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1. 发明申请

WO2012118782A1 HISTONE DEACETYLASE INHIBITORS 审中-公开
标题翻译： HISTONE脱乙酰酶抑制剂
公开(公告)号：WO2012118782A1
公开(公告)日：2012-09-07
申请号：PCT/US2012/026874
申请日：2012-02-28
申请人： REPLIGEN CORPORATION , JACQUES, Vincent , RUSCHE, James R. , PEET, Norton P. , SINGH, Jasbir
发明人： JACQUES, Vincent , RUSCHE, James R. , PEET, Norton P. , SINGH, Jasbir
IPC分类号： A01N37/18 , A61K31/16
CPC分类号： C07D513/04 , C07D211/34 , C07D211/70 , C07D231/12 , C07D233/64 , C07D261/08 , C07D263/32 , C07D277/30 , C07D401/06 , C07D403/06 , C07D471/04
摘要： This invention relates to generally inhibiting histone deacetylase (HDAC) enzymes (e.g., HDAC1, HDAC2, and HDAC3).
摘要翻译：本发明涉及通常抑制组蛋白脱乙酰酶（HDAC）酶（例如HDAC1，HDAC2和HDAC3）。

2. 发明申请

WO2009055675A1 METHODS OF IDENTIFYING HISTONE DEACETYLASE INHIBITORS USEFUL FOR NEUROLOGICAL DISORDERS 审中-公开
标题翻译：鉴定用于神经病的HISTONE脱乙酰壳菌酶抑制剂的方法
公开(公告)号：WO2009055675A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/081121
申请日：2008-10-24
申请人： REPLIGEN CORPORATION , RUSCHE, James R. , COOPER, Andrew
发明人： RUSCHE, James R. , COOPER, Andrew
IPC分类号： A01N37/28 , A61K31/19 , A61K38/00
CPC分类号： G01N33/6896 , G01N2333/98 , G01N2500/04 , G01N2800/2835 , G01N2800/2878 , G01N2800/2892
摘要： A method of identifying a candidate compound for treatment of a neurological condition includes obtaining a test compound; assaying a first activity of the test compound to inhibit histone deacetylase activity of a histone deacetylase 3 (HDAC3); assaying a second activity of the test compound to inhibit histone deacetylase activity of a histone deacetylase other than a HDAC3; and identifying the test compound as a candidate compound for treatment of a neurological condition if the first activity of the test compound is greater than the second activity of the test compound.
摘要翻译：鉴定用于治疗神经病症的候选化合物的方法包括获得测试化合物; 测定测试化合物的第一活性以抑制组蛋白脱乙酰酶3（HDAC3）的组蛋白脱乙酰酶活性; 测定测试化合物的第二活性以抑制除HDAC3之外的组蛋白脱乙酰酶的组蛋白脱乙酰酶活性; 并且如果所述测试化合物的第一活性大于所述测试化合物的第二活性，则将所述测试化合物鉴定为用于治疗神经病症的候选化合物。

3. 发明公开

EP0478689A1 HUMAN MONOCLONAL ANTIBODIES TO HIV-1 MN? gp 120 失效
标题翻译：人类单克隆抗体的HIV-1-MN-gp120的。
公开(公告)号：EP0478689A1
公开(公告)日：1992-04-08
申请号：EP90910991.0
申请日：1990-06-05
申请人： SCOTT, Charles F. Jr. , CARSON, Helen F. , WHITE-SCHARF, Mary E. , SILVER, Sandra , RUSCHE, James R.
发明人： SCOTT, Charles F. Jr. , CARSON, Helen F. , WHITE-SCHARF, Mary E. , SILVER, Sandra , RUSCHE, James R.
IPC分类号： A61K39 , A61P31 , C07K1 , C07K14 , C07K16 , C07K19 , C12N7 , C12N15 , C12P21 , G01N33 , A61K38 , C12R1
CPC分类号： C12N15/86 , A61K38/00 , C07K14/005 , C07K16/1063 , C07K2317/34 , C12N2710/24143 , C12N2740/16222
摘要： Dans un anticorps capable de neutraliser le prototype MN ou un virus variant MN, une séquence d'acides aminés contenue dans le domaine principal de neutralisation du prototype MN comprend, aux positions A1-A17 du domaine principal de neutralisation, une sous-séquence formée des résidus d'acides aminés KRKRIHIGPGRAFYTTK. La sous-séquence correspondante d'acides aminés du virus variant MN comprend une séquence complètement homologue entre les résidus IGPGR aux positions A7-A11 et au moins 36 % d'homologues dans les résidus restants de la sous-séquence prototype MN.

4. 发明申请

WO2018022661A1 ALTERNATING TANGENTIAL FLOW RAPID HARVESTING 审中-公开
标题翻译：改变切向流动快速收获
公开(公告)号：WO2018022661A1
公开(公告)日：2018-02-01
申请号：PCT/US2017/043797
申请日：2017-07-25
申请人： REPLIGEN CORPORATION
发明人： KUDUGUNTI, Shashi Kiran , LIN, Wenglong Roy , BONHAM-CARTER, John , RUSCHE, James R.
IPC分类号： B01D69/08 , B01D15/26 , C12N7/02 , C12M3/06 , C07K14/005 , C07K1/34 , F04B43/02 , F04B53/16
摘要： Methods and systems of harvesting a cell product from a cell culture by culturing cells in a fluid medium until the cells have produced a cell product at a harvest concentration are disclosed. The cells are cultured in a cell culture system including a bioreactor connected to an ATF device. The methods include draining fluid medium from the bioreactor through the outlet and the ATF device until the bioreactor volume reaches a predetermined volume, and the ATF column yields at an ATF outlet a liquid containing cell product and passes fluid medium with a concentration of cell product that is lower than the harvest concentration back into the bioreactor, extracting the liquid containing cell product from the ATF outlet, refilling the bioreactor with sterile phosphate buffered saline or fluid medium without any cell product, and repeating steps until a desired amount of cell product has been removed.
摘要翻译：通过在流体培养基中培养细胞直至细胞已经以收获浓度产生细胞产物从细胞培养物中收获细胞产物的方法和系统被公开。细胞在包括连接到ATF装置的生物反应器的细胞培养系统中培养。该方法包括从生物反应器中通过出口和ATF装置排出流体介质，直到生物反应器体积达到预定体积，并且ATF柱在ATF出口处产生含有细胞产物的液体并且使细胞产物的浓度低于回收到生物反应器中的收获浓度，从ATF出口提取含有细胞产物的液体，用无菌磷酸盐缓冲盐水或无细胞产物的流体介质重新填充生物反应器，并且重复步骤直到获得所需量的细胞产物除去。

5. 发明公开

EP2680694A1 HISTONE DEACETYLASE INHIBITORS 失效转让
标题翻译： HISTONE DEACETYLASE抑制剂
公开(公告)号：EP2680694A1
公开(公告)日：2014-01-08
申请号：EP12751918.9
申请日：2012-02-28
申请人： REPLIGEN CORPORATION
发明人： JACQUES, Vincent , RUSCHE, James R. , PEET, Norton P. , SINGH, Jasbir
IPC分类号： A01N37/18 , A61K31/16
CPC分类号： C07D513/04 , C07D211/34 , C07D211/70 , C07D231/12 , C07D233/64 , C07D261/08 , C07D263/32 , C07D277/30 , C07D401/06 , C07D403/06 , C07D471/04
摘要： This invention relates to generally inhibiting histone deacetylase (HDAC) enzymes (e.g., HDAC1, HDAC2, and HDAC3).
摘要翻译：本发明涉及通常抑制组蛋白脱乙酰酶（HDAC）酶（例如HDAC1，HDAC2和HDAC3）。

6. 发明公开

EP3487609A1 ALTERNATING TANGENTIAL FLOW RAPID HARVESTING 审中-公开
公开(公告)号：EP3487609A1
公开(公告)日：2019-05-29
申请号：EP17835142.5
申请日：2017-07-25
申请人： Repligen Corporation
发明人： KUDUGUNTI, Shashi Kiran , LIN, Wenglong Roy , BONHAM-CARTER, John , RUSCHE, James R.
IPC分类号： B01D69/08 , B01D15/26 , C12N7/02 , C12M3/06 , C07K14/005 , C07K1/34 , F04B43/02 , F04B53/16

7. 发明授权

EP2214483B1 METHODS OF IDENTIFYING HISTONE DEACETYLASE INHIBITORS USEFUL FOR NEUROLOGICAL DISORDERS 有权
标题翻译：一种用于识别组蛋白去乙酰化酶抑制剂适合于神经系统疾病
公开(公告)号：EP2214483B1
公开(公告)日：2012-06-20
申请号：EP08841518.7
申请日：2008-10-24
申请人： REPLIGEN CORPORATION
发明人： RUSCHE, James R. , COOPER, Andrew
IPC分类号： G01N33/68 , C12Q1/34
CPC分类号： G01N33/6896 , G01N2333/98 , G01N2500/04 , G01N2800/2835 , G01N2800/2878 , G01N2800/2892
摘要： A method of identifying a candidate compound for treatment of a neurological condition includes obtaining a test compound; assaying a first activity of the test compound to inhibit histone deacetylase activity of a histone deacetylase 3 (HDAC3); assaying a second activity of the test compound to inhibit histone deacetylase activity of a histone deacetylase other than a HDAC3; and identifying the test compound as a candidate compound for treatment of a neurological condition if the first activity of the test compound is greater than the second activity of the test compound.

8. 发明公开

EP2214483A1 METHODS OF IDENTIFYING HISTONE DEACETYLASE INHIBITORS USEFUL FOR NEUROLOGICAL DISORDERS 有权
标题翻译：一种用于识别组蛋白去乙酰化酶抑制剂适合于神经系统疾病
公开(公告)号：EP2214483A1
公开(公告)日：2010-08-11
申请号：EP08841518.7
申请日：2008-10-24
申请人： REPLIGEN CORPORATION
发明人： RUSCHE, James R. , COOPER, Andrew
IPC分类号： A01N37/28 , A61K31/19 , A61K38/00
CPC分类号： G01N33/6896 , G01N2333/98 , G01N2500/04 , G01N2800/2835 , G01N2800/2878 , G01N2800/2892
摘要： A method of identifying a candidate compound for treatment of a neurological condition includes obtaining a test compound; assaying a first activity of the test compound to inhibit histone deacetylase activity of a histone deacetylase 3 (HDAC3); assaying a second activity of the test compound to inhibit histone deacetylase activity of a histone deacetylase other than a HDAC3; and identifying the test compound as a candidate compound for treatment of a neurological condition if the first activity of the test compound is greater than the second activity of the test compound.

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