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1. 发明专利

AU6186173A XANTHENE DERIVATIVES 未知
公开(公告)号：AU6186173A
公开(公告)日：1975-05-01
申请号：AU6186173
申请日：1973-10-26
申请人： RICHARDSON MERRELL INC
发明人： CARR ALBERT ANTHONY , GRUNWELL JOYCE FRANCIS
IPC分类号： C07D311/82 , C07D7/42 , A61K27/00
摘要： 1416039 Bis-basic alkoxyxanthanes RICHARDSON-MERRELL Inc 17 Dec 1973 [21 Dec 1972] 58262/73 Heading C2C Novel compounds of Formula I wherein n is an integer of from 2 to 6; Y is oxygen or sulphur; R and R 1 are each hydrogen, lower alkyl having from 1 to 6 carbon atoms, cycloalkyl having from 3 to. 6 carbon atoms, alkenyl having from 3 to 6 carbon atoms in which the unsaturation is in a position other than in the 1-position of the alkenyl group, or when R and R 1 are taken together with the nitrogen atom to which they are attached represent the pyrrolidinyl, morpholino or piperidino radical; R 2 is hydrogen, halogen, C 1-6 alkyl or C 1-6 alkoxy; and the pharmaceutically acceptable acid addition salts thereof are prepared by dehydration of a compound of Formula III or by reaction of an R-substituted benzaldehyde and a compound of formula optionally followed by salt formation. Intermediates of Formula III above are prepared by action of the appropriate Grignard reagent with the ketone of Formula II which is formed by etherification of 3,6-dihydroxyxanthen-9-one or by reduction of the bis-thioester. 3,6 - Dihydroxyxanthen - 9 - one is prepared by cyclization of 2,2 1 ,4,4 1 -tetrahydroxybenzophenone. 5,5 - Bis - 3,6 - (9 - oxo - xanthenyl)dimethylthiocarbamate is prepared by pyrolysis of 0,0-bis- 3,6 - (9 - oxo - xanthenyl)dimethylthiocarbamate which is prepared by reacting 3,6-dihydroxyxanthen-9-one with NaH and dimethylthiocarbamoyl chloride. Antiviral compositions in conventional forms for oral, topical and parenteral administration comprise an above novel compound and a carrier or diluent.

2. 发明专利

DK137762B 未知
公开(公告)号：DK137762B
公开(公告)日：1978-05-01
申请号：DK568674
申请日：1974-10-31
申请人： RICHARDSON MERRELL INC
发明人： GRUNWELL JOYCE FRANCIS , BENSON HARVEY DOUGLAS
IPC分类号： C07J1/00 , A61K31/045 , A61K31/075 , A61K31/35 , A61K31/565 , A61K31/58 , A61K31/695 , C07J17/00 , C07J63/00
摘要： 7 alpha -Methylestr-4-ene-3 alpha , 17 beta -diol and derivatives thereof useful as antifertility agents.

3. 发明专利

DE2404332A1 未知
公开(公告)号：DE2404332A1
公开(公告)日：1974-08-08
申请号：DE2404332
申请日：1974-01-30
申请人： RICHARDSON MERRELL INC
发明人： GRUNWELL JOYCE FRANCIS , PETROW VLADIMIR
IPC分类号： C07J1/00 , C07J17/00 , C07J51/00 , C07C169/22 , A61K17/06 , C07C169/20

4. 发明专利

AU2422877A CONTRACEPTION 未知
公开(公告)号：AU2422877A
公开(公告)日：1978-10-19
申请号：AU2422877
申请日：1977-04-13
申请人： RICHARDSON MERRELL INC
发明人： BENSON HARVEY DOUGLAS , GRUNWELL JOYCE FRANCIS , JOHNSTON JOHN O'NEAL , PETROW VLADIMIR
IPC分类号： C07J1/00 , C07J17/00 , A61K31/565 , C07J13/00

5. 发明专利

AU7369074A 7A-METHYLESTR-4-ENE-3A,17B-DIOLS 未知
公开(公告)号：AU7369074A
公开(公告)日：1976-04-01
申请号：AU7369074
申请日：1974-09-25
申请人： RICHARDSON MERRELL INC
发明人： BENSON HARVEY DOUGLAS , GRUNWELL JOYCE FRANCIS
IPC分类号： C07J1/00 , A61K31/045 , A61K31/075 , A61K31/35 , A61K31/565 , A61K31/58 , A61K31/695 , C07J17/00 , C07J63/00 , A61K27/00 , C07C169/10 , C07C169/08
摘要： 7 alpha -Methylestr-4-ene-3 alpha , 17 beta -diol and derivatives thereof useful as antifertility agents.

6. 发明专利

AU6397673A 19-HYDROXY-ANDROST-4-ENES 未知
公开(公告)号：AU6397673A
公开(公告)日：1975-07-03
申请号：AU6397673
申请日：1973-12-27
申请人： RICHARDSON MERRELL INC
发明人： GRUNWELL JOYCE FRANCIS , PETROW VLADIMIR
IPC分类号： C07J1/00 , C07J17/00 , C07J51/00 , C07C169/14 , A61K27/00

7. 发明专利

DK146555C 未知
公开(公告)号：DK146555C
公开(公告)日：1984-05-14
申请号：DK203277
申请日：1977-05-09
申请人： RICHARDSON MERRELL INC
发明人： BENSON HARVEY DOUGLAS , GRUNWELL JOYCE FRANCIS , JOHNSTON JOHN O'NEAL , PETROW VLADIMIR
IPC分类号： C07J1/00 , C07J17/00 , A61K31/565

8. 发明专利

DK146555B 未知
公开(公告)号：DK146555B
公开(公告)日：1983-11-07
申请号：DK203277
申请日：1977-05-09
申请人： RICHARDSON MERRELL INC
发明人： BENSON HARVEY DOUGLAS , GRUNWELL JOYCE FRANCIS , JOHNSTON JOHN O'NEAL , PETROW VLADIMIR
IPC分类号： C07J1/00 , C07J17/00 , A61K31/565

9. 发明专利

PH15545A A CONTRACEPTIVE COMPOSITION CONSISTING OF AN ANDROSTENE AND A PROCESTOGEN AND METHOD OF USE THEREOF 未知
公开(公告)号：PH15545A
公开(公告)日：1983-02-09
申请号：PH19676
申请日：1977-04-15
申请人： RICHARDSON MERRELL INC
发明人： BENSON HARVEY DOUGLAS , JOHNSTON JOHN O'NEAL , GRUNWELL JOYCE FRANCIS , PETROW VLADIMIR
IPC分类号： C07J1/00 , C07J17/00 , C07J21/00 , A61K31/56

10. 发明专利

CH614721A5 未知
公开(公告)号：CH614721A5
公开(公告)日：1979-12-14
申请号：CH1441074
申请日：1974-10-28
申请人： RICHARDSON MERRELL INC
发明人： GRUNWELL JOYCE FRANCIS , BENSON HARVEY DOUGLAS
IPC分类号： C07J1/00 , A61K31/045 , A61K31/075 , A61K31/35 , A61K31/565 , A61K31/58 , A61K31/695 , C07J17/00 , C07J63/00
摘要： 7 alpha -Methylestr-4-ene-3 alpha , 17 beta -diol and derivatives thereof useful as antifertility agents.

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