专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US3875006A Proteolytic enzyme from streptomyces hygroscopicus 失效
标题翻译：来自结构蛋白的蛋白酶
公开(公告)号：US3875006A
公开(公告)日：1975-04-01
申请号：US27929972
申请日：1972-08-10
申请人： RHONE POULENC SA
发明人： BELLOC ANDRE , FLORENT JEAN , MANCY DENISE , VERRIER JEAN
IPC分类号： A21D8/04 , C12N9/52 , C12R1/55 , C07G7/028 , A21D13/00
CPC分类号： C12N9/52 , A21D8/042 , Y10S435/814 , Y10S435/816 , Y10S435/898
摘要： A proteolytic enzyme useful in the manufacture of baked goods made with flour is prepared by the culture of the microorganism Streptomyces hygroscopicus DS 14649 (NRRL 3999).

2. 发明授权

US3875010A Process for the preparation of daunorubicin 失效
标题翻译：制备DAUNORUBICIN的方法
公开(公告)号：US3875010A
公开(公告)日：1975-04-01
申请号：US87751169
申请日：1969-11-17
申请人： RHONE POULENC SA
发明人： MANCY DENISE , FLORENT JEAN , PREUD HOMME JEAN
IPC分类号： C12P1/06 , C07H15/252 , C12D9/00
CPC分类号： C07H15/252 , Y10S435/886 , Y10S435/901
摘要： The antibiotic daunorubicin is prepared by aerobically cultivating Streptomyces bifurcus, strain DS 23,219 (NRRL 3539), or a daunorubicin-producing mutant thereof, in an aqueous nutrient medium containing assimilable sources of carbon, nitrogen and inorganic substances, and separating daunorubicin formed during the culture.

3. 发明授权

US3906113A New amylase and its preparation by fermentation of a penicillium 失效
标题翻译：新型淀粉酶及其通过青霉素发酵制备
公开(公告)号：US3906113A
公开(公告)日：1975-09-16
申请号：US33348973
申请日：1973-02-20
申请人： RHONE POULENC SA
发明人： BELLOC ANDRE , FLORENT JEAN , MANCY DENISE , VERRIER JEAN
IPC分类号： C12N9/28 , C12N9/30 , C12D13/10 , A21D8/04
CPC分类号： C12N9/242 , Y10S435/933
摘要： The enzyme preparation 27591 RP useful in the manufacture of baked goods made with flour is made by the culture of Penicillium expansum strain F 1046, (NRRL 5437).
摘要翻译：用于制造用面粉制成的烘焙食品的酶制剂27591 RP是通过培养青霉菌菌株F 1046（NRRL 5437）制备的。

4. 发明授权

US3892849A Antibiotic 21,190 RP 失效
标题翻译：抗生素21,190 RP
公开(公告)号：US3892849A
公开(公告)日：1975-07-01
申请号：US38963873
申请日：1973-08-21
申请人： RHONE POULENC SA
发明人： MANCY DENISE , FLORENT JEAN , PREUD HOMME JEAN
IPC分类号： A23K20/195 , C07G11/00
CPC分类号： A23K20/195
摘要： The new antibiotic 21,190 RP is prepared by cultivating the hitherto unknown microorganism Streptomyces hygroscopicus DS 23,230 (NRRL 3576) under aerobic conditions in an aqueous nutrient medium. The antibiotic is active against Gram positive and some Gram negative microorganisms. It can be used as a growth promoting agent for animals.
摘要翻译：通过在需氧条件下在含水营养培养基中培养迄今未知的微生物吸水链霉菌DS 23,230（NRRL 3576）来制备新的抗生素21,190 RP。抗生素对革兰氏阳性和一些革兰氏阴性微生物具有活性。它可以用作动物的生长促进剂。

5. 发明授权

US3875005A Thrombolytic and fibrinolytic enzyme from streptomyces 失效
标题翻译：来自溶菌酶的凝血酶和纤维蛋白酶
公开(公告)号：US3875005A
公开(公告)日：1975-04-01
申请号：US27509172
申请日：1972-07-25
申请人： RHONE POULENC SA
发明人： BELLOC ANDRE , FLORENT JEAN , LUNEL JEAN , MANCY DENISE , VERRIER JEAN
IPC分类号： C12N9/52 , C07G7/02 , C07G7/028
CPC分类号： C12N9/52 , Y10S435/814 , Y10S435/815 , Y10S435/816 , Y10S435/886
摘要： A thrombolytic and fibrinolytic proteolytic enzyme is produced by aerobically culturing in an aqueous medium a newly discovered microorganism Streptomcyes venetus DS 24,288 (NRRL 3987) and isolating the enzyme after culturing.

6. 发明授权

US3703439A Process for the preparation of l-beta-(3,4-dihydroxyphenyl)-alpha-alanine by fermentation 失效
标题翻译：通过发酵制备L-BETA-（3,4-二羟基苯基）-ALPHA-ALANINE的方法
公开(公告)号：US3703439A
公开(公告)日：1972-11-21
申请号：US3703439D
申请日：1971-01-20
申请人： RHONE POULENC SA
发明人： FLORENT JEAN , LUNEL JEAN , RENAUT JACQUES
IPC分类号： C12P13/22 , C12D3/00
CPC分类号： C12P13/225 , Y10S435/909
摘要： L-B-(3,4-DIHYDROXYPHENYL)-A-ALANINE IS PREPARED BY THE MICROBIOLOGICAL HYDROXYLATION OF L-TYROSINE USING VIBRIO TYROSINATICUS ATCC 19,378 AS MICROORGANISM FOR THE CONVERSION.

7. 发明专利

DE2258537A1 未知
公开(公告)号：DE2258537A1
公开(公告)日：1973-06-07
申请号：DE2258537
申请日：1972-11-29
申请人： RHONE POULENC SA
发明人： MANCY DENISE , FLORENT JEAN , PREUD HOMME JEAN
IPC分类号： A23K20/195 , C07G11/00
摘要： 1381180 Antibiotic 21,190 RP RHONEPOULENC SA 27 Nov 1972 [29 Nov 1971] 54695/72 Heading C2A The novel antibiotic 21,190 RP, having the following characteristics: being a white crystalline powder melting at 226-228‹ C.; soluble in water at pH9 and dimethylformamide, slightly soluble in methanol and ethanol, insoluble in hexane and benzene; containing carbon, hydrogen, oxygen and chlorine with the elementary composition: C=50À5%, H=6À6%, O=38À4%, Cl=4À5%; having an ultra-violet spectrum in 0À1 N.NaOH with an absorption maximum at 292 nm (E 100 1cm =59) and an absorption minimum at 257 nm (E 100 1cm =33) as shown in Fig. 1; an infra-red spectrum (in KBr) as shown in Fig. 2, the main absorption bands being at 3440, 2970, 2930, 2900, 2840, 1735, 1715, 1630, 1570, 1450, 1403, 1380, 1350, 1335, 1305, 1248, 1220, 1192, 1165, 1122, 1090, 1060, 1035, 975, 942, 920, 900, 865, 848, 828, 815, 775, 730, 690, 655, 630, 612, 570, and 548; and showing optical rotation of [α] 20 D =+3‹Œ3‹, [α] 20 436 = + 7‹Œ3‹ and [α] 20 365 = +20Œ3‹ (C=0À5 in 0À1 N.NaOH); is produced by aerobically cultivating Streptomyces hygroscopicus (NRRL 3576) or a mutant thereof capable of producing the antibiotic, in an aqueous nutrient medium and isolating antibiotic 21,190 RP from the medium thus produced. The antibiotic is isolated by extraction from the culture filtrate with a water-immiscible organic solvent (e.g. butanol, methylene chloride, methyl isobutyl ketone or ethyl acetate), concentrating the extract, cooling the concentrate to crystallize the crude antibiotic, dissolving in ethanol and decolorizing with charcoal, concentrating and cooling, and recrystallizing the resulting precipitate from dimethylformamide by adding water. 21,190 RP has antibacterial activity against a broad range of Gram positive and negative bacteria. It may be added to animal feedstuffs or edible carriers to form domestic animal growth promoting compositions or concentrated premixes therefor, and may be admixed with a pharmaceutically acceptable diluent or carrier to provide antibiotic pharmaceutical compositions.

8. 发明专利

DE1957980A1 未知
公开(公告)号：DE1957980A1
公开(公告)日：1970-08-13
申请号：DE1957980
申请日：1969-11-18
申请人： RHONE POULENC SA
发明人： COURTILLET MANCY GEB , FLORENT JEAN , PREUD HOMME JEAN
IPC分类号： C12P1/06 , C07H15/252 , C12D9/14
摘要： 1,241,750. Preparing daunorubicin. RHONEPOULENC S.A. 17 Nov., 1969 [18 Nov., 1968], No. 56210/69. Heading C2A. The antibiotic daunorabicin is prepared by aerobically cultivating Streptomyces bifurcus, strain D.S. 23,219, NRRL 3539, or a daunorubicin-producing mutant thereof, on a nutrient medium containing assimilable sources of carbon, nitrogen and inorganic substances, and separating daunorubicin from the culture medium. The preferred culture conditions are pH 6À0 to 7À8 at 23‹ to 33‹ C. The daunorubicin may be separated by extracting the fermentation broth with water-immiscible solvent (e.g. butanol, ethyl acetate or chloroform) at a pH between 5À5 and 9, or preferably by filtering the broth either acidified to pH 1À5 to 2À0 with oxalic acid or admixed with a C 1 -C 3 , aliphatic alcohol and then extracting the filtrate with a water-immiscible solvent. The antibiotic may be recovered by evaporating the solvent or by addition of a non-solvent. The daunorubicin may be converted to its acid-addition salt, e.g. the hydrochloride. Antibiotics 13213 R.P. and 13330 R.P. are also produced in the culture but are not isolated.

9. 发明专利

HU168297B PROCESS FOR PRODUCTION OF DIHYDROAUNOMICINE 未知
公开(公告)号：HU168297B
公开(公告)日：1976-03-27
申请号：HURO000811
申请日：1974-11-25
申请人： RHONE POULENC SA
发明人： FLORENT JEAN , LUNEL JEAN , RENAULT JACQUES
IPC分类号： C12P1/06 , C07H15/252 , C12P1/04 , C12P19/56 , C07C91/10 , C07C93/02 , C07C15/32 , C07B29/02
摘要： 20,798 R.P., which has valuable anti-tumor properties, and acid addition salts thereof are prepared by the microbiological reduction of daunorubicin of the formula:

10. 发明专利

CA981611A ENZYME THROMBOLITIQUE ET SA PREPARATION PAR FERMENTATION DE STREPTOMYCES VENETUS 未知
公开(公告)号：CA981611A
公开(公告)日：1976-01-13
申请号：CA148034
申请日：1972-07-26
申请人： RHONE POULENC SA
发明人： BELLOC ANDRE , FLORENT JEAN , LUNEL JEAN , MANCY DENISE NEE COURTILLET , VERRIER JEAN
IPC分类号： C12N9/52

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式