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2. 发明专利

AT317863B 未知
公开(公告)号：AT317863B
公开(公告)日：1974-09-25
申请号：AT601672
申请日：1972-07-13
申请人： RICHTER GEDEON VEGYESZET
发明人： DR LAJOS KISFALUDY , LAJOS DANCSI , AGNES PATTHY , EGON KLUMPP
IPC分类号： C07C271/08 , B01J23/00 , B01J23/04 , C07C67/00 , C07C239/00 , C07C239/08 , C07C239/20 , C07C313/00 , C07C323/59 , C07C83/08

3. 发明专利

RO84709B1 PROCEDEU PENTRU PREPARAREA ESTERILOR ACIDULUI ALCOXIAPOVINCAMINIC 未知
公开(公告)号：RO84709B1
公开(公告)日：1984-09-30
申请号：RO10850482
申请日：1982-08-25
申请人： RICHTER GEDEON VEGYESZET
发明人： CSABA SZANTAY , LAJOS SZABO , GYORGY KALAUS , TIBOR KEVE , LAJOS DANCSI , JANOS GALAMBOS , FERENC VEZEKENYI , TIBOR ACS
IPC分类号： C07D519/04

4. 发明专利

IT8024150D0 未知
公开(公告)号：IT8024150D0
公开(公告)日：1980-08-13
申请号：IT2415080
申请日：1980-08-13
申请人： RICHTER GEDEON VEGYESZET
发明人： CSABA SZANTAY , LAJOS SZABO , GYORGY KALAUS , LAJOS DANCSI , TIBOR KEVE , FERENC DREXLER
IPC分类号： A61K31/435 , A61P9/08 , C07D461/00 , A61K

5. 发明专利

IT7824055D0 未知
公开(公告)号：IT7824055D0
公开(公告)日：1978-05-31
申请号：IT2405578
申请日：1978-05-31
申请人： RICHTER GEDEON VEGYESZET
发明人： KAROLA JOVANOVICS , GYORGY FEKETE , ESZTER DEZSERI , LAJOS DANCSI , CSABA LORINCZ , BELA SZARVADY , GYORGY DOBO , CSABA SZANTAY , LAJOS SZABO
IPC分类号： C07D471/18 , C07D471/20 , C07D471/22 , C07D519/04 , C07D
摘要： Tumor inhibiting alkaloids are recovered from Vinca Rosea L. by a method which comprises extracting the dried leaves with a solvent selected from the group consisting of an alkanol having 1 to 5 carbon atoms, a mixture of an alkanol having 1 to 5 carbon atoms and a dilute, aqueous solution, benzene and benzene homologs; subsequently purifying the alkaloid extract obtained by a phase-change method between immiscible solvents, precipitating the main amount of dimeric alkaloids in form of their sulphuric acid addition salts, isolating leurosine, vincistine, vinblastine, desacetoxy-vinblastine, N-desmethyl-vinblastine and desacetyl-vinblastine from the salt mixture obtained, and then completing the separation and isolation of the remaining alkaloids by separation and isolation by adjusting the pH-value of the mother liquor, after precipitation and removal of the salt mixture, to 5.5 to 10, extracting the solution with a water-immiscible organic solvent and separating vindoline, catharantine, 3',4' -anhydrovinblastine and leurosine from the extract by chromatography, extracting vindoline in the pH-range of 2.5 to 3.5 and catharantine 3',4'-anhydrovinblastine and leurosine in the pH-range of 5 to 6 with benzene or a benzene homologue, from the mother liquor obtained when isolating the salt mixture, and separating a mixture of leurosine and 3',4'-anhydrovinblastine by crystallization, epoxidizing this mixture with an oxygen source, or separating the mixture into its components by chromatography, and subsequently epoxidizing the 3',4'-anhydrovinblastine component to leurosine, and isolating catharantine remaining from the mother liquor obtained when separating the crystalline mixture, or separating the extract containing catharantine, 3',4'-anhydrovinblastine and leurosine into its components by chromatography.

6. 发明专利

CH510620A Verfahren zur Herstellung von neuen, blutdrucksenkend wirkenden Hydroxylaminderivaten 未知
公开(公告)号：CH510620A
公开(公告)日：1971-07-31
申请号：CH422069
申请日：1969-03-20
申请人： RICHTER GEDEON VEGYESZET
发明人： KISFALUDY LAJOS DR , LAJOS DANCSI , AGNES PATTHY , SZPORNY LASZOLO DR , DOMOK LIVIA DR , KARPATI EGON DR
IPC分类号： A61K31/16 , A61K31/165 , A61P9/12 , A61P25/04 , A61P25/20 , C07C67/00 , C07C231/00 , C07C239/00 , C07C259/06 , C07D207/16 , C07D213/78 , C07K5/06 , C07C83/00

7. 发明专利

IT1138155B 未知
公开(公告)号：IT1138155B
公开(公告)日：1986-09-17
申请号：IT2354181
申请日：1981-08-17
申请人： RICHTER GEDEON VEGYESZET
发明人： LAJOS DANCSI , TIBOR KEVE , GYORGY FEKETE , ESZTER DEZSERI , SANDOR GOROG , TIBOR ACS , CSABA SZANTAY , LAJOS SZABO , KATALIN HONTY , SANDOR ECKHARDT , IVAN HINDI , SANDOR KERPEL-FRONIUS , ZSUZSANNA RELLE SOMFAI , JANOS SUGAR
IPC分类号： A61K31/475 , A61P35/00 , C07D519/04 , A61K
摘要： The invention relates to new cytostatic compound, process for their preparation and pharmaceutical compositions containing them. More particularly, there are provided new compounds of the general formula /I/ in which R4 is beta -hydroxyl and R3 is alpha -ethyl; or R4 is hydrogen and R3 is beta -ethyl; R'' is a straight chained alkyl having from 1 to 10 carbon atoms, or a branched chained alkyl having from 3 to 10 carbon atoms, in which groups the carbon atom attached to the >Na-CH2-O- group has a primary or secondary configuration or an alkenyl or alkinyl having from 3 to 6 carbon atoms, or an aralkyl having from 1 to 3 carbon atoms in the alkyl moiety; R1 is methoxy and R2 is acetyl, provided that if R3 is alpha -ethyl and R4 beta -hydroxyl, R4 is other than ethyl. These compounds and N-desmethyl-N-(ethoxymethyl)-vinblastine can be prepared according to the invention by transetherification of compounds of the compounds of the general formula /II/ with a large excess of alcohols of the general formula R''-OH [III] Pharmaceutical compositions containing compounds of the general formula [I] as active ingredients are also within the scope of invention.

8. 发明专利

IT8024015D0 未知
公开(公告)号：IT8024015D0
公开(公告)日：1980-08-05
申请号：IT2401580
申请日：1980-08-05
申请人： RICHTER GEDEON VEGYESZET
发明人： CSABA SZANTAY , LAJOS SZABO , GYORGY KALAUS , LAJOS DANCSI , TIBOR KEVE , FERENC DRAXLER
IPC分类号： C07D461/00 , A61K31/4375 , A61P9/08 , C07D471/22 , C07D

9. 发明专利

IT7823601D0 未知
公开(公告)号：IT7823601D0
公开(公告)日：1978-05-19
申请号：IT2360178
申请日：1978-05-19
申请人： RICHTER GEDEON VEGYESZET
发明人： CSABA SZANTAY , LAJOS SZABO , KTALAIN HONTY , KATALIN NOGRADI , KAROLA JOVANOVICS , ESZTER DEZSERI , LAJOS DANCSI , CSABA LORINCZ , BELA SZARVADY , LAJOS KOVACS
IPC分类号： A61K31/407 , A61K31/475 , A61P35/00 , C07D471/20 , C07D519/04 , C07J
摘要： A process for the preparation of alkaloids of the leurosine type having the formula I (I) and the acid addition salts thereof. In the formula I R is hydrogen or methyl. The compounds prepared according to the invention are known compounds showing cytostatic activity.

10. 发明专利

CH515878A Verfahren zur Herstellung von neuen, blutdrucksenkend wirkenden Hydroxylaminderivaten 未知
公开(公告)号：CH515878A
公开(公告)日：1971-11-30
申请号：CH634171
申请日：1969-03-20
申请人： RICHTER GEDEON VEGYESZET
发明人： KISFALUDY LAJOS DR , LAJOS DANCSI , AGNES PATTHY , SZPORNY LASZLO DR , DOEMOEK LIVIA DR , KARPATI EGON DR
IPC分类号： C07D207/16 , C07D213/78 , C07K5/06 , C07C83/00

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