专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004064693A1 HYDROGEL-BASED PROSTHETIC DEVICE FOR REPLACING AT LEAST A PART OF THE NUCLEUS OF A SPINAL DISC 审中-公开
标题翻译：用于替代脊髓核的一部分的基于水凝胶的前置装置
公开(公告)号：WO2004064693A1
公开(公告)日：2004-08-05
申请号：PCT/US2003/001434
申请日：2003-01-16
申请人： REPLICATION MEDICAL, INC. , STOY, Vladimir, A.
发明人： STOY, Vladimir, A.
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61F2002/30014 , A61F2002/30016 , A61F2002/30075 , A61F2002/30125 , A61F2002/30324 , A61F2002/30448 , A61F2002/30563 , A61F2002/30971 , A61F2002/444 , A61F2002/4495 , A61F2210/0061 , A61F2220/005 , A61F2230/0008 , A61F2250/0018 , A61F2250/0019 , A61F2250/0036 , A61F2310/00365
摘要： The present invention is a prosthetic for replacement of at least a part of the nucleus of a intravertebral disc. The prosthetic device is composed of at least two substantially parallel soft layers (13, 15, 17, 19) of an elastically deformable hydrogel and at least one more rigid layer (21, 23, 25), the more rigid layer having less compressibility than the soft layers, being adjacent to the soft layers, and firmly attached to them. In some embodiments, the soft layers have the same thickness and composition. Typically, the prosthesis has more than one more rigid layer and these more rigid layers have the same thickness and composition. The number of soft layers is usually one more than the number of more rigid layers, with, e.g., at least three soft layers. The invention also includes a method of prosthesis production, which involves prefabricating soft and more rigid layers; stacking at least two prefabricated soft and at least one prefabricated more rigid layer in a substantially parallel fashion into their final form, and, permitting the layers to firmly connect to one another by mutual interaction. In this method, at least one type of the layers is prefabricated in the dehydrated state, which is done by dehydrating stretched foil in an apparatus preventing its contraction and thereby decreasing its area. There is at least partial dehydration of the prosthesis under pressure applied in a direction tangent to the planes of the layers. In preferred embodiments, while in the state of almost full dehydration, the implant is sterilized using ionizing radiation or a gaseous chemical agent, after which it is partially rehydrated within a sterile wrapper using water vapor.
摘要翻译：本发明是用于替代椎间盘的核的至少一部分的假体。假体装置由至少两个基本上平行的可弹性变形的水凝胶和至少一个更刚性层（21,23,25）的软层（13,15,17,19）组成，更刚性层具有比软层，与软层相邻，并牢固地附着在它们上。在一些实施例中，软层具有相同的厚度和组成。通常，假体具有多于一个的刚性层，并且这些更刚性的层具有相同的厚度和组成。软层的数量通常比刚性层的数量多一个，例如至少三个软层。本发明还包括假体生产方法，其涉及预制柔性和更刚性的层; 将至少两个预制的软的和至少一个预制的更刚性的层以基本上平行的方式堆叠成其最终形式，并且允许层通过相互作用彼此牢固地连接。在这种方法中，至少一种类型的层是在脱水状态下预制的，这是通过在防止其收缩的装置中脱水拉伸的箔而由此减小其面积而完成的。在与层的平面相切的方向施加压力的假体至少部分脱水。在优选的实施方案中，当处于几乎完全脱水的状态时，使用电离辐射或气体化学试剂对植入物进行灭菌，然后使用水蒸汽在无菌包装内将其部分再水化。

2. 发明申请

WO2001022902A9 SPINAL NUCLEUS IMPLANT 审中-公开
公开(公告)号：WO2001022902A9
公开(公告)日：2001-04-05
申请号：PCT/US2000/027027
申请日：2000-09-28
申请人： STOY, Vladimir, A.
发明人： STOY, Vladimir, A.
IPC分类号： A61F2/00 , A61F2/44 , A61L27/16 , A61L27/18 , A61L27/20 , A61L27/44 , A61L27/50 , A61L27/52
摘要： The present invention is a spinal nucleus implant (21A) for replacement of at least a portion of nucleus pulposus tissue (13) removed from a spinal disc of a living vertebrate to restore function of the spinal disc (1) and related vertebral joint. The implant is an anisotropically swellable, biomimetic xerogel plastic, having a two phase structure with a hydrophobic phase having high crystallinity and low water content and with hydrophilic phase having low crystallinity and high water content and having negatively charged lubricious surface. The xerogel plastic is capable of rehydration and of osmotic movement of liquid therethrough in response to osmotic pressure change to thereby increase and decrease liquid content in its hydrated state. The present invention also relates to surgical implant procedures utilizing this spinal nucleus implant (21A).

3. 发明授权

EP1583490B1 HYDROGEL-BASED PROSTHETIC DEVICE FOR REPLACING AT LEAST A PART OF THE NUCLEUS OF A SPINAL DISC 有权
标题翻译：在带式垫圈的核内水凝胶基接枝到至少取代部分
公开(公告)号：EP1583490B1
公开(公告)日：2008-12-10
申请号：EP03703860.1
申请日：2003-01-16
申请人： Replication Medical, INC.
发明人： STOY, Vladimir, A.
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61F2002/30014 , A61F2002/30016 , A61F2002/30075 , A61F2002/30125 , A61F2002/30324 , A61F2002/30448 , A61F2002/30563 , A61F2002/30971 , A61F2002/444 , A61F2002/4495 , A61F2210/0061 , A61F2220/005 , A61F2230/0008 , A61F2250/0018 , A61F2250/0019 , A61F2250/0036 , A61F2310/00365
摘要： The present invention is a prosthetic for replacement of at least a part of the nucleus of a intravertebral disc. The prosthetic device is composed of at least two substantially parallel soft layers (13, 15, 17, 19) of an elastically deformable hydrogel and at least one more rigid layer (21, 23, 25), the more rigid layer having less compressibility than the soft layers, being adjacent to the soft layers, and firmly attached to them. In some embodiments, the soft layers have the same thickness and composition. Typically, the prosthesis has more than one more rigid layer and these more rigid layers have the same thickness and composition. The number of soft layers is usually one more than the number of more rigid layers, with, e.g., at least three soft layers. The invention also includes a method of prosthesis production, which involves prefabricating soft and more rigid layers; stacking at least two prefabricated soft and at least one prefabricated more rigid layer in a substantially parallel fashion into their final form, and, permitting the layers to firmly connect to one another by mutual interaction. In this method, at least one type of the layers is prefabricated in the dehydrated state, which is done by dehydrating stretched foil in an apparatus preventing its contraction and thereby decreasing its area. There is at least partial dehydration of the prosthesis under pressure applied in a direction tangent to the planes of the layers. In preferred embodiments, while in the state of almost full dehydration, the implant is sterilized using ionizing radiation or a gaseous chemical agent, after which it is partially rehydrated within a sterile wrapper using water vapor.

4. 发明公开

EP1583490A1 HYDROGEL-BASED PROSTHETIC DEVICE FOR REPLACING AT LEAST A PART OF THE NUCLEUS OF A SPINAL DISC 有权
标题翻译：在带式垫圈的核内水凝胶基接枝到至少取代部分
公开(公告)号：EP1583490A1
公开(公告)日：2005-10-12
申请号：EP03703860.1
申请日：2003-01-16
申请人： Replication Medical, INC.
发明人： STOY, Vladimir, A.
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61F2002/30014 , A61F2002/30016 , A61F2002/30075 , A61F2002/30125 , A61F2002/30324 , A61F2002/30448 , A61F2002/30563 , A61F2002/30971 , A61F2002/444 , A61F2002/4495 , A61F2210/0061 , A61F2220/005 , A61F2230/0008 , A61F2250/0018 , A61F2250/0019 , A61F2250/0036 , A61F2310/00365
摘要： The present invention is a prosthetic for replacement of at least a part of the nucleus of a intravertebral disc. The prosthetic device is composed of at least two substantially parallel soft layers (13, 15, 17, 19) of an elastically deformable hydrogel and at least one more rigid layer (21, 23, 25), the more rigid layer having less compressibility than the soft layers, being adjacent to the soft layers, and firmly attached to them. In some embodiments, the soft layers have the same thickness and composition. Typically, the prosthesis has more than one more rigid layer and these more rigid layers have the same thickness and composition. The number of soft layers is usually one more than the number of more rigid layers, with, e.g., at least three soft layers. The invention also includes a method of prosthesis production, which involves prefabricating soft and more rigid layers; stacking at least two prefabricated soft and at least one prefabricated more rigid layer in a substantially parallel fashion into their final form, and, permitting the layers to firmly connect to one another by mutual interaction. In this method, at least one type of the layers is prefabricated in the dehydrated state, which is done by dehydrating stretched foil in an apparatus preventing its contraction and thereby decreasing its area. There is at least partial dehydration of the prosthesis under pressure applied in a direction tangent to the planes of the layers. In preferred embodiments, while in the state of almost full dehydration, the implant is sterilized using ionizing radiation or a gaseous chemical agent, after which it is partially rehydrated within a sterile wrapper using water vapor.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式