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1. 发明申请

WO2011154829A3 SHEATHED NANOTUBE FIBER AND METHOD OF FORMING SAME 审中-公开
公开(公告)号：WO2011154829A3
公开(公告)日：2012-06-07
申请号：PCT/IB2011001401
申请日：2011-06-20
申请人： RENSSELAER POLYTECH INST , MIYAUCHI MINORU , MIAO JIANJUN , SIMMONS TREVOR J , LEE JONG-WON , DOHERTY THOMAS V , DORDICK JONATHAN S , LINHARDT ROBERT J
发明人： MIYAUCHI MINORU , MIAO JIANJUN , SIMMONS TREVOR J , LEE JONG-WON , DOHERTY THOMAS V , DORDICK JONATHAN S , LINHARDT ROBERT J
IPC分类号： H01B3/48 , H01B5/06
CPC分类号： B82Y30/00 , D01D5/0007 , D01F1/09 , D01F2/02 , D01F8/02 , H01G9/02 , H01G11/52 , Y02E60/13 , Y10T428/2918
摘要： Embodiments of the invention provide a cellulose- sheathed carbon nanotube fiber. One aspect of the invention provides a sheathed nanotube fiber comprising: a carbon nanotube fiber; and a cellulose sheath extending co-axially along at least a first portion of a length of the carbon nanotube fiber. Another aspect of the invention provides a method of forming a sheathed carbon nanotube fiber, the method comprising: co-electrospinning a carbon nanotube fiber gel core within a cellulose solution sheath.
摘要翻译：本发明的实施方案提供一种纤维素包覆的碳纳米管纤维。本发明的一个方面提供一种护套纳米管纤维，其包含：碳纳米管纤维; 以及沿所述碳纳米管纤维的长度的至少第一部分同轴延伸的纤维素护套。本发明的另一方面提供了一种形成护套碳纳米管纤维的方法，所述方法包括：在纤维素溶液鞘内共同静电纺丝碳纳米管纤维凝胶芯。

2. 发明申请

WO2010123534A9 ENZYME-BASED NANOSCALE DECONTAMINATING COMPOSITES 审中-公开
标题翻译：基于酶的纳米尺度去除复合材料
公开(公告)号：WO2010123534A9
公开(公告)日：2010-12-16
申请号：PCT/US2010000104
申请日：2010-01-15
申请人： RENSSELAER POLYTECH INST , DINU CERASELA ZOICA , DORDICK JONATHAN S , KANE RAVINDRA S , SANFORD KARL , WHITED GREGORY M , ZHU GUANGYU , DANISCO US INC
发明人： DINU CERASELA ZOICA , DORDICK JONATHAN S , KANE RAVINDRA S , SANFORD KARL , WHITED GREGORY M , ZHU GUANGYU
IPC分类号： C12N11/14
CPC分类号： C12N11/14 , A01N59/00 , A01N63/02 , B82Y5/00 , C08K3/041 , C08K3/34 , C08K9/04 , C09D5/025 , C09D5/14 , C09D7/62 , C09D7/67 , C09D7/70 , C11D3/38636 , C12N9/18 , A01N25/10 , A01N25/34 , A01N37/16
摘要： The invention relates to decontaminating composites, and methods, compositions, and kits comprising the same. In some aspects, the invention relates to a decontaminating composite, comprising a perhydrolase associated with a carbon nanotube, that is useful for producing peracids.
摘要翻译：本发明涉及去污复合材料，以及包含该复合材料的方法，组合物和试剂盒。在一些方面，本发明涉及一种去污复合材料，其包含与碳纳米管缔合的过水解酶，其可用于生产过酸。

3. 发明申请

WO2010123534A3 ENZYME-BASED NANOSCALE DECONTAMINATING COMPOSITES 审中-公开
标题翻译：基于酶的纳米尺度去除复合材料
公开(公告)号：WO2010123534A3
公开(公告)日：2011-02-10
申请号：PCT/US2010000104
申请日：2010-01-15
申请人： RENSSELAER POLYTECH INST , DINU CERASELA ZOICA , DORDICK JONATHAN S , KANE RAVINDRA S , SANFORD KARL , WHITED GREGORY M , ZHU GUANGYU , DANISCO US INC
发明人： DINU CERASELA ZOICA , DORDICK JONATHAN S , KANE RAVINDRA S , SANFORD KARL , WHITED GREGORY M , ZHU GUANGYU
IPC分类号： C12N11/14
CPC分类号： C12N11/14 , A01N59/00 , A01N63/02 , B82Y5/00 , C08K3/041 , C08K3/34 , C08K9/04 , C09D5/025 , C09D5/14 , C09D7/62 , C09D7/67 , C09D7/70 , C11D3/38636 , C12N9/18 , A01N25/10 , A01N25/34 , A01N37/16
摘要： The invention relates to decontaminating composites, and methods, compositions, and kits comprising the same. In some aspects, the invention relates to a decontaminating composite, comprising a perhydrolase associated with a carbon nanotube, that is useful for producing peracids.
摘要翻译：本发明涉及去污复合材料，以及包含其的方法，组合物和试剂盒。在一些方面，本发明涉及一种去污复合材料，其包含与碳纳米管缔合的过水解酶，其可用于生产过酸。

4. 发明申请

WO2007053561A3 THREE-DIMENSIONAL CELLULAR ARRAY CHIP AND PLATFORM FOR TOXICOLOGY ASSAYS 审中-公开
标题翻译：三维细胞阵列芯片和毒理学测定平台
公开(公告)号：WO2007053561A3
公开(公告)日：2009-05-07
申请号：PCT/US2006042345
申请日：2006-10-31
申请人： RENSSELAER POLYTECH INST , LEE MOO-YEAL , KUMAR R ANAND , CLARK DOUGLAS S , DORDICK JONATHAN S
发明人： LEE MOO-YEAL , KUMAR R ANAND , CLARK DOUGLAS S , DORDICK JONATHAN S
IPC分类号： C12M1/00
CPC分类号： G01N33/5014 , B01J19/0046 , B01J2219/00387 , B01J2219/00527 , B01J2219/0065 , B01J2219/00659 , B01J2219/00664 , B01J2219/00743 , C12N2503/00 , C12N2533/54
摘要： The present invention is directed to a screening platform employing a miniaturized three-dimensional cell chip for high-throughput toxicology screening of test and lead compounds, prodrugs, drugs and P-450 generated drug metabolites. To this end, the three-dimensional cell chip, employs human cells encapsulated in a matrix (e.g., collagen or alginate gels) in volumes as small as 10 nL arrayed on a functionalized substrates (e.g., glass microscope slides) for spatially addressable screening against multiple test compounds. With the present platform, over 3,000 cell-matrix islands may be spotted providing for simultaneous screening against multiple compounds at multiple doses and in high replicate.
摘要翻译：本发明涉及采用小型化三维细胞芯片用于测试和引导化合物，前药，药物和P-450产生的药物代谢物的高通量毒理学筛选的筛选平台。为此，三维细胞芯片采用封装在矩阵（例如，胶原或藻酸胶体）中的人体细胞，其体积小于排列在官能化底物（例如，玻璃显微镜载玻片）上的10nL，用于空间可寻址筛选多种试验化合物。利用目前的平台，可以发现超过3,000个细胞基质岛可以同时筛选多个剂量的多种化合物和高度复制。

5. 发明申请

WO2007001355A3 ENHANCED STABILITY OF PROTEINS IMMOBILIZED ON NANOPARTICLES 审中-公开
标题翻译：纳米粒子固定化蛋白质的增强稳定性
公开(公告)号：WO2007001355A3
公开(公告)日：2007-12-06
申请号：PCT/US2005031652
申请日：2005-09-07
申请人： RENSSELAER POLYTECH INST , DORDICK JONATHAN S , KANE RAVINDRA S , ASURI PRASHANTH , KARAJANAGI SANDEEP S
发明人： DORDICK JONATHAN S , KANE RAVINDRA S , ASURI PRASHANTH , KARAJANAGI SANDEEP S
IPC分类号： A61K9/14
CPC分类号： G01N33/54346 , B82Y15/00 , C12Q1/001 , G01N33/587 , G01N33/588
摘要： This invention is directed to the application of a previously unknown property of nanomaterials - its ability to enhance protein activity and stability at high temperatures, in organic solvents, and in polymer composites. Nanomaterials such as single-walled carbon nanotubes (SWNTs) can significantly enhance enzyme function and stability in strongly denaturing environments. Experimental results and theoretical analysis reveal that the enhancement in stability is a result of the curvature of these nanoscale materials, which suppresses unfavorable protein-protein interactions. The enhanced stability is also exploited in the preparation of highly stable and active nanocomposite films that resist nonspecific protein absorption, i.e., inhibit fouling of the films. The protein-nanoparticles conjugates represent a new generation of highly selective, active, and stable catalytic materials. Furthermore, the ability to enhance protein function by interfacing them with nanomaterials has a profound impact on applications ranging from biosensing, diagnostics, vaccines, drug delivery, and biochips, to novel hybrid materials that integrate biotic and abiotic components.
摘要翻译：本发明涉及以前未知的纳米材料性质的应用 - 其在高温下，在有机溶剂和聚合物复合材料中提高蛋白质活性和稳定性的能力。纳米材料如单壁碳纳米管（SWNTs）可显着增强酶在强变性环境中的功能和稳定性。实验结果和理论分析表明，稳定性的提高是这些纳米材料弯曲的结果，其抑制了不利的蛋白质 - 蛋白质相互作用。增强的稳定性也用于制备能够抵抗非特异性蛋白质吸收的高稳定性和活性的纳米复合膜，即抑制膜的结垢。蛋白质纳米粒子偶联物代表了新一代高选择性，活性和稳定的催化材料。此外，通过将它们与纳米材料接合来增强蛋白质功能的能力对从生物传感，诊断，疫苗，药物递送和生物芯片到整合生物组分和非生物组分的新型杂合物材料的应用具有深远影响。

6. 发明专利

SG178349A1 K5 HEPAROSAN FERMENTATION AND PURIFICATION 未知
公开(公告)号：SG178349A1
公开(公告)日：2012-03-29
申请号：SG2012009262
申请日：2010-08-30
申请人： WANG ZHENYU , LINHARDT ROBERT J , DORDICK JONATHAN S , BHASKAR UJJWAL
发明人： WANG ZHENYU , LINHARDT ROBERT J , DORDICK JONATHAN S , BHASKAR UJJWAL
摘要： A method for the production of heparosan from fermentation culture of E. coli K5 suitable for industrial production, exhibiting superior yield and purity, smaller culture volumes, faster growth, and lower costs.

7. 发明申请

WO2011028668A4 K5 HEPAROSAN FERMENTATION AND PURIFICATION 审中-公开
标题翻译： K5 HEPAROSAN发酵和纯化
公开(公告)号：WO2011028668A4
公开(公告)日：2011-09-09
申请号：PCT/US2010047183
申请日：2010-08-30
申请人： WANG ZHENYU , LINHARDT ROBERT J , DORDICK JONATHAN S , BHASKAR UJJWAL
发明人： WANG ZHENYU , LINHARDT ROBERT J , DORDICK JONATHAN S , BHASKAR UJJWAL
IPC分类号： C12P19/04 , C08B37/10 , C12N1/20
CPC分类号： C08B37/0063 , C08B37/0003 , C12P19/26
摘要： A method for the production of heparosan from fermentation culture of E. coli K5 suitable for industrial production, exhibiting superior yield and purity, smaller culture volumes, faster growth, and lower costs.
摘要翻译：一种适用于工业生产的大肠杆菌K5发酵培养生产肝素的方法，具有优异的产量和纯度，较小的培养体积，更快的生长和更低的成本。

8. 发明申请

WO2011028668A2 K5 HEPAROSAN FERMENTATION AND PURIFICATION 审中-公开
标题翻译： K5 HEPAROSAN发酵和净化
公开(公告)号：WO2011028668A2
公开(公告)日：2011-03-10
申请号：PCT/US2010047183
申请日：2010-08-30
申请人： WANG ZHENYU , LINHARDT ROBERT J , DORDICK JONATHAN S , BHASKAR UJJWAL
发明人： WANG ZHENYU , LINHARDT ROBERT J , DORDICK JONATHAN S , BHASKAR UJJWAL
IPC分类号： C12P19/04 , C08B37/10 , C12N1/20
CPC分类号： C08B37/0063 , C08B37/0003 , C12P19/26
摘要： A method for the production of heparosan from fermentation culture of E. coli K5 suitable for industrial production, exhibiting superior yield and purity, smaller culture volumes, faster growth, and lower costs.
摘要翻译：一种从适于工业生产的大肠杆菌K5发酵培养物生产肝素的方法，其显示出优异的产量和纯度，更小的培养体积，更快的生长和更低的成本。

9. 发明公开

KR20180020914A 코어와 그의 표면에 결합된 시알산, 시알릴락토스 또는 이들의 유도체를 포함하는 결합체 및 그의 용도 审中-公开
标题翻译：包含核心和唾液酸唾液酸内切酶或其衍生物的结合物以及使用它们的结合物
公开(公告)号：KR20180020914A
公开(公告)日：2018-02-28
申请号：KR20170104364
申请日：2017-08-17
申请人： KABIO R&D SOO CO LTD , RENSSELAER POLYTECH INST
发明人： KWAK JONG HWAN , NA DONG HEE , KWON SEOK JOON , LINHARDT ROBERT J , DORDICK JONATHAN S , ZHANG FUMING
IPC分类号： A61K47/58 , A23L33/125 , A61K31/7012 , A61K47/69
CPC分类号： A61K31/7016 , A61K47/6935
摘要： 본발명은코어와그의표면에결합된시알산, 시알릴락토스또는이들의유도체를포함하는결합체및 그의용도에관한것이다. 본발명에서제공하는결합체는인플루엔자바이러스의표면에존재하는헤마글루티닌과결합하여인플루엔자바이러스의감염과정을억제함으로써, 인플루엔자바이러스감염증을예방또는치료할수 있을뿐만아니라, 항바이러스제제에대하여내성을나타내는인플루엔자바이러스에대하여도그의감염증을예방또는치료할수 있으므로, 인플루엔자바이러스감염증의예방또는치료용제제의개발에널리활용될수 있다.
摘要翻译：提供了包含结合到芯表面的核心和唾液酸或其衍生物的缀合物及其用途。本发明提供的缀合物与流感病毒表面上的血凝素结合以抑制流感病毒的感染过程，由此预防或治疗流感病毒的感染并且还预防或治疗对抗病毒剂耐受的流感病毒的感染。因此，缀合物可以广泛用于开发流感病毒感染的预防或治疗剂。

10. 发明公开

EP1943330A4 THREE-DIMENSIONAL CELLULAR ARRAY CHIP AND PLATFORM FOR TOXICOLOGY ASSAYS 审中-公开
标题翻译：元胞阵列芯片和平台进行毒理学测试安排
公开(公告)号：EP1943330A4
公开(公告)日：2009-12-09
申请号：EP06836660
申请日：2006-10-31
申请人： RENSSELAER POLYTECH INST
发明人： LEE MOO-YEAL , KUMAR R ANAND , CLARK DOUGLAS S , DORDICK JONATHAN S
IPC分类号： C12M3/00 , H01L51/00
CPC分类号： G01N33/5014 , B01J19/0046 , B01J2219/00387 , B01J2219/00527 , B01J2219/0065 , B01J2219/00659 , B01J2219/00664 , B01J2219/00743 , C12N2503/00 , C12N2533/54

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