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1. 发明申请

WO1998025575A2 IMPROVED HYDROGEL COMPOSITION 审中-公开
标题翻译：改进的水凝胶组合物
公开(公告)号：WO1998025575A2
公开(公告)日：1998-06-18
申请号：PCT/US1997022860
申请日：1997-12-10
申请人： REPROGENESIS, INC. , CHILDREN'S MEDICAL CENTER CORPORATION
发明人： REPROGENESIS, INC. , CHILDREN'S MEDICAL CENTER CORPORATION , BORLAND, Kermit, M. , ZHOU, Tao , NELSON, Gordon, P. , ATALA, Anthony
IPC分类号： A61K00/00
CPC分类号： A61F2/02 , A61K47/30
摘要： This invention provides compositions for use in implanting cells into an animal comprising cells (which may be dissociated cells and/or cell aggregates); a biodegradable, biocompatible polymer which forms a hydrogel upon cross-linking by multivalent ions; a soluble salt of a multivalent ion; and a sparingly soluble salt of a multivalent ion, these components being combined into a mixture which forms a partially hardened, injectable hydrogel in which the cells are uniformly suspended, the consistency of the mixture being suitable for implanting the partially hardened hydrogel mixture into the animal, where the implanted, partially hardened hydrogel forms in situ a fully hardened hydrogel containing the cells. Preferably, the mixture also contains a biocompatible sequestrant which competes with the biocompatible polymer for binding of the multivalent cross-linking ion. The invention also provides methods for implanting cells in an animal using the composition.
摘要翻译：本发明提供用于将细胞植入包含细胞（其可以是解离的细胞和/或细胞聚集体）的动物中的组合物; 一种可生物降解的生物相容性聚合物，通过多价离子交联形成水凝胶; 多价离子的可溶性盐; 和多价离子的微溶盐，这些组分被组合成形成部分硬化的可注射的水凝胶的混合物，其中细胞被均匀悬浮，混合物的稠度适于将部分硬化的水凝胶混合物植入动物体内其中植入的部分硬化的水凝胶原位形成含有细胞的完全硬化的水凝胶。优选地，混合物还含有与生物相容性聚合物竞争结合多价交联离子的生物相容性螯合剂。本发明还提供了使用该组合物在动物中植入细胞的方法。

2. 发明公开

EP0944403A2 IMPROVED HYDROGEL FOR TISSUE ENGINEERING 失效
标题翻译：改进的水凝胶组织科技
公开(公告)号：EP0944403A2
公开(公告)日：1999-09-29
申请号：EP97953182.0
申请日：1997-12-10
申请人： Reprogenesis, Inc
发明人： BORLAND, Kermit, M. , ZHOU, Tao , NELSON, Gordon, P. , OMSTEAD, Daniel R.
IPC分类号： A61L27 , A61L31
CPC分类号： A61L31/145 , A61L27/20 , A61L27/38 , A61L27/52 , C08L5/04
摘要： This invention provides compositions for use in implanting into an animal comprising a biodegradable, biocompatible polymer which forms a hydrogel upon cross-linking. In a preferred mode, the polymer is cross-linked by multivalent ions; more preferably, a soluble salt of a multivalent ion and a sparingly soluble salt of a multivalent ion, these components being combined into a mixture which forms a partially hardened, injectable hydrogel, the consistency of the mixture being suitable for implanting the partially hardened hydrogel mixture into the animal, where the implanted, partially hardened hydrogel forms in situ a fully hardened hydrogel. Preferably, the mixture also contains a biocompatible sequestrant which competes with the biocompatible polymer for binding of the multivalent cross-linking ion. The composition may or may not contain living cells. The invention also provides methods for implanting the composition in an animal, optionally as an implant containing living cells.

3. 发明公开

EP1015042A1 IMPROVED HYDROGEL FOR TISSUE ENGINEERING 审中-公开
标题翻译：改进的水凝胶组织科技
公开(公告)号：EP1015042A1
公开(公告)日：2000-07-05
申请号：EP98948313.6
申请日：1998-09-18
申请人： Reprogenesis, Inc
发明人： BORLAND, Kermit, M. , OMSTEAD, Daniel, R. , ZHOU, Tao , NELSON, Gordon, P.
IPC分类号： A61L27/00 , A61L31/00
CPC分类号： A61L31/145 , A61L27/20 , A61L27/38 , A61L27/52 , C08L5/04
摘要： This invention provides compositions for use in implanting into an animal comprising a biodegradable, biocompatible polymer which forms a hydrogel upon cross-linking. In a preferred mode, the polymer is cross-linked by multivalent ions; more preferably, a soluble salt of a multivalent ion and a sparingly soluble salt of a multivalent ion, these components being combined into a mixture which forms a partially hardened, injectable hydrogel, the consistency of the mixture being suitable for implanting the partially hardened hydrogel mixture into the animal, where the implanted, partially hardened hydrogel forms in situ a fully hardened hydrogel. Preferably, the mixture also contains a biocompatible sequestrant which competes with the biocompatible polymer for binding of the multivalent cross-linking ion. The composition may or may not contain living cells. The invention also provides methods for implanting the composition in an animal, optionally as an implant containing living cells.

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