COMPOSITIONS AND METHODS OF USE 审中-公开
公开(公告)号：WO2001064913A3
公开(公告)日：2001-09-07
申请号：PCT/US2001/006849
申请日：2001-03-02
申请人： RIGEL PHARMACEUTICALS, INC. , XU, Xiang , LUO, Ying
发明人： XU, Xiang , LUO, Ying
IPC分类号： C12N15/55
摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

9. 发明申请

WO2018035128A1 BENZIMIDAZOLE DIRECT AMPK ACTIVATORS 审中-公开
标题翻译：苯并咪唑直接AMPK活化剂
公开(公告)号：WO2018035128A1
公开(公告)日：2018-02-22
申请号：PCT/US2017/046959
申请日：2017-08-15
申请人： RIGEL PHARMACEUTICALS, INC.
发明人： SHAW, Simon , XU, Xiang , ISSAKANI, Sarkiz , SINGH, Rajinder , HITOSHI, Yasumichi , DUNCTON, Matthew , LIN, Nan
IPC分类号： C07D235/26 , C07D403/04 , C07D403/12 , A61K31/41 , A61K31/4184 , A61P3/10 , A61P9/00
摘要： Disclosed are benzimidazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure Formula (I) and pharmaceutically acceptable salts, prodrugs and N -oxides thereof (and solvates and hydrates thereof), wherein R 1 , R 2 , R 3 , R 4 , Y and X are as described herein. In certain embodiments, a compound disclosed herein activates AMPK, and can be used to treat disease by activating the AMPK pathway.
摘要翻译：公开了苯并咪唑化合物，以及药物组合物及其使用方法。一个实施方案是具有结构式（I）的化合物及其药学上可接受的盐，前药和N-氧化物（及其溶剂合物和水合物），其中R 1，R 2，R 3，R 4，Y和X如本文所述。在某些实施方案中，本文公开的化合物激活AMPK，并可用于通过激活AMPK途径来治疗疾病。

10. 发明申请

WO2002086170A1 TANKYRASE H, COMPOSITIONS INVOLVED IN THE CELL CYCLE AND METHODS OF USE 审中-公开
标题翻译： TANKYRASE H，参与细胞周期的组合物和使用方法
公开(公告)号：WO2002086170A1
公开(公告)日：2002-10-31
申请号：PCT/US2002/013185
申请日：2002-04-25
申请人： RIGEL PHARMACEUTICALS, INC.
发明人： LUO, Ying , CHAN, Eva , XU, Xiang , HUANG, Betty , OSSOVSKAYA, Valeria
IPC分类号： C12Q1/68
CPC分类号： C12N9/1077 , A61K38/00
摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
摘要翻译：本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。本发明还提供了鉴定介导细胞周期生物活性的新组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

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